FB2025_05 , released December 11, 2025
Gene: Dmel\Pabp2
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General Information
Symbol
Dmel\Pabp2
Species
D. melanogaster
Name
Pabp2
Annotation Symbol
CG2163
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005648
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Summary
Pabp2 (Pabp2) encodes a nuclear poly(A) binding protein that is involved in both the cleavage and polyadenylation steps of the nuclear cleavage/polyadenylation reaction. Cytoplasmic protein encoded by Pabp2 acts to shorten the poly(A) tails of specific mRNAs in oocytes and syncytial blastoderm embryos. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

PABPN1, rox2

Key Links
Genomic Location
Cytogenetic map
44B3-44B3
Sequence location
Recombination map
2-58
RefSeq locus
NT_033778 REGION:8131431..8134374
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables poly(A) binding
inferred from direct assay
(Benoit et al., 2005)
inferred from direct assay
(Benoit et al., 1999)
enables protein binding
inferred from physical interaction with UniProtKB:Q9VSK8
(Hurt et al., 2009)
enables RNA binding
inferred from direct assay
(Benoit et al., 1999)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables nucleic acid binding
inferred from electronic annotation with InterPro:IPR035979
(InterPro Project Members, 2004-)
enables poly(A) binding
inferred from biological aspect of ancestor with PANTHER:PTN001924388
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with SGD:S000005075
(Mount and Salz, 2000)
enables RNA binding
inferred from electronic annotation with InterPro:IPR000504
(InterPro Project Members, 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
inferred from mutant phenotype
(Benoit et al., 2005)
involved_in mRNA 3'-end processing
inferred from direct assay
(Benoit et al., 1999)
involved_in nuclear-transcribed mRNA poly(A) tail shortening
inferred from mutant phenotype
(Benoit et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in mRNA splicing, via spliceosome
inferred by curator from GO:0071011,GO:0071013
(Herold et al., 2009)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
located_in cytoplasm
inferred from direct assay
(Benoit et al., 1999)
located_in cytosol
inferred from direct assay
(Benoit et al., 2005)
located_in nucleus
inferred from high throughput direct assay
(Sarov et al., 2016)
inferred from direct assay
(Benoit et al., 1999)
inferred from direct assay
(Chartier et al., 2006, Benoit et al., 2005)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002540822
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Pabp2 (Pabp2) encodes a nuclear poly(A) binding protein that is involved in both the cleavage and polyadenylation steps of the nuclear cleavage/polyadenylation reaction. Cytoplasmic protein encoded by Pabp2 acts to shorten the poly(A) tails of specific mRNAs in oocytes and syncytial blastoderm embryos. [Date last reviewed: 2018-09-13]
Protein Function (UniProtKB)
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (PubMed:10481015). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Binds to poly(A) and to poly(G) with high affinity (PubMed:10481015). May protect the poly(A) tail from degradation (By similarity). Plays a role in the positive regulation of alpha-1,3 fucosylation, possibly by cooperating with swm which regulates nuclear export of fucosyltransferase FucTA (PubMed:21203496). Involved in germline stem cell transit amplification, differentiation and mitosis-to-meiosis transition (PubMed:28190776).
(UniProt, Q7KNF2)
Summary (Interactive Fly)

poly(A) binding protein - functions in nuclear polyadenylation - cytoplasmic PABP2 acts to shorten the poly(A) tails of specific mRNAs

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Pabp2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7KNF2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pabp2-RA
FBtr0088785
NM_057554
1869
224
Pabp2-RB
FBtr0088786
NM_165589
1378
224
Additional Transcript Data and Comments
Reported size (kB)

1.7, 1.3, 1.0 (northern blot)

(Benoit et al., 1999)

1.757 (longest cDNA)

(Brand et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Pabp2-PA
FBpp0087863
25.0
224
4.88
Q7KNF2
NP_476902
AAF59127
Pabp2-PB
FBpp0087864
25.0
224
4.88
Q7KNF2
NP_724648
AAM68852
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

224 aa isoforms: Pabp2-PA, Pabp2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

224 (aa); 33 (kD observed)

(Benoit et al., 1999)

224 (aa); 25 (kD predicted)

(Brand et al., 1995)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with ZC3H3.

(UniProt, Q7KNF2)
Domain

The RRM domain is essential for specific adenine bases recognition in the poly(A) tail but not sufficient for poly(A) binding.

(UniProt, Q7KNF2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pabp2 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.01

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Benoit et al., 1999)
embryonic stage 1 -- 2
organism
(Benoit et al., 1999)
embryonic stage 3 -- 4
organism
(Benoit et al., 1999)
embryonic stage 5
cell
• nucleus
(Benoit et al., 1999)
larval stage
(Benoit et al., 1999)
adult stage | female & oogenesis
female germline stem cell
(Benoit et al., 1999)
follicle cell
(Benoit et al., 1999)
female germline stem cell
• nucleus
(Benoit et al., 1999)
follicle cell
• nucleus
(Benoit et al., 1999)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
located_in cytoplasm
inferred from direct assay
(Benoit et al., 1999)
located_in cytosol
inferred from direct assay
(Benoit et al., 2005)
located_in nucleus
inferred from high throughput direct assay
(Sarov et al., 2016)
inferred from direct assay
(Benoit et al., 1999)
inferred from direct assay
(Chartier et al., 2006, Benoit et al., 2005)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Expression Deduced from Reporters
Reporter: P{PTT-GC}Pabp2CC00380
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis & adult stage | female
female germline cell
(Neumüller et al., 2012)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pabp2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pabp2
Transgenic constructs containing regulatory region of Pabp2
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4insc-Mz1407
lethal (with Df(2R)Exel6056)
lethal | female limited, with Scer\GAL4dome-PG14
lethal | first instar larval stage (with Df(2R)CA53)
lethal | first instar larval stage | recessive
lethal | recessive
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die | embryonic stage | germline clone | maternal effect
partially lethal - majority die | embryonic stage | maternal effect
partially lethal - majority die | late embryonic stage (with Df(2R)CA53)
partially lethal - majority die | late embryonic stage | recessive
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.otu
female semi-sterile | recessive
Other Phenotypes
Allele
abnormal locomotor behavior | larval stage
abnormal mitotic cell cycle | embryonic stage | germline clone | maternal effect
abnormal mitotic cell cycle | embryonic stage | maternal effect
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
neoplasia | adult stage | male, with Scer\GAL4VP16.bam
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4nub-AC-62
Phenotype manifest in
Allele
egg chamber | oogenesis stage S8
egg chorion
egg chorion | germline clone
elongation stage spermatid | decreased number, with Scer\GAL4VP16.bam
embryo | germline clone | maternal effect
embryo | maternal effect
female germline cell, with Avic\GFPRNAi.UAS.V22.1, Scer\GAL4VP16.nanos.UTR
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
sarcomere, with Scer\GAL4Mef2.PR
spermatogonium, with Scer\GAL4VP16.bam
testis, with Scer\GAL4VP16.bam
wing vein, with Scer\GAL4nub-AC-62
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (45)
Hsap\PABPN1
13 of 14
Yes
Yes
8  
Hsap\PABPN1L
6 of 14
No
Yes
Hsap\BCL2L2-PABPN1
3 of 14
No
Yes
Hsap\BOLL
1 of 14
No
No
2  
Hsap\CELF4
1 of 14
No
No
Hsap\CIRBP
1 of 14
No
No
Hsap\CSTF2
1 of 14
No
No
Hsap\CSTF2T
1 of 14
No
No
Hsap\DAZAP1
1 of 14
No
No
Hsap\DAZL
1 of 14
No
No
3  
Hsap\EIF4H
1 of 14
No
No
1  
Hsap\EWSR1
1 of 14
No
No
4  
Hsap\HNRNPA1L2
1 of 14
No
No
Hsap\HNRNPA1P48
1 of 14
No
No
Hsap\MSI1
1 of 14
No
No
1  
Hsap\MSI2
1 of 14
No
No
1  
Hsap\NCBP2
1 of 14
No
No
Hsap\PABPC1L
1 of 14
No
No
Hsap\RBM3
1 of 14
No
No
Hsap\RBM7
1 of 14
No
No
Hsap\RBM11
1 of 14
No
No
Hsap\RBM14
1 of 14
No
No
Hsap\RBM14-RBM4
1 of 14
No
No
Hsap\RBM19
1 of 14
No
No
1  
Hsap\RBM23
1 of 14
No
No
Hsap\RBM34
1 of 14
No
No
Hsap\RBM39
1 of 14
No
No
Hsap\RBMY1A1
1 of 14
No
No
Hsap\RBMY1B
1 of 14
No
No
Hsap\RBMY1C
1 of 14
No
Yes
Hsap\RBMY1D
1 of 14
No
No
Hsap\RBMY1E
1 of 14
No
Yes
Hsap\RBMY1F
1 of 14
No
Yes
Hsap\RBMY1J
1 of 14
No
No
Hsap\RNPS1
1 of 14
No
No
Hsap\SART3
1 of 14
No
No
Hsap\SF3B6
1 of 14
No
No
Hsap\SLIRP
1 of 14
No
No
1  
Hsap\SNRNP70
1 of 14
No
No
Hsap\SREK1
1 of 14
No
No
1  
Hsap\SRSF2
1 of 14
No
No
0  
Hsap\SRSF3
1 of 14
No
No
2  
Hsap\SRSF6
1 of 14
No
No
1  
Hsap\SRSF7
1 of 14
No
No
1  
Hsap\ZCRB1
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (19)
Rnor\Pabpn1
13 of 14
Yes
Yes
Rnor\Pabpn1l
7 of 14
No
Yes
Rnor\Cstf2
1 of 14
No
No
Rnor\Cstf2t
1 of 14
No
No
Rnor\Dazap1
1 of 14
No
No
Rnor\Eif4h
1 of 14
No
No
Rnor\Ewsr1
1 of 14
No
No
Rnor\Ncbp2
1 of 14
No
No
Rnor\Rbm3
1 of 14
No
No
Rnor\Rbm11
1 of 14
No
No
Rnor\Rbm19
1 of 14
No
No
Rnor\Rbm34
1 of 14
No
No
Rnor\Rbm39
1 of 14
No
No
Rnor\Rnps1
1 of 14
No
No
Rnor\Sart3
1 of 14
No
No
Rnor\Slirp
1 of 14
No
No
Rnor\Snrnp70
1 of 14
No
No
Rnor\Srek1
1 of 14
No
No
Rnor\Srsf2
1 of 14
No
No
Mus musculus (laboratory mouse) (20)
Mmus\Pabpn1
13 of 14
Yes
Yes
Mmus\Pabpn1l
5 of 14
No
Yes
Mmus\Celf4
1 of 14
No
No
Mmus\Cstf2
1 of 14
No
No
Mmus\Cstf2t
1 of 14
No
No
Mmus\Dazap1
1 of 14
No
No
Mmus\Eif4h
1 of 14
No
No
Mmus\Ewsr1
1 of 14
No
No
Mmus\Gm17190
1 of 14
No
No
Mmus\Ncbp2
1 of 14
No
No
Mmus\Rbm11
1 of 14
No
No
Mmus\Rbm19
1 of 14
No
No
Mmus\Rbm34
1 of 14
No
No
Mmus\Rbm39
1 of 14
No
No
Mmus\Rnps1
1 of 14
No
No
Mmus\Sart3
1 of 14
No
No
Mmus\Slirp
1 of 14
No
No
Mmus\Snrnp70
1 of 14
No
No
Mmus\Srsf2
1 of 14
No
No
Mmus\Tia1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (26)
Xtro\pabpn1
9 of 13
Yes
Yes
Xtro\ccdc181
3 of 13
No
Yes
Xtro\pabpn1l
3 of 13
No
Yes
Xtro\celf5
1 of 13
No
No
Xtro\cirbp
1 of 13
No
No
Xtro\dazap1
1 of 13
No
No
Xtro\hnrnpab
1 of 13
No
No
Xtro\hnrnpd
1 of 13
No
No
Xtro\msi1
1 of 13
No
No
Xtro\msi2
1 of 13
No
No
Xtro\ncbp2
1 of 13
No
No
Xtro\ndufs5
1 of 13
No
No
Xtro\nifk
1 of 13
No
No
Xtro\ralyl
1 of 13
No
No
Xtro\rbm19
1 of 13
No
No
Xtro\rbm34
1 of 13
No
No
Xtro\sf3b6
1 of 13
No
No
Xtro\slirp
1 of 13
No
No
Xtro\snrnp70
1 of 13
No
No
Xtro\srek1
1 of 13
No
No
Xtro\srsf3
1 of 13
No
No
Xtro\srsf7
1 of 13
No
No
Xtro\srsf9
1 of 13
No
No
Xtro\tia1
1 of 13
No
No
Xtro\tram2
1 of 13
No
No
Xtro\zcrb1
1 of 13
No
Yes
Danio rerio (Zebrafish) (29)
Drer\pabpn1
12 of 14
Yes
Yes
Drer\pabpn1l
8 of 14
No
Yes
Drer\cstf2
1 of 14
No
No
Drer\dazap1
1 of 14
No
No
Drer\eif4h
1 of 14
No
No
Drer\hnrnpa0l
1 of 14
No
No
Drer\hnrnpa1b
1 of 14
No
No
Drer\hnrnpaba
1 of 14
No
No
Drer\hnrnpabb
1 of 14
No
No
Drer\hnrnpd
1 of 14
No
No
Drer\hnrnpdl
1 of 14
No
No
Drer\msi1b
1 of 14
No
No
Drer\msi2a
1 of 14
No
No
Drer\msi2b
1 of 14
No
No
Drer\ncbp2
1 of 14
No
No
Drer\nono
1 of 14
No
No
Drer\pabpc1l
1 of 14
No
No
Drer\ppil4
1 of 14
No
No
Drer\rbm34
1 of 14
No
No
Drer\rbm38
1 of 14
No
No
Drer\rbm39a
1 of 14
No
No
Drer\rbm39b
1 of 14
No
No
Drer\sart3
1 of 14
No
No
Drer\slirp
1 of 14
No
No
Drer\snrnp70
1 of 14
No
No
Drer\srek1
1 of 14
No
No
Drer\srsf2a
1 of 14
No
No
Drer\srsf2b
1 of 14
No
No
Drer\tial1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (34)
Cele\pabp-2
14 of 14
Yes
Yes
Cele\EEED8.4
7 of 14
No
Yes
Cele\EEED8.12
7 of 14
No
Yes
Cele\sgnh-1
6 of 14
No
Yes
Cele\T08B6.1
3 of 14
No
Yes
Cele\C38C6.5
1 of 14
No
Yes
Cele\cpf-2
1 of 14
No
No
Cele\eif-3.G
1 of 14
No
No
Cele\msi-1
1 of 14
No
No
Cele\ncbp-2
1 of 14
No
No
Cele\R06C1.4
1 of 14
No
No
Cele\rbm-3.1
1 of 14
No
No
Cele\rbm-3.2
1 of 14
No
No
Cele\rbm-25
1 of 14
No
No
Cele\rbm-34
1 of 14
No
No
Cele\rbm-39
1 of 14
No
No
Cele\rnp-5
1 of 14
No
No
Cele\rnp-7
1 of 14
No
No
Cele\rsp-2
1 of 14
No
No
Cele\rsp-3
1 of 14
No
No
Cele\rsp-4
1 of 14
No
No
Cele\rsp-6
1 of 14
No
No
Cele\rsp-7
1 of 14
No
No
Cele\sart-3
1 of 14
No
No
Cele\sig-7
1 of 14
No
No
Cele\slrp-1
1 of 14
No
No
Cele\sqd-1
1 of 14
No
No
Cele\T08B6.9
1 of 14
No
Yes
Cele\uaf-1
1 of 14
No
No
Cele\Y51H4A.22
1 of 14
No
Yes
Cele\Y51H4A.23
1 of 14
No
Yes
Cele\Y57G11A.5
1 of 14
No
No
Cele\ZK1225.4
1 of 14
No
Yes
Cele\ZK1225.5
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (25)
Agam\AgaP_AGAP005117
12 of 12
Yes
Yes
Agam\AgaP_AGAP000399
1 of 12
No
No
Agam\AgaP_AGAP000526
1 of 12
No
No
Agam\AgaP_AGAP000977
1 of 12
No
No
Agam\AgaP_AGAP001883
1 of 12
No
No
Agam\AgaP_AGAP002256
1 of 12
No
No
Agam\AgaP_AGAP002959
1 of 12
No
No
Agam\AgaP_AGAP003171
1 of 12
No
No
Agam\AgaP_AGAP003173
1 of 12
No
No
Agam\AgaP_AGAP003899
1 of 12
No
No
Agam\AgaP_AGAP004414
1 of 12
No
No
Agam\AgaP_AGAP006668
1 of 12
No
No
Agam\AgaP_AGAP006755
1 of 12
No
No
Agam\AgaP_AGAP007325
1 of 12
No
No
Agam\AgaP_AGAP008303
1 of 12
No
No
Agam\AgaP_AGAP008433
1 of 12
No
No
Agam\AgaP_AGAP009142
1 of 12
No
No
Agam\AgaP_AGAP009179
1 of 12
No
No
Agam\AgaP_AGAP009570
1 of 12
No
No
Agam\AgaP_AGAP009742
1 of 12
No
No
Agam\AgaP_AGAP009952
1 of 12
No
No
Agam\AgaP_AGAP010918
1 of 12
No
No
Agam\AgaP_AGAP013048
1 of 12
No
No
Agam\AgaP_AGAP013420
1 of 12
No
Yes
Agam\NCBP2_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (71)
Atha\AT5G10350
13 of 13
Yes
Yes
Atha\AT5G65260
13 of 13
Yes
Yes
Atha\PABN1
12 of 13
No
Yes
Atha\AtRZ-1b
2 of 13
No
Yes
Atha\AT1G01080
1 of 13
No
No
Atha\AT1G17640
1 of 13
No
No
Atha\AT1G72800
1 of 13
No
Yes
Atha\AT1G73490
1 of 13
No
Yes
Atha\AT2G16940
1 of 13
No
No
Atha\AT2G19380
1 of 13
No
No
Atha\AT2G22100
1 of 13
No
No
Atha\AT2G24350
1 of 13
No
Yes
Atha\AT2G27330
1 of 13
No
Yes
Atha\AT2G33410
1 of 13
No
No
Atha\AT2G35410
1 of 13
No
No
Atha\AT2G37220
1 of 13
No
No
Atha\AT2G43370
1 of 13
No
No
Atha\AT3G07810
1 of 13
No
No
Atha\AT3G12640
1 of 13
No
No
Atha\AT3G15010
1 of 13
No
No
Atha\AT3G23900
1 of 13
No
No
Atha\AT4G14300
1 of 13
No
No
Atha\AT4G19610
1 of 13
No
No
Atha\AT4G26650
1 of 13
No
No
Atha\AT5G03480
1 of 13
No
Yes
Atha\AT5G04600
1 of 13
No
No
Atha\AT5G06210
1 of 13
No
Yes
Atha\AT5G08695
1 of 13
No
No
Atha\AT5G09880
1 of 13
No
No
Atha\AT5G19350
1 of 13
No
No
Atha\AT5G40490
1 of 13
No
No
Atha\AT5G47620
1 of 13
No
No
Atha\AT5G51730
1 of 13
No
Yes
Atha\AT5G53700
1 of 13
No
Yes
Atha\ATRZ-1A
1 of 13
No
No
Atha\AtRZ-1c
1 of 13
No
Yes
Atha\CBP20
1 of 13
No
No
Atha\CID8
1 of 13
No
No
Atha\CID9
1 of 13
No
No
Atha\CID10
1 of 13
No
No
Atha\CID11
1 of 13
No
No
Atha\CID12
1 of 13
No
Yes
Atha\CID13
1 of 13
No
No
Atha\CP33
1 of 13
No
No
Atha\CSTF64
1 of 13
No
No
Atha\CYP59
1 of 13
No
No
Atha\EMB140
1 of 13
No
No
Atha\GRP4
1 of 13
No
No
Atha\GR-RBP3
1 of 13
No
Yes
Atha\GR-RBP5
1 of 13
No
Yes
Atha\LIF2
1 of 13
No
No
Atha\ML4
1 of 13
No
Yes
Atha\NUC-L1
1 of 13
No
No
Atha\NUC-L2
1 of 13
No
No
Atha\PAB2
1 of 13
No
No
Atha\PAB4
1 of 13
No
No
Atha\PAB7
1 of 13
No
No
Atha\PHIP1
1 of 13
No
No
Atha\PSRP2
1 of 13
No
No
Atha\RBP45A
1 of 13
No
No
Atha\RSZ21
1 of 13
No
No
Atha\RSZ22a
1 of 13
No
No
Atha\RSZ22
1 of 13
No
No
Atha\SC35
1 of 13
No
No
Atha\SR30
1 of 13
No
No
Atha\SR34a
1 of 13
No
No
Atha\SR34
1 of 13
No
No
Atha\SR34b
1 of 13
No
No
Atha\U1-70K
1 of 13
No
No
Atha\U11/U12-31K
1 of 13
No
Yes
Atha\UBA1A
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (13)
Scer\SGN1
9 of 13
Yes
Yes
Scer\CBC2
1 of 13
No
No
Scer\GBP2
1 of 13
No
No
Scer\HRB1
1 of 13
No
No
Scer\MRD1
1 of 13
No
No
Scer\NOP12
1 of 13
No
No
Scer\NOP13
1 of 13
No
Yes
Scer\NOP15
1 of 13
No
No
Scer\PUB1
1 of 13
No
No
Scer\RNA15
1 of 13
No
No
Scer\RNP1
1 of 13
No
Yes
Scer\SBP1
1 of 13
No
Yes
Scer\SNP1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (15)
Spom\pab2
11 of 12
Yes
Yes
Spom\ctf1
1 of 12
No
No
Spom\cwf29
1 of 12
No
No
Spom\gar2
1 of 12
No
No
Spom\nop12
1 of 12
No
No
Spom\rnp24
1 of 12
No
Yes
Spom\rsd1
1 of 12
No
No
Spom\SPAC25G10.01
1 of 12
No
No
Spom\SPAC644.16
1 of 12
No
No
Spom\SPBC13A2.01c
1 of 12
No
No
Spom\SPBC365.04c
1 of 12
No
No
Spom\SPBC660.15
1 of 12
No
No
Spom\SPBC1861.04c
1 of 12
No
No
Spom\SPBP22H7.02c
1 of 12
No
No
Spom\usp101
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Pabp2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (24)
Caper
1 of 13
Cbp20
1 of 13
CG3335
1 of 13
CG3594
1 of 13
CG6937
1 of 13
CG11454
1 of 13
CG12288
1 of 13
CstF64
1 of 13
eIF4H1
1 of 13
eIF4H2
1 of 13
Hrb87F
1 of 13
Hrb98DE
1 of 13
msi
1 of 13
Rb97D
1 of 13
Rbp1-like
1 of 13
Rbp1
1 of 13
RnpS1
1 of 13
Rsf1
1 of 13
SC35
1 of 13
Sf3b6
1 of 13
snRNP-U1-70K
1 of 13
sqd
1 of 13
U2af50
1 of 13
x16
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
PABPN1; poly(A) binding protein nuclear 1
model of  oculopharyngeal muscular dystrophy
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PABPN1; poly(A) binding protein nuclear 1
13 of 14
POLYADENYLATE-BINDING PROTEIN, NUCLEAR, 1; PABPN1
 
PABPN1L; PABPN1 like, cytoplasmic
6 of 14
      BCL2L2-PABPN1; BCL2L2-PABPN1 readthrough
      3 of 14
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          dom
          enhanceable
          Pabp2
          (Kwon et al., 2013)
          mam
          enhanceable
          Pabp2
          (Kwon et al., 2013)
          Nab2
          enhanceable
          Pabp2
          (Lee et al., 2020, Pak et al., 2011)
          Nab2
          suppressible
          Pabp2
          (Pak et al., 2011)
          orb
          suppressible
          Pabp2
          (Benoit et al., 2005)
          Rbf
          enhanceable
          Pabp2
          (Kwon et al., 2013)
          External Data
          Subunit Structure (UniProtKB)
          Interacts with ZC3H3.
          (UniProt, Q7KNF2 )
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Linkouts
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-58
          Cytogenetic map
          44B3-44B3
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          44B3-44B3
          Limits computationally determined from genome sequence between P{lacW}Vps28k16503 and P{EP}kermitEP493
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          44B-44B
          (Bourbon, 1998.12.23)
          Experimentally Determined Recombination Data
          Location

          2-58

          (FlyBase, 2016)

          2-57.4

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (20)
          Genomic Clones (14)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (84)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          monoclonal

          (Na et al., 2016)

          polyclonal

          (Benoit et al., 1999)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

              (Boutros et al., 2004)

              Pabp2 stimulates poly(A) polymerase and is able to control poly(A) tail length in vitro.

              (Benoit et al., 1999)

              Pabp2 is identified as an RRM-type RNA-binding protein that may control important aspects of development.

              (Brand et al., 1995)
              Relationship to Other Genes
              Source for database merge of
              Additional comments
              Nomenclature History
              Source for database identify of

              Source for identity of: Rox2 CG2163

              (Heiman, 1999.11)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (13)
              Reported As
              Symbol Synonym
              CG2163
              (National Institute of Genetics Fly Stocks, 2022-, Na et al., 2016, Horan et al., 2015, Hosono et al., 2015, Fukuoh et al., 2014, White-Grindley et al., 2014, Schertel et al., 2013, Ellis and Carney, 2010, Ni et al., 2010.12.1, Yamamoto-Hino et al., 2010, Herold et al., 2009, Keleman et al., 2009.8.5, Behm-Ansmant et al., 2007, Quinones-Coello, 2007, Mount and Salz, 2000)
              PABP2
              (Layalle et al., 2021, Liguori et al., 2021, Potikanond et al., 2018, Chou et al., 2015, Bradley et al., 2012, Chartier et al., 2006)
              PABPN1
              (Singer and Gall, 2011, Behm-Ansmant et al., 2007)
              Pabp2
              (Malik et al., 2021, Pennemann et al., 2021, Meltzer et al., 2019, Gene Disruption Project members, 2018-, Podolsky et al., 2018, Shan et al., 2017, Transgenic RNAi Project members, 2017-, Na et al., 2016, Rathore et al., 2016, Sarov et al., 2016, Sysoev et al., 2016, Chartier et al., 2015, Horan et al., 2015, Khan et al., 2015, White-Grindley et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Zhan et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Neumüller et al., 2012, Lindquist et al., 2011, Neumüller et al., 2011, Pak et al., 2011, Waldholm et al., 2011, Ellis and Carney, 2010, Yamamoto-Hino et al., 2010, Clements et al., 2009, Herold et al., 2009, Hurt et al., 2009, Christensen et al., 2008.12.28, Farny et al., 2008, McDermott and Kliman, 2008, Buszczak et al., 2007, Quinones-Coello, 2007, Stuart et al., 2007, Zhang et al., 2007, Larsen et al., 2006, Liebl et al., 2006, Benoit et al., 2005, Staudt et al., 2005)
              ROX2
              (Brand et al., 1995)
              Rox2
              dpabII
              (Benoit et al., 1999)
              pAbp2
              (Berson et al., 2019, Lasko, 2000)
              pabp2
              (Lefebvre et al., 2016, Czech et al., 2013, Kwon et al., 2013, Singer and Gall, 2011, Sofola et al., 2007, Clyne et al., 2003)
              rox2
              (Temme et al., 2009, Brand, 1994)
              Name Synonyms
              Pabp2
              nuclear poly(A)-binding protein
              (Temme et al., 2009)
              poly-A binding protein 2
              (Zhan et al., 2013)
              polyA-binding protein II
              (Benoit et al., 1999)
              Secondary FlyBase IDs
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 59 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (120)