FlyBase Allele Report: Dmel\Pabp2[EP2264]

General Information

Symbol

Dmel\Pabp2^EP2264

Species

D. melanogaster

Name

FlyBase ID

FBal0130834

Feature type

allele

Associated gene

Dmel\Pabp2

Associated Insertion(s)

P{EP}Pabp2^EP2264

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Benoit et al., 2005)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EP}Pabp2^EP2264

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:8,131,920..8,131,920 [+]

(Sofola et al., 2007, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal recessive intellectual developmental disorder 56

modeled by Nab2^ex3

(Pak et al., 2011)

ameliorates autosomal recessive intellectual developmental disorder

modeled by Nab2^EP3716

(Bienkowski et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | first instar larval stage (with Df(2R)CA53)

(Benoit et al., 2005)

lethal | first instar larval stage | recessive

(Benoit et al., 2005)

partially lethal - majority die | embryonic stage | germline clone | maternal effect

(Benoit et al., 2005)

partially lethal - majority die | late embryonic stage (with Df(2R)CA53)

(Benoit et al., 2005)

Phenotype Manifest In

egg chorion | germline clone

(Benoit et al., 2005)

embryo | germline clone | maternal effect

(Benoit et al., 2005)

Detailed Description

Statement

Reference

Pabp2^EP2264 homozygous germ-line clones are recovered at an incidence 30X lower than wild-type clones. About half the resulting embryos fail to hatch, and of those that do, 10% show chorion or embryonic patterning defects.

(Benoit et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Pabp2^EP2264, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Pak et al., 2011)

Pabp2^EP2264/Pabp2[+] is a suppressor of partially lethal - majority die | maternal effect | embryonic stage phenotype of orb^mel

(Benoit et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Pabp2^EP2264, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Pak et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Pabp2^EP2264 significantly suppresses the rough eye phenotype caused by expression of Nab2^EP3716 under the control of Scer\GAL4^GMR.PU.

(Pak et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Pabp2^EP2264 is rescued by Pabp2^EP2264/Scer\GAL4^da.G32

(Benoit et al., 2005)

Pabp2^EP2264/Df(2R)CA53 is rescued by Pabp2^+t.g

(Benoit et al., 2005)

Partially rescued by

Pabp2^EP2264 is partially rescued by Pabp2^I61S.g

(Benoit et al., 2005)

Rescues

Pabp2^EP2264/Scer\GAL4^da.G32 rescues Pabp2^EP2264

(Benoit et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Pabp2^EP2264

(Bienkowski et al., 2017, Pak et al., 2011, Benoit et al., 2005)

pabp2^EP2264

(Sofola et al., 2007)

pabp^EP2264

(Kanke et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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