FlyBase Gene Report: Hsap\TARDBP

CEA

(Li et al., 2010)

CEA

(Guo et al., 2011)

CEC

(Wang et al., 2019)

Hsap\TARDBP^WT.UAS

CEA

(Voigt et al., 2010)

CEA

(Khalil et al., 2017)

Hsap\TARDBP^A315T.UAS

CEA

(Voigt et al., 2010)

Hsap\TARDBP^UAS.cHa

CEA

(Deshpande et al., 2016, Zhan et al., 2013, Kim et al., 2012, Hanson et al., 2010)

Hsap\TARDBP^UAS.YFP.cEa

CEA

(Coyne et al., 2015, Joardar et al., 2015, Estes et al., 2011)

Hsap\TARDBP^WT.UAS.GFP

model of neurodegenerative disease

CEA

(Hans et al., 2014)

Hsap\TARDBP^{A315T.UAS.YFP}

CEA

(Estes et al., 2013, Estes et al., 2011)

Hsap\TARDBP^{D169G.UAS.YFP}

CEA

(Estes et al., 2013)

Hsap\TARDBP^{G298S.UAS.YFP}

CEA

(Coyne et al., 2015, Joardar et al., 2015, Estes et al., 2013)

Hsap\TARDBP^{N345K.UAS.YFP}

CEA

(Estes et al., 2013)

Hsap\TARDBP^UAS.cEa

CEA

(Elden et al., 2010)

CEA

(Altanbyek et al., 2016)

Hsap\TARDBP^Q331K.UAS

CEA

(Elden et al., 2010)

Hsap\TARDBP^UAS.YFP

Hsap\TARDBP^{TDP-25.UAS.Tag:HA}

CEA

(Elden et al., 2010)

Hsap\TARDBP^UAS.Tag:HA

model of neurodegenerative disease

CEA

(Gregory et al., 2012)

model of neurodegenerative disease

CEA

(Gregory et al., 2012)

Hsap\TARDBP^{M.UAS.Tag:FLAG}

model of neurodegenerative disease

CEA

(Miguel et al., 2011)

CEA

(Couly et al., 2020)

Hsap\TARDBP^mutNLS.UAS

model of neurodegenerative disease

CEA

(Miguel et al., 2011)

Hsap\TARDBP^{ΔN251.UAS.EGFP}

Hsap\TARDBP^{S5A.ΔN251.UAS.EGFP}

CEA

(Li et al., 2011)

model of frontotemporal dementia

CEA

(Li et al., 2011)

CEA

(Li et al., 2011)

model of frontotemporal dementia

CEA

(Li et al., 2011)

Hsap\TARDBP^UAS.Tag:FLAG

Hsap\TARDBP^{AggIn.UAS.Tag:FLAG}

CEA with TBPH^Δ23

(Romano et al., 2015)

Hsap\TARDBP^{TDP-35.UAS.Tag:HA}

CEA

(Langellotti et al., 2016)

model of neurodegenerative disease

CEA

(Crippa et al., 2016)

Hsap\TARDBP^UAS.cIa

CEA

(Ihara et al., 2013)

CEA

(Matsukawa et al., 2016)

Hsap\TARDBP^G298S.UAS

CEA

(Ihara et al., 2013)

Hsap\TARDBP^{A315T.UAS.cIa}

CEA

(Ihara et al., 2013)

Hsap\TARDBP^{M337V.UAS.cIa}

CEA

(Ihara et al., 2013)

Hsap\TARDBP^Q343R.UAS

CEA

(Ihara et al., 2013)

Hsap\TARDBP^NLSmt.UAS

CEA

(Ihara et al., 2013)

Hsap\TARDBP^{NLSmut.G298S.UAS}

CEA

(Matsukawa et al., 2016)

Hsap\TARDBP^{NLSmut.M337V.UAS}

CEA

(Ihara et al., 2013)

CEA

(Ihara et al., 2013)

Hsap\TARDBP^UAS.Tag:MYC

Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}

CEA

(Uechi et al., 2018)

model of neurodegenerative disease

CEA

(Crippa et al., 2016, Ritson et al., 2010)

Hsap\TARDBP^{Δ1-79.UAS.Tag:MYC}

model of neurodegenerative disease

CEA

(Ritson et al., 2010)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}

CEA

(Uechi et al., 2018, Crippa et al., 2016)

model of neurodegenerative disease

CEA

(Ritson et al., 2010)

CEA

(Periz et al., 2015)

Hsap\TARDBP^ΔN.UAS

CEA

(Ishiguro et al., 2017)

Hsap\TARDBP^{Q331K.UAS.cLa}

CEA

(Choksi et al., 2014)

Hsap\TARDBP^ΔC.UAS

DOES NOT model amyotrophic lateral sclerosis

CEA

(Ishiguro et al., 2017)

Hsap\TARDBP^RRM.UAS

DOES NOT model amyotrophic lateral sclerosis

CEA

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb

CEA

(Ishiguro et al., 2017)

Hsap\TARDBP^{G298S.UAS.cIb}

CEA

(Ishiguro et al., 2017)

Hsap\TARDBP^{Q331K.UAS.cSa}

CEA

(Sreedharan et al., 2015)

Hsap\TARDBP^{12xQN.UAS.EGFP}

CEA

(Cragnaz et al., 2015)

CEA with TBPH^Δ23

(Cragnaz et al., 2015)

CEA with TBPH^GD6943

(Cragnaz et al., 2015)

Hsap\TARDBP^{N267S.UAS.cMa}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{G298S.UAS.cMa}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{A315T.UAS.cLa}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{M337V.UAS.cMa}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{Q343R.UAS.cMa}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{N267S.UAS.TDPBR}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{G298S.UAS.TDPBR}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{A315T.UAS.TDPBR}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{M337V.UAS.TDPBR}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{Q343R.UAS.TDPBR}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^UAS.cDa

CEC

(Duan et al., 2019)

Hsap\TARDBP^{A315T.UAS.Venus}

CEA

(Alami et al., 2014)

Hsap\TARDBP^{M337V.UAS.Venus}

Hsap\TARDBP^{A315T.UAS.RFP(Unk)}

CEA

(Alami et al., 2014)

Hsap\TARDBP^{UAS.cKa.Tag:FLAG}

CEA

(Xu et al., 2019, Guo et al., 2011)

CEC

(Wang et al., 2019)

Hsap\TARDBP^{G298S.UAS.Tag:FLAG}

CEA

(Khalil et al., 2017)

Hsap\TARDBP^{UAS.Tag:HA,RFP(Unk)}

CEA

(Khalil et al., 2017)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 37 )

Allele

Disease

Interaction

References

is exacerbated by Lon^GD14030

(Wang et al., 2019)

is exacerbated by Lon^TRiP.cUa

(Wang et al., 2019)

Hsap\TARDBP^UAS.cHa

Hsap\TARDBP^{UAS.x10.Tag:FLAG}

is ameliorated by Dad^j1E4

(Deshpande et al., 2016)

is ameliorated by Rab11^N124I.UAS

(Deshpande et al., 2016)

is exacerbated by Hsap\UBQLN1^UAS.cHa

(Hanson et al., 2010)

is ameliorated by Itpr^ug3

(Kim et al., 2012)

is ameliorated by Itpr^sv35

(Kim et al., 2012)

is ameliorated by Itpr^90B.0

(Kim et al., 2012)

is ameliorated by TBPH^Δ142

(Zhan et al., 2013)

is ameliorated by stg^EY12388

(Zhan et al., 2013)

ameliorates amyotrophic lateral sclerosis

modeled by TBPH^Δ23, TBPH¹

(Baldwin et al., 2016)

Hsap\TARDBP^UAS.YFP.cEa

Hsap\TARDBP^{M337V.UAS.x10.Tag:FLAG}

is ameliorated by Fmr1^UAS.YFP

(Coyne et al., 2015)

is exacerbated by Fmr1^GD1288

(Coyne et al., 2015)

is exacerbated by Fmr1^Δ50M

(Coyne et al., 2015)

is ameliorated by BacA\p35^UAS.cHa

(Estes et al., 2011)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Estes et al., 2011)

is exacerbated by Prosβ2^1.UAS

(Estes et al., 2011)

is exacerbated by Pabp2⁵⁵

(Chou et al., 2015)

is ameliorated by futsch^EP1419

(Coyne et al., 2014)

ameliorates amyotrophic lateral sclerosis

modeled by TBPH^Δ23, TBPH¹

(Baldwin et al., 2016)

Hsap\TARDBP^WT.UAS.GFP

model of neurodegenerative disease

is exacerbated by Usp8^KK100733

(Hans et al., 2014)

Hsap\TARDBP^{A315T.UAS.YFP}

is exacerbated by Prosβ2^1.UAS

(Estes et al., 2011)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Estes et al., 2011)

is ameliorated by BacA\p35^UAS.cHa

(Estes et al., 2011)

is exacerbated by Pabp2⁵⁵

(Chou et al., 2015)

Hsap\TARDBP^{D169G.UAS.YFP}

is exacerbated by Pabp2⁵⁵

(Chou et al., 2015)

Hsap\TARDBP^{G298S.UAS.YFP}

is ameliorated by Fmr1^UAS.YFP

(Coyne et al., 2015)

is exacerbated by Fmr1^GD1288

(Coyne et al., 2015)

is exacerbated by Fmr1^Δ50M

(Coyne et al., 2015)

is exacerbated by Pabp2⁵⁵

(Chou et al., 2015)

is ameliorated by futsch^EP1419

(Coyne et al., 2014)

Hsap\TARDBP^UAS.cEa

Hsap\TARDBP^{TDP-25.UAS.Tag:HA}

is ameliorated by Atx2^X1

(Elden et al., 2010)

is exacerbated by Atx2^EP3145

(Elden et al., 2010)

is ameliorated by PEK^GL00030

(Kim et al., 2014)

is ameliorated by pAbp^JF03104

(Kim et al., 2014)

is exacerbated by pAbp^UAS.cSa

(Kim et al., 2014)

is exacerbated by Hsap\ATXN2^32Q.UAS

(Kim et al., 2014)

is ameliorated by Rox8^HMS00472

(Kim et al., 2014)

is exacerbated by PPP1R15^HMS00811

(Kim et al., 2014)

Hsap\TARDBP^UAS.Tag:HA

model of neurodegenerative disease

is ameliorated by CG14207^EP1348

(Gregory et al., 2012)

model of neurodegenerative disease

is ameliorated by CG14207^EP1348

(Gregory et al., 2012)

Hsap\TARDBP^{M.UAS.Tag:FLAG}

Hsap\TARDBP^{TDP-35.UAS.Tag:HA}

is ameliorated by Hsap\SIGMAR1^UAS.cCa

(Couly et al., 2020)

Hsap\TARDBP^UAS.Tag:FLAG

ameliorates neurodegenerative disease

modeled by TBPH^Δ23

(Feiguin et al., 2009)

model of neurodegenerative disease

is ameliorated by Hsp67Bc^UAS.Tag:V5

(Crippa et al., 2016)

Hsap\TARDBP^UAS.cIa

is NOT exacerbated by Hsap\PFN1^UAS.cMa

(Matsukawa et al., 2016)

is exacerbated by Hsap\PFN1^C71G.UAS

(Matsukawa et al., 2016)

is exacerbated by Hsap\PFN1^M114T.UAS

(Matsukawa et al., 2016)

is NOT exacerbated by chic^NIG.9553R

(Matsukawa et al., 2016)

Hsap\TARDBP^NLSmt.UAS

is NOT exacerbated by Hsap\PFN1^M114T.UAS

(Matsukawa et al., 2016)

is NOT exacerbated by Hsap\PFN1^UAS.cMa

(Matsukawa et al., 2016)

is NOT exacerbated by Hsap\PFN1^C71G.UAS

(Matsukawa et al., 2016)

Hsap\TARDBP^UAS.Tag:MYC

Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}

is exacerbated by CG5445^NIG.5445R

(Uechi et al., 2018)

is ameliorated by CG5445^UAS.cUa

(Uechi et al., 2018)

exacerbates neurodegenerative disease

modeled by TER94^R152H.UAS.R

(Ritson et al., 2010)

exacerbates neurodegenerative disease

modeled by TER94^R152H.UAS.R

(Ritson et al., 2010)

model of neurodegenerative disease

is ameliorated by Hsp67Bc^UAS.Tag:V5

(Crippa et al., 2016)

Hsap\TARDBP^{NESmut.UAS.Tag:MYC}

exacerbates neurodegenerative disease

modeled by TER94^R152H.UAS.R

(Ritson et al., 2010)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}

is ameliorated by CG5445^UAS.cUa

(Uechi et al., 2018)

is exacerbated by CG5445^NIG.5445R

(Uechi et al., 2018)

is ameliorated by Rpn11^UAS.cTa

(Uechi et al., 2018)

is ameliorated by Hsp67Bc^UAS.Tag:V5

(Crippa et al., 2016)

is ameliorated by Ube4B^JF02691

(Periz et al., 2015)

Hsap\TARDBP^ΔN.UAS

ameliorates spinocerebellar ataxia type 31

modeled by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^{Q331K.UAS.cLa}

is exacerbated by dco^UAS.cUa

(Choksi et al., 2014)

Hsap\TARDBP^ΔC.UAS

ameliorates spinocerebellar ataxia type 31

modeled by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cLa

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Galloway et al., 2014)

Hsap\TARDBP^RRM.UAS

DOES NOT ameliorate spinocerebellar ataxia type 31

modeled by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb

is ameliorated by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

is ameliorated by Zzzz\UGGAA^22.UAS

(Ishiguro et al., 2017)

ameliorates spinocerebellar ataxia type 31

modeled by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^{G298S.UAS.cIb}

is ameliorated by Zzzz\UGGAA^22.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^{Q331K.UAS.cSa}

is ameliorated by htk³⁹

(Sreedharan et al., 2015)

is ameliorated by xmas⁴⁵

(Sreedharan et al., 2015)

is ameliorated by sgg^J11

(Sreedharan et al., 2015)

is ameliorated by htk⁷¹

(Sreedharan et al., 2015)

is ameliorated by xmas^f04114

(Sreedharan et al., 2015)

is ameliorated by htk⁴⁷

(Sreedharan et al., 2015)

Hsap\TARDBP^{D169G.UAS.cVBa}

modeled by TBPH^Δ142, TBPH^Δ23

(Vanden Broeck et al., 2015)

Hsap\TARDBP^UAS.cVBa

modeled by TBPH^Δ142, TBPH^Δ23

(Vanden Broeck et al., 2015)

Hsap\TARDBP^{12xQN.UAS.EGFP}

modeled by TBPH^{UAS.cCa.Tag:FLAG}

(Cragnaz et al., 2014)

Hsap\TARDBP^UAS.cDa

is ameliorated by Parg^UAS.cHa

(Duan et al., 2019)

is ameliorated by Parp^HMC04658

(Duan et al., 2019)

Hsap\TARDBP^CTR.UAS

Hsap\TARDBP^{A315T.UAS.RFP(Unk)}

modeled by TBPH^Δ23

(Donde et al., 2019)

Hsap\TARDBP^{UAS.cKa.Tag:FLAG}

is exacerbated by Lon^GD14030

(Wang et al., 2019)

is exacerbated by Lon^TRiP.cUa

(Wang et al., 2019)

Hsap\TARDBP^{G298S.UAS.Tag:FLAG}

is ameliorated by Marf^{UAS.cSa.Tag:HA}

(Khalil et al., 2017)

is ameliorated by Drp1¹

(Khalil et al., 2017)