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Citation
Bolus, H., Crocker, K., Boekhoff-Falk, G., Chtarbanova, S. (2020). Modeling Neurodegenerative Disorders in Drosophila melanogaster.  Int. J. Mol. Sci. 21(9): E3055.
FlyBase ID
FBrf0245506
Publication Type
Review
Abstract

Drosophila melanogaster provides a powerful genetic model system in which to investigate the molecular mechanisms underlying neurodegenerative diseases. In this review, we discuss recent progress in Drosophila modeling Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington's Disease, Ataxia Telangiectasia, and neurodegeneration related to mitochondrial dysfunction or traumatic brain injury. We close by discussing recent progress using Drosophila models of neural regeneration and how these are likely to provide critical insights into future treatments for neurodegenerative disorders.

PubMed ID
PubMed Central ID
PMC7246467 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Int. J. Mol. Sci.
    Title
    International journal of molecular sciences
    ISBN/ISSN
    1422-0067
    Data From Reference