FB2025_05 , released December 11, 2025
Gene: Dmel\Lrrk
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General Information
Symbol
Dmel\Lrrk
Species
D. melanogaster
Name
Leucine-rich repeat kinase
Annotation Symbol
CG5483
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038816
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

LRRK2, dLRRK, dLrrk2

Key Links
Genomic Location
Cytogenetic map
92F3-92F4
Sequence location
Recombination map
3-69
RefSeq locus
NT_033777 REGION:20635480..20644279
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (34 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:Q9W596
(Lee et al., 2010)
enables protein kinase activity
inferred from direct assay
(Imai et al., 2008)
enables protein serine/threonine kinase activity
inferred from direct assay
(Matta et al., 2012, Kanao et al., 2010)
inferred from mutant phenotype
(Chuang et al., 2014, Imai et al., 2008)
enables small GTPase binding
inferred from physical interaction with FLYBASE:Rab18; FB:FBgn0015794
(Gillingham et al., 2014)
inferred from physical interaction with FLYBASE:Rab5; FB:FBgn0014010
(Dodson et al., 2012)
inferred from physical interaction with FLYBASE:Rab7; FB:FBgn0015795
(Dodson et al., 2012)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(InterPro Project Members, 2004-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271
(InterPro Project Members, 2004-)
Biological Process (18 terms)
Terms Based on Experimental Evidence (18 terms)
CV Term
Evidence
References
involved_in autophagy
inferred from mutant phenotype
(Dodson et al., 2014)
involved_in axo-dendritic transport
inferred from mutant phenotype
(Godena et al., 2014)
involved_in cellular response to starvation
inferred from mutant phenotype
(Soukup et al., 2016)
involved_in establishment of Golgi localization
inferred from mutant phenotype
(Lin et al., 2015)
involved_in intracellular distribution of mitochondria
inferred from mutant phenotype
(Lee et al., 2010)
involved_in locomotion
inferred from mutant phenotype
(Godena et al., 2014)
involved_in lysosome localization
inferred from mutant phenotype
(Dodson et al., 2012)
inferred from genetic interaction with FLYBASE:Rab7; FB:FBgn0015795
(Dodson et al., 2012)
involved_in negative regulation of dendrite morphogenesis
inferred from mutant phenotype
(Lin et al., 2015)
acts_upstream_of negative regulation of neuron apoptotic process
inferred from mutant phenotype
(Chuang et al., 2014)
involved_in neuromuscular junction development
inferred from mutant phenotype
(Lee et al., 2010)
involved_in regulation of autophagosome assembly
inferred from mutant phenotype
(Soukup et al., 2016)
involved_in regulation of microtubule cytoskeleton organization
inferred from mutant phenotype
(Lee et al., 2010)
involved_in regulation of synapse maturation
inferred from mutant phenotype
(Lee et al., 2010)
involved_in regulation of synaptic vesicle endocytosis
inferred from mutant phenotype
(Matta et al., 2012)
involved_in regulation of terminal button organization
inferred from mutant phenotype
(Lee et al., 2010)
involved_in retrograde transport, endosome to Golgi
inferred from genetic interaction with FLYBASE:Rab9; FB:FBgn0032782
(Dodson et al., 2014)
involved_in synapse organization
inferred from mutant phenotype
(Lee et al., 2010)
involved_in synaptic vesicle endocytosis
inferred from genetic interaction with FLYBASE:Vps35; FB:FBgn0034708
(Inoshita et al., 2017)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (11 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
located_in cell body
inferred from direct assay
(Lin et al., 2015)
located_in cytoplasm
inferred from direct assay
(Lee et al., 2010)
located_in dendritic branch point
inferred from direct assay
(Lin et al., 2015)
located_in dendritic shaft
inferred from direct assay
(Lin et al., 2015)
located_in Golgi stack
inferred from direct assay
(Lin et al., 2015)
located_in late endosome membrane
inferred from direct assay
(Dodson et al., 2012)
located_in lysosomal membrane
inferred from direct assay
(Dodson et al., 2012)
located_in neuromuscular junction
inferred from direct assay
(Lee et al., 2010)
located_in subsynaptic reticulum
inferred from direct assay
(Inoshita et al., 2017)
located_in terminal bouton
inferred from direct assay
(Inoshita et al., 2017)
located_in type I terminal bouton
inferred from direct assay
(Soukup et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN008288294
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
NON-RECEPTOR TKL KINASES -
Non-receptor tyrosine kinase-like (TKL) kinases are a diverse group of intracellular serine-threonine protein kinases with sequence similarity to tyrosine kinases (TK) but lacking TK-specific motifs.
Summary (Interactive Fly)

a cytoplasmic protein that controls synaptic morphogenesis at the neuromuscular junction targeting distinct downstream effectors at the presynaptic and postsynaptic compartments

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Lrrk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4KHT3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Lrrk-RB
FBtr0112788
NM_001104377
7572
2445
Lrrk-RC
FBtr0334640
NM_001275842
7572
2422
Lrrk-RD
FBtr0334641
NM_001275843
7845
2513
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Lrrk-PB
FBpp0111700
271.5
2445
7.07
Q9VDJ9
NP_001097847
AAF55793
Lrrk-PC
FBpp0306702
269.0
2422
7.12
A0A0B4KH16
NP_001262771
AGB96151
Lrrk-PD
FBpp0306703
279.0
2513
7.35
A0A0B4KHT3
NP_001262772
AGB96152
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lrrk using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.03

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cell body
inferred from direct assay
(Lin et al., 2015)
located_in cytoplasm
inferred from direct assay
(Lee et al., 2010)
located_in dendritic branch point
inferred from direct assay
(Lin et al., 2015)
located_in dendritic shaft
inferred from direct assay
(Lin et al., 2015)
located_in Golgi stack
inferred from direct assay
(Lin et al., 2015)
located_in late endosome membrane
inferred from direct assay
(Dodson et al., 2012)
located_in lysosomal membrane
inferred from direct assay
(Dodson et al., 2012)
located_in neuromuscular junction
inferred from direct assay
(Lee et al., 2010)
located_in subsynaptic reticulum
inferred from direct assay
(Inoshita et al., 2017)
located_in terminal bouton
inferred from direct assay
(Inoshita et al., 2017)
located_in type I terminal bouton
inferred from direct assay
(Soukup et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Lrrk in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Lrrk
Transgenic constructs containing regulatory region of Lrrk
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene partially disrupted in
Df(3R)del6
(Lin et al., 2015)
In(3LR)TM3-2
(Miller et al., 2016)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4ppk.PU
viable, with Scer\GAL4tin.CΔ4
viable (with Df(3R)BSC141)
Sterility
Allele
female semi-fertile
female semi-sterile
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
female semi-sterile (with Df(3R)BSC141)
female sterile
semi-sterile (with Lrrk1)
semi-sterile (with Lrrk2)
semi-sterile (with Lrrk3)
semi-sterile (with Lrrk4)
Other Phenotypes
Allele
abnormal cell death
abnormal chemosensory behavior | adult stage
abnormal locomotor behavior
abnormal locomotor behavior | adult stage, with Scer\GAL4elav-C155
abnormal locomotor behavior | adult stage, with Scer\GAL4Toll-6-D42
abnormal locomotor behavior | adult stage | progressive
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4109(2)80
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy, with Scer\GAL4Mhc.PW
abnormal neuroanatomy, with Scer\GAL4ple.PF
abnormal neuroanatomy, with Scer\GAL4ppk.PU
abnormal neuroanatomy (with Df(3R)del6)
abnormal neuroanatomy (with DfLrrk)
abnormal neuroanatomy | adult stage, with Scer\GAL4ple.PF
abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4Fer2.2359
abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4GMR58E02
abnormal neuroanatomy | dominant | third instar larval stage
abnormal neuroanatomy | larval stage
abnormal neuroanatomy | recessive | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4109(2)80
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4da.G32
abnormal neuroanatomy | third instar larval stage (with Lrrke03680)
abnormal neuroanatomy | third instar larval stage (with Lrrkex1)
abnormal neurophysiology
abnormal neurophysiology | adult stage
abnormal neurophysiology | adult stage | conditional
abnormal neurophysiology | third instar larval stage
abnormal neurophysiology | third instar larval stage, with Scer\GAL4G14
abnormal neurophysiology | third instar larval stage, with Scer\GAL4how-24B
abnormal neurophysiology | third instar larval stage, with Scer\GAL4Mhc.PW
abnormal smell perception | adult stage
chemical resistant
chemical resistant, with Scer\GAL4da.G32
chemical sensitive, with Scer\GAL4da.G32
decreased body size
decreased cell number | adult stage | conditional
decreased cell number | adult stage | progressive, with Scer\GAL4Fer2.2359
decreased cell number | adult stage | progressive, with Scer\GAL4GMR58E02
decreased fecundity | female | progressive
short lived
visible
Phenotype manifest in
Allele
adult abdomen | female
adult dopaminergic PAM neuron | adult stage | decreased number, with Scer\GAL4Fer2.2359
adult dopaminergic PAM neuron | adult stage | decreased number, with Scer\GAL4GMR58E02
antennal sense organ | increased number
autophagosome | increased number
autophagosome | third instar larval stage | nutrition conditional
bouton | third instar larval stage
bouton | third instar larval stage (with Lrrke03680)
bouton | third instar larval stage (with Lrrkex1)
dendrite, with Scer\GAL4109(2)80
dendrite, with Scer\GAL4ppk.PU
dendrite (with Df(3R)del6)
dendritic arborizing neuron, with Scer\GAL4109(2)80
dendritic arborizing neuron, with Scer\GAL4ppk.PU
dendritic arborizing neuron (with Df(3R)del6)
dendritic arborizing neuron | third instar larval stage, with Scer\GAL4109(2)80
dopaminergic neuron
dopaminergic neuron, with Scer\GAL4ple.PF
early endosome
embryonic/larval neuromuscular junction
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4G14
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4how-24B
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Mhc.PW
embryonic/larval neuromuscular junction | third instar larval stage (with Lrrke03680)
embryonic/larval neuromuscular junction | third instar larval stage (with Lrrkex1)
eye
follicle cell
Golgi stack, with Scer\GAL4ppk.PU
Golgi stack (with Df(3R)del6)
lamina | adult stage | conditional
late endosome
lysosome
lysosome, with Scer\GAL4CY2
mitochondrion
mitochondrion | adult stage
neuromuscular junction
neuromuscular junction, with Scer\GAL4elav-C155
neuromuscular junction, with Scer\GAL4Mhc.PW
neuromuscular junction (with DfLrrk)
NMJ bouton
NMJ bouton (with DfLrrk)
NMJ bouton | increased number
ommatidium
ommatidium | adult stage | conditional
outer medulla | adult stage
photoreceptor neuron | adult stage | conditional
rhabdomere | adult stage | conditional
type I bouton, with Scer\GAL4elav-C155
type I bouton, with Scer\GAL4Mhc.PW
type I bouton | third instar larval stage, with Scer\GAL4da.G32
type I terminal bouton | third instar larval stage
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (41)
Hsap\LRRK1
8 of 14
Yes
Yes
Hsap\LRRK2
6 of 14
No
Yes
 
50  
Hsap\ALK
1 of 14
No
No
16  
Hsap\ANKK1
1 of 14
No
No
Hsap\DSTYK
1 of 14
No
Yes
Hsap\EPHA6
1 of 14
No
No
Hsap\EPHB1
1 of 14
No
No
2  
Hsap\EPHB2
1 of 14
No
No
1  
Hsap\ERBB3
1 of 14
No
No
1  
Hsap\ERBB4
1 of 14
No
No
Hsap\FLT1
1 of 14
No
No
Hsap\FLT4
1 of 14
No
No
Hsap\FPGT-TNNI3K
1 of 14
No
No
Hsap\INSR
1 of 14
No
No
1  
Hsap\INSRR
1 of 14
No
No
Hsap\KDR
1 of 14
No
No
2  
Hsap\KIT
1 of 14
No
No
Hsap\LRCH3
1 of 14
No
No
1  
Hsap\LRRC1
1 of 14
No
No
Hsap\LRRC15
1 of 14
No
No
1  
Hsap\LRRC20
1 of 14
No
No
Hsap\LRSAM1
1 of 14
No
Yes
1  
Hsap\MAP3K7
1 of 14
No
No
Hsap\MAP3K9
1 of 14
No
No
Hsap\MAP3K10
1 of 14
No
No
1  
Hsap\MAP3K11
1 of 14
No
No
Hsap\MAP3K20
1 of 14
No
No
Hsap\MAP3K21
1 of 14
No
No
Hsap\MFHAS1
1 of 14
No
No
Hsap\MLKL
1 of 14
No
Yes
Hsap\MOS
1 of 14
No
No
Hsap\MST1R
1 of 14
No
No
Hsap\MUSK
1 of 14
No
No
1  
Hsap\PBK
1 of 14
No
No
Hsap\PHLPP2
1 of 14
No
No
Hsap\RIPK1
1 of 14
No
No
Hsap\RIPK2
1 of 14
No
No
Hsap\RIPK3
1 of 14
No
No
Hsap\RIPK4
1 of 14
No
No
Hsap\ROR2
1 of 14
No
No
Hsap\TNNI3K
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (19)
Rnor\Lrrk1
8 of 14
Yes
Yes
Rnor\Lrrk2
6 of 14
No
Yes
Rnor\Dstyk
1 of 14
No
Yes
Rnor\Lgr6
1 of 14
No
No
Rnor\Lrrc1
1 of 14
No
No
Rnor\Lrrc15
1 of 14
No
No
Rnor\Lrrd1
1 of 14
No
No
Rnor\Map3k7
1 of 14
No
No
Rnor\Map3k9
1 of 14
No
No
Rnor\Map3k10
1 of 14
No
No
Rnor\Map3k11
1 of 14
No
No
Rnor\Mfhas1
1 of 14
No
No
Rnor\Mos
1 of 14
No
No
Rnor\Pbk
1 of 14
No
No
Rnor\Ripk1
1 of 14
No
No
Rnor\Ripk2
1 of 14
No
No
Rnor\Ripk3
1 of 14
No
No
Rnor\Ripk4
1 of 14
No
No
Rnor\Tnni3k
1 of 14
No
No
Mus musculus (laboratory mouse) (21)
Mmus\Lrrk1
7 of 14
Yes
Yes
Mmus\Lrrk2
6 of 14
No
Yes
Mmus\Ankk1
1 of 14
No
No
Mmus\Dstyk
1 of 14
No
Yes
Mmus\Lgr6
1 of 14
No
No
Mmus\Lrrc1
1 of 14
No
No
Mmus\Lrrc15
1 of 14
No
No
Mmus\Map3k7
1 of 14
No
No
Mmus\Map3k9
1 of 14
No
No
Mmus\Map3k11
1 of 14
No
No
Mmus\Map3k20
1 of 14
No
No
Mmus\Map3k21
1 of 14
No
No
Mmus\Mfhas1
1 of 14
No
No
Mmus\Mlkl
1 of 14
No
Yes
Mmus\Mos
1 of 14
No
No
Mmus\Pbk
1 of 14
No
No
Mmus\Ripk1
1 of 14
No
No
Mmus\Ripk2
1 of 14
No
No
Mmus\Ripk3
1 of 14
No
No
Mmus\Ripk4
1 of 14
No
No
Mmus\Tnni3k
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\lrrk1
6 of 13
Yes
Yes
Xtro\lrrk2
4 of 13
No
Yes
Xtro\dpy30
1 of 13
No
No
Xtro\erbb3
1 of 13
No
No
Xtro\erbb4
1 of 13
No
No
Xtro\gp5
1 of 13
No
No
Xtro\lrrc20
1 of 13
No
No
Xtro\lrriq4
1 of 13
No
No
Xtro\mfhas1
1 of 13
No
Yes
Xtro\srgap3
1 of 13
No
No
Danio rerio (Zebrafish) (14)
Drer\lrrk2
6 of 14
Yes
Yes
Drer\lrrk1
3 of 14
No
Yes
Drer\ankk1
1 of 14
No
No
Drer\dstyk
1 of 14
No
Yes
Drer\lgr6
1 of 14
No
No
Drer\LOC405768
1 of 14
No
No
Drer\LOC101886393
1 of 14
No
No
Drer\lrrc1
1 of 14
No
No
Drer\lrrc40
1 of 14
No
No
Drer\map3k10
1 of 14
No
No
Drer\mos
1 of 14
No
No
Drer\pbk
1 of 14
No
No
Drer\tnni3k
1 of 14
No
No
Drer\zgc:85936
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
Cele\lrk-1
12 of 14
Yes
Yes
Cele\ZK546.2
2 of 14
No
No
Cele\ark-1
1 of 14
No
No
Cele\daf-2
1 of 14
No
No
Cele\F09G2.1
1 of 14
No
No
Cele\hir-1
1 of 14
No
No
Cele\K08E7.8
1 of 14
No
No
Cele\kin-5
1 of 14
No
No
Cele\kin-9
1 of 14
No
No
Cele\kin-16
1 of 14
No
No
Cele\let-23
1 of 14
No
No
Cele\mom-4
1 of 14
No
No
Cele\phlp-2
1 of 14
No
No
Cele\Y53F4B.1
1 of 14
No
No
Cele\Y105C5A.24
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (13)
Agam\AgaP_AGAP000810
11 of 12
Yes
Yes
Agam\AgaP_AGAP000147
1 of 12
No
No
Agam\AgaP_AGAP002575
1 of 12
No
No
Agam\AgaP_AGAP002710
1 of 12
No
No
Agam\AgaP_AGAP004832
1 of 12
No
No
Agam\AgaP_AGAP007060
1 of 12
No
No
Agam\AgaP_AGAP007061
1 of 12
No
No
Agam\AgaP_AGAP007598
1 of 12
No
No
Agam\AgaP_AGAP008611
1 of 12
No
No
Agam\AgaP_AGAP009775
1 of 12
No
No
Agam\AgaP_AGAP011648
1 of 12
No
No
Agam\EGFR
1 of 12
No
No
Agam\INR
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (136)
Atha\AT1G72180
2 of 13
Yes
Yes
Atha\AT5G01890
2 of 13
Yes
Yes
Atha\PEPR2
2 of 13
Yes
Yes
Atha\AT1G01450
1 of 13
No
No
Atha\AT1G04700
1 of 13
No
No
Atha\AT1G07550
1 of 13
No
Yes
Atha\AT1G08590
1 of 13
No
Yes
Atha\AT1G12460
1 of 13
No
Yes
Atha\AT1G16270
1 of 13
No
No
Atha\AT1G17230
1 of 13
No
Yes
Atha\AT1G17910
1 of 13
No
Yes
Atha\AT1G18160
1 of 13
No
No
Atha\AT1G19390
1 of 13
No
Yes
Atha\AT1G25320
1 of 13
No
Yes
Atha\AT1G34110
1 of 13
No
Yes
Atha\AT1G34420
1 of 13
No
Yes
Atha\AT1G53420
1 of 13
No
No
Atha\AT1G56145
1 of 13
No
No
Atha\AT1G61610
1 of 13
No
Yes
Atha\AT1G62950
1 of 13
No
Yes
Atha\AT1G64300
1 of 13
No
No
Atha\AT1G67890
1 of 13
No
No
Atha\AT1G69730
1 of 13
No
Yes
Atha\AT1G73660
1 of 13
No
No
Atha\AT1G79570
1 of 13
No
No
Atha\AT2G01210
1 of 13
No
Yes
Atha\AT2G14510
1 of 13
No
No
Atha\AT2G15300
1 of 13
No
Yes
Atha\AT2G16250
1 of 13
No
Yes
Atha\AT2G19230
1 of 13
No
Yes
Atha\AT2G24360
1 of 13
No
No
Atha\AT2G25790
1 of 13
No
Yes
Atha\AT2G27060
1 of 13
No
Yes
Atha\AT2G31010
1 of 13
No
No
Atha\AT2G31800
1 of 13
No
No
Atha\AT2G33170
1 of 13
No
Yes
Atha\AT2G35050
1 of 13
No
No
Atha\AT2G40860
1 of 13
No
No
Atha\AT2G41820
1 of 13
No
Yes
Atha\AT2G42640
1 of 13
No
No
Atha\AT2G43850
1 of 13
No
No
Atha\AT3G01490
1 of 13
No
No
Atha\AT3G06620
1 of 13
No
No
Atha\AT3G06630
1 of 13
No
No
Atha\AT3G06640
1 of 13
No
No
Atha\AT3G08680
1 of 13
No
Yes
Atha\AT3G22750
1 of 13
No
No
Atha\AT3G23750
1 of 13
No
No
Atha\AT3G24240
1 of 13
No
Yes
Atha\AT3G24715
1 of 13
No
No
Atha\AT3G28040
1 of 13
No
Yes
Atha\AT3G46400
1 of 13
No
No
Atha\AT3G46920
1 of 13
No
No
Atha\AT3G46930
1 of 13
No
No
Atha\AT3G47110
1 of 13
No
Yes
Atha\AT3G47580
1 of 13
No
Yes
Atha\AT3G50720
1 of 13
No
No
Atha\AT3G50730
1 of 13
No
No
Atha\AT3G53590
1 of 13
No
No
Atha\AT3G56370
1 of 13
No
No
Atha\AT3G58640
1 of 13
No
No
Atha\AT3G58760
1 of 13
No
No
Atha\AT3G59830
1 of 13
No
No
Atha\AT4G08850
1 of 13
No
No
Atha\AT4G14780
1 of 13
No
No
Atha\AT4G18950
1 of 13
No
No
Atha\AT4G23050
1 of 13
No
No
Atha\AT4G24480
1 of 13
No
No
Atha\AT4G26540
1 of 13
No
Yes
Atha\AT4G28650
1 of 13
No
Yes
Atha\AT4G31170
1 of 13
No
No
Atha\AT4G34220
1 of 13
No
Yes
Atha\AT4G37250
1 of 13
No
Yes
Atha\AT5G01850
1 of 13
No
No
Atha\AT5G06940
1 of 13
No
Yes
Atha\AT5G07140
1 of 13
No
No
Atha\AT5G10020
1 of 13
No
Yes
Atha\AT5G11850
1 of 13
No
No
Atha\AT5G25930
1 of 13
No
Yes
Atha\AT5G35370
1 of 13
No
Yes
Atha\AT5G40540
1 of 13
No
No
Atha\AT5G41730
1 of 13
No
No
Atha\AT5G47070
1 of 13
No
No
Atha\AT5G48740
1 of 13
No
Yes
Atha\AT5G48940
1 of 13
No
Yes
Atha\AT5G49470
1 of 13
No
No
Atha\AT5G50000
1 of 13
No
No
Atha\AT5G50180
1 of 13
No
No
Atha\AT5G56040
1 of 13
No
Yes
Atha\AT5G57610
1 of 13
No
No
Atha\AT5G58520
1 of 13
No
No
Atha\AT5G58950
1 of 13
No
No
Atha\AT5G63930
1 of 13
No
Yes
Atha\AT5G66710
1 of 13
No
No
Atha\ATMRK1
1 of 13
No
No
Atha\ATN1
1 of 13
No
No
Atha\BAM1
1 of 13
No
Yes
Atha\BAM2
1 of 13
No
Yes
Atha\BAM3
1 of 13
No
Yes
Atha\CLV1
1 of 13
No
Yes
Atha\CLV2
1 of 13
No
Yes
Atha\CRK25
1 of 13
No
No
Atha\CTR1
1 of 13
No
No
Atha\EDR1
1 of 13
No
No
Atha\EFR
1 of 13
No
Yes
Atha\EMS1
1 of 13
No
No
Atha\ER
1 of 13
No
No
Atha\ERL1
1 of 13
No
No
Atha\ERL2
1 of 13
No
Yes
Atha\FEI2
1 of 13
No
No
Atha\GHR1
1 of 13
No
Yes
Atha\HAE
1 of 13
No
Yes
Atha\HSL1
1 of 13
No
No
Atha\HSL2
1 of 13
No
No
Atha\HT1
1 of 13
No
No
Atha\IKU2
1 of 13
No
No
Atha\IMK2
1 of 13
No
Yes
Atha\LRR XI-23
1 of 13
No
Yes
Atha\MOL1
1 of 13
No
Yes
Atha\MRLK
1 of 13
No
Yes
Atha\PEPR1
1 of 13
No
Yes
Atha\PXY
1 of 13
No
Yes
Atha\RK1
1 of 13
No
Yes
Atha\RK2
1 of 13
No
Yes
Atha\RLK
1 of 13
No
Yes
Atha\RLP2
1 of 13
No
Yes
Atha\RLP19
1 of 13
No
Yes
Atha\RPK2
1 of 13
No
Yes
Atha\SOBIR1
1 of 13
No
Yes
Atha\STY8
1 of 13
No
No
Atha\STY17
1 of 13
No
No
Atha\STY46
1 of 13
No
No
Atha\VIK
1 of 13
No
No
Atha\WAK3
1 of 13
No
Yes
Atha\WAKL2
1 of 13
No
Yes
Atha\XIP1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Lrrk. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (21)
Mos
2 of 13
slpr
2 of 13
Tak1
2 of 13
Takl1
2 of 13
Takl2
2 of 13
Alk
1 of 13
cdi
1 of 13
CG6749
1 of 13
CG7896
1 of 13
CG8173
1 of 13
CG41099
1 of 13
Egfr
1 of 13
Ilk
1 of 13
InR
1 of 13
ksr
1 of 13
LIMK1
1 of 13
Lrch
1 of 13
Raf
1 of 13
Sclp
1 of 13
Tollo
1 of 13
wnd
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 12 )
Allele
Disease
Evidence
References
LrrkR1441C.UAS
model of  Parkinson's disease
CEA
(Penney et al., 2016)
LrrkR1441G.UAS
model of  Parkinson's disease
CEA
(Penney et al., 2016)
Lrrke03680
model of  Parkinson's disease
CEA
(Lin et al., 2015)
model of  Parkinson's disease 8
CEA
(Fellgett et al., 2021, Sarkar et al., 2021, Lee et al., 2007)
LrrkRC.UAS.Tag:FLAG
model of  Parkinson's disease
CEA
(Godena et al., 2014)
DOES NOT model  Parkinson's disease 8
CEA
(Lee et al., 2007)
Lrrkex1
model of  late onset Parkinson's disease
CEA
(West et al., 2015)
model of  Parkinson's disease
CEA
(De Rose et al., 2016, De Rose et al., 2016)
CEA with park25
(Aggarwal et al., 2019)
model of  Parkinson's disease 8
CEA
(Setzu et al., 2024, Casu et al., 2020, Aggarwal et al., 2019, Lee et al., 2007)
CEC
(Himmelberg et al., 2018)
LrrkG1914S.UAS
model of  Parkinson's disease 8
CEA
(Sarkar et al., 2021)
LrrkGL00136
model of  Parkinson's disease 8
CEA
(Liu et al., 2024)
LrrkUAS.cIa
model of  Parkinson's disease
CEA
(Penney et al., 2016)
model of  Parkinson's disease 8
CEA
(Miozzo et al., 2022, Sarkar et al., 2021)
LrrkY1383C.UAS
model of  Parkinson's disease
CEA
(Godena et al., 2014)
model of  Parkinson's disease 8
CEA
(Sarkar et al., 2021)
CEC
(Inoshita et al., 2022)
LrrkI1915T.UAS
model of  Parkinson's disease
CEA
(Imai et al., 2008)
CEC
(Gehrke et al., 2010)
model of  Parkinson's disease 8
CEA
(Stickley et al., 2023, Miozzo et al., 2022, Sarkar et al., 2021)
CEC
(Inoshita et al., 2022)
Lrrk3KD.UAS
model of  Parkinson's disease 8
CEC
(Inoshita et al., 2022)
Lrrk1
model of  Parkinson's disease 8
CEC
(Inoshita et al., 2022)
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 11 )
Allele
Disease
Interaction
References
Lrrke03680
ameliorates  Parkinson's disease
modeled by Pink1B9
(Tain et al., 2009)
modeled by park25
(Tain et al., 2009)
exacerbates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Bardai et al., 2018)
exacerbates  Parkinson's disease 1
modeled by Hsap\SNCAQUAS.cOa
(Sarkar et al., 2021)
model of  Parkinson's disease 8
is ameliorated by tsrUAS.Tag:polyHis
(Sarkar et al., 2021)
LrrkG1914S.UAS
exacerbates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Bardai et al., 2018)
exacerbates  Parkinson's disease 1
modeled by Hsap\SNCAQUAS.cOa
(Sarkar et al., 2021)
LrrkGD11670
exacerbates  Parkinson's disease 1
modeled by Hsap\SNCAQUAS.cOa
(Olsen and Feany, 2021)
LrrkUAS.cIa
model of  Parkinson's disease
is ameliorated by eIF4E1S058911
(Penney et al., 2016)
is ameliorated by Hsap\LRRK2G2019S.UAS
(Penney et al., 2016)
is ameliorated by S6kl-1
(Penney et al., 2016)
is ameliorated by mTorΔP
(Penney et al., 2016)
exacerbates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Bardai et al., 2018)
exacerbates  Parkinson's disease 1
modeled by Hsap\SNCAQUAS.cOa
(Sarkar et al., 2021)
model of  Parkinson's disease 8
is exacerbated by Fer2MB09480
(Miozzo et al., 2022)
is ameliorated by Fer2fTRG00336.sfGFP-TVPTBF
(Miozzo et al., 2022)
LrrkY1383C.UAS
exacerbates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Bardai et al., 2018)
exacerbates  Parkinson's disease 1
modeled by Hsap\SNCAQUAS.cOa
(Sarkar et al., 2021)
LrrkI1915T.UAS
model of  Parkinson's disease
is ameliorated by ThorTA.UAS
(Imai et al., 2008)
is ameliorated by E2f107172
(Gehrke et al., 2010)
is ameliorated by mir-184UAS.cGa
(Gehrke et al., 2010)
is ameliorated by Dcr-1UAS.cDa
(Gehrke et al., 2010)
is exacerbated by Dcr-1VDRC.cUa
(Gehrke et al., 2010)
is ameliorated by mir-let7UAS.cGa
(Gehrke et al., 2010)
is exacerbated by AGO1k08121
(Gehrke et al., 2010)
is ameliorated by RbfUAS.cDa
(Gehrke et al., 2010)
is ameliorated by Dp49Fk-1
(Gehrke et al., 2010)
is exacerbated by Dcr-1RNAi.UAS.cUa
(Gehrke et al., 2010)
exacerbates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Bardai et al., 2018)
exacerbates  Parkinson's disease 1
modeled by Hsap\SNCAQUAS.cOa
(Sarkar et al., 2021)
model of  Parkinson's disease 8
is exacerbated by Fer2MB09480
(Miozzo et al., 2022)
is ameliorated by Fer2fTRG00336.sfGFP-TVPTBF
(Miozzo et al., 2022)
LrrkRNAi.UAS.cIa
exacerbates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Bardai et al., 2018)
exacerbates  Parkinson's disease 1
modeled by Hsap\SNCAQUAS.cOa
(Sarkar et al., 2021)
LrrkHMS00456
ameliorates  Parkinson's disease
modeled by Hsc70-5KK100233
(Zhu et al., 2021)
exacerbates  mitochondrial DNA depletion syndrome 15
modeled by TFAMNIG.4217R, TFAMc01716
(Duncan et al., 2018)
Lrrk1
model of  Parkinson's disease 8
is ameliorated by Aplip1KK107996
(Inoshita et al., 2022)
is exacerbated by Rab3T35N.UASp.YFP
(Inoshita et al., 2022)
is exacerbated by Rab3-GEFHM05165
(Inoshita et al., 2022)
is ameliorated by Rab3-GEFUAS.cBa
(Inoshita et al., 2022)
is exacerbated by Rab32UASp.YFP
(Inoshita et al., 2022)
is ameliorated by Rme-8fl.UAS.mRFP1
(Inoshita et al., 2022)
is exacerbated by Vps35MH20
(Inoshita et al., 2022)
is ameliorated by Vps35UAS.cIa
(Inoshita et al., 2022)
is ameliorated by gαTub84B.mCherry
(Inoshita et al., 2022)
is ameliorated by g1
(Inoshita et al., 2022)
is exacerbated by sp3LL05626
(Inoshita et al., 2022)
is ameliorated by sp3UAS.cIa
(Inoshita et al., 2022)
is ameliorated by unc-104P350
(Inoshita et al., 2022)
is exacerbated by unc-104UAS.RVB.GFP(S65T)
(Inoshita et al., 2022)
LrrkQ1003H.UAS
ameliorates  Parkinson's disease 1
modeled by Hsap\SNCAQUAS.cOa
(Sarkar et al., 2021)
LrrkRNAi.UAS.cUa
exacerbates  Parkinson's disease 1
modeled by Hsap\SNCAQUAS.cOa
(Olsen and Feany, 2021)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
LRRK1; leucine rich repeat kinase 1
8 of 14
610986
LRRK2; leucine rich repeat kinase 2
6 of 14
LEUCINE-RICH REPEAT KINASE 2; LRRK2
 
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Lrrk
Hsap\LRRK2
(Pech et al., 2025, Penney et al., 2016, Soukup et al., 2016, Lin et al., 2015, Chuang et al., 2014, Dodson et al., 2014)
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Lrrk
enhanceable
Atg7
(Dodson et al., 2014)
Lrrk
enhanceable
Dcr-1
(Gehrke et al., 2010)
Lrrk
suppressible
Dcr-1
(Gehrke et al., 2010)
Lrrk
suppressible
Dhc64C
(Dodson et al., 2012)
Lrrk
suppressible
Diap1
(Dodson et al., 2014)
Lrrk|foxo
enhanceable
Diap1
(Kanao et al., 2010)
Lrrk
suppressible
Dp
(Gehrke et al., 2010)
Lrrk|foxo
suppressible
Dronc
(Kanao et al., 2010)
Lrrk
suppressible
E2f1
(Gehrke et al., 2010)
Lrrk
suppressible
eIF4E1
(Penney et al., 2016, Imai et al., 2008)
Lrrk
suppressible
EndoA
(Soukup et al., 2016, Matta et al., 2012)
Lrrk
enhanceable
Fer2
(Miozzo et al., 2022)
Lrrk
suppressible
Fer2
(Miozzo et al., 2022)
Lrrk
suppressible
Fur1
(Penney et al., 2016)
Lrrk
suppressible
futsch
(Lee et al., 2010)
Lrrk|foxo
suppressible
hid
(Kanao et al., 2010)
Lrrk
suppressible
mir-184
(Gehrke et al., 2010)
Lrrk
suppressible
mir-let7
(Gehrke et al., 2010)
Lrrk
suppressible
mTor
(Penney et al., 2016)
Lrrk
suppressible
Rab7
(Dodson et al., 2012)
Lrrk
suppressible
Rab9
(Dodson et al., 2014)
Lrrk
suppressible
Rbf
(Gehrke et al., 2010)
Lrrk
suppressible
S6k
(Penney et al., 2016)
Lrrk
suppressible
Thor
(Lee et al., 2010, Imai et al., 2008)
Lrrk
suppressible
tsr
(Sarkar et al., 2021)
Lrrk
suppressible
Vps35
(Inoshita et al., 2017)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Delta
suppressible
Lrrk
(Imai et al., 2015)
Delta
enhanceable
Lrrk
(Imai et al., 2015)
egr
suppressible
Lrrk
(Ruan et al., 2016)
egr
enhanceable
Lrrk
(Ruan et al., 2016)
eIF4E1
suppressible
Lrrk
(Imai et al., 2008)
Fer2
enhanceable
Lrrk
(Miozzo et al., 2022)
for|foxo
enhanceable
Lrrk
(Kanao et al., 2012)
foxo
enhanceable
Lrrk
(Kanao et al., 2010)
Hsc70-5
suppressible
Lrrk
(Zhu et al., 2021)
lva
suppressible
Lrrk
(Lin et al., 2015)
mTor
suppressible
Lrrk
(Penney et al., 2016)
neur
suppressible
Lrrk
(Imai et al., 2015)
park
suppressible
Lrrk
(Tain et al., 2009)
Pink1
suppressible
Lrrk
(Tain et al., 2009)
Rab7
suppressible
Lrrk
(Dodson et al., 2012)
Rab7
enhanceable
Lrrk
(Dodson et al., 2012)
Vps35
suppressible
Lrrk
(Inoshita et al., 2017)
External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-69
Cytogenetic map
92F3-92F4
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
92F3-92F4
; Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

3-69

(FlyBase, 2016)

3-72.8

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (13)
Genomic Clones (20)
cDNA Clones (17)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Bardai et al., 2018, Lin et al., 2015, Imai et al., 2008)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                Lrrk negatively regulates Rab7-dependent perinuclear localisation of lysosomes.

                (Dodson et al., 2012)

                When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells and centrosome abnormalities are seen.

                (Bettencourt-Dias et al., 2004)

                dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                (Kiger et al., 2003)
                Relationship to Other Genes
                Source for database merge of
                Additional comments
                Nomenclature History
                Source for database identify of
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (13)
                Reported As
                Symbol Synonym
                CG5483
                (Wu et al., 2016, Yang et al., 2012, Ni et al., 2011.7.19, Lin et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Liu et al., 2008)
                CT17358
                (Hynes and Zhao, 2000)
                LRRK
                (Ciampelli et al., 2025, Pech et al., 2025, Casu et al., 2020, Langston et al., 2016, Gillingham et al., 2014, Lee et al., 2010, Imai et al., 2008, Marín, 2008, Wang et al., 2008, Lee et al., 2007)
                LRRK2
                (Victor Atoki et al., 2025, Zhang et al., 2024, Cheng et al., 2023, Li et al., 2023, Asthana and Shravage, 2022, Olguín et al., 2022, Zhou et al., 2022, Ham et al., 2021, Naz and Siddique, 2021, De Lazzari et al., 2020, Johnson et al., 2020, Cai et al., 2019, Lin et al., 2019, Bayer et al., 2017, De Rose et al., 2016, De Rose et al., 2016, Schreij et al., 2015, Frank et al., 2013, Muñoz-Soriano and Paricio, 2011, Lee et al., 2010)
                Lrrk
                (Afsheen et al., 2024, Quintero-Espinosa et al., 2024, Shweta et al., 2024, Stickley et al., 2023, Ecovoiu et al., 2022, Hernandez-Diaz et al., 2022, Miozzo et al., 2022, Suzuki et al., 2022, Liang et al., 2021, Olsen and Feany, 2021, Sarkar et al., 2021, Vos and Klein, 2021, Zhu et al., 2021, Diana et al., 2020, Miller et al., 2020, Salazar et al., 2020, Valenzuela et al., 2020, Wang et al., 2020, Aggarwal et al., 2019, Aryal and Lee, 2019, Bajracharya et al., 2019, Evangelakou et al., 2019, Calap-Quintana et al., 2018, Gene Disruption Project members, 2018-, Quintero-Espinosa et al., 2017, Langston et al., 2016, Miller et al., 2016, Calap-Quintana et al., 2015, Kanoh et al., 2015, Lin et al., 2015, Vanhauwaert and Verstreken, 2015, Wangler et al., 2015, West et al., 2015, Chuang et al., 2014, Godena et al., 2014, Korenjak et al., 2014, Sopko et al., 2014, Dodson et al., 2012, Matta et al., 2012, Wasbrough et al., 2010, Tain et al., 2009)
                Lrrk2
                (Aromolaran et al., 2021, Yang et al., 2018)
                dLRRK
                (Jeong, 2024, Rahul and Siddique, 2022, Seegobin et al., 2020, Schaffner et al., 2019, Dung and Thao, 2018, Himmelberg et al., 2018, Xiong and Yu, 2018, Iyer et al., 2016, Ruan et al., 2016, Imai et al., 2015, Afsari et al., 2014, Martin et al., 2014, Hindle et al., 2013, Kanao et al., 2012, Gehrke et al., 2010, Kanao et al., 2010, Imai et al., 2008, Wang et al., 2008)
                dLRRK2
                (Breger and Fuzzati Armentero, 2019, Huang et al., 2012)
                dLrrk
                (Penney et al., 2016, West et al., 2015)
                dLrrk2
                (Quintero-Espinosa et al., 2024, Sun et al., 2020)
                lrrk
                (Denton et al., 2020, Soukup et al., 2016, Wu et al., 2016, Dodson et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Lin et al., 2010, Dodson et al., 2008)
                Name Synonyms
                CG5483
                LRRK
                (Lee et al., 2007)
                LRRK2
                (Bolus et al., 2020)
                Leucine-rich repeat kinase
                (Calap-Quintana et al., 2015)
                ortholog of LRRK2
                (Shadrina and Slominsky, 2021)
                Secondary FlyBase IDs
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 51 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Flygut - An atlas of the Drosophila adult midgut
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  References (153)