FlyBase Gene Report: Dmel\Fur1

General Information

Symbol

Dmel\Fur1

Species

D. melanogaster

Name

Furin 1

Annotation Symbol

CG10772

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004509

Gene Model Status

Current

Stock Availability

192 publicly available

Enzyme Name (EC)

Gene Summary

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. (UniProt, P26016 P30430)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dfur1, Dfurin1, dKLIP-1, Furin, l(3)rL205

Key Links

Genomic Location

Cytogenetic map

96D2-96E1

Sequence location

3R:25,347,431..25,473,058 [-]

Recombination map

3-87

RefSeq locus

NT_033777 REGION:25347431..25473058

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from genetic interaction with FLYBASE:Fur2; FB:FBgn0004598

(Künnapuu et al., 2009)

inferred from direct assay

(Hayflick et al., 1992)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from electronic annotation with InterPro:IPR002884, InterPro:IPR036852

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN002451026

(GO Reference Genome Project, 2011-)

enables serine-type peptidase activity

inferred from electronic annotation with InterPro:IPR000209

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in glutamate receptor clustering

inferred from mutant phenotype

(Kim et al., 2015)

involved_in postsynaptic membrane organization

inferred from mutant phenotype

(Kim et al., 2015)

involved_in presynaptic membrane organization

inferred from mutant phenotype

(Kim et al., 2015)

involved_in synaptic target recognition

inferred from mutant phenotype

(Kurusu et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in peptide hormone processing

inferred from biological aspect of ancestor with PANTHER:PTN000082901

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR000209, InterPro:IPR002884, InterPro:IPR036852

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Hayflick et al., 1992)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in Golgi membrane

inferred from biological aspect of ancestor with PANTHER:PTN000082856

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from sequence or structural similarity with FLYBASE:Fur2; FB:FBgn0004598

(Roebroek et al., 1993)

inferred from sequence or structural similarity with SGD:S000005182

(Hayflick et al., 1992)

is_active_in trans-Golgi network

inferred from biological aspect of ancestor with PANTHER:PTN000082856

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PROPROTEIN CONVERTASES

Protein Family (UniProt)

Belongs to the peptidase S8 family. Furin subfamily. (P26016 P30430)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

serine-type endopeptidase activity

Summaries

Gene Group (FlyBase)

PROPROTEIN CONVERTASES -: Proprotein convertases are serine endopeptidases related to bacterial subtilisin-like enzymes. They activate a broad range of secretory proteins via post-translational cleavage of inactive precursor molecules. The targets and substrates of these convertases are very varied covering many aspects of cellular biology and communication. (Adapted from PMID:22204726.)

Protein Function (UniProtKB)

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

(UniProt, P26016 P30430)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Fur1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P26016)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Fur1-RA

FBtr0089982

NM_170654

4215

1101

Fur1-RB

FBtr0089983

NM_080146

5043

1269

Fur1-RC

FBtr0089984

NM_170655

3912

892

Fur1-RD

FBtr0089985

NM_170656

3847

892

Fur1-RF

FBtr0089987

NM_206570

3968

892

Fur1-RG

FBtr0310618

NM_001276026

1822

285

Fur1-RH

FBtr0336804

NM_001276024

3735

864

Fur1-RI

FBtr0336805

NM_206571

6225

892

Fur1-RJ

FBtr0336806

NM_001276025

5346

1478

Additional Transcript Data and Comments

Reported size (kB)

7.6, 6.5, 4.5, 4.0 (northern blot)

(Roebroek et al., 1993)

8.4, 6.8, 4.5, 4.0 (northern blot)

(Hayflick et al., 1992)

6.5, 4.5, 4.0 (northern blot)

(Roebroek et al., 1991)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Fur1-PA

FBpp0089025

121.0

1101

6.71

FBpp0089026

138.6

1269

9.82

FBpp0089027

97.9

892

8.56

NP_733103

AAF56463

Fur1-PD

FBpp0089028

97.9

892

8.56

NP_733104

AAN14052

Fur1-PF

FBpp0089030

97.9

892

8.56

NP_996293

AAS65215

Fur1-PG

FBpp0302738

30.2

285

10.45

FBpp0307775

94.5

864

7.92

FBpp0307776

97.9

892

8.56

NP_996294

AAS65216

Fur1-PJ

FBpp0307777

161.7

1478

8.31

A0A0B4KHV0

NP_001262954

AGB96334

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

892 aa isoforms: Fur1-PC, Fur1-PD, Fur1-PF, Fur1-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

1101, 892 (aa)

(Roebroek et al., 1993)

1101 (aa); 140 (kD observed); 131 (kD predicted)

(Hayflick et al., 1992)

899 (aa)

(Roebroek et al., 1991)

Comments

The 1101aa Fur1 protein is identical over most of its length to the other Fur1 isoforms but has two cysteine-rich regions near the carboxyl end of the protein (called CRR by authors). Its activity as a proprotein processing enzyme was demonstrated in gene transfer experiments, where it is capable of processing the precursor of the β_A-chain of activin-A and the precursor of von Willebrand factor to the mature forms.

(Roebroek et al., 1993)

The 1269aa Fur1 protein is identical over most of its length to the other Fur1 isoforms but has a unique domain of 377aa inserted near the carboxyl end (called domain X by authors). Its activity as a proprotein processing enzyme was demonstrated in gene transfer experiments, where it is capable of processing the precursor of the β_A-chain of activin-A and the precursor of von Willebrand factor to the mature forms.

(Roebroek et al., 1993)

The 892aa Fur1 protein is identical over most of its length to the other Fur1 isoforms but lacks the inserted domains present near the carboxyl end in the other two isoforms. Its activity as a proprotein processing enzyme was demonstrated in gene transfer experiments, where it is capable of processing the precursor of the β_A-chain of activin-A and the precursor of von Willebrand factor to the mature forms.

(Roebroek et al., 1993)

One of several protein products generated by alternative splicing.

(FlyBase, 1992-)

When coexpressed with pro-β-NGF, Fur1 protein greatly enhances the endoproteolytic conversion of the precursor to mature β-NGF by cleavage at a -Lys-Arg- doublet. In vitro translation and translocation experiments show that Fur1 protein can be translocated across microsomal membranes.

(Hayflick et al., 1992)

The 899aa Fur1 protein species was predicted from a composite cDNA sequence from two cDNA clones.

(Roebroek et al., 1991)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

S08.071

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fur1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.17

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 16

central nervous system | restricted

(Hayflick et al., 1992)

adult stage

fat body

(Hayflick et al., 1992)

adult brain cell body rind

(Hayflick et al., 1992)

gnathal ganglion

(Hayflick et al., 1992)

adult stage | female

oviduct

(Hayflick et al., 1992)

adult stage & oogenesis

oocyte

(Hayflick et al., 1992)

follicle cell

(Hayflick et al., 1992)

nurse cell

(Hayflick et al., 1992)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

peptidergic neuron | subset of larval central nervous system

(Hewes et al., 2003)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Co-localisation of Fur1 and ScerGAL4^dimm-929 is observed in a subset of Fur1-positive neurons of the central nervous system.

(Hewes et al., 2003)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Hayflick et al., 1992)

Expression Deduced from Reporters

Reporter: P{GMR27A07-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 12

embryonic head

(Manning et al., 2012)

embryonic stage 16

embryonic/larval hypodermal muscle cell

(Manning et al., 2012)

larval central nervous system

Comment: scattered cells

(Manning et al., 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Fur1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Fur1

View exonic expression by tissue for Dmel\Fur1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004509

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47220/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004509

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004509

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004509

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10772

Flygut - An atlas of the Drosophila adult midgut

FBgn0004509

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 39 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Fur1

Transgenic constructs containing regulatory region of Fur1

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene not disrupted in

Df(3R)XTA1

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Gene disrupted in

Df(3R)Exel6202

(Ryder, 2004.4.26)

Gene partially disrupted in

Df(3R)Vps33B^5.20

(Akbar et al., 2016)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

Fur1^rL205

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Fur1^GD12608

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Fur1^GD12608

viable, with Scer\GAL4^tin.CΔ4

Fur1^GD12608

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Fur1^GD12608

abnormal flight, with Scer\GAL4^Mef2.PR

Fur1^GD12608

abnormal locomotor behavior | adult stage

Fur1^MB06661

abnormal neuroanatomy, with Scer\GAL4^G14

Fur1^GL01340

abnormal size | larval stage, with Scer\GAL4^bnl.PU

some die during larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^G14

Fur1^GL01340

some die during larval stage | heat sensitive, with Scer\GAL4^G14

Fur1^GL01340

some die during pupal stage, with Scer\GAL4^pnr-MD237

Fur1^GD12608

visible, with Scer\GAL4^pnr-MD237

Fur1^GD12608

Phenotype manifest in

Allele

air sac primordium | larval stage, with Scer\GAL4^bnl.PU

air sac primordium | larval stage | increased number, with Scer\GAL4^bnl.PU

Fur1^JF01855

mesonotum, with Scer\GAL4^pnr-MD237

Fur1^GD12608

terminal bouton, with Scer\GAL4^G14

Fur1^GL01340

trichogen cell, with Scer\GAL4^pnr-MD237

Fur1^GD12608

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\FURIN

9 of 14

Yes

Hsap\PCSK4

8 of 14

Yes

Hsap\PCSK1

6 of 14

Yes

Hsap\PCSK5

6 of 14

Hsap\PCSK6

6 of 14

Hsap\PCSK7

5 of 14

Yes

4 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (14)

Rnor\Furin

9 of 14

Yes

Rnor\Pcsk4

8 of 14

Yes

Rnor\Pcsk5

7 of 14

Rnor\Pcsk6

7 of 14

Rnor\Pcsk1

5 of 14

Yes

Rnor\Pcsk7

5 of 14

Yes

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (15)

Mmus\Furin

9 of 14

Yes

Mmus\Pcsk4

8 of 14

Yes

Mmus\Pcsk5

6 of 14

Mmus\Pcsk6

6 of 14

Mmus\Pcsk1

5 of 14

Yes

Mmus\Pcsk7

5 of 14

Yes

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\furin

6 of 13

Yes

Xtro\pcsk4

5 of 13

Yes

4 of 13

4 of 13

3 of 13

3 of 13

2 of 13

2 of 13

Yes

Xtro\htr6

1 of 13

Yes

Xtro\LOC100486641

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (16)

Drer\furina

9 of 14

Yes

Drer\furinb

9 of 14

Yes

Drer\pcsk1

6 of 14

Yes

Drer\pcsk5a

6 of 14

Drer\pcsk5b

5 of 14

Drer\pcsk7

5 of 14

Yes

4 of 14

3 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\kpc-1

8 of 14

Yes

5 of 14

3 of 14

3 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP001330

9 of 12

Yes

4 of 12

4 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (56)

Atha\AT3G14240

2 of 13

Yes

Atha\S1P

2 of 13

Yes

Atha\AIR3

1 of 13

Atha\ARA12

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT2G39850

1 of 13

Atha\AT3G14067

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\ATSBT5.2

1 of 13

Atha\SBT1.3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\SDD1

1 of 13

Yes

Atha\SLP2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\KEX2

7 of 13

Yes

Scer\PRB1

2 of 13

Scer\RRT12

2 of 13

Scer\YSP3

2 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\krp1

7 of 12

Yes

Spom\psp3

2 of 12

Spom\tpp2

2 of 12

Spom\isp6

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Fur1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

Fur2

8 of 13

amon

7 of 13

S1P

2 of 13

TppII

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

Fur1^GL01340

model of schizophrenia

CEA

(Foka et al., 2022)

Fur1^MI06808

model of schizophrenia

CEA

(Foka et al., 2022)

Fur1^MI08357

model of schizophrenia

CEA

(Foka et al., 2022)

Fur1^MI03544

model of schizophrenia

CEA

(Foka et al., 2022)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PCSK1; proprotein convertase subtilisin/kexin type 1

model of proprotein convertase 1/3 deficiency

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Fur1^MI06808

model of schizophrenia

is ameliorated by Hsap\FURIN^UAS.Tag:HA

(Foka et al., 2022)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FURIN; furin, paired basic amino acid cleaving enzyme

9 of 14

136950

PCSK4; proprotein convertase subtilisin/kexin type 4

8 of 14

600487

PCSK1; proprotein convertase subtilisin/kexin type 1

6 of 14

162150

proprotein convertase 1/3 deficiency

PCSK5; proprotein convertase subtilisin/kexin type 5

6 of 14

600488

PCSK6; proprotein convertase subtilisin/kexin type 6

6 of 14

167405

PCSK7; proprotein convertase subtilisin/kexin type 7

5 of 14

604872

PCSK2; proprotein convertase subtilisin/kexin type 2

4 of 14

162151

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Fur1 - B52

electrophoretic mobility shift assay, autoradiography, systematic evolution of ligands by exponential enrichment, full identification by DNA sequencing

(Kim et al., 2003)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Lrrk

suppressible

Fur1

(Penney et al., 2016)

pbl

suppressible

Fur1

(Gregory et al., 2007)

trk

enhanceable

Fur1

(Johnson et al., 2015)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

70692

DroID - A comprehensive database of gene and protein interactions.

FBgn0004509

MIST (protein-protein) - An integrated Molecular Interaction Database

47220

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Viral life cycle - HIV-1

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P26016

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-87

Cytogenetic map

96D2-96E1

Sequence location

3R:25,347,431..25,473,058 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

96D2-96E1

Limits computationally determined from genome sequence between P{PZ}Aats-gln⁰⁵⁴⁶¹ and P{EP}EP3354

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

96D1-96D2

(Hayflick, 1992.11.23)

96C1-96C2

(determined by in situ hybridisation)

(Spradling et al., 1999)

96C1-6C2

(determined by in situ hybridisation)

(BDGP Project Members, 1994-1999)

96D-96D

(determined by in situ hybridisation)

(Roebroek et al., 1993)

96D1-96D2

(determined by in situ hybridisation)

(Hayflick et al., 1992)

Experimentally Determined Recombination Data

Location

3-87

(FlyBase, 2016)

3-86.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (192)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

11963

P{VT047320-GAL4}attP2

12776

P{VT047325-GAL4}attP2

14547

P{VT047325-lexA}attP2

15675

P{VT047320-lexA}attP2

15898

P{GMR26B12-lexA}JK22C

16035

P{GMR25G03-lexA}attP2

16120

P{GMR26B12-lexA}attP2

11029

P{EP}Fur1^G7489

16203

P{R27A07-lexA::GADfl}attP2

17601

P{R27A07-lexA::GADfl}attP40

16250

P{R26G05-nlslexA::GADfl}attP2

VDRC

v330186

P{VSH330186}attP40

More stocks available...

Genomic Clones (77)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (74)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP19876

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004509

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004509

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The Fur1 gene encodes structurally different subtilisin-like proprotein processing enzymes with distinct physiological functions.

(Roebroek et al., 1993)

Cloning, tissue and developmental expression, and endoproteolytic activity of Fur1 is studied.

(Hayflick et al., 1992)

Isolated from a genomic library using a human furin cDNA as a probe, under reduced stringency conditions.

(Roebroek et al., 1991)

Fur1 has been cloned and sequenced.

(Roebroek et al., 1991)

Relationship to Other Genes

Source for database merge of

Source for merge of: Fur1 l(3)rL205

(Spradling et al., 1999)

Source for merge of: Fur1 CG10772

(Bayraktaroglu, 2000.4.17)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

CG10772

(Meadows, 2017.1.11, Hosono et al., 2015, Ni et al., 2010.12.1, Perkins et al., 2009.1.15, Kurusu et al., 2008, Quinones-Coello, 2007, Fulton et al., 2001)

Dfur1

(Zhang et al., 2014, Künnapuu et al., 2009, Siekhaus and Fuller, 1999, de Bie et al., 1995, McKay et al., 1995, Roebroek et al., 1995, Roebroek et al., 1993, Roebroek, 1991.5.3, Roebroek et al., 1991)

Dfurin1

(Cano-Monreal et al., 2010, Bruning et al., 2007)

Furin

(Hewes et al., 2003, Lopez-Schier, 2003)

Furl

(Iida and Akashi, 2000)

Klip1

dFur1

(Jiang et al., 2000)

dFurin 1

(O'Brien and Taghert, 1998)

dKLIP-1

(Sappington and Raikhel, 1998, Hayflick, 1992.11.23, Hayflick et al., 1992)

fur-1

(Kurusu et al., 2008)

fur1

(Sohr et al., 2019, Siezen and Leunissen, 1997, Roebroek, 1993.3.15, Roebroek, 1993.3.15, Roebroek, 1993.3.15, Roebroek, 1993.3.25, Roebroek, 1993.3.25, Roebroek, 1993.3.25)

fur¹

(Yedvobnick et al., 2001)

furin

(Artavanis-Tsakonas et al., 1999, Roebroek, 1993.3.15)

furin1

(Elgueta-Reyes et al., 2025)

l(3)rL205

(BDGP Project Members, 1994-1999)

Name Synonyms

Dfurin1

(Künnapuu et al., 2009, Roebroek et al., 1991)

Furin

(Guruharsha et al., 2012)

Furin 1

(Kim et al., 2015, Gregory et al., 2007, Gauthier and Hewes, 2006, Burnette et al., 2005)

Furin-like protease

(Allman et al., 2002)

Furin1

(Salazar and Yamamoto, 2018, Künnapuu et al., 2007)

furin1

(Lake et al., 2009)

Secondary FlyBase IDs

FBgn0010236
FBgn0024579
FBgn0039334

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 116 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

47220

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P26016

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P26016

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004509

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47220/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004509

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004509

FlyMine - An integrated database for Drosophila genomics

FBgn0004509

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10772

MARRVEL_MODEL - MARRVEL (model organism gene)

47220

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

S08.071

Linkouts

BioGRID - A database of protein and genetic interactions.

70692

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004509

DroID - A comprehensive database of gene and protein interactions.

FBgn0004509

DRSC - Results frm RNAi screens

FBgn0004509

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004509

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004509

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10772

Flygut - An atlas of the Drosophila adult midgut

FBgn0004509

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004509

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Viral life cycle - HIV-1

MIST (protein-protein) - An integrated Molecular Interaction Database

47220

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P26016

References (141)

The following external sites may use different assemblies or annotations than FlyBase.

-1.17

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