secreted - ligand for torso - crucial for establishment of anterior and posterior cell identity of the embryo - Trunk and Torsolike alone are ineffective but acted synergistically to stimulate Torso signaling
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\trk using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\trk in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
trk protein is cleaved multiple times in vivo and these proteolytic events are essential for its function.
Different amounts of tor or trk molecules correlate with the expression of different zygotic genes, implicating changes in the number of activated tor molecules as one of the mechanisms defining differential gene expression.
trk encodes a protein that resembles spz in several aspects, in particular the sequence suggests that trk is a secreted protein which contains an internal site for proteolytic cleavage. Overall orientation not stated: anon-31BCa+ trk+ anon-31BCb-
It is proposed that trk encodes an extracellular ligand involved in specifying terminal body pattern and suggests, by analogy with spz, that a cleaved form of trk constitutes the ligand for the tor receptor.
Distribution of tud protein in mutant embryos has been studied. Maternal genes such as bcd, tor and trk that are necessary for anteroposterior axis formation, but not required for germ cell formation or abdominal segmentation, have no effect on the distribution of tud protein.
The maternal terminal system is necessary to activate tll expression in the terminal caps.
Zygotically active locus involved in the terminal developmental program in the embryo in the embryo.
Mature follicles are immunologically stained for asymmetric distribution of ecdysteroid-related antigen. During late oogenesis localisation of the antigen changes dramatically suggesting the antigen plays a role in early embryogenesis and, perhaps, in pattern formation.