FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\trk5
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General Information
Symbol
Dmel\trk5
Species
D. melanogaster
Name
FlyBase ID
FBal0017043
Feature type
allele
Associated gene
Dmel\trk
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Furriols et al., 1996)
Mutagen
ethyl methanesulfonate
(Schupbach and Wieschaus, 1989)
Progenitor genotype
Cytology
Description

No change has been found in the sequence of the coding region when compared to the wild type gene.

(Furriols et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      98% of embryos derived from homozygous females terminate in the A7 abdominal segment.

      (Casci et al., 1999)

      Embryos from homozygous females display a range of phenotypes from trk- to almost wild type. Those embryos with partial terminal development always lack the most terminal structures. Embryos from females carrying two copies of trk5 have more terminal structures than embryos from females hemizygous for trk5.

      (Furriols et al., 1996)

      Eggs derived from homozygous females cellularise normally but become abnormal at gastrulation; the cephalic furrow is shifted forward, the posterior midgut is missing and the germband forms to the posterior end of the embryo. The embryos lack anterior head structures and structures posterior to segment A7 (the labral segment and telson).

      (Schupbach and Wieschaus, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      trk5 has embryonic abdominal segment 8 phenotype, suppressible by styS73

      (Casci et al., 1999)

      trk5 has embryo | posterior phenotype, suppressible by styS73

      (Casci et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      If trk5 females are also heterozygous for styS73, 53% of the embryos terminate in the A7 abdominal segment, 39% terminate in the A8 abdominal segment and 8% are wild type.

      (Casci et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      trk5
      (Mao and Freeman, 2009)
      trkPK
      Name Synonyms
      Secondary FlyBase IDs
        References (4)