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Citation
Stathopoulos, A., Newcomb, S. (2020). Setting up for gastrulation: D. melanogaster.  Curr. Topics Dev. Biol. 136(): 3--32.
FlyBase ID
FBrf0244630
Publication Type
Review
Abstract

Drosophila melanogaster embryos develop initially as a syncytium of totipotent nuclei and subsequently, once cellularized, undergo morphogenetic movements associated with gastrulation to generate the three somatic germ layers of the embryo: mesoderm, ectoderm, and endoderm. In this chapter, we focus on the first phase of gastrulation in Drosophila involving patterning of early embryos when cells differentiate their gene expression programs. This patterning process requires coordination of multiple developmental processes including genome reprogramming at the maternal-to-zygotic transition, combinatorial action of transcription factors to support distinct gene expression, and dynamic feedback between this genetic patterning by transcription factors and changes in cell morphology. We discuss the gene regulatory programs acting during patterning to specify the three germ layers, which involve the regulation of spatiotemporal gene expression coupled to physical tissue morphogenesis.

PubMed ID
PubMed Central ID
PMC7296044 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Topics Dev. Biol.
    Title
    Current Topics in Developmental Biology
    Publication Year
    1966-
    ISBN/ISSN
    0070-2153
    Data From Reference