FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\btd
Open Close
General Information
Symbol
Dmel\btd
Species
D. melanogaster
Name
buttonhead
Annotation Symbol
CG12653
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000233
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Summary
buttonhead (btd) encodes a triple C(2)H(2) zinc finger protein structurally and functionally related to the human transcription factors Sp5, Sp8, and Sp9. The product of btd contributes to embryonic head segmentation, leg development, embryonic hematopoiesis, PNS formation, and maintenance of the functional heterogeneity of brain neural stem cells. [Date last reviewed: 2018-09-06] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
8F10-8F10
Sequence location
Recombination map
1-29
RefSeq locus
NC_004354 REGION:9694186..9697558
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from direct assay
(Yin et al., 1997)
enables DNA-binding transcription factor activity
inferred from direct assay
(Wimmer et al., 1993)
inferred from genetic interaction with UniProtKB:P08047
(Wimmer et al., 1993)
enables sequence-specific DNA binding
inferred from direct assay
(Brown et al., 2005, Wimmer et al., 1993)
enables TBP-class protein binding
inferred from physical interaction with FLYBASE:Taf4; FB:FBgn0010280
(Schock et al., 1999)
inferred from physical interaction with FLYBASE:Taf2; FB:FBgn0011836
(Schock et al., 1999)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(GO Reference Genome Project, 2011-)
Biological Process (9 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in cephalic furrow formation
inferred from mutant phenotype
(Vincent et al., 1997)
involved_in imaginal disc-derived leg morphogenesis
inferred from mutant phenotype
(Estella and Mann, 2010)
involved_in negative regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Yin et al., 1997)
involved_in positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Schock et al., 1999, Wimmer et al., 1993)
involved_in regulation of neuroblast proliferation
inferred from genetic interaction with UniProtKB:P51023
(Xie et al., 2016)
involved_in regulation of neuron differentiation
inferred from genetic interaction with UniProtKB:P51023
(Xie et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in anterior head segmentation
traceable author statement
(Peel, 2004)
involved_in posterior head segmentation
traceable author statement
(Peel, 2004)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN009066117
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
buttonhead (btd) encodes a triple C(2)H(2) zinc finger protein structurally and functionally related to the human transcription factors Sp5, Sp8, and Sp9. The product of btd contributes to embryonic head segmentation, leg development, embryonic hematopoiesis, PNS formation, and maintenance of the functional heterogeneity of brain neural stem cells. [Date last reviewed: 2018-09-06]
Gene Group (FlyBase)
SP1/KLF TRANSCRIPTION FACTORS -
The Sp1/KLF (Sp1-like/Kruppel-like factors) family of zinc finger proteins are DNA binding proteins. They can act as activators or repressors and some members bind sequences within Polycomb Response Elements (PREs). (Adapted from FBrf0188187).
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Protein Function (UniProtKB)
Required for the development of the antennal, intercalary and mandibular segments of the head.
(UniProt, Q24266)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
btd: buttonhead
Homozygous lethal; head involution incomplete.
Summary (Interactive Fly)

transcription factor - zinc finger - transcriptonal activator that regulates the segmentation of the head - along with Ems, serves as a major activator of string expression in mitotic domain 2

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\btd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24266)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
btd-RA
FBtr0071379
NM_078545
2934
644
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
btd-PA
FBpp0071314
68.6
644
9.08
Q24266
NP_511100
AAF46518
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

644 (aa)

(Wimmer et al., 1993)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\btd using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.36

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
leg | precursor
(Wimmer et al., 1996)
organism | striped
(Wimmer et al., 1996)
embryonic stage 3 -- 4
embryonic head | restricted
(Wimmer et al., 1996)
blastoderm stage
embryonic mandibular segment | precursor
(Wimmer et al., 1996)
embryonic deutocerebrum | precursor
(Wimmer et al., 1996)
embryonic intercalary segment | precursor
(Wimmer et al., 1996)
embryonic stage 4
organism | 10-20% egg length
(Schaeper et al., 2010)
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
clypeo-labral anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
hypopharynx anlage in statu nascendi
(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic cycle 12 -- embryonic cycle 14
organism | 60-80% egg length

Comment: 65-77% egg length

(Wimmer et al., 1993)
embryonic stage 5
organism | 70-80% egg length

Comment: 67-75% egg length

(Rudolph et al., 1997)
embryonic stage 5 -- 6
cephalic furrow | anterior to
(Shandala et al., 1999)
organism | 0-10% egg length | dorsal
(Schaeper et al., 2010)
embryonic stage 6 -- 7
cephalic furrow | anterior to
(Rudolph et al., 1997)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
embryonic stage 7 -- 17
procephalic neurogenic region | restricted
(Rudolph et al., 1997)
embryonic stage 8 -- 11
organism | segmentally repeated
(Schaeper et al., 2010)
extended germ band stage
presumptive embryonic/larval peripheral nervous system | restricted
(Wimmer et al., 1996)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
gnathal primordium

Comment: reported as gnathal lobes anlage

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11
neuroblast
(Wimmer et al., 1996)
procephalic neurogenic region | anterior
(Lemons et al., 2010)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
pars intercerebralis primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 12
larval ventral nerve cord | restricted
(Wimmer et al., 1996)
embryonic stage 13
ventral thoracic disc primordium
(Estella and Mann, 2010)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic pars intercerebralis
(Fisher et al., 2012)
embryonic central brain surface glial cell
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
third instar larval stage
leg disc | restricted
(Estella and Mann, 2010)
antennal disc | restricted
(Estella and Mann, 2010)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
type II neuroblast
(Komori et al., 2014)
larval brain
(Komori et al., 2014)
Additional Descriptive Data

btd mRNA is highly enriched in the lysate extracted from larval brains enriched with type II neuroblasts.

(Komori et al., 2014)

btd is expressed in the entire leg imaginal disc except in the most proximal ring of cells that will become the body wall. In the antennal disc it is expressed in a medial ring of cells along the rpoximal-distal axis. No expression is observed in the wing, haltere, or eye discs.

(Estella and Mann, 2010)

btd is transcribed in the anterior protocerebral neurectoderm in a pattern that overlaps Dll.

(Lemons et al., 2010)

btd is first expressed in the embryo in an anterior head stripe that is roughly located in the area of the intercalary and mandibulary segment and later abuts the cephalic furrow. Later a segmentally repeated pattern emerges.

(Schaeper et al., 2010)

btd transcripts are expressed at roughly 67-75% egg length in the cellular blastoderm embryo. Beginning at gastrulation, btd expression becomes divided into two domains. One is in the anterior dorsomedial region and overlaps partially with the tll expression domain. The other is a set of stripes just anterior to the cephalic furrow. Expression in the protocerebral domain of the head is mostly gone by stage 9.

(Rudolph et al., 1997)

In blastoderm embryos, btd is expressed in the anlage of the antennal, intercalary, and mandibular segments. During cellularization a dorsal head spot appears in the proneural region anterior to the head stripe. Head spot expression continues and splits into several small spots during germ band retraction. These become integrated into the brain, marking different brain regions. During early germ band extension, btd is expressed in a metameric pattern. This pattern breaks up in fully germ band extended embryos, but btd expression continues in single neuroblasts which eventually become part of the ventral nerve cord. During germ band extension, btd expression is also observed in the lateral part of the embryo in the region of the proneural clusters. It is also expressed in the leg anlagen located in the thoracic segments and continues there until the end of embryogenesis.

(Wimmer et al., 1996)

btd transcript is first detected in embryonic cycle 12 as a stripe at 65-77% egg length. In late embryonic cycle 14, the stripe assumes a wedge shape which is narrower dorsally, and wider ventrally. Subsequently, an additional spot of btd expression appears more dorsally and anteriorly. In gastrulation, the cephalic furrow forms at the posterior edge of btd expression.

(Wimmer et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GawB}btdMD808
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 8
embryonic head
(Estella et al., 2003)
embryonic stage 9 -- 11
abdominal segment | ventral
(Estella et al., 2003)
thoracic segment | ventral
(Estella et al., 2003)
head segment | ventral
(Estella et al., 2003)
embryonic stage 12 -- 13
imaginal disc primordium | subset
(Estella et al., 2003)
peripheral nervous system
(Estella et al., 2003)
larval stage
leg disc | ventral
(Estella et al., 2003)
first instar larval stage
leg disc
(Córdoba et al., 2016)
third instar larval stage
leg disc | restricted
(Córdoba et al., 2016)
prepupal stage
leg disc | restricted
(Córdoba et al., 2016)
presumptive femur
(Córdoba et al., 2016)
presumptive metatarsus
(Córdoba et al., 2016)
presumptive tarsal segment 2
(Córdoba et al., 2016)
presumptive tarsal segment 3
(Córdoba et al., 2016)
presumptive tarsal segment 4
(Córdoba et al., 2016)
presumptive tarsal segment 5
(Córdoba et al., 2016)
adult stage
antenna
(Estella et al., 2003)
antennal disc | ventral
(Estella et al., 2003)
genitalia
(Estella et al., 2003)
leg
(Estella et al., 2003)
proboscis
(Estella et al., 2003)
embryonic stage 13
ventral thoracic disc primordium
(Estella and Mann, 2010)
third instar larval stage
leg disc | restricted
(Estella and Mann, 2010)
antennal disc | restricted
(Estella and Mann, 2010)
pupal stage
leg disc | restricted
(Estella and Mann, 2010)
Reporter: P{GMR85C07-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
type II neuroblast
(Komori et al., 2014)
larval brain
(Komori et al., 2014)
adult stage
prow | intense | restricted
(Jenett and Svirskas, 2012.9.24)
adult gnathal ganglion | restricted
(Jenett and Svirskas, 2012.9.24)
flange | intense | restricted
(Jenett and Svirskas, 2012.9.24)
adult lateral horn
(Varela et al., 2019)
adult neuron | subset of adult brain
(Varela et al., 2019)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\btd in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of btd
Transgenic constructs containing regulatory region of btd
Aberrations (Deficiencies and Duplications) ( 15 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
lethal - all die before end of P-stage (with Df(1)btd-Sp1)
lethal - all die during embryonic stage
lethal - all die during embryonic stage | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
abnormal cell shape | embryonic stage 6, with Scer\GAL4GCN4.nanos.bcd3'UTR
abnormal neuroanatomy | larval stage | somatic clone, with Scer\GAL4Act.PU
decreased size | adult stage (with Df(1)btd-Sp1)
homeotic | adult stage, with Scer\GAL4dpp.blk1
homeotic | somatic clone, with Scer\GAL4Tub.PU
some die during embryonic stage
some die during embryonic stage | recessive
visible, with Scer\GAL4sca-537.4
visible | adult stage, with Scer\GAL4Dll-em212
visible | adult stage, with Scer\GAL4dpp.blk1
visible | adult stage (with Df(1)btd-Sp1)
visible | female limited, with Scer\GAL4Bx-MS1096
visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
wild-type
Phenotype manifest in
Allele
abdominal 1 lateral pentascolopidial chordotonal organ lch5
abdominal 2 lateral pentascolopidial chordotonal organ lch5
abdominal 3 lateral pentascolopidial chordotonal organ lch5
abdominal 4 lateral pentascolopidial chordotonal organ lch5
abdominal 5 lateral pentascolopidial chordotonal organ lch5
abdominal 6 lateral pentascolopidial chordotonal organ lch5
abdominal 7 lateral pentascolopidial chordotonal organ lch5
adult cuticle | somatic clone
antenna
antenna, with Scer\GAL4ey.PH
antenna | ectopic, with Scer\GAL4ey.PH
antennal segment
antennal sense organ
anterior pharyngeal organ
associated organ
cephalic furrow
cephalic furrow | absent | embryonic stage 6
cephalic furrow | embryonic stage 6, with Scer\GAL4GCN4.nanos.bcd3'UTR
cephalopharyngeal skeleton
cephalopharyngeal skeleton | ventral
dorsolateral papilla
embryo
embryonic/larval optic lobe | embryonic stage
embryonic abdominal segment
embryonic antennal segment
embryonic deutocerebrum
embryonic head
embryonic head & sclerite | ectopic
embryonic intercalary segment
embryonic Malpighian tubule
embryonic mandibular segment
embryonic tritocerebrum
epithelial cell | embryonic stage 6, with Scer\GAL4GCN4.nanos.bcd3'UTR
eye, with Scer\GAL4ey.PH
femur | somatic clone
femur | somatic clone - Minute background, with Scer\GAL4Dll-em212
haltere, with Scer\GAL4bi-omb-Gal4
haltere, with Scer\GAL4Dll-MD743
haltere, with Scer\GAL4nub-AC-62
haltere | somatic clone, with Scer\GAL4Act5C.PP
intercalary segment
Keilin organ
Keilin organ, with Scer\GAL4btd-MD808
lateropharyngeal organ
leg, with Scer\GAL4ptc.PU
leg | adult stage, with Scer\GAL4Dll-em212
leg | adult stage (with Df(1)btd-Sp1)
leg | distal | ectopic | somatic clone, with Scer\GAL4Tub.PU
leg | ectopic, with Scer\GAL4bi-omb-Gal4
leg | ectopic, with Scer\GAL4Dll-MD743
leg | ectopic, with Scer\GAL4nub-AC-62
leg | ectopic | proximal | somatic clone, with Scer\GAL4Tub.PU
leg | ectopic | somatic clone, with Scer\GAL4Act5C.PP
leg | somatic clone
leg joint, with Scer\GAL4ptc.PU
mandibular segment
maxillary segment | anterior
papilla organ
scolopidium
segment of leg | adult stage, with Scer\GAL4Dll-em212
segment of leg | adult stage (with Df(1)btd-Sp1)
tibia | somatic clone
tibia | somatic clone - Minute background, with Scer\GAL4Dll-em212
type I neuroblast | larval stage | somatic clone, with Scer\GAL4Act.PU
wing, with Scer\GAL4bi-omb-Gal4
wing, with Scer\GAL4Dll-MD743
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4sca-537.4
wing | female limited, with Scer\GAL4Bx-MS1096
wing | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
wing | somatic clone, with Scer\GAL4Act5C.PP
wing | somatic clone, with Scer\GAL4Tub.PU
wing margin bristle, with Scer\GAL4sca-537.4
wing margin bristle | ectopic, with Scer\GAL4sca-537.4
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (171)
Hsap\EGR1
2 of 14
Yes
No
Hsap\EGR3
2 of 14
Yes
No
Hsap\SALL1
2 of 14
Yes
No
Hsap\SP5
2 of 14
Yes
No
Hsap\FEZF1
1 of 14
No
No
Hsap\GFI1B
1 of 14
No
No
1  
Hsap\GLI1
1 of 14
No
No
9  
Hsap\IKZF4
1 of 14
No
No
Hsap\KLF1
1 of 14
No
No
Hsap\KLF2
1 of 14
No
No
Hsap\KLF3
1 of 14
No
No
1  
Hsap\KLF4
1 of 14
No
No
Hsap\KLF5
1 of 14
No
No
Hsap\KLF6
1 of 14
No
No
2  
Hsap\KLF7
1 of 14
No
No
1  
Hsap\KLF8
1 of 14
No
No
Hsap\KLF9
1 of 14
No
No
Hsap\KLF10
1 of 14
No
No
Hsap\KLF11
1 of 14
No
No
Hsap\KLF12
1 of 14
No
No
1  
Hsap\KLF13
1 of 14
No
No
Hsap\KLF14
1 of 14
No
No
Hsap\KLF15
1 of 14
No
No
1  
Hsap\KLF16
1 of 14
No
No
Hsap\KLF17
1 of 14
No
No
Hsap\KLF18
1 of 14
No
No
Hsap\MECOM
1 of 14
No
No
Hsap\MTF1
1 of 14
No
No
1  
Hsap\MZF1
1 of 14
No
No
Hsap\OSR1
1 of 14
No
No
Hsap\OSR2
1 of 14
No
No
Hsap\PRDM4
1 of 14
No
No
Hsap\PRDM5
1 of 14
No
No
Hsap\RBAK
1 of 14
No
No
Hsap\SALL2
1 of 14
No
No
Hsap\SALL3
1 of 14
No
No
Hsap\SP1
1 of 14
No
No
0  
Hsap\SP2
1 of 14
No
No
Hsap\SP3
1 of 14
No
No
0  
Hsap\SP4
1 of 14
No
No
Hsap\SP6
1 of 14
No
No
Hsap\SP7
1 of 14
No
No
Hsap\SP8
1 of 14
No
No
Hsap\SP9
1 of 14
No
No
Hsap\WT1
1 of 14
No
No
2  
Hsap\ZBTB7A
1 of 14
No
No
1  
Hsap\ZBTB16
1 of 14
No
Yes
Hsap\ZBTB49
1 of 14
No
Yes
Hsap\ZFP2
1 of 14
No
No
Hsap\ZFP3
1 of 14
No
No
Hsap\ZFP28
1 of 14
No
No
Hsap\ZFP42
1 of 14
No
No
Hsap\ZFP90
1 of 14
No
No
Hsap\ZIC3
1 of 14
No
No
Hsap\ZIC4
1 of 14
No
No
Hsap\ZIC5
1 of 14
No
No
Hsap\ZKSCAN4
1 of 14
No
No
1  
Hsap\ZKSCAN8
1 of 14
No
No
Hsap\ZNF3
1 of 14
No
No
Hsap\ZNF7
1 of 14
No
No
Hsap\ZNF16
1 of 14
No
No
Hsap\ZNF17
1 of 14
No
No
Hsap\ZNF22
1 of 14
No
No
Hsap\ZNF34
1 of 14
No
Yes
Hsap\ZNF35
1 of 14
No
No
Hsap\ZNF45
1 of 14
No
No
Hsap\ZNF71
1 of 14
No
No
Hsap\ZNF76
1 of 14
No
No
Hsap\ZNF83
1 of 14
No
No
Hsap\ZNF84
1 of 14
No
No
Hsap\ZNF100
1 of 14
No
No
Hsap\ZNF112
1 of 14
No
No
Hsap\ZNF124
1 of 14
No
No
Hsap\ZNF132
1 of 14
No
No
Hsap\ZNF134
1 of 14
No
Yes
Hsap\ZNF135
1 of 14
No
No
Hsap\ZNF141
1 of 14
No
No
Hsap\ZNF143
1 of 14
No
Yes
Hsap\ZNF157
1 of 14
No
No
Hsap\ZNF181
1 of 14
No
Yes
Hsap\ZNF184
1 of 14
No
No
Hsap\ZNF205
1 of 14
No
No
Hsap\ZNF224
1 of 14
No
No
Hsap\ZNF225
1 of 14
No
No
Hsap\ZNF229
1 of 14
No
No
Hsap\ZNF233
1 of 14
No
No
Hsap\ZNF236
1 of 14
No
Yes
Hsap\ZNF248
1 of 14
No
No
Hsap\ZNF257
1 of 14
No
No
Hsap\ZNF267
1 of 14
No
No
1  
Hsap\ZNF274
1 of 14
No
No
Hsap\ZNF281
1 of 14
No
Yes
1  
Hsap\ZNF304
1 of 14
No
No
Hsap\ZNF316
1 of 14
No
No
Hsap\ZNF347
1 of 14
No
No
Hsap\ZNF350
1 of 14
No
No
Hsap\ZNF354B
1 of 14
No
No
Hsap\ZNF358
1 of 14
No
No
Hsap\ZNF367
1 of 14
No
No
Hsap\ZNF382
1 of 14
No
No
Hsap\ZNF394
1 of 14
No
No
Hsap\ZNF397
1 of 14
No
No
Hsap\ZNF408
1 of 14
No
No
Hsap\ZNF410
1 of 14
No
Yes
Hsap\ZNF415
1 of 14
No
No
Hsap\ZNF420
1 of 14
No
No
Hsap\ZNF436
1 of 14
No
No
Hsap\ZNF449
1 of 14
No
No
1  
Hsap\ZNF454
1 of 14
No
No
Hsap\ZNF460
1 of 14
No
No
Hsap\ZNF468
1 of 14
No
No
Hsap\ZNF480
1 of 14
No
No
Hsap\ZNF483
1 of 14
No
Yes
Hsap\ZNF497
1 of 14
No
No
Hsap\ZNF510
1 of 14
No
No
Hsap\ZNF519
1 of 14
No
No
Hsap\ZNF527
1 of 14
No
No
Hsap\ZNF530
1 of 14
No
No
Hsap\ZNF534
1 of 14
No
No
Hsap\ZNF543
1 of 14
No
No
Hsap\ZNF546
1 of 14
No
No
Hsap\ZNF549
1 of 14
No
No
Hsap\ZNF555
1 of 14
No
No
Hsap\ZNF570
1 of 14
No
No
Hsap\ZNF572
1 of 14
No
No
Hsap\ZNF574
1 of 14
No
No
Hsap\ZNF578
1 of 14
No
No
Hsap\ZNF583
1 of 14
No
No
Hsap\ZNF594
1 of 14
No
No
Hsap\ZNF606
1 of 14
No
No
Hsap\ZNF615
1 of 14
No
No
Hsap\ZNF628
1 of 14
No
No
Hsap\ZNF629
1 of 14
No
No
Hsap\ZNF630
1 of 14
No
No
Hsap\ZNF648
1 of 14
No
No
Hsap\ZNF674
1 of 14
No
No
Hsap\ZNF682
1 of 14
No
No
Hsap\ZNF689
1 of 14
No
No
Hsap\ZNF700
1 of 14
No
No
Hsap\ZNF701
1 of 14
No
Yes
Hsap\ZNF705A
1 of 14
No
No
Hsap\ZNF705B
1 of 14
No
Yes
Hsap\ZNF705D
1 of 14
No
Yes
Hsap\ZNF705F
1 of 14
No
Yes
Hsap\ZNF714
1 of 14
No
No
Hsap\ZNF717
1 of 14
No
No
Hsap\ZNF724
1 of 14
No
No
Hsap\ZNF726
1 of 14
No
No
Hsap\ZNF749
1 of 14
No
No
Hsap\ZNF777
1 of 14
No
No
Hsap\ZNF787
1 of 14
No
No
Hsap\ZNF792
1 of 14
No
No
Hsap\ZNF808
1 of 14
No
No
Hsap\ZNF813
1 of 14
No
No
Hsap\ZNF835
1 of 14
No
No
Hsap\ZNF845
1 of 14
No
No
Hsap\ZNF860
1 of 14
No
No
Hsap\ZNF875
1 of 14
No
No
Hsap\ZNF879
1 of 14
No
No
Hsap\ZNF880
1 of 14
No
No
Hsap\ZNF888
1 of 14
No
No
Hsap\ZSCAN5DP
1 of 14
No
Yes
Hsap\ZSCAN16
1 of 14
No
No
Hsap\ZSCAN21
1 of 14
No
No
Hsap\ZSCAN22
1 of 14
No
No
Hsap\ZSCAN23
1 of 14
No
No
Hsap\ZSCAN25
1 of 14
No
No
Hsap\ZSCAN31
1 of 14
No
No
Hsap\ZXDA
1 of 14
No
No
Hsap\ZXDB
1 of 14
No
No
Hsap\ZXDC
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (93)
Rnor\Egr1
1 of 14
Yes
No
Rnor\Egr3
1 of 14
Yes
No
Rnor\Egr4
1 of 14
Yes
No
Rnor\Fezf2
1 of 14
Yes
No
Rnor\Ikzf4
1 of 14
Yes
No
Rnor\Klf1
1 of 14
Yes
No
Rnor\Klf2
1 of 14
Yes
No
Rnor\Klf3
1 of 14
Yes
No
Rnor\Klf4
1 of 14
Yes
No
Rnor\Klf5
1 of 14
Yes
No
Rnor\Klf6
1 of 14
Yes
No
Rnor\Klf8
1 of 14
Yes
No
Rnor\Klf9
1 of 14
Yes
No
Rnor\Klf10
1 of 14
Yes
No
Rnor\Klf11
1 of 14
Yes
No
Rnor\Klf12
1 of 14
Yes
No
Rnor\Klf14
1 of 14
Yes
No
Rnor\Klf15
1 of 14
Yes
No
Rnor\Klf16
1 of 14
Yes
No
Rnor\Klf17
1 of 14
Yes
No
Rnor\LOC100911196
1 of 14
Yes
Yes
Rnor\LOC102546648
1 of 14
Yes
No
Rnor\LOC102548917
1 of 14
Yes
No
Rnor\LOC102554315
1 of 14
Yes
Yes
Rnor\Mecom
1 of 14
Yes
No
Rnor\Mtf1
1 of 14
Yes
No
Rnor\Mzf1
1 of 14
Yes
No
Rnor\Osr1
1 of 14
Yes
No
Rnor\Osr2
1 of 14
Yes
No
Rnor\Prdm1
1 of 14
Yes
No
Rnor\Prdm4
1 of 14
Yes
No
Rnor\Prdm5
1 of 14
Yes
Yes
Rnor\Prdm14
1 of 14
Yes
Yes
Rnor\Sall3
1 of 14
Yes
No
Rnor\Sall4
1 of 14
Yes
No
Rnor\Sp1
1 of 14
Yes
No
Rnor\Sp2
1 of 14
Yes
No
Rnor\Sp3
1 of 14
Yes
No
Rnor\Sp4
1 of 14
Yes
No
Rnor\Sp5
1 of 14
Yes
No
Rnor\Sp6
1 of 14
Yes
No
Rnor\Sp7
1 of 14
Yes
No
Rnor\Sp8
1 of 14
Yes
No
Rnor\Sp9
1 of 14
Yes
No
Rnor\Wt1
1 of 14
Yes
Yes
Rnor\Yy2
1 of 14
Yes
No
Rnor\Zbtb7a
1 of 14
Yes
Yes
Rnor\Zbtb7c
1 of 14
Yes
Yes
Rnor\Zbtb17
1 of 14
Yes
Yes
Rnor\Zbtb49
1 of 14
Yes
Yes
Rnor\Zfp2
1 of 14
Yes
No
Rnor\Zfp3
1 of 14
Yes
No
Rnor\Zfp13
1 of 14
Yes
No
Rnor\Zfp17
1 of 14
Yes
No
Rnor\Zfp26
1 of 14
Yes
No
Rnor\Zfp78
1 of 14
Yes
No
Rnor\Zfp90
1 of 14
Yes
No
Rnor\Zfp110
1 of 14
Yes
Yes
Rnor\Zfp143
1 of 14
Yes
No
Rnor\Zfp184
1 of 14
Yes
No
Rnor\Zfp236
1 of 14
Yes
Yes
Rnor\Zfp251
1 of 14
Yes
Yes
Rnor\Zfp263
1 of 14
Yes
No
Rnor\Zfp316
1 of 14
Yes
No
Rnor\Zfp317
1 of 14
Yes
No
Rnor\Zfp358
1 of 14
Yes
Yes
Rnor\Zfp367
1 of 14
Yes
Yes
Rnor\Zfp386
1 of 14
Yes
Yes
Rnor\Zfp394
1 of 14
Yes
No
Rnor\Zfp647
1 of 14
Yes
No
Rnor\Zfp648
1 of 14
Yes
No
Rnor\Zfp691
1 of 14
Yes
Yes
Rnor\Zfp764
1 of 14
Yes
No
Rnor\Zfp772
1 of 14
Yes
Yes
Rnor\Zfp773-ps1
1 of 14
Yes
No
Rnor\Zfp775
1 of 14
Yes
Yes
Rnor\Zfp777
1 of 14
Yes
Yes
Rnor\Zfp786
1 of 14
Yes
Yes
Rnor\Zfp787
1 of 14
Yes
No
Rnor\Zfp867
1 of 14
Yes
Yes
Rnor\Zfp945
1 of 14
Yes
No
Rnor\Zfp956
1 of 14
Yes
Yes
Rnor\Zic3
1 of 14
Yes
No
Rnor\Zic4
1 of 14
Yes
No
Rnor\Zic5
1 of 14
Yes
No
Rnor\Zim1
1 of 14
Yes
Yes
Rnor\Zkscan3
1 of 14
Yes
No
Rnor\Zkscan4
1 of 14
Yes
No
Rnor\Zkscan8
1 of 14
Yes
Yes
Rnor\Znf8
1 of 14
Yes
No
Rnor\Zscan10
1 of 14
Yes
Yes
Rnor\Zscan22
1 of 14
Yes
Yes
Rnor\Zxdc
1 of 14
Yes
No
Mus musculus (laboratory mouse) (129)
Mmus\Egr1
2 of 14
Yes
No
Mmus\Egr3
2 of 14
Yes
No
Mmus\Egr4
2 of 14
Yes
Yes
Mmus\Klf14
2 of 14
Yes
Yes
Mmus\Klf16
2 of 14
Yes
Yes
Mmus\Sp5
2 of 14
Yes
No
Mmus\2010315B03Rik
1 of 14
No
No
Mmus\5730507C01Rik
1 of 14
No
No
Mmus\9130019O22Rik
1 of 14
No
Yes
Mmus\E430018J23Rik
1 of 14
No
No
Mmus\Egr2
1 of 14
No
No
Mmus\Fezf1
1 of 14
No
No
1  
Mmus\Fezf2
1 of 14
No
No
1  
Mmus\Gm2007
1 of 14
No
No
Mmus\Gm2026
1 of 14
No
No
Mmus\Gm4631
1 of 14
No
No
Mmus\Gm4724
1 of 14
No
No
Mmus\Gm4924
1 of 14
No
No
Mmus\Gm6710
1 of 14
No
No
Mmus\Gm7145
1 of 14
No
No
Mmus\Gm10033
1 of 14
No
No
Mmus\Gm11007
1 of 14
No
Yes
Mmus\Gm14124
1 of 14
No
No
Mmus\Gm14139
1 of 14
No
No
Mmus\Gm14295
1 of 14
No
No
Mmus\Gm14308
1 of 14
No
No
Mmus\Gm14391
1 of 14
No
No
Mmus\Gm14399
1 of 14
No
Yes
Mmus\Gm14412
1 of 14
No
No
Mmus\Gm14430
1 of 14
No
Yes
Mmus\Gm14434
1 of 14
No
No
Mmus\Gm14444
1 of 14
No
No
Mmus\Gm15446
1 of 14
No
No
Mmus\Gm19965
1 of 14
No
No
Mmus\Ikzf4
1 of 14
No
No
Mmus\Klf1
1 of 14
No
No
Mmus\Klf2
1 of 14
No
No
Mmus\Klf3
1 of 14
No
No
Mmus\Klf4
1 of 14
No
No
Mmus\Klf5
1 of 14
No
No
Mmus\Klf6
1 of 14
No
No
Mmus\Klf7
1 of 14
No
No
Mmus\Klf8
1 of 14
No
No
Mmus\Klf9
1 of 14
No
No
Mmus\Klf10
1 of 14
No
No
Mmus\Klf11
1 of 14
No
No
Mmus\Klf12
1 of 14
No
No
Mmus\Klf15
1 of 14
No
No
Mmus\Klf17
1 of 14
No
No
Mmus\Mecom
1 of 14
No
No
Mmus\Mtf1
1 of 14
No
No
Mmus\Mzf1
1 of 14
No
No
Mmus\Osr1
1 of 14
No
No
1  
Mmus\Osr2
1 of 14
No
No
Mmus\Platr25
1 of 14
No
No
Mmus\Prdm1
1 of 14
No
No
Mmus\Prdm4
1 of 14
No
No
Mmus\Prdm5
1 of 14
No
No
Mmus\Prdm14
1 of 14
No
Yes
Mmus\Sall3
1 of 14
No
No
Mmus\Sp1
1 of 14
No
No
Mmus\Sp2
1 of 14
No
No
Mmus\Sp3
1 of 14
No
No
Mmus\Sp4
1 of 14
No
No
Mmus\Sp6
1 of 14
No
No
Mmus\Sp7
1 of 14
No
No
Mmus\Sp8
1 of 14
No
No
1  
Mmus\Sp9
1 of 14
No
No
Mmus\Wt1
1 of 14
No
No
Mmus\Yy2
1 of 14
No
No
Mmus\Zbtb7a
1 of 14
No
Yes
Mmus\Zbtb7c
1 of 14
No
Yes
Mmus\Zfp13
1 of 14
No
No
Mmus\Zfp26
1 of 14
No
No
Mmus\Zfp51
1 of 14
No
No
Mmus\Zfp61
1 of 14
No
No
Mmus\Zfp90
1 of 14
No
No
Mmus\Zfp94
1 of 14
No
No
Mmus\Zfp110
1 of 14
No
Yes
Mmus\Zfp112
1 of 14
No
No
Mmus\Zfp128
1 of 14
No
No
Mmus\Zfp143
1 of 14
No
No
Mmus\Zfp180
1 of 14
No
No
Mmus\Zfp184
1 of 14
No
No
Mmus\Zfp213
1 of 14
No
Yes
Mmus\Zfp229
1 of 14
No
No
Mmus\Zfp235
1 of 14
No
No
Mmus\Zfp236
1 of 14
No
Yes
Mmus\Zfp248
1 of 14
No
No
Mmus\Zfp251
1 of 14
No
Yes
Mmus\Zfp263
1 of 14
No
No
Mmus\Zfp282
1 of 14
No
Yes
Mmus\Zfp286
1 of 14
No
Yes
Mmus\Zfp287
1 of 14
No
Yes
Mmus\Zfp316
1 of 14
No
No
Mmus\Zfp345
1 of 14
No
No
Mmus\Zfp367
1 of 14
No
Yes
Mmus\Zfp410
1 of 14
No
Yes
Mmus\Zfp449
1 of 14
No
Yes
Mmus\Zfp454
1 of 14
No
No
Mmus\Zfp617
1 of 14
No
No
Mmus\Zfp628
1 of 14
No
Yes
Mmus\Zfp647
1 of 14
No
No
Mmus\Zfp658
1 of 14
No
No
Mmus\Zfp683
1 of 14
No
Yes
Mmus\Zfp691
1 of 14
No
Yes
Mmus\Zfp735
1 of 14
No
No
Mmus\Zfp777
1 of 14
No
Yes
Mmus\Zfp787
1 of 14
No
Yes
Mmus\Zfp809
1 of 14
No
Yes
Mmus\Zfp865
1 of 14
No
Yes
Mmus\Zfp867
1 of 14
No
Yes
Mmus\Zfp932
1 of 14
No
No
Mmus\Zfp956
1 of 14
No
Yes
Mmus\Zfp963
1 of 14
No
Yes
Mmus\Zfp970
1 of 14
No
No
Mmus\Zfp971
1 of 14
No
No
Mmus\Zfp977
1 of 14
No
No
Mmus\Zfp983
1 of 14
No
No
Mmus\Zfp988
1 of 14
No
No
Mmus\Zfp998
1 of 14
No
No
Mmus\Zic3
1 of 14
No
No
Mmus\Zic4
1 of 14
No
No
Mmus\Zim1
1 of 14
No
Yes
Mmus\Zkscan3
1 of 14
No
No
Mmus\Zkscan8
1 of 14
No
Yes
Mmus\Zscan10
1 of 14
No
Yes
Mmus\Zscan22
1 of 14
No
No
Mmus\Zxdc
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (66)
Xtro\asb8
1 of 13
Yes
No
Xtro\egr3
1 of 13
Yes
No
Xtro\egr4
1 of 13
Yes
No
Xtro\fezf1
1 of 13
Yes
No
Xtro\ikzf3
1 of 13
Yes
Yes
Xtro\klf4
1 of 13
Yes
No
Xtro\klf5
1 of 13
Yes
No
Xtro\klf7
1 of 13
Yes
No
Xtro\klf9
1 of 13
Yes
Yes
Xtro\klf10
1 of 13
Yes
No
Xtro\klf11
1 of 13
Yes
No
Xtro\klf12
1 of 13
Yes
No
Xtro\klf13
1 of 13
Yes
No
Xtro\klf15.2
1 of 13
Yes
No
Xtro\klf15
1 of 13
Yes
No
Xtro\LOC496795
1 of 13
Yes
No
Xtro\LOC100485062
1 of 13
Yes
No
Xtro\LOC100485124
1 of 13
Yes
No
Xtro\LOC100485218
1 of 13
Yes
No
Xtro\LOC100486951
1 of 13
Yes
Yes
Xtro\LOC100487103
1 of 13
Yes
Yes
Xtro\LOC100487628
1 of 13
Yes
No
Xtro\LOC100490952
1 of 13
Yes
No
Xtro\LOC100492687
1 of 13
Yes
Yes
Xtro\LOC100493522
1 of 13
Yes
No
Xtro\LOC100493797
1 of 13
Yes
No
Xtro\LOC100495895
1 of 13
Yes
No
Xtro\LOC100496074
1 of 13
Yes
No
Xtro\LOC101731232
1 of 13
Yes
No
Xtro\LOC101731620
1 of 13
Yes
No
Xtro\LOC101732880
1 of 13
Yes
No
Xtro\LOC101733761
1 of 13
Yes
No
Xtro\LOC108645295
1 of 13
Yes
No
Xtro\LOC116406443
1 of 13
Yes
Yes
Xtro\LOC116407549
1 of 13
Yes
No
Xtro\mtf1
1 of 13
Yes
No
Xtro\osr1
1 of 13
Yes
No
Xtro\prdm1
1 of 13
Yes
No
Xtro\sp3
1 of 13
Yes
No
Xtro\sp4
1 of 13
Yes
No
Xtro\sp5
1 of 13
Yes
No
Xtro\sp8
1 of 13
Yes
No
Xtro\sp9
1 of 13
Yes
No
Xtro\tsc22d3
1 of 13
Yes
No
Xtro\vps28
1 of 13
Yes
No
Xtro\wt1
1 of 13
Yes
No
Xtro\XB5772961
1 of 13
Yes
Yes
Xtro\zbtb7c
1 of 13
Yes
Yes
Xtro\zbtb16
1 of 13
Yes
No
Xtro\zbtb37
1 of 13
Yes
No
Xtro\zfp64
1 of 13
Yes
Yes
Xtro\zic2
1 of 13
Yes
No
Xtro\zic3
1 of 13
Yes
No
Xtro\znf208
1 of 13
Yes
No
Xtro\znf229
1 of 13
Yes
No
Xtro\znf282
1 of 13
Yes
No
Xtro\znf329
1 of 13
Yes
No
Xtro\znf367
1 of 13
Yes
Yes
Xtro\znf408
1 of 13
Yes
Yes
Xtro\znf423
1 of 13
Yes
No
Xtro\znf524
1 of 13
Yes
No
Xtro\znf526
1 of 13
Yes
No
Xtro\znf527
1 of 13
Yes
Yes
Xtro\znf574
1 of 13
Yes
No
Xtro\znf883l
1 of 13
Yes
No
Xtro\zxdc
1 of 13
Yes
Yes
Danio rerio (Zebrafish) (104)
Drer\sp5a
2 of 14
Yes
No
Drer\znf281b
2 of 14
Yes
Yes
Drer\e4f1
1 of 14
No
Yes
Drer\egr1
1 of 14
No
No
Drer\egr2a
1 of 14
No
No
Drer\egr3
1 of 14
No
No
Drer\egr4
1 of 14
No
No
Drer\fezf1
1 of 14
No
No
Drer\hic2
1 of 14
No
Yes
Drer\klf1
1 of 14
No
No
Drer\klf2a
1 of 14
No
No
Drer\klf2b
1 of 14
No
No
Drer\klf3
1 of 14
No
No
Drer\klf4
1 of 14
No
No
Drer\klf5a
1 of 14
No
No
Drer\klf5b
1 of 14
No
No
Drer\klf5l
1 of 14
No
No
Drer\klf6a
1 of 14
No
No
Drer\klf6b
1 of 14
No
No
Drer\klf7a
1 of 14
No
No
Drer\klf7b
1 of 14
No
No
Drer\klf8
1 of 14
No
No
Drer\klf9
1 of 14
No
No
Drer\klf11a
1 of 14
No
No
Drer\klf11b
1 of 14
No
No
Drer\klf12a
1 of 14
No
No
Drer\klf12b
1 of 14
No
No
Drer\klf13
1 of 14
No
No
Drer\klf15
1 of 14
No
No
Drer\klf17
1 of 14
No
No
Drer\LOC100006216
1 of 14
No
Yes
Drer\LOC100148620
1 of 14
No
Yes
Drer\LOC100329258
1 of 14
No
No
Drer\LOC100329790
1 of 14
No
No
Drer\LOC100534672
1 of 14
No
Yes
Drer\LOC100536867
1 of 14
No
Yes
Drer\LOC101882267
1 of 14
No
Yes
Drer\LOC101883139
1 of 14
No
No
Drer\LOC101883356
1 of 14
No
No
Drer\LOC101884367
1 of 14
No
No
Drer\LOC101885363
1 of 14
No
Yes
Drer\LOC108183930
1 of 14
No
No
Drer\LOC108184006
1 of 14
No
No
Drer\LOC110437815
1 of 14
No
No
Drer\LOC110437839
1 of 14
No
Yes
Drer\mtf1
1 of 14
No
No
Drer\osr1
1 of 14
No
No
Drer\osr2
1 of 14
No
No
Drer\prdm5
1 of 14
No
Yes
Drer\prdm9
1 of 14
No
No
Drer\scrt1a
1 of 14
No
No
Drer\si:cabz01032454.3
1 of 14
No
No
Drer\si:cabz01054394.5
1 of 14
No
Yes
Drer\si:cabz01069022.1
1 of 14
No
Yes
Drer\si:ch73-144d13.4
1 of 14
No
Yes
Drer\si:ch73-266f23.4
1 of 14
No
Yes
Drer\si:ch73-367f21.4
1 of 14
No
No
Drer\si:ch211-117k10.3
1 of 14
No
No
Drer\si:ch211-155e24.3
1 of 14
No
Yes
Drer\si:dkey-7l6.3
1 of 14
No
Yes
Drer\si:dkey-14d8.1
1 of 14
No
Yes
Drer\si:dkey-30k6.5
1 of 14
No
Yes
Drer\si:dkey-33c14.6
1 of 14
No
No
Drer\si:dkey-34m19.3
1 of 14
No
No
Drer\si:dkey-77f5.4
1 of 14
No
Yes
Drer\si:dkey-182i3.9
1 of 14
No
Yes
Drer\si:dkey-201g16.1
1 of 14
No
Yes
Drer\si:dkey-262g12.9
1 of 14
No
Yes
Drer\si:dkeyp-2e4.6
1 of 14
No
No
Drer\si:dkeyp-2e4.8
1 of 14
No
Yes
Drer\si:zfos-932h1.3
1 of 14
No
No
Drer\sp1
1 of 14
No
No
Drer\sp2
1 of 14
No
No
Drer\sp3a
1 of 14
No
No
Drer\sp3b
1 of 14
No
No
Drer\sp4
1 of 14
No
No
Drer\sp5b
1 of 14
No
No
Drer\sp5l
1 of 14
No
No
Drer\sp6
1 of 14
No
No
Drer\sp7
1 of 14
No
No
Drer\sp8a
1 of 14
No
No
Drer\sp8b
1 of 14
No
No
Drer\sp9
1 of 14
No
No
Drer\wt1a
1 of 14
No
No
Drer\zbtb7c
1 of 14
No
Yes
Drer\zbtb49
1 of 14
No
Yes
Drer\zgc:113119
1 of 14
No
Yes
Drer\zgc:162971
1 of 14
No
Yes
Drer\zgc:173577
1 of 14
No
Yes
Drer\zgc:174314
1 of 14
No
No
Drer\zgc:174315
1 of 14
No
Yes
Drer\zic2a
1 of 14
No
No
Drer\zic2b
1 of 14
No
No
Drer\zic3
1 of 14
No
No
Drer\zic5
1 of 14
No
No
Drer\zic6
1 of 14
No
No
Drer\znf143a
1 of 14
No
Yes
Drer\znf236
1 of 14
No
Yes
Drer\znf410
1 of 14
No
Yes
Drer\znf526
1 of 14
No
Yes
Drer\znf770
1 of 14
No
Yes
Drer\znf971
1 of 14
No
Yes
Drer\znf973
1 of 14
No
Yes
Drer\znf1177
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\sptf-3
4 of 14
Yes
No
Cele\sptf-2
2 of 14
No
No
Cele\egrh-1
1 of 14
No
No
Cele\egrh-2
1 of 14
No
No
Cele\K11D12.12
1 of 14
No
Yes
Cele\klf-1
1 of 14
No
No
Cele\klf-2
1 of 14
No
No
Cele\klf-3
1 of 14
No
No
Cele\odd-2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (25)
Agam\AgaP_AGAP000674
7 of 12
Yes
Yes
Agam\AgaP_AGAP000587
1 of 12
No
No
Agam\AgaP_AGAP000673
1 of 12
No
No
Agam\AgaP_AGAP001258
1 of 12
No
Yes
Agam\AgaP_AGAP001781
1 of 12
No
No
Agam\AgaP_AGAP002702
1 of 12
No
No
Agam\AgaP_AGAP002773
1 of 12
No
No
Agam\AgaP_AGAP004282
1 of 12
No
No
Agam\AgaP_AGAP004331
1 of 12
No
No
Agam\AgaP_AGAP004438
1 of 12
No
No
Agam\AgaP_AGAP004517
1 of 12
No
No
Agam\AgaP_AGAP004580
1 of 12
No
Yes
Agam\AgaP_AGAP004994
1 of 12
No
No
Agam\AgaP_AGAP004995
1 of 12
No
Yes
Agam\AgaP_AGAP006592
1 of 12
No
No
Agam\AgaP_AGAP006736
1 of 12
No
No
Agam\AgaP_AGAP006758
1 of 12
No
No
Agam\AgaP_AGAP007038
1 of 12
No
No
Agam\AgaP_AGAP007389
1 of 12
No
No
Agam\AgaP_AGAP008827
1 of 12
No
No
Agam\AgaP_AGAP009566
1 of 12
No
No
Agam\AgaP_AGAP009889
1 of 12
No
No
Agam\AgaP_AGAP010520
1 of 12
No
No
Agam\AgaP_AGAP011502
1 of 12
No
No
Agam\DRM_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT5G22890
1 of 13
Yes
No
Atha\DOT5
1 of 13
Yes
Yes
Atha\NTT
1 of 13
Yes
Yes
Atha\TT1
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\FZF1
1 of 13
Yes
No
Scer\MET32
1 of 13
Yes
Yes
Scer\MOT3
1 of 13
Yes
Yes
Scer\MSN2
1 of 13
Yes
Yes
Scer\USV1
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\hsr1
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:btd. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (32)
Sp1
5 of 13
dar1
4 of 13
luna
4 of 13
cbt
3 of 13
CG3065
3 of 13
CG42741
3 of 13
Klf15
3 of 13
Spps
3 of 13
Cf2
2 of 13
hkb
2 of 13
sr
2 of 13
Blimp-1
1 of 13
CG5245
1 of 13
CG7368
1 of 13
CG11902
1 of 13
CG12299
1 of 13
CG16779
1 of 13
crol
1 of 13
drm
1 of 13
esg
1 of 13
gl
1 of 13
Kah
1 of 13
klu
1 of 13
l(3)neo38
1 of 13
lmd
1 of 13
lola
1 of 13
mamo
1 of 13
Meics
1 of 13
nerfin-1
1 of 13
odd
1 of 13
pad
1 of 13
pho
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    btd
    suppressible
    btd::Hsap\SP1
    (Schock et al., 2000)
    btd
    suppressible
    btd::Mmmm\Sp1
    (Schock et al., 1999)
    btd
    suppressible
    Dll
    (Estella and Mann, 2010)
    btd
    enhanceable
    Sp1
    (Blom-Dahl et al., 2020)
    btd
    suppressible
    Sp1
    (Schock et al., 1999)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    brat
    suppressible
    btd
    (Komori et al., 2014)
    pnt
    suppressible
    btd
    (Xie et al., 2016)
    pnt
    enhanceable
    btd
    (Xie et al., 2016)
    trx
    suppressible
    btd
    (Komori et al., 2014)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-29
    Cytogenetic map
    8F10-8F10
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    8F10-8F10
    Limits computationally determined from genome sequence between P{EP}nejEP1149&P{EP}nejEP1179 and P{EP}α-Man-IEP1628&P{EP}α-Man-IEP1307
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    8A5-9A1
    (Tearle and Nusslein-Volhard, 1987)
    Cytological location determined by segmental aneuploidy.
    (Tearle and Nusslein-Volhard, 1987)
    Experimentally Determined Recombination Data
    Location

    1-29

    (FlyBase, 2016)

    1-30.6

    (Comeron et al., 2012)

    1-31

    (Tearle and Nusslein-Volhard, 1987)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (18)
    Genomic Clones (22)
    cDNA Clones (11)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          ems is able to specify head identity when acting in concert with btd.

          (Schock et al., 2000)

          Mis-expression of btd in the trunk causes ems-dependent structures to develop.

          (Schock et al., 2000)

          ems and btd gene products interact in vitro.

          (Schock et al., 2000)

          btd and Sp1 play essential and redundant roles for mechanosensory development.

          (Schock et al., 1999)

          tll expression in brain neuroblasts is not detectably regulated by btd, oc, l(1)sc or tll itself.

          (Rudolph et al., 1997)

          The spatial limits of btd are not instructive for metamerisation of the head region and btd activity does not contribute to a combinatorial code for specification of segment identity.

          (Wimmer et al., 1997)

          Sp1 and btd may represent a gene pair with partially redundant functions.

          (Wimmer et al., 1996)

          Cis-acting elements required for btd head stripe expression are contained in a 1kb DNA fragment, located about 3kb upstream of the promoter. The four maternal coordinate systems are necessary for correct btd head stripe expression, likely by acting through the 1kb cis-acting control region.

          (Wimmer et al., 1995)

          Activation of cnc in intercalary and mandibular primordia requires zygotic gap gene products, activation by btd and repression by oc (anteriorly) or sna (ventrally).

          (Mohler, 1993)

          When expressed in the spatial pattern of btd, a transgene providing Mmmm\Sp1 activity can support development of the mandibular segment in the head of btd mutant embryos.

          (Wimmer et al., 1993)

          btd has a gap-gene-like role in mediating the development of head structures.

          (Eldon and Pirrotta, 1991)

          Mutations in zygotic gene btd do not interact with RpII140wimp.

          (Parkhurst and Ish-Horowicz, 1991)

          btd, ems and oc are required to establish contiguous blocks of segments and may behave like gap genes that mediate bcd function in the embryonic head.

          (Cohen and Jurgens, 1990)

          A screen for X-linked genes that affect embryo morphology revealed btd.

          (Eberl and Hilliker, 1988)

          btd mutants display incomplete head involution.

          (Wieschaus et al., 1984)
          Relationship to Other Genes
          Source for database merge of
          Additional comments
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (7)
          Reported As
          Symbol Synonym
          BTD
          (Suske et al., 2005, Wimmer, 1994.1.11)
          Btd
          (Cattenoz et al., 2021, Rajan et al., 2021, Stathopoulos and Newcomb, 2020, Bischof et al., 2018, Ruiz-Losada et al., 2018, Chambers et al., 2017, Chen et al., 2016, Huylmans and Parsch, 2014, Noyes et al., 2008, Kaplan et al., 2005)
          CG12653
          (Ni et al., 2011.7.19, Ni et al., 2010.12.1, Perkins et al., 2009, Laviolette et al., 2005)
          btd
          (Dey et al., 2025, Lee et al., 2024, Posnien et al., 2023, Deshpande et al., 2022, Fukaya, 2021, Irizarry and Stathopoulos, 2021, Michki et al., 2021, Chandler et al., 2020, Eritano et al., 2020, Gheisari et al., 2020, Banerjee et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Datta et al., 2018, Newcomb et al., 2018, Palmer et al., 2018, Karaiskos et al., 2017, Transgenic RNAi Project members, 2017-, Córdoba et al., 2016, Peng et al., 2016, Skottheim Honn et al., 2016, Urbach et al., 2016, Xie et al., 2016, Duque and Sinha, 2015, Schertel et al., 2015, Komori et al., 2014, Navarro et al., 2014, Spahn et al., 2014, Xie et al., 2014, Combs and Eisen, 2013, Menoret et al., 2013, Saunders et al., 2013, Webber et al., 2013, Andrioli et al., 2012, Chen et al., 2012, He et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Loncle and Williams, 2012, Nikulova et al., 2012, Cherbas et al., 2011, Lott et al., 2011, Estella and Mann, 2010, Fernandes et al., 2010, Lemons et al., 2010, Popodi et al., 2010-, Schaeper et al., 2010, Venken et al., 2010, Löhr et al., 2009, McKay et al., 2009, Ochoa-Espinosa et al., 2009, Blanco and Gehring, 2008, Sanders et al., 2008, Segal et al., 2008, Stofanko et al., 2008, Tomancak et al., 2007, Urbach, 2007, Chanut-Delalande et al., 2006, Franch-Marro et al., 2006, Scholtz and Edgecombe, 2006, Brown et al., 2005, Kaplan et al., 2005, Laviolette et al., 2005, Grad et al., 2004, Loop et al., 2004)
          buttonhead
          (Skottheim Honn et al., 2016)
          Name Synonyms
          Buttonhead
          (Gilmour et al., 2017)
          button-head
          (Blanco and Gehring, 2008)
          buttonhead
          (Urbach et al., 2016, Wieschaus and Nüsslein-Volhard, 2016, Andrioli et al., 2012, Lott et al., 2011, Estella and Mann, 2010, Lemons et al., 2010, Löhr et al., 2009, McKay et al., 2009, Ochoa-Espinosa et al., 2009, Coiffier et al., 2008, Ishihara and Shibata, 2008, Sanders et al., 2008, Stofanko et al., 2008, Munoz-Descalzo et al., 2007, Scholtz and Edgecombe, 2006, Yucel and Small, 2006)
          Secondary FlyBase IDs
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 40 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            References (211)