FlyBase Allele Report: Dmel\btd[XG]

Full-leg btd^XG homozygous clones result in moderate leg defects as compared to controls, which, at the extreme, are the fusion and size reduction of femur and tibia, while the other leg segments remain apparently normal; btd^XG homozygous clones in mosaic legs exhibit no obvious defects, except for some cuticle abnormalities in the tibia, as compared to controls.

(Córdoba et al., 2016)

btd^XG/+ mutant larvae do not exhibit an obvious loss of intermediate neural progenitors or change in the number of Asense-negative type II neuroblasts, as compared to wild type.

(Xie et al., 2016)

Generation of btd^XG mutant leg clones during the second instar larval stage (in a minute background) produces weak phenotypes in the femur and tibia, which are partially fused. No phenotypes are seen when clones are generated in the antenna.

Generation of btd^XG clones during embryogenesis (in a minute background using Scer\FLP1^Scer\UAS.cUa under the control of Scer\GAL4^Dll-em212) produces relatively minor fusions of the femur and tibia, but leaves the tarsal segments largely unaffected. The tarsus, trochanter and coxa are unaffected. No ventral to dorsal transformations are observed in these flies.

(Estella and Mann, 2010)

45% of mutant larvae have no Keilin's organ (KO) and in the rest the KO is defective. When homozygous mutant clones are made during the larval period, these clones develop and differentiate normally.

(Estella et al., 2003)

Homozygous embryos fail to form a cephalic furrow.

(Vincent et al., 1997)

Strong allele. Embryos have defects in the deutocerebrum and tritocerebrum, but there are no significant defects in the protocerebrum. Early deutocerebral neuroblasts (Dc1-4, Dp1) seem to develop normally, but later deutocerebral neuroblasts (Dp2) do not appear. The protocerebrum is normal, but the deutocerebrum and tritocerebrum are reduced in size in late embryos.

(Younossi-Hartenstein et al., 1997)

The mandibular and antennal segments, and the anterior border of the maxillary segment are missing in mutant embryos. The labral, labial and posterior part of the maxillary segments are present. The number of scolopidia and polyscolopidial organs are reduced in the thoracic and abdominal segments respectively. The lateral pentascolopidial chordotonal organs (lch5) in the abdominal segments contain an average of 3 scolopidia. The head phenotype of hemizygous btd^XG embryos is rescued with approximately 100% frequency by btd^+t10.5. The reduction in the number of scolopidia in lch5 in btd^XG embryos is partially rescued by btd^+t10.5.

(Wimmer et al., 1996)

Malpighian tubules are variable in diameter in homozygous embryos.

(Harbecke and Lengyel, 1995)

The dorso-lateral papilla, dorsal organ, associated organ, latero-pharyngeal organ and papilla organ are absent in homozygous embryos. The optic lobes often fuse dorsomedially.

(Schmidt-Ott et al., 1995)

Mandibular segment, intercalary segment, antennal segment, antennal sense organ, dorsolateral papilla, papilla organ, associated organ, lateropharyngeal organ and anterior pharyngeal organ are deleted. Stomatogastric nervous system is present.

(Schmidt-Ott et al., 1994)

Strong allele of btd. Mandibular, intercalary and antennal segments absent.

(Cohen and Jurgens, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

btd[+]/btd^XG is an enhancer of decreased cell number | larval stage phenotype of pnt^P1-90

(Xie et al., 2016)

btd[+]/btd^XG is an enhancer of abnormal neuroanatomy | larval stage phenotype of pnt^P1-90

(Xie et al., 2016)

Suppressor of

Statement

Reference

btd[+]/btd^XG is a suppressor of increased cell number | larval stage phenotype of pnt^P1-90

(Xie et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

btd^XG has phenotype, suppressible by btd::Hsap\SP1^Sp1zf

(Schock et al., 2000)

btd^XG has lateropharyngeal organ phenotype, suppressible by btd::Mmmm\Sp1^BTDzf

(Schock et al., 1999)

btd^XG has cephalopharyngeal skeleton phenotype, suppressible by btd::Mmmm\Sp1^BTDzf

(Schock et al., 1999)

NOT suppressed by

Statement

Reference

btd^XG has intercalary segment | embryonic stage phenotype, non-suppressible by btd::Mmmm\Sp1^BTDzf

(Schock et al., 1999)

btd^XG has antennal segment | embryonic stage phenotype, non-suppressible by btd::Mmmm\Sp1^BTDzf

(Schock et al., 1999)

Enhancer of

Statement

Reference

btd[+]/btd^XG is an enhancer of intermediate neuronal progenitor | larval stage phenotype of pnt^P1-90

(Xie et al., 2016)

Suppressor of

Statement

Reference

btd[+]/btd^XG is a suppressor | partially of type II neuroblast | larval stage phenotype of pnt^P1-90

(Xie et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

btd^XG/+ enhances the loss of intermediate neural progenitors, but suppresses the increased number of Asense-negative type II neuroblasts seen in pnt^P1-90/pnt^P1-90 mutant larvae.

(Xie et al., 2016)

btd^XG/btd^XG; Taf4^S-466/+ embryos carrying one copy of btd^+t10.5 develop a normal head segmentation pattern.

(Schock et al., 1999)

Xenogenetic Interactions

Statement

Reference

btd::Mmmm\Sp1^BTDzf partially rescues the btd^XG phenotype; the mandibular segment is partially rescued (the lateropharyngeal organ is rescued and the ventral arm of the head skeleton is partially rescued), but the intercalary and antennal segments of the embryo are not rescued.

(Schock et al., 1999)

Complementation and Rescue Data

Rescued by

btd^XG is rescued by btd^ΔS:T

(Schock et al., 2000)

btd^XG is rescued by btd^fl.S

(Schock et al., 2000)

btd^XG is rescued by btd^ΔU

(Schock et al., 2000)

btd^XG is rescued by btd^ΔN

(Schock et al., 2000)

btd^XG is rescued by btd^+t10.5

(Schock et al., 1999)

btd^XG is rescued by btd^hb.PW

(Vincent et al., 1997)

btd^XG is rescued by btd^RV-2ndB

(Wimmer et al., 1997)

btd^XG is rescued by btd^hb.PW

(Wimmer et al., 1997)

Partially rescued by

btd^XG is partially rescued by btd^ZF.VP16

(Schock et al., 2000)

btd^XG is partially rescued by btd^ΔC

(Schock et al., 2000)

btd^XG is partially rescued by btd^ΔQ

(Schock et al., 2000)

btd^XG is partially rescued by btd^+t10.5

(Wimmer et al., 1996)

btd^XG is partially rescued by btd^+t10.5

(Wimmer et al., 1993)

Not rescued by

btd^XG is not rescued by btd^FRT.hb

(Wimmer et al., 1997)

btd^XG is not rescued by btd^FRT.RV-2ndB

(Wimmer et al., 1997)

Comments

The cephalic furrow phenotype is rescued by btd^hb.PW.

(Vincent et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The effects of the btd^XG mutation on the spatial expression of hh and wg during embryogenesis have been investigated.

(Mohler, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

XG81

(Wimmer et al., 1993)

btd^XG81

(Blom-Dahl et al., 2020, Córdoba et al., 2016, Xie et al., 2016, Xie et al., 2014, Estella and Mann, 2010, McKay et al., 2009, Estella et al., 2003, Crozatier et al., 1999, Kuhnlein et al., 1997, Vincent et al., 1997, Crozatier et al., 1996, Macias and Morata, 1996, Mohler, 1995, Gonzalez-Reyes and Morata, 1991)

btd^XG8

(Harbecke and Lengyel, 1995)

btd^XG

(Álvarez and Díaz-Benjumea, 2018)

Name Synonyms

Secondary FlyBase IDs

References (30)

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