FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

negative regulation of transcription by RNA polymerase II

ID (Ontology)

GO:0000122 (Gene Ontology)

Definition

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.

Also Known As

"down regulation of transcription from RNA polymerase II promoter" ; "down-regulation of transcription from RNA polymerase II promoter" ; "downregulation of transcription from RNA polymerase II promoter" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
negative regulation of transcription by RNA polymerase II (all annotations which use CV term, excluding "NOT" statements)
involved_in \| negative regulation of transcription by RNA polymerase II

Spanning Tree (Parents/Children)

regulation of DNA-templated transcription
 |__regulation of transcription by RNA polymerase II____
 |__negative regulation of DNA-templated transcription__|
transcription by RNA polymerase II                      |
 |__regulation of transcription by RNA polymerase II____|
negative regulation of RNA biosynthetic process         |
 |__negative regulation of DNA-templated transcription__|
                                                        negative regulation of transcription by RNA polymerase II  224 rec.
                                                         |__negative regulation of ribosomal protein gene transcription by RNA polymerase II
                                                         |   |__negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus
                                                         |   |__negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels
                                                         |   |__negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress
                                                         |__negative regulation of snRNA transcription by RNA polymerase II
                                                         |__negative regulation of termination of RNA polymerase II transcription
                                                         |   |__negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled
                                                         |__negative regulation of transcription initiation by RNA polymerase II 1 rec.
                                                             |__negative regulation of RNA polymerase II transcription preinitiation complex assembly 1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription
Part of
Synonyms & Secondary IDs
Synonyms
	"down regulation of global transcription from RNA polymerase II promoter" RELATED "down regulation of transcription from RNA polymerase II promoter" EXACT "down-regulation of global transcription from RNA polymerase II promoter" RELATED "down-regulation of transcription from RNA polymerase II promoter" EXACT "downregulation of global transcription from RNA polymerase II promoter" RELATED "downregulation of transcription from RNA polymerase II promoter" EXACT "inhibition of global transcription from RNA polymerase II promoter" RELATED "inhibition of transcription from RNA polymerase II promoter" EXACT "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED "negative regulation of global transcription from Pol II promoter" RELATED "negative regulation of transcription from Pol II promoter" EXACT "negative regulation of transcription from RNA polymerase II promoter" EXACT "negative regulation of transcription from RNA polymerase II promoter, global" RELATED
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-2173795 "Downregulation of SMAD2/3:SMAD4 transcriptional activity" Reactome:R-HSA-8866904 "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"