FB2026_01 , released March 12, 2026

CV Term Report

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General Information

Term

DNA-binding transcription factor activity

ID (Ontology)

GO:0003700 (Gene Ontology)

Definition

A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Also Known As

"DNA binding transcription factor activity" ; "gene-specific transcription factor activity" ; "sequence-specific DNA binding transcription factor activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
DNA-binding transcription factor activity (all annotations which use CV term, excluding "NOT" statements)	46	294
contributes_to \| DNA-binding transcription factor activity	--	5
enables \| DNA-binding transcription factor activity	--	293

Spanning Tree (Parents/Children)

  molecular_function
   |__transcription regulator activity
       |__DNA-binding transcription factor activity  621 rec.
           |__DNA-binding transcription activator activity 111 rec.
           |   |__DNA-binding transcription activator activity, RNA polymerase II-specific 108 rec.
           |   |__ligand-modulated transcription activator activity
           |__DNA-binding transcription factor activity, RNA polymerase II-specific 498 rec.
           |   |__DNA-binding transcription activator activity, RNA polymerase II-specific 108 rec.
           |   |__DNA-binding transcription repressor activity, RNA polymerase II-specific 60 rec.
           |   |__nuclear receptor activity(+) 23 rec.
           |__DNA-binding transcription repressor activity 63 rec.
           |   |__DNA-binding transcription repressor activity, RNA polymerase II-specific 60 rec.
           |   |__DNA-binding transcription repressor activity, RNA polymerase III-specific
           |   |__ligand-modulated transcription repressor activity
           |__ligand-modulated transcription factor activity 23 rec.
           |   |__ligand-modulated transcription activator activity
           |   |__ligand-modulated transcription repressor activity
           |   |__nuclear receptor activity(+) 23 rec.
           |__sigma factor activity

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	transcription regulator activity
Part of
Synonyms & Secondary IDs
Synonyms
	"bacterial-type DNA binding transcription factor activity" NARROW "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" NARROW "bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity" NARROW "bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW "bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding" NARROW "DNA binding transcription factor activity" EXACT "gene-specific transcription factor activity" EXACT "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW "metal ion regulated sequence-specific DNA binding transcription factor activity" NARROW "nucleic acid binding transcription factor activity" BROAD "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW "sequence-specific DNA binding transcription factor activity" EXACT "transcription factor activity" BROAD "transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW "transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" NARROW "transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding" NARROW "transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-163666 "Formation of ChREBP:MLX heterodimer"