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FB2026_01
,
released March 12, 2026
D-Sp1
zinc finger transcription factor - master regulator of both wing and leg development - modifies leg-to-wing transdetermination in Drosophila
Please see the JBrowse view of Dmel\Sp1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Gene model reviewed during 5.41
Gene model reviewed during 5.44
Gene model reviewed during 5.42
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.52
Gene model reviewed during 5.56
2.270 (longest cDNA)
None of the polypeptides share 100% sequence identity.
523 (aa); 67 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sp1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Sp1 is expressed in the entire leg imaginal disc except in the most proximal ring of cells that will become the body wall. In the antennal disc it is expressed in a medial ring of cells along the proximal-distal axis. No expression is observed in the wing, haltere, or eye discs. Sp1 expression overlaps the expression of btd.
Sp1 is maternally contributed and the earliest embryonic expression is observed in the brain. Later, strong expression is seen in the limb primordia of the antennae and legs and in a punctate pattern in the ventral nerve cord.
Sp1 transcripts are expressed in the nurse cells and transported into the developing oocyte. Transcripts are detected in the early embryo but are not detected by the blastoderm stage. Later in development transcripts are detected in the larval brain and in the ventral imaginal discs (in the antennal but NOT eye disc, and the leg discs).
Sp1 transcripts are expressed in nurse cells during oogenesis and then are transported to the oocyte. They are observed at low levels in preblastoderm embryos but are not detected in the blastoderm. Later they are expressed in the lateral regions of the embryo in the developing peripheral nervous system. In larvae, they are observed in the larval brain and in a subset of imaginal discs. They are found in concentric rings in antennal discs but not eye discs, and in leg discs but not wing discs.
In third instar larvae, Sp1 is expressed throughout the medial and distal regions of the leg disc but is excluded from the body wall and the distal tip of the leg. In prepupal leg discs, expression is restricted to the tarsal segments and specifically to the interjoint regions.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Sp1 in JBrowse1-30
1-31.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Sp1, a btd-related gene, has been cloned and sequenced, and its expression pattern has been analysed. Sp1 and btd may represent a gene pair with partially redundant functions. Isolated from genomic Drosophila DNA by PCR, using degenerate primers corresponding to parts of the first and third zinc finger motifs of btd.
Source for identity of: Sp1 CG1343
