FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Hsap\GLI1
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General Information
Symbol
Hsap\GLI1
Species
H. sapiens
Name
GLI family zinc finger 1
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0029165
Gene Model Status
Not Applicable
Stock Availability
None publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

GLI, Gli1

Key Links
Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == GLI1; HGNC:4317.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hsap\GLI1
Transgenic constructs containing regulatory region of Hsap\GLI1
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Other Phenotypes
Allele
visible
Phenotype manifest in
Allele
wing
wing vein L4
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (22)
ci
6 of 14
Yes
No
0  
Blimp-1
1 of 14
No
No
0  
btd
1 of 14
No
No
0  
Cf2
1 of 14
No
No
0  
CG12299
1 of 14
No
Yes
0  
CG32772
1 of 14
No
No
0  
esg
1 of 14
No
No
0  
gl
1 of 14
No
No
0  
jim
1 of 14
No
No
0  
jing
1 of 14
No
No
0  
Kah
1 of 14
No
No
0  
Klf15
1 of 14
No
No
0  
Kr
1 of 14
No
No
0  
lmd
1 of 14
No
No
0  
Meics
1 of 14
No
No
0  
MTF-1
1 of 14
No
No
0  
peb
1 of 14
No
No
0  
phol
1 of 14
No
No
0  
pho
1 of 14
No
No
0  
Phs
1 of 14
No
No
0  
Sp1
1 of 14
No
No
0  
sug
1 of 14
No
No
0  
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
Summary of Genetic Interactions
Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
Class of Gene
Stocks and Reagents
Stocks (0)
Other Comments

ci null alleles are partially functionally complemented by Hsap\GLI, which rescues viability to late third instar, but produces larvae with grossly enlarged wing discs. ci null alleles are also partially functionally complemented by a combination of Hsap\GLI and Hsap\GLI3, rescuing to pupal or late third instar larvae and producing wild-type wing discs.

(von Mering and Basler, 1999)
Relationship to Other Genes
Source for database merge of
Additional comments

FlyBase curator comment: Symbol and name changed to reflect current HGNC symbol and name (19th Nov. 2012).

(FlyBase Curators, 1992-)
Nomenclature History
Source for database identify of
Nomenclature comments
Etymology
Synonyms and Secondary IDs (9)
Reported As
Symbol Synonym
GLI
(HGNC Curators and FlyBase Curators, 2013-, von Mering and Basler, 1999)
GLI1
(HGNC Curators and FlyBase Curators, 2013-, von Mering and Basler, 1999)
Gli1
(Marks and Kalderon, 2011, von Mering and Basler, 1999)
Hsap\GLI
Hsap\GLI1
Name Synonyms
GLI family zinc finger 1
(HGNC Curators and FlyBase Curators, 2013-)
Glioma-associated oncogene homolog
glioma-associated oncogene family zinc finger 1
(HGNC Curators and FlyBase Curators, 2013-)
glioma-associated oncogene homolog 1 (zinc finger protein)
(HGNC Curators and FlyBase Curators, 2013-)
Secondary FlyBase IDs
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (0)
    Result
    Result Type
    Title
    External Crossreferences and Linkouts ( 7 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    Other crossreferences
    Ensembl_Homo_sapiens -
    HUGO Gene Nomenclature Committee -
    MARRVEL - MARRVEL (human gene)
    OMIM_GENE - Online Mendelian Inheritance in Man (Genes)
    OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)
    References (4)