FlyBase Gene Report: Dmel\jim

General Information

Symbol

Dmel\jim

Species

D. melanogaster

Name

jim

Annotation Symbol

CG11352

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027339

Gene Model Status

Current

Stock Availability

25 publicly available

Gene Summary

jim (jim) encodes a zinc finger C2H2 transcription factor involved in dendrite morphogenesis and regulation of chromatin silencing. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

ovfc.K, ovk

Key Links

Genomic Location

Cytogenetic map

80A2-80A4

Sequence location

3L:22,789,233..22,835,194 [-]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:22789233..22835194

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN002810793

(GO Reference Genome Project, 2011-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN002810793

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in dendrite morphogenesis

inferred from mutant phenotype

(Iyer et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of DNA-templated transcription

inferred from biological aspect of ancestor with PANTHER:PTN002810793

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002810793

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

jim (jim) encodes a zinc finger C2H2 transcription factor involved in dendrite morphogenesis and regulation of chromatin silencing. [Date last reviewed: 2019-07-11]

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\jim for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PGG2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

jim-RC

FBtr0078582

NM_143699

13458

820

jim-RD

FBtr0100184

NM_001014601

4749

820

jim-RE

FBtr0304985

NM_001259959

12379

825

jim-RF

FBtr0330076

NM_001275292

6714

938

jim-RG

FBtr0333211

NM_001275293

5542

794

jim-RH

FBtr0333212

NM_168964

5620

820

jim-RI

FBtr0333213

NM_001275294

6193

792

Additional Transcript Data and Comments

Reported size (kB)

6.5, 5.5 (northern blot)

(Doerflinger et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

jim-PC

FBpp0078231

89.1

820

8.87

FBpp0099541

89.1

820

8.87

FBpp0293522

89.7

825

8.87

FBpp0303109

100.8

938

8.87

FBpp0305413

86.1

794

8.76

FBpp0305414

89.1

820

8.87

FBpp0305415

85.9

792

8.76

M9PIL6

NP_001262223

AGB94916

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

820 aa isoforms: jim-PC, jim-PD, jim-PH

Additional Polypeptide Data and Comments

Reported size (kDa)

820 (aa); 115 (kD observed)

(Doerflinger et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jim using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.66

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage oogenesis stage S12 -- S14

main body follicle cell

(Doerflinger et al., 1999)

adult stage oogenesis stage S9 -- S14

stretch follicle cell

(Doerflinger et al., 1999)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle cell

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic esophagus

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

adult stage oogenesis stage S10A -- S14

main body follicle cell

(Doerflinger et al., 1999)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

embryonic/larval hindgut

(Doerflinger et al., 1999)

embryonic/larval anterior midgut

(Doerflinger et al., 1999)

pharyngeal muscle cell

(Doerflinger et al., 1999)

adult stage oogenesis stage S9 -- S14

stretch follicle cell

(Doerflinger et al., 1999)

adult stage oogenesis stage S10 -- S14

main body follicle cell

(Doerflinger et al., 1999)

Additional Descriptive Data

jim protein is detected from stage 10 of oogenesis in the non-antero-dorsal columnar follicle cells. It is also detected in squamous cells from stage 9 onward and in a single row of 10-15 antero-dorsal columnar cells in stage 12 follicles. In stage 15 embryos, jim protein accumulates in the anterior midgut and hindgut and in glossopharyngeal muscles.

(Doerflinger et al., 1999)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{lacW}jim^OVK

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage oogenesis stage S10 -- S14

main body follicle cell

(Doerflinger et al., 1999)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\jim in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\jim

View exonic expression by tissue for Dmel\jim

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027339

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43924/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027339

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027339

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027339

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11352

Flygut - An atlas of the Drosophila adult midgut

FBgn0027339

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 38 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of jim

Transgenic constructs containing regulatory region of jim

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PI

jim^LA3.1

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

jim^GD4363

viable

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

some die during pupal stage, with Scer\GAL4^pnr-MD237

jim^GD4363

Phenotype manifest in

Allele

embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4^Pxn.PS

jim^EY14392

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (304)

Hsap\MZF1

3 of 14

Yes

Hsap\ERV3-1-ZNF117

2 of 14

Yes

Hsap\ZBTB11

2 of 14

Yes

Hsap\ZNF66

2 of 14

Yes

Hsap\ZNF85

2 of 14

Yes

Hsap\ZNF92

2 of 14

Hsap\ZNF98

2 of 14

Hsap\ZNF117

2 of 14

Yes

Hsap\ZNF135

2 of 14

Hsap\ZNF141

2 of 14

Yes

Hsap\ZNF195

2 of 14

Yes

Hsap\ZNF257

2 of 14

Yes

Hsap\ZNF430

2 of 14

Yes

Hsap\ZNF431

2 of 14

Yes

Hsap\ZNF460

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\ZNF519

2 of 14

Yes

Hsap\ZNF626

2 of 14

Hsap\ZNF628

2 of 14

Yes

Hsap\ZNF678

2 of 14

Yes

Hsap\ZNF679

2 of 14

Yes

Hsap\ZNF708

2 of 14

Yes

Hsap\ZNF714

2 of 14

Yes

Hsap\ZNF723

2 of 14

Yes

Hsap\ZNF724

2 of 14

Yes

Hsap\ZNF727

2 of 14

Yes

Hsap\ZNF732

2 of 14

Yes

Hsap\ZNF736

2 of 14

Hsap\ZNF737

2 of 14

Hsap\ZNF775

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Hsap\LOC344065

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PRDM4

1 of 14

Hsap\PRDM5

1 of 14

Hsap\PRDM10

1 of 14

Yes

Hsap\PRDM14

1 of 14

Hsap\PRDM15

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZBTB4

1 of 14

Yes

Hsap\ZBTB6

1 of 14

Hsap\ZBTB7C

1 of 14

Yes

Hsap\ZBTB17

1 of 14

Yes

Hsap\ZBTB20

1 of 14

Hsap\ZBTB24

1 of 14

Hsap\ZBTB26

1 of 14

Yes

Hsap\ZBTB39

1 of 14

Yes

Hsap\ZBTB40

1 of 14

Yes

Hsap\ZBTB41

1 of 14

Hsap\ZBTB45

1 of 14

Yes

Hsap\ZBTB47

1 of 14

Hsap\ZBTB49

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZFP37

1 of 14

Hsap\ZFP57

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZIM3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF33A

1 of 14

Hsap\ZNF34

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF416

1 of 14

Yes

Hsap\ZNF418

1 of 14

Hsap\ZNF419

1 of 14

Yes

Hsap\ZNF439

1 of 14

Hsap\ZNF444

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF493

1 of 14

Hsap\ZNF496

1 of 14

Yes

Hsap\ZNF497

1 of 14

Hsap\ZNF500

1 of 14

Hsap\ZNF501

1 of 14

Yes

Hsap\ZNF510

1 of 14

Hsap\ZNF517

1 of 14

Yes

Hsap\ZNF521

1 of 14

Hsap\ZNF525

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF652

1 of 14

Yes

Hsap\ZNF658B

1 of 14

Hsap\ZNF658

1 of 14

Hsap\ZNF660-ZNF197

1 of 14

Hsap\ZNF664

1 of 14

Yes

Hsap\ZNF667

1 of 14

Hsap\ZNF672

1 of 14

Yes

Hsap\ZNF675

1 of 14

Hsap\ZNF676

1 of 14

Hsap\ZNF677

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Hsap\ZNF765-ZNF761

1 of 14

Hsap\ZNF766

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZSCAN5C

1 of 14

Hsap\ZSCAN9

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (89)

Rnor\Mzf1

3 of 14

Yes

Rnor\LOC102556967

2 of 14

Rnor\Zfp143

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\LOC100912787

1 of 14

Yes

Rnor\LOC102546572

1 of 14

Yes

Rnor\LOC102547412

1 of 14

Yes

Rnor\LOC102555183

1 of 14

Yes

Rnor\LOC102556092

1 of 14

Yes

Rnor\Mecom

1 of 14

Rnor\Patz1

1 of 14

Yes

Rnor\Prdm10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zbtb7c

1 of 14

Yes

Rnor\Zbtb11

1 of 14

Rnor\Zbtb17

1 of 14

Yes

Rnor\Zbtb47

1 of 14

Rnor\Zbtb48

1 of 14

Rnor\Zbtb49

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zfp202

1 of 14

Yes

Rnor\Zfp236

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zfp324

1 of 14

Rnor\Zfp335

1 of 14

Rnor\Zfp358

1 of 14

Yes

Rnor\Zfp398

1 of 14

Rnor\Zfp410

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zfp523

1 of 14

Yes

Rnor\Zfp566

1 of 14

Yes

Rnor\Zfp583

1 of 14

Rnor\Zfp605

1 of 14

Rnor\Zfp623

1 of 14

Yes

Rnor\Zfp652

1 of 14

Rnor\Zfp707

1 of 14

Rnor\Zfp711

1 of 14

Yes

Rnor\Zfp764

1 of 14

Rnor\Zfp773-ps1

1 of 14

Rnor\Zfp775

1 of 14

Yes

Rnor\Zfp799

1 of 14

Rnor\Zfp800

1 of 14

Rnor\Zfp846

1 of 14

Yes

Rnor\Zfp958

1 of 14

Rnor\Zfx

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zkscan7

1 of 14

Rnor\Znf8

1 of 14

Rnor\Znf768

1 of 14

Yes

Rnor\Zscan2

1 of 14

Rnor\Zscan5b

1 of 14

Yes

Rnor\Zscan10

1 of 14

Yes

Rnor\Zscan25

1 of 14

Yes

Rnor\Zscan29

1 of 14

Mus musculus (laboratory mouse) (103)

Mmus\Mzf1

3 of 14

Yes

Mmus\Gm19965

2 of 14

Yes

Mmus\Zfp719

2 of 14

Mmus\Zfp768

2 of 14

Yes

Mmus\2610008E11Rik

1 of 14

Mmus\5430403G16Rik

1 of 14

Mmus\9130019O22Rik

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zbtb7c

1 of 14

Yes

Mmus\Zbtb11

1 of 14

Mmus\Zbtb17

1 of 14

Mmus\Zbtb20

1 of 14

Yes

Mmus\Zbtb48

1 of 14

Mmus\Zfp2

1 of 14

Yes

Mmus\Zfp3

1 of 14

Yes

Mmus\Zfp11

1 of 14

Mmus\Zfp26

1 of 14

Mmus\Zfp57

1 of 14

Yes

Mmus\Zfp60

1 of 14

Mmus\Zfp61

1 of 14

Mmus\Zfp69

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp128

1 of 14

Mmus\Zfp143

1 of 14

Mmus\Zfp202

1 of 14

Yes

Mmus\Zfp236

1 of 14

Yes

Mmus\Zfp260

1 of 14

Mmus\Zfp263

1 of 14

Mmus\Zfp287

1 of 14

Yes

Mmus\Zfp316

1 of 14

Mmus\Zfp319

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp420

1 of 14

Mmus\Zfp467

1 of 14

Yes

Mmus\Zfp523

1 of 14

Yes

Mmus\Zfp551

1 of 14

Mmus\Zfp558

1 of 14

Mmus\Zfp566

1 of 14

Yes

Mmus\Zfp568

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp664

1 of 14

Yes

Mmus\Zfp668

1 of 14

Yes

Mmus\Zfp689

1 of 14

Yes

Mmus\Zfp692

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp775

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp870

1 of 14

Yes

Mmus\Zfp871

1 of 14

Yes

Mmus\Zfp974

1 of 14

Mmus\Zfp977

1 of 14

Mmus\Zfx

1 of 14

Yes

Mmus\Zfy1

1 of 14

Yes

Mmus\Zfy2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zkscan5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (78)

Xtro\zbtb39

2 of 13

Yes

Xtro\bcl6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ikzf3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100498327

1 of 13

Yes

Xtro\LOC100498520

1 of 13

Xtro\LOC100498654

1 of 13

Yes

Xtro\LOC101731232

1 of 13

Xtro\LOC101731414

1 of 13

Yes

Xtro\LOC101732880

1 of 13

Xtro\LOC101733242

1 of 13

Xtro\LOC101734390

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\prdm14

1 of 13

Xtro\prdm15

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\zbtb6

1 of 13

Yes

Xtro\zbtb14

1 of 13

Yes

Xtro\zbtb20

1 of 13

Yes

Xtro\zbtb41

1 of 13

Xtro\zbtb47

1 of 13

Yes

Xtro\zfat

1 of 13

Xtro\zfp64

1 of 13

Yes

Xtro\zfx

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\znf205

1 of 13

Yes

Xtro\znf276

1 of 13

Yes

Xtro\znf292

1 of 13

Yes

Xtro\znf319

1 of 13

Yes

Xtro\znf335

1 of 13

Xtro\znf341

1 of 13

Xtro\znf408

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (123)

Drer\zbtb47a

2 of 14

Yes

Drer\znf865

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100150619

1 of 14

Drer\LOC100151570

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100534672

1 of 14

Yes

Drer\LOC100536922

1 of 14

Drer\LOC100537361

1 of 14

Drer\LOC100537891

1 of 14

Yes

Drer\LOC101882575

1 of 14

Drer\LOC101883936

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC110437839

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\plagl2

1 of 14

Yes

Drer\plagx

1 of 14

Yes

Drer\prdm10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:cabz01032454.3

1 of 14

Drer\si:cabz01071909.2

1 of 14

Yes

Drer\si:ch73-40a17.4

1 of 14

Drer\si:ch73-109d9.2

1 of 14

Drer\si:ch73-144d13.7

1 of 14

Yes

Drer\si:ch73-158p21.7

1 of 14

Drer\si:ch73-266f23.4

1 of 14

Yes

Drer\si:ch73-299h12.4

1 of 14

Yes

Drer\si:ch73-367f21.4

1 of 14

Drer\si:ch73-367f21.6

1 of 14

Drer\si:ch211-79k12.2

1 of 14

Yes

Drer\si:ch211-119o8.6

1 of 14

Yes

Drer\si:ch211-161m3.4

1 of 14

Drer\si:ch211-191d2.2

1 of 14

Yes

Drer\si:ch211-202h22.10

1 of 14

Yes

Drer\si:ch211-222k6.2

1 of 14

Yes

Drer\si:ch211-229l10.11

1 of 14

Drer\si:ch211-235i11.4

1 of 14

Yes

Drer\si:ch211-241b2.1

1 of 14

Yes

Drer\si:ch211-241e1.5

1 of 14

Yes

Drer\si:ch211-261d7.6

1 of 14

Yes

Drer\si:ch1073-127d16.1

1 of 14

Drer\si:dkey-30k6.5

1 of 14

Yes

Drer\si:dkey-33c14.6

1 of 14

Drer\si:dkey-77f5.8

1 of 14

Yes

Drer\si:dkey-89b17.4

1 of 14

Yes

Drer\si:dkeyp-69b9.6

1 of 14

Yes

Drer\si:dkeyp-84f3.9

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\zgc:66448

1 of 14

Yes

Drer\zgc:101130

1 of 14

Yes

Drer\zgc:110249

1 of 14

Yes

Drer\zgc:113135

1 of 14

Yes

Drer\zgc:113220

1 of 14

Yes

Drer\zgc:162972

1 of 14

Drer\zgc:174288

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\znf143a

1 of 14

Yes

Drer\znf143b

1 of 14

Yes

Drer\znf236

1 of 14

Yes

Drer\znf271

1 of 14

Drer\znf319b

1 of 14

Yes

Drer\znf408

1 of 14

Yes

Drer\znf526

1 of 14

Yes

Drer\znf532

1 of 14

Yes

Drer\znf646

1 of 14

Yes

Drer\znf652

1 of 14

Yes

Drer\znf687a

1 of 14

Yes

Drer\znf711

1 of 14

Yes

Drer\znf770

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\znf1041

1 of 14

Drer\znf1059

1 of 14

Drer\znf1077

1 of 14

Yes

Drer\znf1102

1 of 14

Drer\znf1124

1 of 14

Drer\znf1144

1 of 14

Yes

Drer\znf1155

1 of 14

Drer\znf1174

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (17)

Cele\ehn-3

1 of 14

Yes

Cele\fezf-1

1 of 14

Yes

Cele\ham-2

1 of 14

Yes

Cele\larp-5

1 of 14

Yes

Cele\lsl-1

1 of 14

Yes

Cele\lsy-2

1 of 14

Yes

Cele\lsy-27

1 of 14

Yes

Cele\pag-3

1 of 14

Yes

Cele\pzf-1

1 of 14

Yes

Cele\sdz-38

1 of 14

Yes

Cele\ZK177.3

1 of 14

Yes

Cele\znf-782

1 of 14

Yes

Cele\ztf-23

1 of 14

Yes

Cele\ztf-25

1 of 14

Yes

Cele\ztf-28

1 of 14

Yes

Cele\ztf-29

1 of 14

Yes

Cele\ztf-30

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (58)

Agam\AgaP_AGAP011544

4 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004637

1 of 12

Agam\AgaP_AGAP004667

1 of 12

Agam\AgaP_AGAP004764

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP005573

1 of 12

Agam\AgaP_AGAP005978

1 of 12

Agam\AgaP_AGAP006129

1 of 12

Yes

Agam\AgaP_AGAP006544

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP008429

1 of 12

Yes

Agam\AgaP_AGAP009010

1 of 12

Agam\AgaP_AGAP009482

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP011963

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (27)

Atha\AT1G02030

1 of 13

Yes

Atha\AT1G49900

1 of 13

Yes

Atha\AT2G28200

1 of 13

Yes

Atha\AT2G28710

1 of 13

Yes

Atha\AT2G45120

1 of 13

Yes

Atha\AT3G10470

1 of 13

Yes

Atha\AT3G29340

1 of 13

Yes

Atha\AT3G46070

1 of 13

Yes

Atha\AT3G46080

1 of 13

Yes

Atha\AT3G49930

1 of 13

Yes

Atha\AT3G53600

1 of 13

Yes

Atha\AT3G60580

1 of 13

Yes

Atha\AT4G04404

1 of 13

Yes

Atha\AT5G03510

1 of 13

Yes

Atha\AT5G04390

1 of 13

Yes

Atha\AT5G56200

1 of 13

Yes

Atha\AT5G61470

1 of 13

Yes

Atha\DAZ1

1 of 13

Yes

Atha\DAZ2

1 of 13

Yes

Atha\RHL41

1 of 13

Yes

Atha\STZ

1 of 13

Yes

Atha\ZAT6

1 of 13

Yes

Atha\ZAT7

1 of 13

Yes

Atha\ZAT11

1 of 13

Yes

Atha\ZF1

1 of 13

Yes

Atha\ZF2

1 of 13

Yes

Atha\ZF3

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\AZF1

1 of 13

Yes

Scer\ZAP1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:jim. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (65)

CG15269

2 of 13

Meics

2 of 13

BEAF-75

1 of 13

Cf2

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Cph

1 of 13

crol

1 of 13

CTCF

1 of 13

dwg

1 of 13

erm

1 of 13

ham

1 of 13

hkb

1 of 13

Imzf

1 of 13

Kr-h1

1 of 13

l(3)neo38

1 of 13

lmd

1 of 13

mld

1 of 13

nerfin-1

1 of 13

nerfin-2

1 of 13

odd

1 of 13

Odj

1 of 13

pad

1 of 13

Paris

1 of 13

peb

1 of 13

phol

1 of 13

Phs

1 of 13

pita

1 of 13

rgr

1 of 13

Saft

1 of 13

Sag1

1 of 13

scrt

1 of 13

sqz

1 of 13

su(Hw)

1 of 13

sug

1 of 13

trem

1 of 13

wor

1 of 13

Zaf1

1 of 13

Zif

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

jim^EY14392

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MZF1; myeloid zinc finger 1

3 of 14

194550

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

jim

(Schneiderman et al., 2010)

upd1

suppressible

jim

(Mukherjee et al., 2006)

upd1

enhanceable

jim

(Mukherjee et al., 2006)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68718

DroID - A comprehensive database of gene and protein interactions.

FBgn0027339

MIST (genetic) - An integrated Molecular Interaction Database

43924

MIST (protein-protein) - An integrated Molecular Interaction Database

43924

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

80A2-80A4

Sequence location

3L:22,789,233..22,835,194 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

80A2-80A4

Limits computationally determined from genome sequence between P{lacW}l(3)j1B10^j1B10 and P{lacW}l(3)j2C4^j2C4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

79F-79F

(determined by in situ hybridisation)

(Doerflinger et al., 1998)

79F-79F

(Doerflinger, 1996.4.29)

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-44.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (25)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

601457

w¹¹¹⁸; P{R80E02-p65.AD}JK22C

600907

w¹¹¹⁸; P{R80E02-GAL4.DBD}attP2

12624

w¹¹¹⁸; P{GT1}jim^BG01625

24202

w¹¹¹⁸; Mi{ET1}jim^MB04583

20927

y¹ w^67c23; P{EPgy2}EY14392

42662

y¹ v¹; P{TRiP.HMS02498}attP40

62748

w¹¹¹⁸; PBac{IT.GAL4}jim^0270-G4

Korea

15582

P{GMR80E02-GAL4}attP2

11352R-2

11352R-3

v330460

v12698

w¹¹¹⁸; P{GD4363}v12698

More stocks available...

Genomic Clones (33)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (43)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GM05638

Other clones

FI01201

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027339

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027339

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Doerflinger et al., 1999)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identification: Enhancer trap screen for genes expressed in follicle cells.

(Doerflinger et al., 1998)

Isolated as an enhancer-trap expressed in ovarian follicles at stage 10.

(Doerflinger et al., 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: jim ovfc.k ovk

(Doerflinger et al., 1999)

Source for merge of: jim CG11352

(Bayraktaroglu, 2000.4.12)

Source for merge of: jim BcDNA:SD14927

(FlyBase, 1996-)

Additional comments

Source for merge of jim BcDNA:SD14927 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

BcDNA:SD14927

CG11352

(Meadows, 2018.4.4, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Schneiderman et al., 2010, Grieder et al., 2007, Mount, 2001.8.14)

Jim

(Luo et al., 2026, Schneiderman et al., 2010, Schneiderman et al., 2010)

OVK

(Doerflinger et al., 1996)

jim

(Allen et al., 2026, Chen et al., 2025, Li et al., 2025, Hersperger et al., 2024, Li et al., 2024, Ding et al., 2022, Guan et al., 2022, Sebastian et al., 2022, Baker et al., 2021, Bilder et al., 2021, Michki et al., 2021, Pang et al., 2021, Winbush and Singh, 2021, Cho et al., 2020, Feuillette et al., 2020, Rust et al., 2020, Samuels et al., 2020, Tang et al., 2020, Birnbaum et al., 2019, Wittes and Schüpbach, 2019, Revaitis et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Mugat et al., 2015, Ashwal-Fluss et al., 2014, Iyer et al., 2013, Terriente-Felix et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Spokony and White, 2012.11.14, Jungreis et al., 2011, Reis et al., 2010, Ayroles et al., 2009, Stofanko et al., 2008, Grieder et al., 2007, Minidorff et al., 2007, Zhang et al., 2007, Mukherjee et al., 2006, Southall et al., 2006, Stanyon et al., 2004)

ovfc.K

(Doerflinger, 1996.4.29, Doerflinger et al., 1996)

ovk

(Doerflinger et al., 1998)

Name Synonyms

jim

Secondary FlyBase IDs

FBgn0016051
FBgn0024201
FBgn0037192
FBgn0064775

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 86 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43924

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PGG2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PGG2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027339

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43924/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027339

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027339

FlyMine - An integrated database for Drosophila genomics

FBgn0027339

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11352

MARRVEL_MODEL - MARRVEL (model organism gene)

43924

Linkouts

BioGRID - A database of protein and genetic interactions.

68718

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027339

DroID - A comprehensive database of gene and protein interactions.

FBgn0027339

DRSC - Results frm RNAi screens

FBgn0027339

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027339

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027339

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11352

Flygut - An atlas of the Drosophila adult midgut

FBgn0027339

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

MIST (genetic) - An integrated Molecular Interaction Database

43924

MIST (protein-protein) - An integrated Molecular Interaction Database

43924

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (92)

The following external sites may use different assemblies or annotations than FlyBase.

-0.66

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