FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\nerfin-1
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General Information
Symbol
Dmel\nerfin-1
Species
D. melanogaster
Name
nervous fingers 1
Annotation Symbol
CG13906
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028999
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
nervous fingers 1 (nerfin-1) encodes a zinc finger transcription factor that regulates early axon guidance at the embryonic stage and is required for the maintenance of larval neuron differentiation. In the larval medulla cortex, nerfin-1 is expressed in medulla neurons at the early stage and protects them from dedifferentiation via the repression of Notch signaling pathway. [Date last reviewed: 2018-10-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Nerfin

Key Links
Genomic Location
Cytogenetic map
61D4-61D4
Sequence location
Recombination map
3-0.5
RefSeq locus
NT_037436 REGION:909112..912319
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR042972
(InterPro Project Members, 2004-)
enables DNA-binding transcription repressor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000386327
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000386327
(GO Reference Genome Project, 2011-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Kuzin et al., 2005)
involved_in positive regulation of neuroblast proliferation
inferred from mutant phenotype
(Hartl et al., 2011)
involved_in positive regulation of neuron differentiation
inferred from mutant phenotype
(Xu et al., 2017, Cayirlioglu et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in negative regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000386327
(GO Reference Genome Project, 2011-)
involved_in neuron differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000386327
(GO Reference Genome Project, 2011-)
involved_in regulation of cell cycle process
inferred from biological aspect of ancestor with PANTHER:PTN000386327
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000386327
(GO Reference Genome Project, 2011-)
part_of transcription repressor complex
inferred from biological aspect of ancestor with PANTHER:PTN000386327
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
nervous fingers 1 (nerfin-1) encodes a zinc finger transcription factor that regulates early axon guidance at the embryonic stage and is required for the maintenance of larval neuron differentiation. In the larval medulla cortex, nerfin-1 is expressed in medulla neurons at the early stage and protects them from dedifferentiation via the repression of Notch signaling pathway. [Date last reviewed: 2018-10-11]
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Summary (Interactive Fly)

zinc finger transcription factor required for the proper development of CNS commissural and connective axon fascicles - prevents reversion of neurons into neural stem cells

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\nerfin-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V3B8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
nerfin-1-RA
FBtr0072592
NM_080044
3208
469
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
nerfin-1-PA
FBpp0072489
51.7
469
7.90
Q9V3B8
NP_524783
AAF47431
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nerfin-1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.26

Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
indirect flight muscle cell
(Katti et al., 2017)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 7 -- 9
stage 1 neuroblast
(Stivers et al., 2000)
stage 2 neuroblast
(Stivers et al., 2000)
neuroblast NB1-3
(Stivers et al., 2000)
neuroblast NB7-1
(Stivers et al., 2000)
neuroblast NB5-2 | intense
(Stivers et al., 2000)
neuroblast MP2
(Stivers et al., 2000)
embryonic stage 9 -- 10
ventral nerve cord primordium
(Fisher et al., 2012)
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 9 -- 15
ganglion mother cell
(Stivers et al., 2000)
embryonic stage 10 -- 12
embryonic neuroblast
(Kuzin et al., 2007)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
embryonic ventral midline neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic primordium of adult anterior midgut
(Fisher et al., 2012)
embryonic primordium of adult posterior midgut
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
larval lateral VNC glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval ventral midline glial cell
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
embryonic stage 11 -- 14
external sensory organ precursor cell I

Comment: fades during stage 14

(Stivers et al., 2000)
external sensory organ precursor cell IIb

Comment: fades during stage 14

(Stivers et al., 2000)
embryonic stage 13 -- 14
larval neuron
(Kuzin et al., 2007)
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
lineage MNB primary interneuron
(Kearney et al., 2004)
larval MP1 neuron
(Kearney et al., 2004)
third instar larval stage
lamina anlage
(Stivers et al., 2000)
ganglion mother cell of larval ventral nerve cord
(Stivers et al., 2000)
photoreceptor neuron | precursor
(Stivers et al., 2000)
Additional Descriptive Data

During embryonic stage 10, most if not all ventral nerve cord neuroblasts express nerfin-1 transcripts, albeit at varying levels. Signals are higher in MP2 neurons than in surrounding neuroblasts. By stage 13, it is expressed in secondary PNS precursor cells and in nascent neurons of the CNS. Expression in the new born neurons is short-lived and declines significantly by late stage 14.

(Kuzin et al., 2007)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10
neuroblast MP2
(Kuzin et al., 2007)
embryonic stage 13 -- 14
larval neuron
(Kuzin et al., 2007)
third instar larval stage
neuron of embryonic/larval optic lobe
(Xu et al., 2017)
neuron of medulla anlage
(Xu et al., 2017)
Additional Descriptive Data

nerfin-1 is present primarily in early-stage differentiated elav positive medulla neurons in the larval optic lobe as expression levels decrease in older neurons. It is absent from pros positive ganglion mother cells.

(Xu et al., 2017)

During embryonic stage 10, nerfin-1 protein expression is only observed in a single neuroblast per hemisegment, that being MP2. By stage 13, it is also expressed in most secondary PNS precursor cells and in nascent neurons of the CNS. Expression in the new born neurons is short-lived and declines significantly by late stage 14.

(Kuzin et al., 2007)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{nerfin-1.iA.GFP-NLS}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
adult optic lobe neuron of embryonic/larval optic lobe
(Xu et al., 2017)
neuron of medulla anlage
(Xu et al., 2017)
Reporter: P{nerfin-1-RFP.1}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13
larval neuron | subset of larval nervous system
(Kuzin et al., 2009)
embryonic ganglion mother cell | subset
(Kuzin et al., 2009)
larval neuroblast | subset
(Kuzin et al., 2009)
third instar larval stage
ganglion mother cell | subset
(Kuzin et al., 2009)
larval neuroblast | subset
(Kuzin et al., 2009)
larval neuron | subset of larval nervous system
(Kuzin et al., 2009)
larval neuron | subset of eye disc
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.2}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 14
abdominal neuron
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.3}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13
larval neuron | subset of larval ventral nerve cord
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.4}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15
larval neuron | subset of embryonic procephalic segment
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.5}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval neuron | subset of larval ventral nerve cord
(Kuzin et al., 2009)
larval neuron | subset of larval outer optic anlage
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.6}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9
stage 1 neuroblast | subset
(Kuzin et al., 2009)
stage 2 neuroblast | subset
(Kuzin et al., 2009)
embryonic stage 13
embryonic ganglion mother cell
(Kuzin et al., 2009)
larval neuron | subset of larval central nervous system
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.7}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
stage 4 neuroblast | subset
(Kuzin et al., 2009)
embryonic ganglion mother cell
(Kuzin et al., 2009)
third instar larval stage
larval neuron | subset of larval brain
(Kuzin et al., 2009)
larval neuron | subset of larval optic anlage
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.8}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
stage 4 neuroblast | subset
(Kuzin et al., 2009)
embryonic ganglion mother cell
(Kuzin et al., 2009)
third instar larval stage
larval neuron | subset of larval brain
(Kuzin et al., 2009)
larval neuron | subset of larval optic anlage
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.11}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval neuron | subset of larval brain
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.12}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 12
embryonic ganglion mother cell | subset
(Kuzin et al., 2009)
larval neuron | subset of larval central nervous system
(Kuzin et al., 2009)
embryonic stage 14
larval neuron | subset of larval nervous system
(Kuzin et al., 2009)
third instar larval stage
ommatidial precursor cluster
(Kuzin et al., 2009)
larval neuron | subset of larval nervous system
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.13}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
stage 4 neuroblast | subset
(Kuzin et al., 2009)
embryonic ganglion mother cell
(Kuzin et al., 2009)
third instar larval stage
larval neuron | subset of larval brain
(Kuzin et al., 2009)
larval neuron | subset of larval optic anlage
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.14}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9
stage 1 neuroblast | subset
(Kuzin et al., 2009)
stage 2 neuroblast | subset
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.15}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9
stage 1 neuroblast | subset
(Kuzin et al., 2009)
stage 2 neuroblast | subset
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.16}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9
stage 1 neuroblast | faint | subset
(Kuzin et al., 2009)
stage 2 neuroblast | faint | subset
(Kuzin et al., 2009)
Reporter: P{nerfin-1-RFP.17}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9
stage 1 neuroblast | faint | subset
(Kuzin et al., 2009)
stage 2 neuroblast | faint | subset
(Kuzin et al., 2009)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\nerfin-1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of nerfin-1
Transgenic constructs containing regulatory region of nerfin-1
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4GMR.PU
viable, with Scer\GAL4tin.CΔ4
viable, with Scer\GAL4twi.PB
Other Phenotypes
Allele
abnormal neuroanatomy | larval stage, with Scer\GAL4elav-C155
abnormal neuroanatomy | larval stage | somatic clone
abnormal neuroanatomy | larval stage | somatic clone, with Scer\GAL4Act.PU
abnormal neuroanatomy | late embryonic stage, with Scer\GAL4elav-C155
abnormal neuroanatomy | late embryonic stage (with Df(3L)Exel6086)
decreased size | adult stage, with Scer\GAL4GMR.PU
increased occurrence of cell division | larval stage | somatic clone
neoplasia | adult stage | somatic clone
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4Bx-MS1096
visible | adult stage, with Scer\GAL4GMR.PU
visible | cold sensitive, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
adult optic lobe | larval stage, with Scer\GAL4elav-C155
adult optic lobe | larval stage | somatic clone
adult optic lobe | larval stage | somatic clone, with Scer\GAL4Act.PU
apterous-expressing neuron of the lateral cluster of the thorax | late embryonic stage, with Scer\GAL4elav-C155
apterous-expressing neuron of the lateral cluster of the thorax | late embryonic stage (with Df(3L)Exel6086)
eye, with Scer\GAL4GMR.PU
intermediate longitudinal fascicle, with Scer\GAL4elav-C155
larval anterior commissure
larval longitudinal connective
larval posterior commissure
lateral longitudinal fascicle, with Scer\GAL4elav-C155
medial longitudinal fascicle, with Scer\GAL4elav-C155
neuroblast | ectopic | larval stage, with Scer\GAL4elav-C155
neuroblast | ectopic | larval stage | somatic clone
neuroblast | ectopic | larval stage | somatic clone, with Scer\GAL4Act.PU
neuron projection bundle of larval ventral nerve cord | late embryonic stage, with Scer\GAL4elav-C155
neuron projection bundle of larval ventral nerve cord | late embryonic stage (with Df(3L)Exel6086)
pCC neuron
wing, with Scer\GAL4Bx-MS1096
wing | cold sensitive, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (106)
Hsap\INSM1
9 of 14
Yes
Yes
Hsap\INSM2
9 of 14
Yes
Yes
Hsap\BCL6
1 of 14
No
Yes
0  
Hsap\CTCFL
1 of 14
No
No
Hsap\FEZF2
1 of 14
No
No
Hsap\GLI4
1 of 14
No
No
Hsap\MECOM
1 of 14
No
No
Hsap\MZF1
1 of 14
No
No
Hsap\PLAG1
1 of 14
No
No
Hsap\PRDM10
1 of 14
No
Yes
Hsap\PRDM16
1 of 14
No
No
1  
Hsap\ZBTB17
1 of 14
No
Yes
Hsap\ZBTB41
1 of 14
No
No
Hsap\ZFP1
1 of 14
No
Yes
Hsap\ZFP2
1 of 14
No
No
Hsap\ZKSCAN8
1 of 14
No
No
Hsap\ZNF3
1 of 14
No
No
Hsap\ZNF17
1 of 14
No
No
Hsap\ZNF18
1 of 14
No
No
Hsap\ZNF19
1 of 14
No
No
Hsap\ZNF48
1 of 14
No
No
Hsap\ZNF70
1 of 14
No
No
Hsap\ZNF75A
1 of 14
No
No
Hsap\ZNF81
1 of 14
No
No
Hsap\ZNF91
1 of 14
No
No
Hsap\ZNF92
1 of 14
No
No
Hsap\ZNF93
1 of 14
No
No
Hsap\ZNF100
1 of 14
No
No
Hsap\ZNF107
1 of 14
No
No
Hsap\ZNF133
1 of 14
No
No
Hsap\ZNF141
1 of 14
No
No
Hsap\ZNF202
1 of 14
No
No
Hsap\ZNF208
1 of 14
No
No
Hsap\ZNF236
1 of 14
No
Yes
Hsap\ZNF253
1 of 14
No
No
Hsap\ZNF254
1 of 14
No
No
Hsap\ZNF257
1 of 14
No
No
Hsap\ZNF263
1 of 14
No
No
Hsap\ZNF275
1 of 14
No
No
Hsap\ZNF283
1 of 14
No
No
Hsap\ZNF286B
1 of 14
No
Yes
Hsap\ZNF316
1 of 14
No
No
Hsap\ZNF319
1 of 14
No
Yes
Hsap\ZNF324B
1 of 14
No
No
Hsap\ZNF324
1 of 14
No
No
Hsap\ZNF337
1 of 14
No
No
Hsap\ZNF341
1 of 14
No
No
Hsap\ZNF345
1 of 14
No
No
Hsap\ZNF354C
1 of 14
No
No
Hsap\ZNF358
1 of 14
No
No
Hsap\ZNF366
1 of 14
No
Yes
1  
Hsap\ZNF383
1 of 14
No
No
Hsap\ZNF430
1 of 14
No
No
Hsap\ZNF431
1 of 14
No
No
Hsap\ZNF445
1 of 14
No
No
Hsap\ZNF486
1 of 14
No
No
Hsap\ZNF493
1 of 14
No
No
Hsap\ZNF510
1 of 14
No
No
Hsap\ZNF519
1 of 14
No
No
Hsap\ZNF521
1 of 14
No
No
Hsap\ZNF527
1 of 14
No
No
Hsap\ZNF530
1 of 14
No
No
Hsap\ZNF554
1 of 14
No
No
Hsap\ZNF557
1 of 14
No
No
Hsap\ZNF558
1 of 14
No
No
Hsap\ZNF559
1 of 14
No
No
Hsap\ZNF574
1 of 14
No
No
Hsap\ZNF579
1 of 14
No
Yes
Hsap\ZNF583
1 of 14
No
No
Hsap\ZNF594
1 of 14
No
No
Hsap\ZNF597
1 of 14
No
Yes
Hsap\ZNF600
1 of 14
No
No
Hsap\ZNF610
1 of 14
No
Yes
Hsap\ZNF616
1 of 14
No
No
Hsap\ZNF629
1 of 14
No
No
Hsap\ZNF646
1 of 14
No
No
Hsap\ZNF648
1 of 14
No
No
Hsap\ZNF649
1 of 14
No
Yes
Hsap\ZNF668
1 of 14
No
Yes
Hsap\ZNF672
1 of 14
No
Yes
Hsap\ZNF678
1 of 14
No
No
Hsap\ZNF680
1 of 14
No
No
Hsap\ZNF689
1 of 14
No
No
Hsap\ZNF708
1 of 14
No
No
Hsap\ZNF714
1 of 14
No
No
Hsap\ZNF716
1 of 14
No
No
Hsap\ZNF723
1 of 14
No
No
Hsap\ZNF724
1 of 14
No
No
Hsap\ZNF729
1 of 14
No
No
Hsap\ZNF737
1 of 14
No
No
Hsap\ZNF768
1 of 14
No
No
Hsap\ZNF775
1 of 14
No
No
Hsap\ZNF776
1 of 14
No
No
Hsap\ZNF780B
1 of 14
No
No
Hsap\ZNF785
1 of 14
No
Yes
Hsap\ZNF792
1 of 14
No
No
Hsap\ZNF813
1 of 14
No
No
Hsap\ZNF836
1 of 14
No
No
Hsap\ZNF846
1 of 14
No
No
Hsap\ZNF865
1 of 14
No
Yes
Hsap\ZNF888
1 of 14
No
No
Hsap\ZSCAN10
1 of 14
No
No
Hsap\ZSCAN16
1 of 14
No
No
Hsap\ZSCAN21
1 of 14
No
No
Hsap\ZSCAN23
1 of 14
No
No
Hsap\ZSCAN25
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (48)
Rnor\Insm2
8 of 14
Yes
Yes
Rnor\LOC100910046
1 of 14
No
No
Rnor\LOC100911196
1 of 14
No
Yes
Rnor\Mecom
1 of 14
No
No
Rnor\Prdm10
1 of 14
No
Yes
Rnor\Prdm14
1 of 14
No
Yes
Rnor\Prdm16
1 of 14
No
No
Rnor\Rbak
1 of 14
No
No
Rnor\Zbtb17
1 of 14
No
Yes
Rnor\Zbtb48
1 of 14
No
No
Rnor\Zbtb49
1 of 14
No
Yes
Rnor\Zfp7
1 of 14
No
No
Rnor\Zfp11
1 of 14
No
No
Rnor\Zfp17
1 of 14
No
No
Rnor\Zfp26
1 of 14
No
No
Rnor\Zfp57
1 of 14
No
Yes
Rnor\Zfp62
1 of 14
No
No
Rnor\Zfp113
1 of 14
No
Yes
Rnor\Zfp133
1 of 14
No
No
Rnor\Zfp184
1 of 14
No
No
Rnor\Zfp202
1 of 14
No
Yes
Rnor\Zfp236
1 of 14
No
Yes
Rnor\Zfp260
1 of 14
No
No
Rnor\Zfp263
1 of 14
No
No
Rnor\Zfp286a
1 of 14
No
No
Rnor\Zfp319
1 of 14
No
Yes
Rnor\Zfp324
1 of 14
No
No
Rnor\Zfp358
1 of 14
No
Yes
Rnor\Zfp366
1 of 14
No
Yes
Rnor\Zfp398
1 of 14
No
No
Rnor\Zfp420
1 of 14
No
No
Rnor\Zfp422
1 of 14
No
No
Rnor\Zfp566
1 of 14
No
Yes
Rnor\Zfp579
1 of 14
No
Yes
Rnor\Zfp583
1 of 14
No
No
Rnor\Zfp641
1 of 14
No
Yes
Rnor\Zfp648
1 of 14
No
No
Rnor\Zfp655
1 of 14
No
Yes
Rnor\Zfp663
1 of 14
No
Yes
Rnor\Zfp689
1 of 14
No
Yes
Rnor\Zfp764
1 of 14
No
No
Rnor\Zfp846
1 of 14
No
Yes
Rnor\Zfp867
1 of 14
No
Yes
Rnor\Zim1
1 of 14
No
Yes
Rnor\Znf8
1 of 14
No
No
Rnor\Zscan10
1 of 14
No
Yes
Rnor\Zscan25
1 of 14
No
Yes
Rnor\Zscan29
1 of 14
No
No
Mus musculus (laboratory mouse) (64)
Mmus\Insm1
8 of 14
Yes
Yes
Mmus\Insm2
8 of 14
Yes
Yes
Mmus\2610021A01Rik
1 of 14
No
No
Mmus\E430018J23Rik
1 of 14
No
No
Mmus\Gm5141
1 of 14
No
No
Mmus\Mecom
1 of 14
No
No
Mmus\Mzf1
1 of 14
No
No
Mmus\Platr25
1 of 14
No
No
Mmus\Prdm14
1 of 14
No
Yes
Mmus\Prdm16
1 of 14
No
No
Mmus\Zbtb17
1 of 14
No
No
Mmus\Zbtb41
1 of 14
No
No
Mmus\Zbtb48
1 of 14
No
No
Mmus\Zbtb49
1 of 14
No
Yes
Mmus\Zfp2
1 of 14
No
Yes
Mmus\Zfp11
1 of 14
No
No
Mmus\Zfp26
1 of 14
No
No
Mmus\Zfp39
1 of 14
No
No
Mmus\Zfp53
1 of 14
No
No
Mmus\Zfp57
1 of 14
No
Yes
Mmus\Zfp72
1 of 14
No
No
Mmus\Zfp78
1 of 14
No
No
Mmus\Zfp87
1 of 14
No
No
Mmus\Zfp92
1 of 14
No
Yes
Mmus\Zfp113
1 of 14
No
Yes
Mmus\Zfp114
1 of 14
No
Yes
Mmus\Zfp128
1 of 14
No
No
Mmus\Zfp184
1 of 14
No
No
Mmus\Zfp202
1 of 14
No
Yes
Mmus\Zfp260
1 of 14
No
No
Mmus\Zfp263
1 of 14
No
No
Mmus\Zfp286
1 of 14
No
Yes
Mmus\Zfp319
1 of 14
No
Yes
Mmus\Zfp324
1 of 14
No
No
Mmus\Zfp341
1 of 14
No
Yes
Mmus\Zfp345
1 of 14
No
No
Mmus\Zfp358
1 of 14
No
No
Mmus\Zfp366
1 of 14
No
Yes
Mmus\Zfp398
1 of 14
No
No
Mmus\Zfp408
1 of 14
No
No
Mmus\Zfp420
1 of 14
No
No
Mmus\Zfp558
1 of 14
No
No
Mmus\Zfp566
1 of 14
No
Yes
Mmus\Zfp583
1 of 14
No
No
Mmus\Zfp607a
1 of 14
No
No
Mmus\Zfp607b
1 of 14
No
No
Mmus\Zfp629
1 of 14
No
No
Mmus\Zfp646
1 of 14
No
Yes
Mmus\Zfp648
1 of 14
No
No
Mmus\Zfp663
1 of 14
No
Yes
Mmus\Zfp668
1 of 14
No
Yes
Mmus\Zfp689
1 of 14
No
Yes
Mmus\Zfp708
1 of 14
No
No
Mmus\Zfp790
1 of 14
No
Yes
Mmus\Zfp846
1 of 14
No
No
Mmus\Zfp865
1 of 14
No
Yes
Mmus\Zfp867
1 of 14
No
Yes
Mmus\Zfp937
1 of 14
No
No
Mmus\Zfp948
1 of 14
No
No
Mmus\Zfp955b
1 of 14
No
Yes
Mmus\Zfp998
1 of 14
No
No
Mmus\Zim1
1 of 14
No
Yes
Mmus\Zscan25
1 of 14
No
No
Mmus\Zscan29
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (26)
Xtro\insm1
7 of 13
Yes
Yes
Xtro\bcl6
1 of 13
No
Yes
Xtro\fezf1
1 of 13
No
No
Xtro\fezf2
1 of 13
No
No
Xtro\LOC100485704
1 of 13
No
No
Xtro\LOC100486443
1 of 13
No
No
Xtro\LOC100487439
1 of 13
No
No
Xtro\LOC100492687
1 of 13
No
Yes
Xtro\LOC100493522
1 of 13
No
No
Xtro\LOC100498327
1 of 13
No
Yes
Xtro\LOC101731232
1 of 13
No
No
Xtro\LOC101731242
1 of 13
No
No
Xtro\LOC105947126
1 of 13
No
No
Xtro\LOC108645295
1 of 13
No
No
Xtro\LOC108648854
1 of 13
No
No
Xtro\prdm10
1 of 13
No
Yes
Xtro\smc1b
1 of 13
No
No
Xtro\zbtb16
1 of 13
No
No
Xtro\zbtb38
1 of 13
No
Yes
Xtro\zbtb41
1 of 13
No
No
Xtro\znf319
1 of 13
No
Yes
Xtro\znf526
1 of 13
No
No
Xtro\znf605
1 of 13
No
No
Xtro\znf628
1 of 13
No
No
Xtro\znf853
1 of 13
No
No
Xtro\zscan2
1 of 13
No
No
Danio rerio (Zebrafish) (68)
Drer\insm1a
9 of 14
Yes
Yes
Drer\insm1b
9 of 14
Yes
Yes
Drer\bcl6aa
1 of 14
No
No
Drer\bif1.1
1 of 14
No
Yes
Drer\im:7141269
1 of 14
No
No
Drer\LOC100148466
1 of 14
No
No
Drer\LOC100329723
1 of 14
No
Yes
Drer\LOC100329844
1 of 14
No
Yes
Drer\LOC100330321
1 of 14
No
No
Drer\LOC100332787
1 of 14
No
No
Drer\LOC100333012
1 of 14
No
No
Drer\LOC100534672
1 of 14
No
Yes
Drer\LOC100537891
1 of 14
No
Yes
Drer\LOC101882596
1 of 14
No
Yes
Drer\LOC101884037
1 of 14
No
No
Drer\LOC101884305
1 of 14
No
No
Drer\LOC101886167
1 of 14
No
No
Drer\LOC101886309
1 of 14
No
No
Drer\LOC110437722
1 of 14
No
No
Drer\LOC110437725
1 of 14
No
Yes
Drer\LOC110437726
1 of 14
No
No
Drer\prdm10
1 of 14
No
Yes
Drer\si:cabz01069020.1
1 of 14
No
No
Drer\si:cabz01071909.2
1 of 14
No
Yes
Drer\si:ch73-367f21.6
1 of 14
No
No
Drer\si:ch211-223a21.4
1 of 14
No
Yes
Drer\si:ch211-241e1.5
1 of 14
No
Yes
Drer\si:dkey-1b17.5
1 of 14
No
Yes
Drer\si:dkey-30k6.5
1 of 14
No
Yes
Drer\si:dkey-57k17.1
1 of 14
No
No
Drer\si:dkey-77f5.4
1 of 14
No
Yes
Drer\si:dkey-89b17.4
1 of 14
No
Yes
Drer\si:dkeyp-104f11.6
1 of 14
No
Yes
Drer\si:zfos-932h1.3
1 of 14
No
No
Drer\zbtb11
1 of 14
No
No
Drer\zbtb12.1
1 of 14
No
Yes
Drer\zbtb17
1 of 14
No
Yes
Drer\zbtb49
1 of 14
No
Yes
Drer\zgc:66448
1 of 14
No
Yes
Drer\zgc:101130
1 of 14
No
Yes
Drer\zgc:113209
1 of 14
No
No
Drer\zgc:113220
1 of 14
No
Yes
Drer\zgc:113343
1 of 14
No
No
Drer\zgc:171673
1 of 14
No
No
Drer\zgc:173486
1 of 14
No
Yes
Drer\zgc:175284
1 of 14
No
No
Drer\zgc:194186
1 of 14
No
Yes
Drer\zgc:194215
1 of 14
No
Yes
Drer\znf236
1 of 14
No
Yes
Drer\znf384a
1 of 14
No
No
Drer\znf526
1 of 14
No
Yes
Drer\znf646
1 of 14
No
Yes
Drer\znf710b
1 of 14
No
Yes
Drer\znf770
1 of 14
No
Yes
Drer\znf865
1 of 14
No
No
Drer\znf1035
1 of 14
No
Yes
Drer\znf1041
1 of 14
No
No
Drer\znf1042
1 of 14
No
No
Drer\znf1043
1 of 14
No
No
Drer\znf1059
1 of 14
No
No
Drer\znf1077
1 of 14
No
Yes
Drer\znf1113
1 of 14
No
No
Drer\znf1117
1 of 14
No
Yes
Drer\znf1154
1 of 14
No
Yes
Drer\znf1155
1 of 14
No
No
Drer\znf1173
1 of 14
No
Yes
Drer\znf1179
1 of 14
No
Yes
Drer\znf1184
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\egl-46
6 of 14
Yes
Yes
Cele\egrh-1
1 of 14
No
No
Cele\K11D12.12
1 of 14
No
Yes
Cele\M03D4.4
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (15)
Agam\AgaP_AGAP002601
9 of 12
Yes
Yes
Agam\AgaP_AGAP002845
5 of 12
No
No
Agam\AgaP_AGAP000062
1 of 12
No
No
Agam\AgaP_AGAP000141
1 of 12
No
No
Agam\AgaP_AGAP000674
1 of 12
No
No
Agam\AgaP_AGAP001555
1 of 12
No
No
Agam\AgaP_AGAP002497
1 of 12
No
No
Agam\AgaP_AGAP003111
1 of 12
No
No
Agam\AgaP_AGAP004269
1 of 12
No
No
Agam\AgaP_AGAP004438
1 of 12
No
No
Agam\AgaP_AGAP005978
1 of 12
No
No
Agam\AgaP_AGAP008135
1 of 12
No
Yes
Agam\AgaP_AGAP008235
1 of 12
No
Yes
Agam\AgaP_AGAP011963
1 of 12
No
Yes
Agam\AgaP_AGAP012768
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\MSN2
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:nerfin-1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (22)
nerfin-2
8 of 13
bowl
1 of 13
btd
1 of 13
CG2202
1 of 13
CG6654
1 of 13
CG7987
1 of 13
CG8319
1 of 13
CG10366
1 of 13
CG12299
1 of 13
CG15269
1 of 13
CG17806
1 of 13
CG32772
1 of 13
dumpless1
1 of 13
erm
1 of 13
gl
1 of 13
jim
1 of 13
lola
1 of 13
Meics
1 of 13
pita
1 of 13
Saft
1 of 13
sqz
1 of 13
su(Hw)
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
nerfin-1159
model of  brain cancer
CEA
(Narbonne-Reveau et al., 2016)
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
INSM1; INSM transcriptional repressor 1
9 of 14
600010
      INSM2; INSM transcriptional repressor 2
      9 of 14
      614027
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          nerfin-1
          suppressible
          Delta
          (Xu et al., 2017)
          nerfin-1
          suppressible
          N
          (Xu et al., 2017)
          nerfin-1
          enhanceable
          pros
          (Kuzin et al., 2005)
          nerfin-1
          enhanceable
          slmb
          (Lin et al., 2018)
          nerfin-1
          suppressible
          slmb
          (Lin et al., 2018)
          nerfin-1
          suppressible
          Su(H)
          (Xu et al., 2017)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          pros
          enhanceable
          nerfin-1
          (Kuzin et al., 2005)
          pros
          suppressible
          nerfin-1
          (Hartl et al., 2011)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Linkouts
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3L
          Recombination map
          3-0.5
          Cytogenetic map
          61D4-61D4
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          61D4-61D4
          Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          61E-61E
          (Stivers, 1999.11.10)
          Experimentally Determined Recombination Data
          Location

          3-0.5

          (FlyBase, 2016)

          3-0.8

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (15)
          Genomic Clones (15)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (24)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Xu et al., 2017)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              dsRNA has been made from templates generated with primers directed against this gene. RNAi of nerfin-1 causes an increase in class I da neurons. Class I neurons from nerfin-1(RNAi)-treated embryos extend mostly unbranched dendrites and the routing pattern of these dendrites often appears abnormal. RNAi also causes alterations in the number of MD neurons and defects in dendrite morphogenesis.

              (Parrish et al., 2006)

              nerfin-1 expression is both spatially and temporally dynamic during neuroblast lineage development.

              (Stivers et al., 2000)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: nerfin-1 CG13906

              (Bayraktaroglu, 2000.8.7)
              Additional comments
              Nomenclature History
              Source for database identify of
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (11)
              Reported As
              Symbol Synonym
              CG13906
              (Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009)
              Nerfin
              (Behm-Ansmant et al., 2006, Rehwinkel et al., 2006)
              Nerfin-1
              (Paraskevopoulos and McGuigan, 2021, Guo et al., 2019, Lin et al., 2018, Froldi et al., 2015, Zekri et al., 2013, Luo and Sehgal, 2012, Eulalio et al., 2009, Eulalio et al., 2008, Parrish et al., 2006)
              nerf
              (Duan et al., 2018)
              nerfin
              (Hartl et al., 2011)
              nerfin-1
              (Leclercq and Maurange, 2025, Narbonne-Reveau et al., 2025, Yun et al., 2025, Balakireva et al., 2024, Manning et al., 2024, Saez-Carrion et al., 2024, Wang et al., 2024, Ma et al., 2021, McLaughlin et al., 2021, Magadi et al., 2020, Meltzer et al., 2019, Stratmann et al., 2019, Bischof et al., 2018, Kavaler et al., 2018, Katti et al., 2017, Transgenic RNAi Project members, 2017-, Xu et al., 2017, Carbone et al., 2016, Narbonne-Reveau et al., 2016, Sarov et al., 2016, Appel et al., 2015, de Taffin et al., 2015, Schertel et al., 2015, Sun et al., 2015, Eroglu et al., 2014, Gonzalez et al., 2014, Majzoub et al., 2014, Rhee et al., 2014, Naval-Sánchez et al., 2013, Kuzin et al., 2011, Biehs et al., 2010, Kuzin et al., 2009, Zekri et al., 2009, Kundu et al., 2008, Garg et al., 2007, Grunwald Kadow et al., 2007, Kuzin et al., 2007, Kuzin et al., 2007, Kuzin et al., 2007, Altenhein et al., 2006, Choksi et al., 2006, Kuzin et al., 2006, Stark et al., 2005, Brodsky et al., 2004)
              nerfin1
              (Theodorou et al., 2022)
              Name Synonyms
              Nerfin
              (Eulalio et al., 2009, Eulalio et al., 2007)
              Nerfin-1
              (Ferrero et al., 2014, Cayirlioglu et al., 2008)
              Nervous finger-1
              (Garg et al., 2007)
              Nervous fingers 1
              (Walker et al., 2011)
              nerfin
              (Chekulaeva et al., 2009)
              nerfin 1
              (Kearney et al., 2004)
              nerfin-1
              (Bravo González-Blas et al., 2020, Cho et al., 2020, Froldi and Cheng, 2016, Pearson et al., 2016, Kuzin et al., 2011, Eulalio et al., 2007, Burgler and Macdonald, 2005)
              nervous fingers 1
              (Rhee et al., 2014, Choksi et al., 2006, Rehmsmeier et al., 2004, Stivers et al., 2000)
              Secondary FlyBase IDs
              • FBgn0035177
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
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              External Crossreferences and Linkouts ( 36 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              References (133)