FlyBase Allele Report: Dmel\nerfin-1[UAS.cKa]

General Information

Symbol

Dmel\nerfin-1^UAS.cKa

Species

D. melanogaster

Name

FlyBase ID

FBal0175566

Feature type

allele

Associated gene

Dmel\nerfin-1

Associated Insertion(s)

Carried in Construct

P{UAS-nerfin-1}

Also Known As

UAS-nerfin-1

Key Links

Transgenic product class

wild_type

(Kuzin et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Kuzin et al., 2005)

Mutagen

in vitro construct

(Kuzin et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-nerfin-1}

Cytology

Description

UASt sequences drive expression of nerfin-1.

(Kuzin et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

nerfin-1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Scer\GAL4^twi.PB

(Kuzin et al., 2005)

Phenotype Manifest In

intermediate longitudinal fascicle, with Scer\GAL4^elav-C155

(Kuzin et al., 2005)

lateral longitudinal fascicle, with Scer\GAL4^elav-C155

(Kuzin et al., 2005)

medial longitudinal fascicle, with Scer\GAL4^elav-C155

(Kuzin et al., 2005)

Detailed Description

Statement

Reference

Expression of nerfin-1^Scer\UAS.cKa under the control of Scer\GAL4^Act.PU the eyFLP technique does not result in an altered targeting pattern of CO[[2]] neurons.

(Hartl et al., 2011)

When nerfin-1^Scer\UAS.cKa is driven by Scer\GAL4^cas-3921, Scer\GAL4^pros.PMG or Scer\GAL4^sca-537.4 no alterations in neuronal or glial development are seen. Axon fascicle patterning is also not affected. When nerfin-1^Scer\UAS.cKa is driven by Scer\GAL4^twi.PB, there is no detectable effect on muscle development or embryonic viability. When nerfin-1^Scer\UAS.cKa is driven by Scer\GAL4^elav-C155 embryos exhibit multiple defects in axon scaffolding throughout the CNS. The development of certain longitudinal connectives is affected. The intermediate and lateral longitudinal fascicles defasciculate, as does the medial longitudinal fascicles, but to a lesser degree.

(Kuzin et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^elav-C155/nerfin-1^UAS.cKa partially rescues nerfin-1⁵⁴

(Kuzin et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

nerfin-1^Scer\UAS.cKa

nerfin-1^UAS.cKa

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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