FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\jing
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General Information
Symbol
Dmel\jing
Species
D. melanogaster
Name
jing
Annotation Symbol
CG9397
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086655
Gene Model Status
Current
Stock Availability
54 publicly available
Gene Summary
May functionally interact with Polycomb group (PcG) and trithorax group (trxG) proteins to repress transcription (Probable). Required for Egfr pathway function and MAPK activity in CNS midline and tracheal placodes and for CNS axon development and tracheal tubule development. Required to establish the primary axon scaffold in the brain and for lateral positioning of longitudinal glia, longitudinal axons and neurons. Required for glial survival. Required to establish the proximo-distal axis of the developing leg and for wing vein and alula development. Required for regenerative growth in leg imaginal disks. Required for the initiation of anterior migration of border cells of the ovary. (UniProt, Q7KHG2)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

1.28, l(2)01094, rhumba, l(2)22F3

Key Links
Genomic Location
Cytogenetic map
42B1-42B2
Sequence location
Recombination map
2-55
RefSeq locus
NT_033778 REGION:6502006..6621792
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein-containing complex binding
inferred from direct assay
(Herz et al., 2012)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (13 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Sun et al., 2006)
involved_in border follicle cell migration
inferred from mutant phenotype
(Liu and Montell, 2001)
involved_in central nervous system development
inferred from mutant phenotype
(Sedaghat and Sonnenfeld, 2002, Sedaghat et al., 2002)
involved_in glial cell migration
inferred from mutant phenotype
(Sun et al., 2006)
involved_in imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Culi et al., 2006)
involved_in leg disc proximal/distal pattern formation
inferred from mutant phenotype
(Culi et al., 2006)
involved_in negative regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Culi et al., 2006)
involved_in open tracheal system development
inferred from mutant phenotype
(Sedaghat et al., 2002)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Sonnenfeld et al., 2010)
involved_in specification of segmental identity, maxillary segment
inferred from expression pattern
(Mahaffey et al., 1993)
inferred from genetic interaction with FLYBASE:Dfd; FB:FBgn0000439
(Mahaffey et al., 1993)
involved_in tissue regeneration
inferred from mutant phenotype
(McClure and Schubiger, 2008)
involved_in ventral midline development
inferred from mutant phenotype
(Sonnenfeld et al., 2004)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN002323211
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Liu and Montell, 2001)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of ESC/E(Z) complex
inferred from biological aspect of ancestor with PANTHER:PTN002323211
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from sequence or structural similarity with FLYBASE:ci; FB:FBgn0004859
(Liu and Montell, 2001)
inferred from sequence or structural similarity with MGI:MGI:1338038
(Liu and Montell, 2001)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the AEBP2/jing C2H2-type zinc-finger family. (Q7KHG2)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
POLYCOMB REPRESSIVE COMPLEX 2, JARID2-JING VARIANT -
The Polycomb repressive complex 2 (PRC2) is a Polycomb group complex. Histone-lysine N-methyltransferase which trimethylates catalyzes the trimethylation of K27 of histone H3 (H3K27me3) which serves to recruit PRC1 and K9 of histone H3 (H3K9me3) and promotes heterochromatin formation. he PRC2 core may preferentially interact with Pcl or Jarid2 giving rise to variants. (Adapted from FBrf0188105 & FBrf0252799).
Protein Function (UniProtKB)
May functionally interact with Polycomb group (PcG) and trithorax group (trxG) proteins to repress transcription (Probable). Required for Egfr pathway function and MAPK activity in CNS midline and tracheal placodes and for CNS axon development and tracheal tubule development. Required to establish the primary axon scaffold in the brain and for lateral positioning of longitudinal glia, longitudinal axons and neurons. Required for glial survival. Required to establish the proximo-distal axis of the developing leg and for wing vein and alula development. Required for regenerative growth in leg imaginal disks. Required for the initiation of anterior migration of border cells of the ovary.
(UniProt, Q7KHG2)
Summary (Interactive Fly)

zinc finger transcription factor - a downstream target of slbo required for border cell migration - also plays an essential role in controlling CNS midline and tracheal cell differentiation

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\jing for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7KHG2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
jing-RD
FBtr0301636
NM_206027
4817
1486
jing-RH
FBtr0114364
NM_001103729
5126
1486
jing-RI
FBtr0114365
NM_001103730
6397
1744
jing-RJ
FBtr0332950
NM_136371
7491
1471
Additional Transcript Data and Comments
Reported size (kB)

2.1 (northern blot)

(Mahaffey et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
jing-PD
FBpp0290850
155.3
1486
9.83
Q7KHG2
NP_995749
AAS64777
jing-PH
FBpp0112913
155.3
1486
9.83
Q7KHG2
NP_001097199
AAM68380
jing-PI
FBpp0112914
181.2
1744
9.97
A8DY48
NP_001097200
ABV53707
jing-PJ
FBpp0305167
153.4
1471
9.55
A0A0C4DHC2
NP_610215
AAF57358
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1486 aa isoforms: jing-PD, jing-PH
Additional Polypeptide Data and Comments
Reported size (kDa)

217 (aa); 22 (kD predicted)

(Mahaffey et al., 1993)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the polycomb repressive complex 2 (also known as the ESC/E(Z) complex) Jarid2-jing variant (PRC2.2), consisting of the core PRC2 components esc, Su(z)12, E(z) and Caf1-55, and the accessory components Jarid2 and jing.

(UniProt, Q7KHG2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jing using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.76

Transcript Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9
supraesophageal ganglion
(Sedaghat et al., 2002)
embryonic stage 9 -- 15
ventral midline of embryo
(Sedaghat et al., 2002)
ventral neurectoderm | segmentally repeated
(Sedaghat et al., 2002)
embryonic stage 10 -- 16
tracheal primordium | anterior
(Sedaghat et al., 2002)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval hindgut
(Mahaffey et al., 1993)
embryonic/larval anterior midgut
(Mahaffey et al., 1993)
embryonic prothoracic segment | restricted
(Mahaffey et al., 1993)
embryonic abdominal segment 8 | restricted
(Mahaffey et al., 1993)
embryonic/larval posterior midgut
(Mahaffey et al., 1993)
epidermis of embryonic maxillary segment
(Mahaffey et al., 1993)
proctodeum
(Mahaffey et al., 1993)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 9
supraesophageal ganglion
(Sedaghat et al., 2002)
embryonic stage 9 -- 10
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 15
ventral midline of embryo
(Sedaghat et al., 2002)
ventral neurectoderm | segmentally repeated
(Sedaghat et al., 2002)
embryonic stage 10 -- 16
tracheal primordium | anterior
(Sedaghat et al., 2002)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle cell
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval somatic muscle cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
midline glial cell
(Kearney et al., 2004)
adult stage
adult mushroom body | restricted
(Kobayashi et al., 2006)
Additional Descriptive Data

jing transcripts are first detected in stage 11 embryos in the proctodeum and in within a cluster of cells in the posterior-lateral portion of the eighth abdominal segment. Transcripts also accumulate in the hindgut and in the developing anterior and posterior midguts. After germ band contraction, transcripts accumulate within a few cells along the posterior-mid-lateral edge of the prothoracic segment. In the maxillary lobe, expression is limited to the posterior-lateral epidermis of the lobe and is first detected in stage 12.

(Mahaffey et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 14
ventral midline of embryo
• nucleus
(Sedaghat et al., 2002)
embryonic stage 10 -- 16
tracheal primordium
• nucleus
(Sedaghat et al., 2002)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Liu and Montell, 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\jing in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 71 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of jing
Transgenic constructs containing regulatory region of jing
Aberrations (Deficiencies and Duplications) ( 11 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
viable (with Df(2R)BSC326)
Other Phenotypes
Allele
abnormal cell cycle | oogenesis, with Scer\GAL4nanos.PG
abnormal locomotor behavior, with Scer\GAL4Appl.G1a
abnormal locomotor behavior, with Scer\GAL4elav.PLu
abnormal locomotor behavior, with Scer\GAL4nrv2.PS
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4elav.PLu
abnormal neuroanatomy, with Scer\GAL4gcm-rA87.P
abnormal neuroanatomy, with Scer\GAL4sim.P3.7
abnormal neuroanatomy, with Scer\GAL4sli.PS
abnormal neuroanatomy (with Df(2R)ST1)
abnormal stress response | oogenesis, with Scer\GAL4nanos.PG
decreased cell death, with Scer\GAL4sli.PS
increased cell death
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4tsh-md621
visible | somatic clone
wild-type
Phenotype manifest in
Allele
abdomen | somatic clone
adult visceral tracheal branch
adult visceral tracheal branch, with Scer\GAL4btl.PS
alar lobe | somatic clone
border follicle cell | somatic clone
commissure & growth cone
dMP2 neuron
embryonic/larval dorsal tracheal branch, with Scer\GAL4btl.PS
embryonic/larval dorsal tracheal branch | embryonic stage 13
embryonic/larval dorsal tracheal branch | embryonic stage 15
embryonic/larval ganglionic tracheal branch | embryonic stage 15
embryonic/larval ganglionic tracheal branch | embryonic stage 15, with Scer\GAL4btl.PS
embryonic/larval tracheal dorsal trunk (with Df(2R)ST1)
embryonic/larval tracheal section, with Scer\GAL4arm.PS
embryonic/larval tracheal section, with Scer\GAL4btl.PS
embryonic brain
embryonic brain, with Scer\GAL4sim.P3.7
embryonic longitudinal glial cell, with Scer\GAL4gcm-rA87.P
embryonic longitudinal glial cell (with Df(2R)ST1)
eye, with Scer\GAL4GMR.PF
female germline stem cell, with Scer\GAL4nanos.PG
femur & bract | somatic clone
femur | somatic clone
interommatidial bristle, with Scer\GAL4GMR.PF
larval anterior commissure, with Scer\GAL4elav.PLu
larval glial cell
larval glial cell, with Scer\GAL4gcm-rA87.P
larval glial cell (with Df(2R)ST1)
larval longitudinal connective
larval longitudinal connective, with Scer\GAL4elav.PLu
larval longitudinal connective, with Scer\GAL4sim.P3.7
larval longitudinal connective (with Df(2R)ST1)
larval MP1 neuron
larval neuron
larval posterior commissure, with Scer\GAL4elav.PLu
larval ventral midline glial cell
larval ventral midline glial cell (with Df(2R)ST1)
larval ventral midline glial cell | ectopic, with Scer\GAL4sli.PS
larval ventral nerve cord commissure, with Scer\GAL4sli.PS
larval VUM neuron
leg | somatic clone
metatarsus | somatic clone
midline glial cell
neuroblast MNB
ommatidium, with Scer\GAL4GMR.PF
presumptive embryonic/larval tracheal system
symmetrical commissure
symmetrical commissure, with Scer\GAL4sim.P3.7
tibia | somatic clone
tracheal dorsal trunk primordium
tracheal dorsal trunk primordium, with Scer\GAL4btl.PS
tracheal dorsal trunk primordium | embryonic stage 13
tracheal dorsal trunk primordium | embryonic stage 15
tracheal lateral trunk anterior branch primordium | embryonic stage 15
tracheal lateral trunk anterior branch primordium | embryonic stage 15, with Scer\GAL4btl.PS
tracheal lateral trunk posterior branch primordium | embryonic stage 15
tracheal lateral trunk posterior branch primordium | embryonic stage 15, with Scer\GAL4btl.PS
tracheal metamere | embryonic stage 15
tracheal metamere | embryonic stage 15, with Scer\GAL4btl.PS
tracheal transverse connective primordium
tracheal transverse connective primordium, with Scer\GAL4btl.PS
ventral midline of embryo
vMP2 neuron
wing margin bristle | somatic clone
wing vein | cell autonomous | somatic clone
wing vein | cell non-autonomous | somatic clone
wing vein | ectopic, with Scer\GAL4en-e16E
wing vein | ectopic | somatic clone
wing vein | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (20)
Hsap\AEBP2
6 of 14
Yes
Yes
Hsap\GLI1
1 of 14
No
No
9  
Hsap\GLI3
1 of 14
No
No
4  
Hsap\GLIS2
1 of 14
No
No
2  
Hsap\GTF3A
1 of 14
No
No
Hsap\GZF1
1 of 14
No
No
Hsap\KLF5
1 of 14
No
No
Hsap\KLF8
1 of 14
No
No
Hsap\MTF1
1 of 14
No
No
1  
Hsap\PRDM1
1 of 14
No
No
Hsap\ZBTB37
1 of 14
No
No
Hsap\ZIC1
1 of 14
No
No
1  
Hsap\ZIC3
1 of 14
No
No
Hsap\ZIC4
1 of 14
No
No
Hsap\ZNF76
1 of 14
No
No
Hsap\ZNF616
1 of 14
No
No
Hsap\ZNF846
1 of 14
No
No
Hsap\ZSCAN5C
1 of 14
No
No
Hsap\ZXDA
1 of 14
No
No
Hsap\ZXDB
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (12)
Rnor\Aebp2
6 of 14
Yes
Yes
Rnor\Glis2
1 of 14
No
No
Rnor\Gtf3a
1 of 14
No
No
Rnor\Klf1
1 of 14
No
No
Rnor\Klf5
1 of 14
No
No
Rnor\Mtf1
1 of 14
No
No
Rnor\Zbtb37
1 of 14
No
No
Rnor\Zfp236
1 of 14
No
Yes
Rnor\Zfp523
1 of 14
No
Yes
Rnor\Zfp653
1 of 14
No
Yes
Rnor\Zic3
1 of 14
No
No
Rnor\Zxdc
1 of 14
No
No
Mus musculus (laboratory mouse) (13)
Mmus\Aebp2
6 of 14
Yes
Yes
Mmus\Arid2
1 of 14
No
No
Mmus\BC024063
1 of 14
No
No
Mmus\Gli1
1 of 14
No
No
Mmus\Glis2
1 of 14
No
No
Mmus\Klf5
1 of 14
No
No
Mmus\Mtf1
1 of 14
No
No
Mmus\Zbtb37
1 of 14
No
Yes
Mmus\Zfp523
1 of 14
No
Yes
Mmus\Zfp653
1 of 14
No
Yes
Mmus\Zfp943
1 of 14
No
No
Mmus\Zic3
1 of 14
No
No
Mmus\Zxdc
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (9)
Xtro\aebp2
2 of 13
Yes
Yes
Xtro\gli2
1 of 13
No
No
Xtro\glis2
1 of 13
No
No
Xtro\glis3
1 of 13
No
No
Xtro\klf11
1 of 13
No
No
Xtro\mtf1
1 of 13
No
No
Xtro\prdm1
1 of 13
No
No
Xtro\rest
1 of 13
No
Yes
Xtro\zic3
1 of 13
No
No
Danio rerio (Zebrafish) (12)
Drer\aebp2
6 of 14
Yes
Yes
Drer\gli2b
1 of 14
No
No
Drer\glis2a
1 of 14
No
No
Drer\gtf3aa
1 of 14
No
No
Drer\klf5a
1 of 14
No
No
Drer\mtf1
1 of 14
No
No
Drer\prdm1a
1 of 14
No
No
Drer\zbtb12.1
1 of 14
No
Yes
Drer\zic2b
1 of 14
No
No
Drer\zic3
1 of 14
No
No
Drer\znf143a
1 of 14
No
Yes
Drer\znf335
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\dpy-6
1 of 14
Yes
Yes
Cele\F59B2.12
1 of 14
Yes
Yes
Cele\klf-1
1 of 14
Yes
No
Cele\lec-2
1 of 14
Yes
No
Cele\ref-2
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (5)
Agam\AgaP_AGAP001291
1 of 12
Yes
No
Agam\AgaP_AGAP002082
1 of 12
Yes
No
Agam\AgaP_AGAP002083
1 of 12
Yes
No
Agam\AgaP_AGAP006736
1 of 12
Yes
No
Agam\AgaP_AGAP008692
1 of 12
Yes
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:jing. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
Cf2
1 of 13
CG7386
1 of 13
MTF-1
1 of 13
scrape
1 of 13
sug
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    AEBP2; AE binding protein 2
    6 of 14
    617934
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        jing
        suppressible
        Egfr
        (Sonnenfeld et al., 2004)
        jing
        suppressible
        Ras85D
        (Sonnenfeld et al., 2004)
        jing
        suppressible
        S
        (Sonnenfeld et al., 2004)
        jing
        enhanceable
        sim
        (Sedaghat et al., 2002)
        jing
        enhanceable
        sli
        (Sedaghat et al., 2002)
        jing
        suppressible
        spi
        (Sonnenfeld et al., 2004)
        jing
        enhanceable
        tgo
        (Sedaghat et al., 2002)
        sim|jing
        enhanceable
        tgo
        (Sedaghat et al., 2002)
        trh|jing
        enhanceable
        tgo
        (Sedaghat et al., 2002)
        jing
        enhanceable
        XNP
        (Sun et al., 2006)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        hng1
        suppressible
        jing
        (Shukla et al., 2014)
        hng1
        enhanceable
        jing
        (Shukla et al., 2014)
        hth
        enhanceable
        jing
        (Culi et al., 2006)
        kay
        enhanceable
        jing
        (Sun et al., 2006)
        lap
        enhanceable
        jing
        (Sun et al., 2006)
        pbl
        suppressible
        jing
        (Gregory et al., 2007)
        Pc
        enhanceable
        jing
        (Culi et al., 2006)
        sim
        enhanceable
        jing
        (Sedaghat et al., 2002)
        slbo
        suppressible
        jing
        (Liu and Montell, 2001)
        trh
        enhanceable
        jing
        (Sedaghat et al., 2002)
        wg
        suppressible
        jing
        (McClure and Schubiger, 2008)
        XNP
        enhanceable
        jing
        (Sun et al., 2006)
        External Data
        Subunit Structure (UniProtKB)
        Component of the polycomb repressive complex 2 (also known as the ESC/E(Z) complex) Jarid2-jing variant (PRC2.2), consisting of the core PRC2 components esc, Su(z)12, E(z) and Caf1-55, and the accessory components Jarid2 and jing.
        (UniProt, Q7KHG2 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-55
        Cytogenetic map
        42B1-42B2
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        42B1-42B2
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        42B2-42B2
        (Sonnenfeld, 2000.7.7)
        42B-42B
        (Liu, 2000.3.10, Mahaffey, 1992)
        42B1-42B3
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        42B3-42C7
        (determined by deficiency mapping, details unspecified).
        (Liu and Montell, 1999)
        42B1-42B3
        42B2--3
        (BDGP Project Members, 1994-1999)
        42B-42B
        (determined by in situ hybridisation)
        (Mahaffey et al., 1993)
        Experimentally Determined Recombination Data
        Location

        2-55

        (FlyBase, 2016)

        2-55.9

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (54)
        Genomic Clones (64)
        cDNA Clones (49)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Nair et al., 2013, Sedaghat et al., 2002)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Host gene for maternally inherited stable intronic sequence RNA (sisRNA).

            (Tay and Pek, 2017)

            The jing and Egfr pathways are functionally related in the embryonic central nervous system midline and trachea.

            (Sonnenfeld et al., 2004)

            jing is required for embryonic brain development.

            (Sedaghat and Sonnenfeld, 2002)

            jing is a mediator of cellular differentiation in the central nervous system and tracheal system.

            (Sedaghat et al., 2002)

            jing is required for the initiation of border cell migration.

            (Liu and Montell, 2001)

            jing is required for the transition of border cells from a stationary state to a motile state during oogenesis. jing appears to act downstream of slbo.

            (Liu and Montell, 2000)

            Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

            (Roch et al., 1998)

            The 1.28 gene is directly activated by Dfd in the maxillary segment but not in the mandibular segment. Four Dfd-product binding sites have been identified within a 664bp fragment of the 1.28 regulatory region, in addition to a Dfd epidermal autoactivation element (DEAE).

            (Pederson and Mahaffey, 1995)

            Identified in an enhancer trap screen for target genes of homeoproteins. The 1.28 gene is a target gene that is activated by Dfd. Dfd is required to activate 1.28 in the maxillary segment, but ectopic expression of Dfd is incapable of activating 1.28 elsewhere.

            (Mahaffey et al., 1993)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: jing l(2)22F3 l(2)01094 rhumba

            (Liu and Montell, 2001)

            Source for merge of: jing 1.28

            (Culi et al., 2006)
            Additional comments

            "1.28" may correspond to "Scim21". Sequence analysis off ends of P{SUPor-P} in Scim insertion mutant places "Scim21" near/in "1.28".

            (Dobie and Karpen, 2001.4.18)
            Nomenclature History
            Source for database identify of
            Nomenclature comments
            Etymology

            The gene is named "jing" (meaning "still") as it is required for the transition of border cells from a stationary state to a motile state.

            (Liu and Montell, 2000)
            Synonyms and Secondary IDs (11)
            Reported As
            Symbol Synonym
            1.28
            (Gistelinck et al., 2012, Blard et al., 2007, Buszczak et al., 2007, Gregory et al., 2007, Reiter et al., 2007, Sambandan et al., 2006, Pearson et al., 2005)
            AEBP2
            (Margueron and Reinberg, 2011)
            CG9397
            (National Institute of Genetics Fly Stocks, 2022-, Meadows, 2018.10.31, Fukuoh et al., 2014, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Dobie and Karpen, 2001.4.18, Mount, 2001.8.14)
            CG9403
            (Perkins et al., 2009.3.31, Quinones-Coello, 2007, Bessa et al., 2002, Brody et al., 2002, Levis, 2002.12.17, Liu and Montell, 2001)
            CT9093
            (Ceriani et al., 2002)
            Jing
            (Martinez, 2025, Fischer et al., 2022, Kang et al., 2022, Chetverina et al., 2020, DeLuca et al., 2020, Kuroda et al., 2020, Herz et al., 2012)
            jing
            (Li et al., 2025, Burghardt et al., 2023, Beaver et al., 2022, Chaouch and Lasko, 2021, Özsoy et al., 2021, Winbush and Singh, 2021, Berlandi et al., 2019, Hall et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Levis, 2018.8.30, Ma et al., 2018, Song et al., 2018, Fochler et al., 2017, Tay and Pek, 2017, Transgenic RNAi Project members, 2017-, Yadav et al., 2017, Clandinin and Owens, 2016-, Hunter et al., 2016, Ma et al., 2016, Pearson et al., 2016, de Taffin et al., 2015, Duff et al., 2015, Kang et al., 2015, Morgante et al., 2015, Schertel et al., 2015, Ugrankar et al., 2015, Dunne et al., 2014, Fedotov et al., 2014, Jalvingh et al., 2014, Rogers et al., 2014, Shukla et al., 2014, Vernes, 2014, Lavagnino et al., 2013, Nair et al., 2013, Sen et al., 2013, Webber et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Mackay et al., 2012, Smibert et al., 2012, Spokony and White, 2012.5.22, Carreira et al., 2011, Grimberg et al., 2011, Morozova et al., 2010, Reis et al., 2010, Sonnenfeld et al., 2010, Klattenhoff et al., 2009, Southall and Brand, 2009, McClure and Schubiger, 2008, Christensen et al., 2007.10.29, Christensen et al., 2007.10.29, Quinones-Coello, 2007, Culi et al., 2006, Kobayashi et al., 2006, Liebl et al., 2006, Otsuna and Ito, 2006, Sun et al., 2006)
            l(2)01094
            (Misra, 2000.8.25, Spradling et al., 1999, Roch et al., 1998, BDGP Project Members, 1994-1999)
            l(2)22F3
            (Liu and Montell, 1999)
            Name Synonyms
            1.28
            Jing
            (Saadin and Starz-Gaiano, 2016)
            deformed
            (Mahaffey, 1992)
            jing
            (Xu et al., 2016, Dunne et al., 2014, Culi et al., 2006)
            rhumba
            (Sonnenfeld, 2000.7.7)
            Secondary FlyBase IDs
            • FBgn0041145
            • FBan0009403
            • FBgn0010347
            • FBgn0010475
            • FBgn0026656
            • FBgn0033077
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 66 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (165)