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FB2025_04
,
released October 2, 2025
Fos, Dfos, AP-1, D-Fos, c-Fos
transcription factor - basic leucine zipper - regulates dorsal closure - also required downstream from Decapentaplegic signaling for the regulation of labial in the midgut - Fos and Jun potentiate individual release sites and mobilize the reserve synaptic-vesicle pool at the Drosophila larval motor synapse
Please see the JBrowse view of Dmel\kay for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Gene model reviewed during 5.39
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Gene model reviewed during 5.56
3.65 (northern blot)
None of the polypeptides share 100% sequence identity.
595 (aa); 70 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kay using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: kay-RA and kay-RB
Comment: kay-RA
Comment: kay-RA
Comment: kay-RA
Comment: kay-RA and kay-RB
Comment: kay-RB
Comment: reported as plasmatocytes anlage
Comment: kay-RB
Comment: NOT polar follicle cell; kay-RB
Comment: kay-RA
Comment: early stage 10A only; kay-RB
Comment: 10-12 hr APF
Comment: kay-RA and kay-RB transcripts
kay expression is generally consistent over this time period, with slight peaks at 6h and 24h APF.
kay transcripts are differentally expressed during oogenesis. kay-RA transcript is expressed in nurse cells from oogenesis stage 5 through stage 9. kay-RB transcription is first detected at oogenesis stage 9 in migrating columnar cells, with weak to no expression in anterior stretching cells posterior follicle cells. During early stage 10A kay-RB transcript levels decrease sharply and is transiently restricted to the anterior-most columnar cells before disappearing completely at mid-stage 10A. At early stage 10B, kay-RB transcript is strongly expressed in anterior stretched cells. From late stage 10B, kay-RB transcript accumulates to a high level in two rows of dorsal anterior follicle cells. During stage 13,kay-RB transcript is strongly expressed in a population of approximately 15 follicle cells located at the posterior pole of the oocyte. kay-RA transcript is uniformly distributed in preblastoderm embryos; this transcript is maternally deposited. kay-RB, by contrast, is not maternally deposited. Both kay transcripts are zygotically expressed at embryonic stage 4, in the amnioserosa anlage, and both continue to be expressed in the amnioserosa, and later in the embryonic leading edge cells. kay-RA is additionally expressed in the cephalic and posterior transverse furrows during gastrulation. kay-RB is additionally expressed in the stomodeal invagination, and in the cells that go on to form midgut constriction 1.
kay transcript is expressed strongly in salivary glands at the beginning of the prepupal ecdysone pulse (10 hr APF).
kay transcripts are detected at a low level on northern blots in 4-8hr embryos and at a higher level in 8-12 and 12-16hr embryos. kay expression was shown to be restricted to certain cell types by in situ hybridization. It is expressed in cells of the head that are thought to be mesodermal soon after gastrulation (4-5hr) and persists until 8hr of embryogenesis. Early expression is also observed in the dorsal ectoderm and the amnioserosa. After ~11hr of embryogenesis, expression is restricted to a subset of PNS cells. They localize near the lateral chordotonal organs and may be the es (extrasensory) or md (multiple dendritic) neurons. Later expression is also observed in the muscle attachment sites, midgut, hindgut, and anal pads.
kay protein is expressed in stretch cells, floor cells and the first row of roof cells of the dorsal appendage primoridium.
kay protein is expressed in the same motor neurons that express the ScerGAL4C380 driver.
JBrowse - Visual display of RNA-Seq signals
View Dmel\kay in JBrowse
3-96.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
The kay α isoform acts as a transcriptional regulator of circadian rhythms. It appears to modulate both circadian feedback loops, with results suggesting it acts as a repressor of the Clk/cyc transactivation complex and as an inhibitor of vri-mediated repression. The kay α protein binds directly to the vri protein.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
kay is required for wound healing.
kay is necessary for the proper posteriorward migration of the main body follicle cells during stage 9 of oogenesis. It also controls, from stage 11 onwards, the morphogenetic reorganisation of the follicle cells that are committed to secrete the dorsal appendages.
kay function is required for its own upregulation.
kay is required for thorax closure during metamorphosis.
Mutations in kay are described.
kay is required for dorsal closure and elongation of cells in the lateral epidermis during embryogenesis.
The AP-1 complex encodes two proteins that have functional and structural properties in common with mammalian Fos and Jun proto-oncogene products; kay and Jra, respectively. The biochemical properties of the kay gene product have been examined in vitro and the expression pattern in developing embryos studied.
Source for merge of: kay CG15507
The sro (shroud) complementation group is not allelic to the kay gene (as stated in FBrf0157169) but instead corresponds to the CG12068 annotation; the sro1 and sroO4-105 alleles each have a nonsense mutation that disrupts the catalytic centre of the predicted CG12068 protein, the P{}sroP54 insertion which is inserted in the region upstream of kay causes a large reduction in the CG12068 transcript level as well as affecting kay and the lethality of the sro1 allele is rescued by overexpression of CG12068.
Annotations CG15507 and CG15509 merged as CG33956 (which corresponds to kay) in release 4.2 of the genome annotation.
FlyBase curator comment: The sro (shroud) complementation group is not allelic to the kay gene (as stated in FBrf0157169) but instead corresponds to the CG12068 annotation (see FBrf0210924).
