FlyBase Gene Report: Dmel\LamC

General Information

Symbol

Dmel\LamC

Species

D. melanogaster

Name

Lamin C

Annotation Symbol

CG10119

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010397

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

Lamin C (LamC) encodes a type V intermediate filament that is essential for development. It contributes to the shape and structural integrity of the nucleus and plays roles in genome integrity and gene regulation, through contacts made with chromatin. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

pG-IF

Key Links

Genomic Location

Cytogenetic map

51B1-51B1

Sequence location

2R:14,570,810..14,575,771 [-]

Recombination map

2-72

RefSeq locus

NT_033778 REGION:14570810..14575771

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables structural constituent of cytoskeleton

inferred from mutant phenotype

(Dialynas et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables structural constituent of cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN001145669

(GO Reference Genome Project, 2011-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in chromatin organization

inferred from mutant phenotype

(Gurudatta et al., 2010)

involved_in heterochromatin formation

inferred from direct assay

(Dialynas et al., 2010)

involved_in muscle tissue morphogenesis

inferred from mutant phenotype

(Dialynas et al., 2010)

involved_in nuclear pore localization

inferred from mutant phenotype

(Dialynas et al., 2010, Schulze et al., 2009)

involved_in regulation of actin filament polymerization

inferred from mutant phenotype

(Dialynas et al., 2010)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in heterochromatin formation

inferred from biological aspect of ancestor with PANTHER:PTN001145669

(GO Reference Genome Project, 2011-)

involved_in nuclear envelope organization

inferred from biological aspect of ancestor with PANTHER:PTN001145669

(GO Reference Genome Project, 2011-)

involved_in nuclear migration

inferred from biological aspect of ancestor with PANTHER:PTN001145669

(GO Reference Genome Project, 2011-)

involved_in nuclear pore localization

inferred from biological aspect of ancestor with PANTHER:PTN001145669

(GO Reference Genome Project, 2011-)

involved_in protein localization to nuclear envelope

inferred from biological aspect of ancestor with PANTHER:PTN001145669

(GO Reference Genome Project, 2011-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in lamin filament

inferred from direct assay

(Klapper et al., 1997)

colocalizes_with nuclear envelope

inferred from direct assay

(Prufert et al., 2004)

located_in nuclear envelope

inferred from direct assay

(Bhide et al., 2018)

is_active_in nuclear lamina

inferred from direct assay

(Hayashi et al., 2016)

located_in nuclear lamina

inferred from direct assay

(Verboon et al., 2020, Riemer et al., 1995)

located_in nuclear periphery

inferred from direct assay

(Dialynas et al., 2010)

located_in spindle envelope

inferred from direct assay

(Katsani et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in lamin filament

non-traceable author statement

(Bellaiche et al., 1998)

is_active_in nuclear lamina

inferred from biological aspect of ancestor with PANTHER:PTN001145669

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

LAMINS

Protein Family (UniProt)

Belongs to the intermediate filament family. (Q03427)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

LAMINS -: Lamins are type V intermediate filament that form the major component of the nuclear lamina (FBrf0200518).

Protein Function (UniProtKB)

Component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (By similarity). Involved in the organization and spacing of nuclear pore complexes on the nucleus surface; complements Lam (PubMed:15996653). In spermatocytes, regulates cytokinesis during meiosis (PubMed:27402967).

(UniProt, Q03427)

Summary (Interactive Fly)

developmentally regulated nuclear intermediate filament - lines the inner nuclear membrane - provides structural support for the nucleus and regulates gene expression - functions in nuclear mechanotransduction, a process through which mechanical forces are converted to biochemical signaling or gene expression, a model for diseases known as laminopathies, required for thorax closure, sustains PcG protein architecture, maintaining transcriptional repression at target genes

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\LamC for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q03427)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

LamC-RA

FBtr0087512

NM_079018

2367

621

LamC-RB

FBtr0333166

NM_001274045

2450

640

Additional Transcript Data and Comments

Reported size (kB)

2.5 (northern blot)

(Riemer and Weber, 1994)

2.3 (northern blot)

(Bossie and Sanders, 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

LamC-PA

FBpp0086641

69.9

621

6.82

FBpp0305369

72.1

640

6.63

A0A0B4KFY9

NP_001260974

AGB93506

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

621 (aa)

(Riemer and Weber, 1994)

621 (aa); 69.855 (kD predicted)

(Bossie and Sanders, 1993)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with MAN1. Associates with chromatin; when not phosphorylated on Ser-27 (PubMed:22393432).

(UniProt, Q03427)

Post Translational Modification

May be phosphorylated on Tyr-391.

(UniProt, Q03427)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\LamC using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

LamC_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.13

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 11 -- 12

hindgut proper primordium

(Fisher et al., 2012)

large intestine primordium

Comment: reported as large intestine specific anlage

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12

oenocyte

Comment: late embryonic stage 12

(Riemer et al., 1995)

embryonic stage 13

oenocyte

(Riemer et al., 1995)

embryonic/larval tracheal dorsal trunk

(Riemer et al., 1995)

embryonic/larval foregut

(Riemer et al., 1995)

embryonic/larval hindgut

(Riemer et al., 1995)

embryonic stage 15 -- 17

Comment: reference states >=12 hr AEL

(Riemer et al., 1995)

larval stage -- adult stage

(Riemer et al., 1995)

Additional Descriptive Data

In Northern blots, LamC transcript is detected starting in 12 hr embryos, and peaks in 19-22 hr embryos. Expression declines after larval stages, and is low in pupal and larval stages. Using in situ hybridization, LamC is first detected in late stage 12 embryos, in oenocytes. At stage 13, expression is detected in oenocytes, the hindgut, the foregut, and in the dorsal longitudinal trunks.

(Riemer et al., 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12

inclusive hindgut primordium

(Riemer et al., 1995)

embryonic stage 16

exit glial cell

(Riemer et al., 1995)

adult stage

stalk follicle cell

• nuclear membrane

(Song and Xie, 2003)

germarium cap cell

• nuclear membrane

(Song and Xie, 2003)

adult stage | male

hub cell

(Chen et al., 2013)

testis sheath muscle cell

(Chen et al., 2013)

adult stage | male & spermatogenesis

cyst cell of testis

(Chen et al., 2013)

spermatogenesis & adult stage | male

male germline cell | restricted

(Chen et al., 2013)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12

posterior spiracle primordium

Comment: late embryonic stage 12

(Riemer et al., 1995)

oenocyte

Comment: late embryonic stage 12

(Riemer et al., 1995)

embryonic stage 15

embryonic/larval tracheal dorsal trunk

(Riemer et al., 1995)

embryonic/larval foregut

(Riemer et al., 1995)

epidermis

(Riemer et al., 1995)

embryonic stage 15 -- 16

Comment: reference states >=12-15 hr AEL

(Riemer et al., 1995)

embryonic stage 16

visceral trunk mesoderm

(Riemer et al., 1995)

dorsal pharyngeal muscle cell

(Riemer et al., 1995)

larval stage

(Riemer et al., 1995)

larval stage -- adult stage

(Riemer et al., 1995)

Additional Descriptive Data

LamC protein is nuclear and is detected mainly in the nuclear periphery. There is some, but not complete, overlap in subcellular Lam and LamC protein expression.

(Chen et al., 2013, Riemer et al., 1995)

LamC protein is first detected in 12-15 hr embryos, reaches peak levels in larval stages, and is at low levels in pupal and adult stages. In embryos, LamC protein is first detected in late stage 12, in oenocytes, in the posterior spiracle, and in the hindgut. At stage 15, expression is detected in the foregut, the epidermis, and the dorsal longitudinal trunks. At stage 16, LamC protein is detected in the dorsal pharyngeal musculature, in exit glia, and in the visceral mesoderm. In larvae, LamC protein is detected in all nuclei, but at varying levels.

(Riemer et al., 1995)

Marker for

nuclear membrane

(Li et al., 2016)

Subcellular Localization

CV Term

Evidence

References

located_in lamin filament

inferred from direct assay

(Klapper et al., 1997)

colocalizes_with nuclear envelope

inferred from direct assay

(Prufert et al., 2004)

located_in nuclear envelope

inferred from direct assay

(Bhide et al., 2018)

is_active_in nuclear lamina

inferred from direct assay

(Hayashi et al., 2016)

located_in nuclear lamina

inferred from direct assay

(Verboon et al., 2020, Riemer et al., 1995)

located_in nuclear periphery

inferred from direct assay

(Dialynas et al., 2010)

located_in spindle envelope

inferred from direct assay

(Katsani et al., 2008)

Expression Deduced from Reporters

Reporter: P{PTT-GB}LamC^G00158

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

follicle cell

• nucleus

(Cooley et al., 2003.5)

nurse cell

• nucleus

(Cooley et al., 2003.5)

oocyte

• nucleus

(Cooley et al., 2003.5)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\LamC in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\LamC

View exonic expression by tissue for Dmel\LamC

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010397

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36615/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010397

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010397

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010397

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10119

Flygut - An atlas of the Drosophila adult midgut

FBgn0010397

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\LamC

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 22 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 56 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of LamC

Transgenic constructs containing regulatory region of LamC

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2L)LamC^EX187

(Schulze et al., 2005)

Df(2L)LamC^EX296

(Schulze et al., 2005)

Df(2R)trix

(Schulze et al., 2005)

Gene partially disrupted in

Df(2L)LamC^EX187

(Schulze et al., 2005)

Df(2L)LamC^EX296

(Schulze et al., 2005)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

LamC^CB04957

lethal, with Scer\GAL4^Act5C.PI

LamC^ΔN.UAS.cSa

lethal, with Scer\GAL4^Act.PU

LamC^ΔN.UAS.cSa

lethal, with Scer\GAL4^C57

LamC^R564P.UAS

lethal, with Scer\GAL4^how-24B

LamC^ΔN.UAS.cSa

lethal, with Scer\GAL4^Mef2.PR

lethal, with Scer\GAL4^T80

LamC^ΔN.UAS.cSa

lethal, with Scer\GAL4^unspecified

LamC^ΔN.UAS

lethal (with Df(2R)BSC357)

LamC^{CR00352-TG4.2}

lethal (with Df(2R)trix)

lethal (with LamC^EP2199)

lethal (with LamC^EX3)

lethal (with LamC^EX5)

lethal (with LamC^EX16)

lethal (with LamC^EX187)

lethal (with LamC^EX265)

lethal (with LamC^EX296)

lethal (with LamC^EX364)

lethal (with LamC^G00158)

lethal (with LamC^UM-8373-3)

lethal | heat sensitive

LamC^hs.PS

lethal | recessive

lethal - all die before end of first instar larval stage, with Scer\GAL4^how-24B

LamC^UAS.cGa

lethal - all die before end of first instar larval stage | recessive

lethal - all die before end of first instar larval stage | temperature conditional, with LamC^{RNAi.Sym.tail.UAS}, Scer\GAL4^hs.PB

LamC^{RNAi.Sym.UTR.UAS}

lethal - all die before end of first instar larval stage | temperature conditional, with LamC^{RNAi.Sym.UTR.UAS}, Scer\GAL4^hs.PB

LamC^{RNAi.Sym.tail.UAS}

lethal - all die before end of prepupal stage (with Df(2R)trix)

LamC^EX296

lethal - all die before end of prepupal stage | heat sensitive

LamC^ΔN.hs

lethal - all die before end of P-stage

lethal - all die before end of P-stage, with Scer\GAL4^C57

lethal - all die before end of P-stage, with Scer\GAL4^how-24B

LamC^NIG.10119R

lethal - all die before end of P-stage, with Scer\GAL4^sr-md710

LamC^NIG.10119R

lethal - all die before end of P-stage (with Df(2R)trix)

lethal - all die before end of pupal stage, with Scer\GAL4^Act5C.PI

LamC^UAS.cGa

partially lethal - majority die, with Scer\GAL4^Act.PU

LamC^W557S.UAS

partially lethal - majority die, with Scer\GAL4^C57

partially lethal - majority die, with Scer\GAL4^how-24B

LamC^W557S.UAS

partially lethal - majority die, with Scer\GAL4^Mef2.PR

LamC^M553R.UAS

partially lethal - majority die, with Scer\GAL4^pnr-MD237

LamC^GD6872

partially lethal - majority die, with Scer\GAL4^T80

LamC^W557S.UAS

partially lethal - majority live, with LamC^{RNAi.Sym.tail.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.UTR.UAS}

partially lethal - majority live, with LamC^{RNAi.Sym.UTR.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.tail.UAS}

viable

LamC^R401K.hs

viable, with Scer\GAL4¹¹⁵¹

LamC^NIG.10119R

viable, with Scer\GAL4^Act5C.PI

LamC^UAS.cSa

viable, with Scer\GAL4^Act.PU

viable, with Scer\GAL4^C57

viable, with Scer\GAL4^CCAP.PP

viable, with Scer\GAL4^dimm-929

viable, with Scer\GAL4^elav.PU

viable, with Scer\GAL4^ey.PU

viable, with Scer\GAL4^futsch-C380

viable, with Scer\GAL4^how-24B

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^Mhc.PU

viable, with Scer\GAL4^Mhc.PW

LamC^NIG.10119R

viable, with Scer\GAL4^NP1029

LamC^NIG.10119R

viable, with Scer\GAL4^NP3239

LamC^NIG.10119R

viable, with Scer\GAL4^NP6657

LamC^NIG.10119R

viable, with Scer\GAL4^T80

Other Phenotypes

Allele

abnormal behavior | larval stage, with Scer\GAL4^C57

LamC^R564P.UAS

abnormal body color, with Scer\GAL4^pnr-MD237

LamC^GD6872

abnormal developmental rate (with Df(2R)trix)

LamC^EX296

abnormal flight, with Scer\GAL4^EDTP-DJ694

abnormal flight | adult stage | progressive, with LamC^E174K.UAS, Scer\GAL4^Mhc.PW

LamC^unspecified

abnormal flight | adult stage | progressive, with LamC^unspecified, Scer\GAL4^Mhc.PW

LamC^E174K.UAS

abnormal flight | progressive, with LamC^A177P.UAS, Scer\GAL4^fln.IFM

LamC^EX296

abnormal flight | progressive, with LamC^EX296, Scer\GAL4^fln.IFM

LamC^A177P.UAS

abnormal flight | progressive, with Scer\GAL4^Act88F.PB

LamC^A177P.UAS

abnormal flight | progressive, with Scer\GAL4^EDTP-DJ694

LamC^A177P.UAS

abnormal flight | progressive, with Scer\GAL4^fln.IFM

LamC^A177P.UAS

abnormal locomotor behavior | larval stage, with Scer\GAL4^C57

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^C57

abnormal size | adult stage, with Scer\GAL4^Act88F.PB

abnormal size | adult stage, with Scer\GAL4^fln.IFM

abnormal size | adult stage | progressive, with LamC^E174K.UAS, Scer\GAL4^Mhc.PW

LamC^unspecified

abnormal size | adult stage | progressive, with LamC^unspecified, Scer\GAL4^Mhc.PW

LamC^E174K.UAS

abnormal size | larval stage, with Scer\GAL4^C57

LamC^R564P.UAS

decreased cell size | larval stage, with Scer\GAL4^Lsp2.PH

decreased rate of larval locomotory behavior, with Scer\GAL4^C57

decreased size | larval stage, with Scer\GAL4^C57

LamC^R564P.UAS

flightless | progressive, with LamC^EX296, Scer\GAL4^fln.IFM

flightless | progressive, with LamC^G489V.UAS, Scer\GAL4^fln.IFM

LamC^EX296

flightless | progressive, with LamC^R205W.UAS, Scer\GAL4^fln.IFM

LamC^EX296

flightless | progressive, with Scer\GAL4^Act88F.PB

flightless | progressive, with Scer\GAL4^fln.IFM

increased cell death, with LamC^{RNAi.Sym.tail.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.UTR.UAS}

increased cell death, with LamC^{RNAi.Sym.UTR.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.tail.UAS}

increased cell death | third instar larval stage, with Scer\GAL4^ptc-559.1

LamC^UAS.cGa

majority die during larval stage, with Scer\GAL4^Act5C.PI

LamC^UAS.cGa

melanotic mass phenotype | heat sensitive

LamC^hs.PS

short lived, with Scer\GAL4^HCH.Hand

some die during prepupal stage | recessive (with Df(2R)trix)

LamC^EX296

some die during prepupal stage | recessive | heat sensitive

LamC^ΔN.hs

some die during P-stage

some die during P-stage, with Scer\GAL4^C57

some die during P-stage, with Scer\GAL4^how-24B

LamC^NIG.10119R

some die during P-stage, with Scer\GAL4^sr-md710

LamC^NIG.10119R

some die during pupal stage, with Scer\GAL4^Act5C.PI

LamC^UAS.cGa

some die during pupal stage, with Scer\GAL4^pnr-MD237

LamC^GD6872

some die during third instar larval stage (with Df(2R)trix)

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-72

suppressor of variegation | dominant, with T(2;3)Sb^V

visible, with LamC^{RNAi.Sym.tail.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.UTR.UAS}

visible, with LamC^{RNAi.Sym.tail.UAS}, Scer\GAL4^ptc-559.1

LamC^{RNAi.Sym.UTR.UAS}

visible, with LamC^{RNAi.Sym.UTR.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.tail.UAS}

visible, with LamC^{RNAi.Sym.UTR.UAS}, Scer\GAL4^ptc-559.1

LamC^{RNAi.Sym.tail.UAS}

visible, with Scer\GAL4^C57

LamC^ΔN.UAS.cSa

visible | adult stage, with Scer\GAL4^Act88F.PU

LamC^R564P.UAS

visible | adult stage | progressive, with LamC^E174K.UAS, Scer\GAL4^Mhc.PW

LamC^unspecified

visible | adult stage | progressive, with LamC^unspecified, Scer\GAL4^Mhc.PW

LamC^E174K.UAS

Phenotype manifest in

Allele

A band | adult stage | progressive, with LamC^E174K.UAS, Scer\GAL4^Mhc.PW

LamC^unspecified

A band | adult stage | progressive, with LamC^unspecified, Scer\GAL4^Mhc.PW

LamC^E174K.UAS

actin cytoskeleton | larval stage, with Scer\GAL4^C57

adult abdominal fat mass, with Scer\GAL4^HCH.Hand

LamC^R205W.UAS

adult abdominal fat mass | progressive, with Scer\GAL4^HCH.Hand

LamC^G489V.UAS

adult heart | progressive, with Scer\GAL4^HCH.Hand

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^ptc-559.1

LamC^UAS.cGa

dorsal longitudinal indirect flight muscle cell | adult stage | progressive, with LamC^E174K.UAS, Scer\GAL4^Mhc.PW

LamC^unspecified

dorsal longitudinal indirect flight muscle cell | adult stage | progressive, with LamC^unspecified, Scer\GAL4^Mhc.PW

LamC^E174K.UAS

embryonic/larval dorsal tracheal branch | larval stage, with Scer\GAL4^btl.PS

LamC^JF01406

embryonic/larval hypodermal muscle | larval stage, with Scer\GAL4^C57

embryonic/larval hypodermal muscle cell | larval stage, with Scer\GAL4^C57

embryonic/larval salivary gland

LamC^EX187

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

LamC^EP2199

imaginal disc

LamC^EX187

indirect flight muscle cell, with Scer\GAL4^pnr-MD237

LamC^UAS.cGa

indirect flight muscle cell | adult stage, with Scer\GAL4^EDTP-DJ694

indirect flight muscle cell | adult stage, with Scer\GAL4^fln.IFM

LamC^A177P.UAS

indirect flight muscle cell | adult stage | progressive, with Scer\GAL4^EDTP-DJ694

indirect flight muscle cell | adult stage | progressive, with Scer\GAL4^fln.IFM

indirect flight muscle cell | pupal stage, with Scer\GAL4^Act88F.PB

larval fat cell, with Scer\GAL4^Lsp2.PH

larval salivary gland & embryo & nucleus | conditional ts

LamC^hs.PS

larval somatic muscle cell, with Scer\GAL4^C57

LamC^ΔN.UAS.cSa

leg, with Scer\GAL4^C57

leg disc, with Scer\GAL4^C57

LamC^ΔN.UAS.cSa

lipid droplet | adult stage, with Scer\GAL4^HCH.Hand

LamC^R205W.UAS

lipid droplet | adult stage | progressive, with Scer\GAL4^HCH.Hand

LamC^G489V.UAS

lipid droplet | larval stage, with Scer\GAL4^Lsp2.PH

LamC^K521W.UAS

longitudinal muscle cell | first instar larval stage, with Scer\GAL4^how-24B

LamC^UAS.cGa

melanotic mass | heat sensitive

LamC^hs.PS

mesonotum, with Scer\GAL4^pnr-MD237

LamC^GD6872

mesothoracic bristle, with LamC^{RNAi.Sym.tail.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.UTR.UAS}

mesothoracic bristle, with LamC^{RNAi.Sym.UTR.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.tail.UAS}

metathoracic femur, with Scer\GAL4^C57

LamC^ΔN.UAS.cSa

metathoracic metatarsus, with Scer\GAL4^C57

LamC^ΔN.UAS.cSa

metathoracic tarsal segment, with Scer\GAL4^C57

LamC^ΔN.UAS.cSa

metathoracic tibia, with Scer\GAL4^C57

LamC^ΔN.UAS.cSa

microtubule | larval stage, with Scer\GAL4^C57

mitochondrial crista | adult stage | progressive, with LamC^E174K.UAS, Scer\GAL4^Mhc.PW

LamC^unspecified

mitochondrial crista | adult stage | progressive, with LamC^unspecified, Scer\GAL4^Mhc.PW

LamC^E174K.UAS

mitochondrion | adult stage, with Scer\GAL4^fln.IFM

mitochondrion | adult stage | progressive, with LamC^E174K.UAS, Scer\GAL4^Mhc.PW

LamC^unspecified

mitochondrion | adult stage | progressive, with LamC^unspecified, Scer\GAL4^Mhc.PW

LamC^E174K.UAS

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage, with LamC^E174K.UAS, Scer\GAL4^BG487

LamC^unspecified

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage, with LamC^EX296/LamC^EX265, Scer\GAL4^BG487

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage, with LamC^unspecified, Scer\GAL4^BG487

LamC^E174K.UAS

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage (with LamC^EX265)

LamC^EX296

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage (with LamC^EX265), with LamC^E174K.UAS, Scer\GAL4^BG487

LamC^EX296

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage (with LamC^EX265), with LamC^R564C.UAS, Scer\GAL4^BG487

LamC^EX296

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage (with LamC^EX296)

LamC^EX265

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage (with LamC^EX296), with LamC^E174K.UAS, Scer\GAL4^BG487

LamC^EX265

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage (with LamC^EX296), with LamC^R564C.UAS, Scer\GAL4^BG487

LamC^EX265

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage, with LamC^E174K.UAS, Scer\GAL4^BG487

LamC^unspecified

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage, with LamC^EX296/LamC^EX265, Scer\GAL4^BG487

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage, with LamC^unspecified, Scer\GAL4^BG487

LamC^E174K.UAS

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage (with LamC^EX265)

LamC^EX296

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage (with LamC^EX265), with LamC^E174K.UAS, Scer\GAL4^BG487

LamC^EX296

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage (with LamC^EX265), with LamC^R564C.UAS, Scer\GAL4^BG487

LamC^EX296

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage (with LamC^EX296)

LamC^EX265

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage (with LamC^EX296), with LamC^E174K.UAS, Scer\GAL4^BG487

LamC^EX265

muscle cell of A1-7 ventral longitudinal muscle 4 | third instar larval stage (with LamC^EX296), with LamC^R564C.UAS, Scer\GAL4^BG487

LamC^EX265

myofibril | adult stage, with Scer\GAL4^EDTP-DJ694

myofibril | adult stage, with Scer\GAL4^fln.IFM

myofibril | adult stage, with Scer\GAL4^HCH.Hand

myotube | adult stage | progressive, with LamC^E174K.UAS, Scer\GAL4^Mhc.PW

LamC^unspecified

myotube | adult stage | progressive, with LamC^unspecified, Scer\GAL4^Mhc.PW

LamC^E174K.UAS

NMJ bouton | larval stage (with LamC^EX265)

LamC^EX296

NMJ bouton | larval stage (with LamC^EX296)

LamC^EX265

nuclear envelope | adult stage, with Scer\GAL4^EDTP-DJ694

nuclear envelope | adult stage, with Scer\GAL4^fln.IFM

nuclear envelope | adult stage, with Scer\GAL4^HCH.Hand

nuclear envelope | larval stage

LamC^EX187

nuclear inner membrane | larval stage

LamC^EX187

nuclear lamina | third instar larval stage, with LamC^E174K.UAS, Scer\GAL4^BG487

LamC^unspecified

nuclear lamina | third instar larval stage, with LamC^EX296/LamC^EX265, Scer\GAL4^BG487

nuclear lamina | third instar larval stage, with LamC^unspecified, Scer\GAL4^BG487

LamC^E174K.UAS

nuclear lamina | third instar larval stage (with LamC^EX265), with LamC^E174K.UAS, Scer\GAL4^BG487

LamC^EX296

nuclear lamina | third instar larval stage (with LamC^EX265), with LamC^R564C.UAS, Scer\GAL4^BG487

LamC^EX296

nuclear lamina | third instar larval stage (with LamC^EX296), with LamC^E174K.UAS, Scer\GAL4^BG487

LamC^EX265

nuclear lamina | third instar larval stage (with LamC^EX296), with LamC^R564C.UAS, Scer\GAL4^BG487

LamC^EX265

nuclear outer membrane | larval stage

LamC^EX187

nuclear pore | larval stage

LamC^EX187

nucleus, with Scer\GAL4^C57

LamC^ΔN.UAS.cSa

nucleus, with Scer\GAL4^ptc-559.1

LamC^UAS.cGa

nucleus, with Scer\GAL4^{Ubx-lac1-GAL4}

LamC^UAS.cGa

nucleus | adult stage, with Scer\GAL4^EDTP-DJ694

nucleus | adult stage, with Scer\GAL4^fln.IFM

nucleus | adult stage, with Scer\GAL4^HCH.Hand

nucleus | larval stage

LamC^EX187

nucleus | larval stage, with Scer\GAL4^C57

pupa, with Scer\GAL4^C57

pupa, with Scer\GAL4^Mef2.PR

LamC^M553R.UAS

sarcomere | adult stage, with Scer\GAL4^fln.IFM

sarcomere | adult stage | progressive, with LamC^E174K.UAS, Scer\GAL4^Mhc.PW

LamC^unspecified

sarcomere | adult stage | progressive, with LamC^unspecified, Scer\GAL4^Mhc.PW

LamC^E174K.UAS

sarcomere | pupal stage | pupal stage, with Scer\GAL4^Act88F.PB

scutellum, with LamC^{RNAi.Sym.tail.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.UTR.UAS}

scutellum, with LamC^{RNAi.Sym.UTR.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.tail.UAS}

somatic muscle cell | P-stage, with Scer\GAL4^how-24B

LamC^NIG.10119R

somatic muscle cell | P-stage, with Scer\GAL4^sr-md710

LamC^NIG.10119R

tendon cell | larval stage, with Scer\GAL4^sr-md710

LamC^NIG.10119R

tendon cell | P-stage

LamC^LC58

tendon cell | P-stage, with Scer\GAL4^sr-md710

LamC^NIG.10119R

thorax, with LamC^{RNAi.Sym.tail.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.UTR.UAS}

thorax, with LamC^{RNAi.Sym.UTR.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.tail.UAS}

wing, with Scer\GAL4^Act88F.PU

LamC^R564P.UAS

wing, with Scer\GAL4^fln.IFM

wing | progressive, with LamC^E174K.UAS, Scer\GAL4^Mhc.PW

LamC^unspecified

wing | progressive, with LamC^unspecified, Scer\GAL4^Mhc.PW

LamC^E174K.UAS

wing blade, with LamC^{RNAi.Sym.tail.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.UTR.UAS}

wing blade, with LamC^{RNAi.Sym.tail.UAS}, Scer\GAL4^ptc-559.1

LamC^{RNAi.Sym.UTR.UAS}

wing blade, with LamC^{RNAi.Sym.UTR.UAS}, Scer\GAL4^ap-md544

LamC^{RNAi.Sym.tail.UAS}

wing blade, with LamC^{RNAi.Sym.UTR.UAS}, Scer\GAL4^ptc-559.1

LamC^{RNAi.Sym.tail.UAS}

wing vein, with LamC^{RNAi.Sym.tail.UAS}, Scer\GAL4^ptc-559.1

LamC^{RNAi.Sym.UTR.UAS}

wing vein, with LamC^{RNAi.Sym.UTR.UAS}, Scer\GAL4^ptc-559.1

LamC^{RNAi.Sym.tail.UAS}

Z disc | adult stage, with Scer\GAL4^HCH.Hand

Z disc | adult stage | progressive, with LamC^E174K.UAS, Scer\GAL4^Mhc.PW

LamC^unspecified

Z disc | adult stage | progressive, with LamC^unspecified, Scer\GAL4^Mhc.PW

LamC^E174K.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (70)

Hsap\LMNB2

13 of 14

Yes

Hsap\LMNA

12 of 14

Yes

Hsap\LMNB1

12 of 14

Yes

Hsap\DES

2 of 14

Yes

Hsap\LMNTD1

2 of 14

Yes

Hsap\LMNTD2

2 of 14

Yes

Hsap\VIM

2 of 14

Yes

Hsap\GFAP

1 of 14

Yes

Hsap\INA

1 of 14

Yes

Hsap\KRT1

1 of 14

Yes

Hsap\KRT2

1 of 14

Yes

Hsap\KRT3

1 of 14

Yes

Hsap\KRT4

1 of 14

Yes

Hsap\KRT5

1 of 14

Yes

Hsap\KRT6A

1 of 14

Yes

Hsap\KRT6B

1 of 14

Yes

Hsap\KRT6C

1 of 14

Yes

Hsap\KRT7

1 of 14

Yes

Hsap\KRT8

1 of 14

Yes

Hsap\KRT9

1 of 14

Yes

Hsap\KRT10

1 of 14

Yes

Hsap\KRT12

1 of 14

Yes

Hsap\KRT13

1 of 14

Yes

Hsap\KRT14

1 of 14

Yes

Hsap\KRT15

1 of 14

Yes

Hsap\KRT16

1 of 14

Yes

Hsap\KRT17

1 of 14

Yes

Hsap\KRT18

1 of 14

Yes

Hsap\KRT19

1 of 14

Yes

Hsap\KRT20

1 of 14

Yes

Hsap\KRT23

1 of 14

Yes

Hsap\KRT24

1 of 14

Yes

Hsap\KRT25

1 of 14

Yes

Hsap\KRT26

1 of 14

Yes

Hsap\KRT27

1 of 14

Yes

Hsap\KRT28

1 of 14

Yes

Hsap\KRT31

1 of 14

Yes

Hsap\KRT32

1 of 14

Yes

Hsap\KRT33A

1 of 14

Yes

Hsap\KRT33B

1 of 14

Yes

Hsap\KRT34

1 of 14

Yes

Hsap\KRT35

1 of 14

Yes

Hsap\KRT36

1 of 14

Yes

Hsap\KRT37

1 of 14

Yes

Hsap\KRT38

1 of 14

Yes

Hsap\KRT39

1 of 14

Yes

Hsap\KRT40

1 of 14

Yes

Hsap\KRT71

1 of 14

Yes

Hsap\KRT72

1 of 14

Yes

Hsap\KRT73

1 of 14

Yes

Hsap\KRT74

1 of 14

Yes

Hsap\KRT75

1 of 14

Yes

Hsap\KRT76

1 of 14

Yes

Hsap\KRT77

1 of 14

Yes

Hsap\KRT78

1 of 14

Yes

Hsap\KRT79

1 of 14

Yes

Hsap\KRT80

1 of 14

Yes

Hsap\KRT81

1 of 14

Yes

Hsap\KRT82

1 of 14

Yes

Hsap\KRT83

1 of 14

Yes

Hsap\KRT84

1 of 14

Yes

Hsap\KRT85

1 of 14

Yes

Hsap\KRT86

1 of 14

Yes

Hsap\KRT87P

1 of 14

Yes

Hsap\LOC100653049

1 of 14

Yes

Hsap\NEFH

1 of 14

Yes

Hsap\NEFL

1 of 14

Yes

Hsap\NEFM

1 of 14

Yes

Hsap\NES

1 of 14

Yes

Hsap\PRPH

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (35)

Rnor\Lmnb2

13 of 14

Yes

Rnor\Lmna

12 of 14

Yes

Rnor\Lmnb1

12 of 14

Yes

Rnor\Des

2 of 14

Yes

Rnor\Lmntd1

2 of 14

Yes

Rnor\Lmntd2

2 of 14

Yes

Rnor\Vim

2 of 14

Yes

Rnor\Gfap

1 of 14

Yes

Rnor\Ina

1 of 14

Yes

Rnor\Kb15

1 of 14

Yes

Rnor\Kb23

1 of 14

Yes

Rnor\Krt1

1 of 14

Yes

Rnor\Krt4

1 of 14

Yes

Rnor\Krt5

1 of 14

Yes

Rnor\Krt7

1 of 14

Yes

Rnor\Krt8

1 of 14

Yes

Rnor\Krt20

1 of 14

Yes

Rnor\Krt35

1 of 14

Yes

Rnor\Krt42

1 of 14

Yes

Rnor\Krt71

1 of 14

Yes

Rnor\Krt72

1 of 14

Yes

Rnor\Krt73

1 of 14

Yes

Rnor\Krt75

1 of 14

Yes

Rnor\Krt76

1 of 14

Yes

Rnor\Krt78

1 of 14

Rnor\Krt79

1 of 14

Yes

Rnor\Krt81

1 of 14

Yes

Rnor\Krt82

1 of 14

Yes

Rnor\Krt83

1 of 14

Yes

Rnor\Krt84

1 of 14

Yes

Rnor\Krt86

1 of 14

Yes

Rnor\LOC683313

1 of 14

Yes

Rnor\Nefl

1 of 14

Yes

Rnor\Nefm

1 of 14

Yes

Rnor\Prph

1 of 14

Yes

Mus musculus (laboratory mouse) (39)

Mmus\Lmnb1

12 of 14

Yes

Mmus\Lmnb2

12 of 14

Yes

Mmus\Lmna

11 of 14

Yes

Mmus\Des

2 of 14

Yes

Mmus\Lmntd1

2 of 14

Yes

Mmus\Lmntd2

2 of 14

Yes

Mmus\Vim

2 of 14

Yes

Mmus\Gfap

1 of 14

Yes

Mmus\Gm5414

1 of 14

Yes

Mmus\Gm5478

1 of 14

Yes

Mmus\Ina

1 of 14

Yes

Mmus\Krt1

1 of 14

Yes

Mmus\Krt2

1 of 14

Yes

Mmus\Krt4

1 of 14

Yes

Mmus\Krt5

1 of 14

Yes

Mmus\Krt6a

1 of 14

Yes

Mmus\Krt6b

1 of 14

Yes

Mmus\Krt7

1 of 14

Yes

Mmus\Krt8

1 of 14

Yes

Mmus\Krt19

1 of 14

Yes

Mmus\Krt35

1 of 14

Yes

Mmus\Krt71

1 of 14

Yes

Mmus\Krt72

1 of 14

Yes

Mmus\Krt73

1 of 14

Yes

Mmus\Krt74

1 of 14

Yes

Mmus\Krt75

1 of 14

Yes

Mmus\Krt76

1 of 14

Yes

Mmus\Krt78

1 of 14

Yes

Mmus\Krt79

1 of 14

Yes

Mmus\Krt81

1 of 14

Yes

Mmus\Krt82

1 of 14

Yes

Mmus\Krt83

1 of 14

Yes

Mmus\Krt84

1 of 14

Yes

Mmus\Krt86

1 of 14

Yes

Mmus\Krt87

1 of 14

Yes

Mmus\Krt90

1 of 14

Yes

Mmus\Nefl

1 of 14

Yes

Mmus\Nefm

1 of 14

Yes

Mmus\Prph

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (29)

Xtro\lmnb3

10 of 13

Yes

Xtro\arrdc1

9 of 13

Yes

Xtro\lmnb2

8 of 13

Yes

Xtro\lmna

7 of 13

Yes

Xtro\lmnb1

6 of 13

Yes

Xtro\ide

5 of 13

Xtro\krt78.1

2 of 13

Yes

Xtro\krt78.7

2 of 13

Yes

Xtro\des.2

1 of 13

Yes

Xtro\eif4h

1 of 13

Xtro\hes5.3

1 of 13

Xtro\ina

1 of 13

Yes

Xtro\krt7

1 of 13

Yes

Xtro\krt8.2

1 of 13

Yes

Xtro\krt18.1

1 of 13

Yes

Xtro\krt23

1 of 13

Yes

Xtro\krt62

1 of 13

Yes

Xtro\krt78.6

1 of 13

Yes

Xtro\lmntd2

1 of 13

Yes

Xtro\nefh

1 of 13

Yes

Xtro\nefl

1 of 13

Yes

Xtro\nefm

1 of 13

Yes

Xtro\nif

1 of 13

Yes

Xtro\optn

1 of 13

Xtro\ouro2

1 of 13

Yes

Xtro\prph

1 of 13

Yes

Xtro\synm

1 of 13

Yes

Xtro\vim.2

1 of 13

Yes

Xtro\XB5722382

1 of 13

Yes

Danio rerio (Zebrafish) (29)

Drer\lmna

12 of 14

Yes

Drer\lmnb2

12 of 14

Yes

Drer\lmnb1

11 of 14

Yes

Drer\lmnl3

10 of 14

Yes

Drer\desma

2 of 14

Yes

Drer\desmb

2 of 14

Yes

Drer\vim

2 of 14

Yes

Drer\viml

2 of 14

Yes

Drer\gfap

1 of 14

Yes

Drer\inaa

1 of 14

Yes

Drer\inab

1 of 14

Yes

Drer\krt4

1 of 14

Yes

Drer\krt5

1 of 14

Yes

Drer\krt8

1 of 14

Yes

Drer\krt18a.1

1 of 14

Yes

Drer\krt96

1 of 14

Yes

Drer\krt97

1 of 14

Yes

Drer\nefla

1 of 14

Yes

Drer\neflb

1 of 14

Yes

Drer\nefma

1 of 14

Yes

Drer\nefmb

1 of 14

Yes

Drer\ngs

1 of 14

Yes

Drer\prph

1 of 14

Yes

Drer\si:dkey-183i3.5

1 of 14

Yes

Drer\si:dkey-222f2.1

1 of 14

Yes

Drer\zgc:65851

1 of 14

Yes

Drer\zgc:136930

1 of 14

Yes

Drer\zgc:158846

1 of 14

Yes

Drer\zgc:172323

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\lmn-1

13 of 14

Yes

Cele\ifa-3

5 of 14

Yes

Cele\ifa-4

5 of 14

Yes

Cele\ifd-2

5 of 14

Yes

Cele\mua-6

5 of 14

Yes

Cele\ifa-1

4 of 14

Yes

Cele\ifb-1

4 of 14

Yes

Cele\ifb-2

4 of 14

Yes

Cele\ifc-1

4 of 14

Yes

Cele\ifc-2

4 of 14

Yes

Cele\ifd-1

4 of 14

Yes

Cele\ifp-1

3 of 14

Yes

Cele\F10C1.8

2 of 14

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP011938

11 of 12

Yes

Agam\AgaP_AGAP008015

7 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:LamC. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

Lam

13 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 20 )

Allele

Disease

Evidence

References

LamC^ΔN.UAS

model of autosomal dominant Emery-Dreifuss muscular dystrophy 2

CEC

(Shaw et al., 2022)

LamC^R401K.hs

model of autosomal dominant Emery-Dreifuss muscular dystrophy 2

CEA

(Schulze et al., 2005)

LamC^G489V.UAS

model of myopathy

CEA

(Dialynas et al., 2012)

model of muscular dystrophy

CEA

(Shaw et al., 2022, Dialynas et al., 2015)

model of congenital muscular dystrophy due to LMNA mutation

CEA

(Chandran et al., 2019)

model of dilated cardiomyopathy 1A

CEC

(Bhide et al., 2018)

LamC^N496I.UAS

model of myopathy

CEA

(Dialynas et al., 2012)

model of muscular dystrophy

CEA

(Dialynas et al., 2015)

LamC^V528P.UAS

model of myopathy

CEA

(Dialynas et al., 2012)

model of muscular dystrophy

CEA

(Dialynas et al., 2015)

model of congenital muscular dystrophy due to LMNA mutation

CEA

(Chandran et al., 2019)

LamC^M553R.UAS

model of myopathy

CEA

(Dialynas et al., 2012)

model of muscular dystrophy

CEA

(Dialynas et al., 2015)

LamC^ΔN.UAS.cSa

model of muscular dystrophy

CEA

(Dialynas et al., 2015, Zwerger et al., 2013)

LamC^E174K.UAS

model of progeria

CEA with LamC^unspecified

(Li et al., 2016)

LamC^unspecified

model of progeria

CEA with LamC^E174K.UAS

(Li et al., 2016)

LamC^R205W.UAS

model of congenital muscular dystrophy due to LMNA mutation

CEA

(Chandran et al., 2019)

model of dilated cardiomyopathy 1A

CEC

(Shaw et al., 2022, Bhide et al., 2018)

LamC^A177P.UAS

model of congenital muscular dystrophy due to LMNA mutation

CEA

(Chandran et al., 2019)

LamC^R264W.UAS

model of congenital muscular dystrophy due to LMNA mutation

CEA

(Hinz et al., 2021)

LamC^R264Q.UAS

model of congenital muscular dystrophy due to LMNA mutation

CEA

(Hinz et al., 2021)

LamC^S37L.UAS

model of dilated cardiomyopathy 1A

CEC

(Shaw et al., 2022)

LamC^ΔK47.UAS

model of autosomal dominant Emery-Dreifuss muscular dystrophy 2

CEC

(Shaw et al., 2022)

LamC^L74R.UAS

model of dilated cardiomyopathy 1A

CEC

(Shaw et al., 2022)

LamC^R237P.UAS

model of congenital muscular dystrophy due to LMNA mutation

CEA

(Shaw et al., 2022)

LamC^K521Q.UAS

model of autosomal recessive Emery-Dreifuss muscular dystrophy 3

CEC

(Shaw et al., 2022)

LamC^R564P.UAS

model of autosomal dominant Emery-Dreifuss muscular dystrophy 2

CEA

(Walker et al., 2023)

CEC

(Shaw et al., 2022)

LamC^K521W.UAS

model of familial partial lipodystrophy type 2

CEA

(Walker et al., 2023)

Potential Models Based on Orthology ( 13 )

Human Ortholog

Disease

Evidence

References

LMNB2; lamin B2

model of autosomal dominant primary microcephaly 27

IEA

(FlyBase, 2019-)

model of progressive myoclonus epilepsy 9

IEA

(FlyBase, 2019-)

LMNB1; lamin B1

model of autosomal dominant primary microcephaly 26

IEA

(FlyBase, 2019-)

LMNA; lamin A/C

model of dilated cardiomyopathy 1A

IEA

(FlyBase, 2019-)

model of congenital muscular dystrophy due to LMNA mutation

IEA

(FlyBase, 2019-)

model of restrictive dermopathy 2

IEA

(FlyBase, 2019-)

model of autosomal dominant Emery-Dreifuss muscular dystrophy 2

IEA

(FlyBase, 2019-)

model of Charcot-Marie-Tooth disease type 2B1

IEA

(FlyBase, 2019-)

model of dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome

IEA

(FlyBase, 2019-)

model of mandibuloacral dysplasia type A lipodystrophy

IEA

(FlyBase, 2019-)

model of progeria

IEA

(FlyBase, 2019-)

model of familial partial lipodystrophy type 2

IEA

(FlyBase, 2019-)

model of autosomal recessive Emery-Dreifuss muscular dystrophy 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

LamC^G00158

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

LamC^k11904

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

LamC^G489V.UAS

model of congenital muscular dystrophy due to LMNA mutation

is exacerbated by AMPKα^HMC04979

(Chandran et al., 2019)

is ameliorated by AMPKα^UAS.cMa

(Chandran et al., 2019)

is ameliorated by S6k^KQ.UAS

(Chandran et al., 2019)

is exacerbated by Thor^KK108272

(Chandran et al., 2019)

is ameliorated by Thor^UAS.cMa

(Chandran et al., 2019)

is exacerbated by foxo^KK108485

(Chandran et al., 2019)

is ameliorated by foxo^UASp.GFP

(Chandran et al., 2019)

is ameliorated by srl^UAS.cRa

(Chandran et al., 2019)

is exacerbated by srl^KK100201

(Chandran et al., 2019)

model of dilated cardiomyopathy 1A

is exacerbated by Atg1^K38Q.UAS

(Bhide et al., 2018)

is ameliorated by Atg1^UAS.cSa

(Bhide et al., 2018)

is ameliorated by cnc^GD4437

(Bhide et al., 2018)

is ameliorated by cnc^KK103976

(Bhide et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

13 of 14

12 of 14

12 of 14

MICROCEPHALY 26, PRIMARY, AUTOSOMAL DOMINANT; MCPH26

autosomal dominant primary microcephaly 26

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

LamC

cosedimentation, western blot, inferred by author, two hybrid

(Zaremba-Czogalla et al., 2012, Schulze et al., 2009)

LamC - Lam

two hybrid

(Schulze et al., 2009)

LamC - MAN1

two hybrid, anti bait coimmunoprecipitation, western blot

(Pinto et al., 2008, Wagner et al., 2006)

LamC - bocks

two hybrid

(Schulze et al., 2009)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

LamC

suppressible

AMPKα

(Chandran et al., 2019)

LamC

enhanceable

AMPKα

(Chandran et al., 2019)

LamC

enhanceable

Atg1

(Bhide et al., 2018)

LamC

suppressible

Atg1

(Bhide et al., 2018)

LamC

suppressible

Atg1|cnc

(Bhide et al., 2018)

LamC

enhanceable

Atg1|cnc

(Bhide et al., 2018)

LamC

suppressible

Atg5

(Bhide et al., 2018)

LamC

suppressible

Atg8a

(Bhide et al., 2018)

LamC

suppressible

cnc

(Bhide et al., 2018)

Atg1|LamC

enhanceable

cnc

(Bhide et al., 2018)

LamC

suppressible

Dad

(Mohar et al., 2025)

LamC

enhanceable

Dad

(Mohar et al., 2025)

LamC

enhanceable

foxo

(Chandran et al., 2019)

LamC

suppressible

foxo

(Chandran et al., 2019)

LamC

suppressible

GstD4

(Bhide et al., 2018)

LamC

suppressible

GstD9

(Bhide et al., 2018)

LamC

enhanceable

Keap1

(Bhide et al., 2018)

LamC

suppressible

lncRNA:Hsrω

(Mallik and Lakhotia, 2011)

suppressible

(Li et al., 2016)

suppressible

(Chandran et al., 2019)

LamC

suppressible

srl

(Chandran et al., 2019)

LamC

enhanceable

srl

(Chandran et al., 2019)

LamC

suppressible

Thor

(Chandran et al., 2019)

LamC

enhanceable

Thor

(Chandran et al., 2019)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Dad

enhanceable

LamC

(Mohar et al., 2025)

kay

suppressible

LamC|dia

(Belyaeva et al., 2022)

Lam

suppressible

LamC

(Penfield and Montell, 2023, Chen et al., 2013)

trc

suppressible

LamC

(Hudson et al., 2023)

External Data

Subunit Structure (UniProtKB)

Interacts with MAN1. Associates with chromatin; when not phosphorylated on Ser-27 (PubMed:22393432).

(UniProt, Q03427 )

Linkouts

BioGRID - A database of protein and genetic interactions.

62363

DroID - A comprehensive database of gene and protein interactions.

FBgn0010397

MIST (protein-protein) - An integrated Molecular Interaction Database

36615

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Apoptosis - fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-72

Cytogenetic map

51B1-51B1

Sequence location

2R:14,570,810..14,575,771 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

51B1-51B1

Limits computationally determined from genome sequence between P{lacW}l(2)k16805^k16805 and P{lacW}ttv^k03617&P{EP}ttv^EP765

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

51A-51A

(Bossie, 1993.5.28)

51A-51A

(determined by in situ hybridisation)

(Bossie and Sanders, 1993)

Experimentally Determined Recombination Data

Location

2-72

(FlyBase, 2016)

2-76.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

605310

w^*; P{UASp-LamC.P}attP2

605590

w^*; LamC^EX296/CyO

31621

y¹ v¹; P{TRiP.JF01406}attP2

76420

y¹ sc^* v¹ sev²¹; P{TKO.GS00589}attP40

79670

y¹ sc^* v¹ sev²¹; P{TOE.GS01246}attP40

60784

y¹ w^*; Mi{MIC}LamC^MI05494 ttv^MI05494/SM6a

6837

y¹ w¹¹¹⁸; P{PTT-GB}LamC^G00158 ttv^G00158/CyO

Kyoto

124505

w¹¹¹⁸; P{RS3}LamC^UM-8373-3

110612

y^* w^* P{PTT-GB}LamC^G00158

10119R-1

10119R-2

v341947

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01228}attP40/CyO-GFP

More stocks available...

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (75)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD31805

Other clones

DPiM_LD31805

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010397

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010397

Antibody Information

Laboratory Generated Antibodies

monoclonal

(von Saucken et al., 2025, Unnikannan et al., 2020, Riemer et al., 1995)

polyclonal

(Gurudatta et al., 2010)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Overexpression of LamC during most larval stages stalls growth, inhibits ecdysteroid signaling, causes melanotic tumours and results in lethality.

(Stuurman et al., 1999)

Biochemical techniques reveal that in living cells lamins are closely associated with both DNA and RNA.

(Rzepecki et al., 1998)

Clone pG-IF (isolated in FBrf0058818) encodes a nuclear lamin whose expression is developmentally controlled.

(Riemer et al., 1995)

LamC gene locus organisation has been determined and its structure compared to the vertebrate lamin genes.

(Riemer and Weber, 1994)

G-IF encodes a 46kD intermediate filament protein with around 60% nucleotide identity to Lam.

(Bossie and Sanders, 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG10119

(National Institute of Genetics Fly Stocks, 2022-, Yamaguchi and Takashima, 2018, Cammarato et al., 2011, Gurudatta et al., 2010, Ni et al., 2008)

DmC

(Melcer et al., 2007)

G-IF

LAMC

(Cesarini et al., 2015, Bassett et al., 1997)

LamC

(Karling and Weavers, 2025, Mohar et al., 2025, Zhang et al., 2025, Aziz et al., 2024, Fleck et al., 2024, Miao et al., 2024, Finger et al., 2023, Floc'hlay et al., 2023, Penfield and Montell, 2023, Belyaeva et al., 2022, Chen et al., 2022, Ilyin et al., 2022, Shaw et al., 2022, Boumard and Bardin, 2021, Hinz et al., 2021, Ishibashi et al., 2021, Reilein et al., 2021, Mehta et al., 2020, Rust et al., 2020, Bouska et al., 2019, Camara et al., 2019, Chandran et al., 2019, Flint Brodsly et al., 2019, Mathiyalagan et al., 2019, Sênos Demarco and Jones, 2019, Story et al., 2019, Bhide et al., 2018, Donohoe et al., 2018, Gene Disruption Project members, 2018-, Lee et al., 2018, Levis, 2018.8.30, Masuko et al., 2018, Rzepecki and Gruenbaum, 2018, Wang et al., 2018, Yamaguchi and Takashima, 2018, Bussmann and Storkebaum, 2017, Parchure et al., 2017, Transgenic RNAi Project members, 2017-, Uchino et al., 2017, Tran et al., 2016, Cesarini et al., 2015, Oliva et al., 2015, Chen et al., 2014, Pathak et al., 2014, Wu et al., 2014, Chen et al., 2013, Jokhi et al., 2013, Luo et al., 2013, Uchino et al., 2013, Yang et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Ji and Tulin, 2012, Kim et al., 2012, Rojas-Ríos et al., 2012, König et al., 2011, Singer and Gall, 2011, Gurudatta et al., 2010, Kallappagoudar et al., 2010, Liu et al., 2010, Guo and Wang, 2009, Maybeck and Röper, 2009, Dansereau and Lasko, 2008, Katsani et al., 2008, López-Onieva et al., 2008, Buszczak et al., 2007, Kaltenbach et al., 2007, Shcherbata et al., 2007)

LamCa

(De Groef et al., 2024)

Lamin C

(Odell and Lammerding, 2023, Li et al., 2021)

LaminC

(Garrido et al., 2025)

lamC

(Napoletano et al., 2021, Li et al., 2016, Speese et al., 2012, Mallik and Lakhotia, 2011, Xu et al., 2011, Gurudatta et al., 2010, Doheny et al., 2008, Pavlovic et al., 2008, Muñoz-Alarcón et al., 2007, Munoz-Alarcon et al., 2006)

lamin C

(Brener et al., 2023, Ulianov et al., 2019, Wagner et al., 2006)

pG-IF

(Georgatos et al., 1994)

Name Synonyms

G intermediate filament

Lamin C

(Clémot et al., 2024, Shaw et al., 2022, Cheng et al., 2021, Verboon et al., 2020, Petrovsky et al., 2018, Wang et al., 2018, Dialynas et al., 2015, Dolezal et al., 2015, Barton et al., 2014, König and Shcherbata, 2013, Picchio et al., 2013, Rohrbaugh et al., 2013, Xin et al., 2013, Yang et al., 2013, Zwerger et al., 2013, Dialynas et al., 2012, Ji and Tulin, 2012, Nagel et al., 2012, Rojas-Ríos et al., 2012, Cammarato et al., 2011, Eliazer and Buszczak, 2011, Eliazer et al., 2011, Matsui et al., 2011, Xu et al., 2011, Zimek and Weber, 2011, Dialynas et al., 2010, Gurudatta et al., 2010, Seong et al., 2010, Guo and Wang, 2009, Schulze et al., 2009, Cryderman et al., 2008, Katsani et al., 2008, Schaefer et al., 2008, Schulze et al., 2008, Challa et al., 2007, Matsui et al., 2007, Song et al., 2007, Ward et al., 2006, Mathew et al., 2005)

Lamin-C

(Reilein et al., 2021)

LaminC

(Hudson et al., 2023, Palacios et al., 2021, Zhao et al., 2020, Yang et al., 2017, Rohrbaugh et al., 2013, König et al., 2011, Parrott et al., 2011, Kaltenbach et al., 2007, Shcherbata et al., 2007, de Haro et al., 2006)

lamin

(Khoroshko et al., 2018)

lamin A

(Herrmann and Strelkov, 2011)

lamin DmC

(Prufert et al., 2004)

laminC

(de Haro et al., 2006)

Secondary FlyBase IDs

FBgn0010037

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36615

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q03427

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q03427

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KFY9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q03427

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010397

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36615/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010397

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010397

FlyMine - An integrated database for Drosophila genomics

FBgn0010397

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10119

MARRVEL_MODEL - MARRVEL (model organism gene)

36615

Linkouts

BioGRID - A database of protein and genetic interactions.

62363

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010397

DroID - A comprehensive database of gene and protein interactions.

FBgn0010397

DRSC - Results frm RNAi screens

FBgn0010397

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

LamC_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010397

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010397

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10119

Flygut - An atlas of the Drosophila adult midgut

FBgn0010397

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Apoptosis - fly

MIST (protein-protein) - An integrated Molecular Interaction Database

36615

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (229)

The following external sites may use different assemblies or annotations than FlyBase.

0.13

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