FlyBase Allele Report: Dmel\LamC[G489V.UAS]

General Information

Symbol

Dmel\LamC^G489V.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0282441

Feature type

allele

Associated gene

Dmel\LamC

Associated Insertion(s)

Carried in Construct

P{UAS-LamC.G489V}

Also Known As

G489V

Key Links

Genomic Maps

JBrowse

Transgenic product class

missense_variant

(Shaw et al., 2022, Dialynas et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Shaw et al., 2022, Dialynas et al., 2012)

Mutagen

in vitro construct

(Dialynas et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-LamC.G489V}

Cytology

Description

UASt regulates expression of G489V LamC, modeling the G449V mutation in human Hsap\LMNA associated with muscular dystrophy.

(Shaw et al., 2022)

UASt regulatory sequences drive expression of LamC containing the amino acid replacement G489V (this is equivalent to a G449V mutation in the human Hsap\LMNA gene).

(Dialynas et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

LamC

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:14,571,713..14,571,713 [-]

Nucleotide change:

G14571713T

Amino acid change:

G489V | LamC-PA; G489V | LamC-PB

Reported amino acid change:

G489V

Comment:

Mutation in analogous codon in human LMNA putatively associated with muscular dystropy; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

Comment:

G449V mutation in analogous codon in human LMNA putatively associated with muscular dystropy; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Shaw et al., 2022, Dialynas et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of myopathy

CEA

(Dialynas et al., 2012)

model of muscular dystrophy

CEA

(Shaw et al., 2022, Dialynas et al., 2015)

model of congenital muscular dystrophy due to LMNA mutation

CEA

(Chandran et al., 2019)

model of dilated cardiomyopathy 1A

CEC

(Bhide et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of congenital muscular dystrophy due to LMNA mutation

is exacerbated by AMPKα^HMC04979

(Chandran et al., 2019)

is ameliorated by AMPKα^UAS.cMa

(Chandran et al., 2019)

is ameliorated by S6k^KQ.UAS

(Chandran et al., 2019)

is exacerbated by Thor^KK108272

(Chandran et al., 2019)

is ameliorated by Thor^UAS.cMa

(Chandran et al., 2019)

is exacerbated by foxo^KK108485

(Chandran et al., 2019)

is ameliorated by foxo^UASp.GFP

(Chandran et al., 2019)

is ameliorated by srl^UAS.cRa

(Chandran et al., 2019)

is exacerbated by srl^KK100201

(Chandran et al., 2019)

model of dilated cardiomyopathy 1A

is exacerbated by Atg1^K38Q.UAS

(Bhide et al., 2018)

is ameliorated by Atg1^UAS.cSa

(Bhide et al., 2018)

is ameliorated by cnc^GD4437

(Bhide et al., 2018)

is ameliorated by cnc^KK103976

(Bhide et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

FlyBase curator comment: "dilated cardiomyopathy 1A" is associated with mutations in human LMNA.

(Bhide et al., 2018)

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Shaw et al., 2022, Dialynas et al., 2012)

LMNA:p.Gly449Val

(FlyBase curators, 2019-)

Variants Synonym(s)

LMNA:p.Gly337Val

LMNA:p.Gly368Val

Associated human disease model(s)

External database links

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal flight, with Scer\GAL4^EDTP-DJ694

(Chandran et al., 2019)

abnormal locomotor behavior | larval stage, with Scer\GAL4^C57

(Dialynas et al., 2015)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^C57

(Dialynas et al., 2012)

abnormal size | adult stage, with Scer\GAL4^Act88F.PB

(Chandran et al., 2019)

abnormal size | adult stage, with Scer\GAL4^fln.IFM

(Chandran et al., 2019)

decreased rate of larval locomotory behavior, with Scer\GAL4^C57

(Shaw et al., 2022)

flightless | progressive, with LamC^EX296, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

flightless | progressive, with Scer\GAL4^Act88F.PB

(Chandran et al., 2019)

flightless | progressive, with Scer\GAL4^fln.IFM

(Chandran et al., 2019)

lethal, with Scer\GAL4^Mef2.PR

(Dialynas et al., 2012)

partially lethal - majority die, with Scer\GAL4^C57

(Shaw et al., 2022, Dialynas et al., 2012)

short lived, with Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

some die during P-stage, with Scer\GAL4^C57

(Dialynas et al., 2015)

viable, with Scer\GAL4^ey.PU

(Dialynas et al., 2012)

viable, with Scer\GAL4^Mhc.PU

(Dialynas et al., 2012)

Phenotype Manifest In

actin cytoskeleton | larval stage, with Scer\GAL4^C57

(Dialynas et al., 2015)

adult abdominal fat mass | progressive, with Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

adult heart | progressive, with Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

embryonic/larval hypodermal muscle | larval stage, with Scer\GAL4^C57

(Shaw et al., 2022)

embryonic/larval hypodermal muscle cell | larval stage, with Scer\GAL4^C57

(Dialynas et al., 2015)

indirect flight muscle cell | adult stage | progressive, with Scer\GAL4^EDTP-DJ694

(Chandran et al., 2019)

indirect flight muscle cell | adult stage | progressive, with Scer\GAL4^fln.IFM

(Chandran et al., 2019)

indirect flight muscle cell | pupal stage, with Scer\GAL4^Act88F.PB

(Chandran et al., 2019)

lipid droplet | adult stage | progressive, with Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

mitochondrion | adult stage, with Scer\GAL4^fln.IFM

(Chandran et al., 2019)

myofibril | adult stage, with Scer\GAL4^EDTP-DJ694

(Chandran et al., 2019)

myofibril | adult stage, with Scer\GAL4^fln.IFM

(Chandran et al., 2019)

myofibril | adult stage, with Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

nuclear envelope | adult stage, with Scer\GAL4^EDTP-DJ694

(Chandran et al., 2019)

nuclear envelope | adult stage, with Scer\GAL4^fln.IFM

(Chandran et al., 2019)

nuclear envelope | adult stage, with Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

nucleus | adult stage, with Scer\GAL4^EDTP-DJ694

(Chandran et al., 2019)

nucleus | adult stage, with Scer\GAL4^fln.IFM

(Chandran et al., 2019)

nucleus | adult stage, with Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

nucleus | larval stage, with Scer\GAL4^C57

(Dialynas et al., 2015)

sarcomere | adult stage, with Scer\GAL4^fln.IFM

(Chandran et al., 2019)

sarcomere | pupal stage | pupal stage, with Scer\GAL4^Act88F.PB

(Chandran et al., 2019)

wing, with Scer\GAL4^fln.IFM

(Chandran et al., 2019)

Z disc | adult stage, with Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Detailed Description

Statement

Reference

The expression of LamC^G489V.UAS under the control of Scer\GAL4^fln.IFM, or Scer\GAL4^Act88F.PB leads to a severe and progressive decrease in flight ability, until individuals are unable to fly; expression under the control of Scer\GAL4^EDTP-DJ694 leads to a milder decrease in flight ability; the Scer\GAL4^fln.IFM-driven flight defects are also observed in a LamC^EX296 heterozygous background.

Expressing LamC^G489V.UAS under the control of Scer\GAL4^Act88F.PB leads to structural defects in pupal indirect flight muscles, with shorter sarcomeres, and disrupted Z-discs and M-lines.

Adult indirect flight muscles expressing LamC^G489V.UAS under the control of either Scer\GAL4^fln.IFM or Scer\GAL4^EDTP-DJ694 show myofibril disorganization, abnormal nuclear morphology, including nuclear envelope blebbing, and nuclear misalignment. The Scer\GAL4^fln.IFM-driven expression also leads to shorter sarcomeres, with partial loss of Z-disc and M-lines, to severe mitochondrial dysmorphology including small and fragmented mitochondria, and to double membrane structures containing mitochondria and vacuoles, suggesting autophagic defects; adults show a nearly fully penetrant 'held-up wing' phenotype.

(Chandran et al., 2019)

Expressing LamC^G489V.UAS under the control of Scer\GAL4^HCH.Hand causes cardiac defects: 3 weeks adults show significant dilation, defective ostia, dysrhythmic beating, non-beating segments and non-beating hearts; there are progressive increases in heart period, diastolic and systolic intervals and a progressive decrease in fractional shortening; there is a significant increase in arrhythmicity index. In 3-week-old adults, cardiomyocytes show myofibrillar disorganization and poorly organized Z-discs and nuclear envelope blebbing.

Expressing LamC^G489V.UAS under the control of Scer\GAL4^HCH.Hand also induces a progressive enlargement of lipid droplets in the adult fat body.

(Bhide et al., 2018)

Expression of LamC^{G489V.Scer\UAS} under the control of Scer\GAL4^C57 leads to larval locomotion defects and semi-lethality at the pupal stage. A subset of the larval body wall muscles show abnormally shaped and spaced nuclei, and disorganization of the actin cytoskeleton.

(Dialynas et al., 2015)

Third instar larvae expressing LamC^{G489V.Scer\UAS} under the control of Scer\GAL4^C57 show reduced mobility. Myonuclei appear aggregated in approximately 30% of body wall muscles.

(Dialynas et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has short lived phenotype, enhanceable by Keap1^KK102175, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has short lived phenotype, enhanceable by Atg1^K38Q.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has short lived phenotype, enhanceable by Atg1^K38Q.UAS/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Suppressed by

Statement

Reference

LamC^G489V.UAS, Scer\GAL4^fln.IFM has flightless | progressive phenotype, suppressible by AMPKα^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has flightless | progressive phenotype, suppressible | partially by srl^UAS.cRa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has flightless | progressive phenotype, suppressible by Thor^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has flightless | progressive phenotype, suppressible by S6k^KQ.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has short lived phenotype, suppressible | partially by Atg5^UASp.EGFP, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has short lived phenotype, suppressible | partially by Atg8a^{UASp.EGFP,mCherry}, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has short lived phenotype, suppressible by Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has short lived phenotype, suppressible | partially by Atg1^UAS.cSa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

NOT suppressed by

Statement

Reference

LamC^G489V.UAS, Scer\GAL4^fln.IFM has flightless | progressive phenotype, non-suppressible by AMPKα^HMC04979, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has flightless | progressive phenotype, non-suppressible by srl^KK100201, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has flightless | progressive phenotype, non-suppressible by foxo^UASp.GFP, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has flightless | progressive phenotype, non-suppressible by foxo^KK108485, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has flightless | progressive phenotype, non-suppressible by Thor^KK108272, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has flightless | progressive phenotype, non-suppressible by S6k^TE.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has short lived phenotype, non-suppressible by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has short lived phenotype, non-suppressible by GstD4^GD16151, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has short lived phenotype, non-suppressible by GstD9^KK113031, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, enhanceable by AMPKα^HMC04979, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nuclear envelope | adult stage phenotype, enhanceable by AMPKα^HMC04979, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, enhanceable by foxo^KK108485, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nucleus | adult stage phenotype, enhanceable by foxo^KK108485, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has myofibril | adult stage phenotype, enhanceable by foxo^KK108485, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nucleus | adult stage phenotype, enhanceable by AMPKα^HMC04979, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has myofibril | adult stage phenotype, enhanceable by AMPKα^HMC04979, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, enhanceable by Thor^KK108272, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nucleus | adult stage phenotype, enhanceable by Thor^KK108272, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has myofibril | adult stage phenotype, enhanceable by Thor^KK108272, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, enhanceable by srl^KK100201, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nucleus | adult stage phenotype, enhanceable by srl^KK100201, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has myofibril | adult stage phenotype, enhanceable by srl^KK100201, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult heart phenotype, enhanceable by Keap1^KK102175, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype, enhanceable by Keap1^KK102175, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype, enhanceable by Keap1^KK102175, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult heart phenotype, enhanceable by Atg1^K38Q.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype, enhanceable by Atg1^K38Q.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype, enhanceable by Atg1^K38Q.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult heart phenotype, enhanceable by Atg1^K38Q.UAS/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype, enhanceable by Atg1^K38Q.UAS/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nuclear envelope | adult stage phenotype, enhanceable by Atg1^K38Q.UAS/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype, enhanceable by Atg1^K38Q.UAS/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

NOT Enhanced by

Statement

Reference

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, non-enhanceable by Keap1^KK102175, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, non-enhanceable by Keap1^KK102175, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, non-enhanceable by Atg1^K38Q.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, non-enhanceable by Atg1^K38Q.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, non-enhanceable by Atg1^K38Q.UAS/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, non-enhanceable by Atg1^K38Q.UAS/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Suppressed by

Statement

Reference

LamC^G489V.UAS, Scer\GAL4^fln.IFM has wing phenotype, suppressible by AMPKα^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, suppressible by AMPKα^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nuclear envelope | adult stage phenotype, suppressible by AMPKα^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nucleus | adult stage phenotype, suppressible by AMPKα^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has myofibril | adult stage phenotype, suppressible by AMPKα^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, suppressible by S6k^KQ.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, suppressible by srl^UAS.cRa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has wing phenotype, suppressible by srl^UAS.cRa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nucleus | adult stage phenotype, suppressible by srl^UAS.cRa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has myofibril | adult stage phenotype, suppressible by srl^UAS.cRa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, suppressible | partially by foxo^UASp.GFP, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nucleus | adult stage phenotype, suppressible | partially by foxo^UASp.GFP, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has myofibril | adult stage phenotype, suppressible | partially by foxo^UASp.GFP, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has wing phenotype, suppressible by S6k^KQ.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nucleus | adult stage phenotype, suppressible by S6k^KQ.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has myofibril | adult stage phenotype, suppressible by S6k^KQ.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has wing phenotype, suppressible by Thor^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, suppressible by Thor^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nucleus | adult stage phenotype, suppressible by Thor^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has myofibril | adult stage phenotype, suppressible by Thor^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has mitochondrion | adult stage phenotype, suppressible by AMPKα^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has mitochondrion | adult stage phenotype, suppressible by srl^UAS.cRa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has mitochondrion | adult stage phenotype, suppressible by Thor^UAS.cMa, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has mitochondrion | adult stage phenotype, suppressible by S6k^KQ.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has mitochondrion | adult stage phenotype, suppressible | partially by foxo^UASp.GFP, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult heart phenotype, suppressible | partially by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype, suppressible | partially by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nuclear envelope | adult stage phenotype, suppressible | partially by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype, suppressible | partially by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult heart phenotype, suppressible | partially by GstD4^GD16151, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype, suppressible | partially by GstD4^GD16151, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nuclear envelope | adult stage phenotype, suppressible | partially by GstD4^GD16151, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype, suppressible | partially by GstD4^GD16151, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult heart phenotype, suppressible | partially by GstD9^KK113031, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype, suppressible | partially by GstD9^KK113031, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nuclear envelope | adult stage phenotype, suppressible | partially by GstD9^KK113031, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype, suppressible | partially by GstD9^KK113031, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult heart phenotype, suppressible | partially by Atg1^UAS.cSa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype, suppressible | partially by Atg1^UAS.cSa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nuclear envelope | adult stage phenotype, suppressible | partially by Atg1^UAS.cSa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype, suppressible | partially by Atg1^UAS.cSa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, suppressible | partially by Atg1^UAS.cSa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, suppressible | partially by Atg1^UAS.cSa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult heart phenotype, suppressible | partially by Atg5^UASp.EGFP, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype, suppressible | partially by Atg5^UASp.EGFP, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nuclear envelope | adult stage phenotype, suppressible | partially by Atg5^UASp.EGFP, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype, suppressible | partially by Atg5^UASp.EGFP, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, suppressible | partially by Atg5^UASp.EGFP, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, suppressible | partially by Atg5^UASp.EGFP, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult heart phenotype, suppressible | partially by Atg8a^{UASp.EGFP,mCherry}, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype, suppressible | partially by Atg8a^{UASp.EGFP,mCherry}, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nuclear envelope | adult stage phenotype, suppressible | partially by Atg8a^{UASp.EGFP,mCherry}, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype, suppressible | partially by Atg8a^{UASp.EGFP,mCherry}, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, suppressible | partially by Atg8a^{UASp.EGFP,mCherry}, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, suppressible | partially by Atg8a^{UASp.EGFP,mCherry}, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult heart phenotype, suppressible by Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype, suppressible by Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has nuclear envelope | adult stage phenotype, suppressible by Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype, suppressible by Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, suppressible by Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, suppressible by Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

NOT suppressed by

Statement

Reference

LamC^G489V.UAS, Scer\GAL4^fln.IFM has wing phenotype, non-suppressible by AMPKα^HMC04979, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, non-suppressible by AMPKα^K56R.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has nucleus | adult stage phenotype, non-suppressible by S6k^TE.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has myofibril | adult stage phenotype, non-suppressible by S6k^TE.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has wing phenotype, non-suppressible by Thor^KK108272, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, non-suppressible by AMPKα^T184D.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, non-suppressible by Thor^LL.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, non-suppressible by Thor^KK108272, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has indirect flight muscle cell | adult stage phenotype, non-suppressible by S6k^TE.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has wing phenotype, non-suppressible by srl^KK100201, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has wing phenotype, non-suppressible by foxo^UASp.GFP, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has wing phenotype, non-suppressible by foxo^KK108485, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^fln.IFM has wing phenotype, non-suppressible by S6k^TE.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, non-suppressible by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, non-suppressible by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, non-suppressible by Keap1^KK102175, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, non-suppressible by Keap1^KK102175, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, non-suppressible by GstD4^GD16151, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, non-suppressible by GstD4^GD16151, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, non-suppressible by GstD9^KK113031, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, non-suppressible by GstD9^KK113031, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, non-suppressible by Atg1^K38Q.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, non-suppressible by Atg1^K38Q.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has adult abdominal fat mass phenotype, non-suppressible by Atg1^K38Q.UAS/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

LamC^G489V.UAS, Scer\GAL4^HCH.Hand has lipid droplet | adult stage phenotype, non-suppressible by Atg1^K38Q.UAS/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

G489V

(Dialynas et al., 2015)

LamC^{G489V.Scer\UAS}

LamC^G489V.UAS

Name Synonyms

Secondary FlyBase IDs

References (6)

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