FlyBase Allele Report: Dmel\Atg1[UAS.cSa]

General Information

Symbol

Dmel\Atg1^UAS.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Scott

FlyBase ID

FBal0221315

Feature type

allele

Associated gene

Dmel\Atg1

Associated Insertion(s)

Carried in Construct

P{UAS-Atg1.S}

Also Known As

UAS-Atg1, UAS-Atg1^6B, UAS-Atg1^6A, ATG1 OE

Key Links

Transgenic product class

cDNA

(Scott et al., 2007)

wild_type

(Scott et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Scott et al., 2007)

wild_type

(Scott et al., 2007)

Mutagen

in vitro construct

(Scott et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-Atg1.S}

Cytology

Description

UASt regulatory sequences drive expression of the Atg1 AT02023 cDNA.

(Scott et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Atg1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by trp^P365

(Huang et al., 2016)

ameliorates cancer

modeled by N^DN.UAS.cUa

(Lee et al., 2021)

modeled by Raf^UAS.F179

(Lee et al., 2021)

ameliorates carcinoma

modeled by hpo^3D

(Pérez et al., 2015)

modeled by yki^UAS.cHa

(Pérez et al., 2015)

ameliorates Niemann-Pick disease

modeled by Npc1a^KK101077

(Danielsen et al., 2016)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cAa

(Chatterjee et al., 2023)

ameliorates short stature, hearing loss, retinitis pigmentosa, and distinctive facies

modeled by Rrp4^KK108526

(Yang et al., 2020)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Cunningham et al., 2020)

ameliorates dilated cardiomyopathy 1A

modeled by LamC^G489V.UAS

(Bhide et al., 2018)

ameliorates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Liu and Lu, 2010)

modeled by Pink1^B9

(Liu and Lu, 2010)

exacerbates frontotemporal dementia and/or amyotrophic lateral sclerosis 2

modeled by Chchd2^S81L.UAS

(Baek et al., 2021)

exacerbates Parkinson's disease

modeled by Hsc70-5^KK100233

(Zhu et al., 2021)

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{R518K.UAS.Tag:HA}

(Marrone et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

The amelioration of the phenotype in Npc1a^KK101077 expressing flies is observed upon simultaneous co-expression of both Atg1^Scer\UAS.cSa and Atg13^Scer\UAS.cCa. sf161013

(Danielsen et al., 2016)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell cycle | oogenesis, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

abnormal cell death, with Scer\GAL4^NP0001

(Denton et al., 2012)

abnormal developmental rate, with Scer\GAL4^Cyp6g1.Cs

(Bjedov et al., 2020)

abnormal eye color | adult stage, with Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

abnormal heat stress response | adult stage, with Scer\GAL4^Cyp6g1.Cs

(Bjedov et al., 2020)

abnormal heat stress response | adult stage, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

abnormal immune response | conditional, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

abnormal neuroanatomy, with Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Thakur and O'Connor-Giles, 2025)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav.PU

(Zhu et al., 2021)

abnormal size | adult stage, with Scer\GAL4^GMR.PU

(Tang et al., 2018)

abnormal starvation stress response | adult stage, with Scer\GAL4^Cyp6g1.Cs

(Bjedov et al., 2020)

abnormal starvation stress response | adult stage, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

abnormal stress response | adult stage, with Scer\GAL4^Cyp6g1.Cs

(Bjedov et al., 2020)

abnormal stress response | adult stage, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

abnormal stress response | oogenesis, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

chemical resistant | adult stage, with Scer\GAL4^Cyp6g1.Cs

(Bjedov et al., 2020)

chemical sensitive | adult stage, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

decreased body weight, with Scer\GAL4^Cyp6g1.Cs

(Bjedov et al., 2020)

decreased cell size | somatic clone, with Scer\GAL4^Act5C.PP

(Denton et al., 2012, Scott et al., 2007)

decreased size | adult stage, with Scer\GAL4^Cyp6g1.Cs

(Bjedov et al., 2020)

decreased size | adult stage, with Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

increased cell death, with Scer\GAL4^Cg.PA

(Scott et al., 2007)

increased cell death, with Scer\GAL4^NP2610-3-1

(Wagner et al., 2009)

increased cell death | embryonic stage 16, with Scer\GAL4^da.G32

(Mohseni et al., 2009)

increased cell death | somatic clone, with Scer\GAL4^Act5C.PP

(Scott et al., 2007)

increased cell growth rate, with Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

increased mortality | adult stage, with Scer\GAL4^Cyp6g1.Cs

(Bjedov et al., 2020)

increased mortality | adult stage, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

lethal, with Scer\GAL4^fat

(Bjedov et al., 2020)

lethal, with Scer\GAL4^NP0001

(Bjedov et al., 2020)

lethal - all die before end of pupal stage, with Scer\GAL4^NP2610-3-1

(Wagner et al., 2009)

lethal - all die during embryonic stage, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

long lived, with Scer\GAL4^Cyp6g1.Cs

(Bjedov et al., 2020)

long lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Ling and Salvaterra, 2011)

long lived | RU486 conditional, with Scer\GAL4^Switch1.106

(Bjedov et al., 2020)

partially lethal, with Scer\GAL4^GMR.PF

(Scott et al., 2007)

short lived, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

some die during P-stage, with Scer\GAL4^NP2610-3-1

(Wagner et al., 2009)

some die during third instar larval stage, with Scer\GAL4^NP2610-3-1

(Wagner et al., 2009)

visible, with Scer\GAL4^GMR.PF

(Scott et al., 2007)

visible | adult stage, with Scer\GAL4^Cyp6g1.Cs

(Bjedov et al., 2020)

visible | adult stage, with Scer\GAL4^ey.PU

(Yang et al., 2020)

visible | adult stage, with Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

visible | adult stage, with Scer\GAL4^GMR.PU

(Tang et al., 2018, Zhu et al., 2017)

Phenotype Manifest In

adult gut, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

adult hemocyte | increased number, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

amnioserosa, with Scer\GAL4^Kr.PM, Scer\GAL4^{Orct2-cald-GAL4}

(Mohseni et al., 2009)

autophagosome | larval stage, with Scer\GAL4^GMR.PU

(Tang et al., 2018)

embryonic/larval midgut, with Scer\GAL4^NP0001

(Denton et al., 2012)

embryonic/larval midgut | somatic clone, with Scer\GAL4^Act5C.PP

(Denton et al., 2012)

embryonic/larval neuromuscular junction, with Scer\GAL4^elav-C155

(Tian et al., 2011)

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav.PU

(Zhu et al., 2021)

embryonic/larval tracheal section, with Scer\GAL4^NP2610-3-1

(Wagner et al., 2009)

eye, with Scer\GAL4^ey.PU

(Yang et al., 2020)

eye, with Scer\GAL4^GMR.PF

(Umargamwala et al., 2025, Scott et al., 2007)

eye, with Scer\GAL4^GMR.PU

(Tang et al., 2018, Zhu et al., 2017)

eye disc, with Scer\GAL4^GMR.PU

(Tang et al., 2018)

fat body, with Scer\GAL4^hs.PH

(Scott et al., 2007)

fat body | somatic clone, with Scer\GAL4^Act5C.PP

(Scott et al., 2007)

female germline stem cell, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

gastric caecum, with Scer\GAL4^NP0001

(Denton et al., 2012)

neuromuscular junction, with Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

NMJ bouton, with Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

NMJ bouton, with Scer\GAL4^elav-C155

(Tian et al., 2011)

NMJ bouton | increased number | larval stage, with Scer\GAL4^elav-C155

(Thakur and O'Connor-Giles, 2025)

synapse, with Scer\GAL4^elav-C155

(Tian et al., 2011)

wing, with Scer\GAL4^Cyp6g1.Cs

(Bjedov et al., 2020)

Detailed Description

Statement

Reference

Third instar larvae expressing Atg1^UAS.cSa under the control of Scer\GAL4^elav.PU show a delayed righting reflex. Their neuromuscular junction exhibits an increased proportion of postsynaptic densities unopposed by active zones.

(Zhu et al., 2021)

Expressing Rrp4^KK108526 under the control of Scer\GAL4^ey.PU occasionally induces irregular eyes.

(Yang et al., 2020)

Under standard nutritional conditions, expression of Atg1^UAS.cSa under the control of Scer\GAL4^GMR.PU leads to a small and rough eye phenotype in adults and to the induction of autophagosomes (identified as mCherry-Atg8 puncta) in the larval eye disc.

(Tang et al., 2018)

Expressing Atg1^UAS.cSa under the control of Scer\GAL4^GMR.PU causes a severe rough eye phenotype with patchy red pigmentation.

(Zhu et al., 2017)

Scer\GAL4^{Myo31DF-NP0001}-mediated expression of Atg1^Scer\UAS.cSa results in more contracted gastric caeca, at an earlier time point, compared to controls. At later time points, once the normal induction of autophagy has initiated, midgut removal occurs normally. Mosaic clones overexpressing Atg1^Scer\UAS.cSa in the midgut of feeding larvae show higher levels of autophagy and smaller cell size compared to surrounding wild type cells.

Scer\GAL4^{Myo31DF-NP0001}-mediated expression of Atg1^Scer\UAS.cSa results in reduced PI3K signalling in the midgut at -4h relative puparium formation, as assayed by localization of phospho-Akt1.

(Denton et al., 2012)

Expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^{elav.Switch.PO} (temporally controlled via RU486 feeding) during the first 15 days of adulthood leads to a significant increase in mean lifespan and maximum lifespan; expression during days 27-42 leads to a significant decrease in mean lifespan but not maximum lifespan; expression during the entire adult stage leads to a significant decrease in mean lifespan and maximum lifespan, as compared to controls.

(Ling and Salvaterra, 2011)

Presynaptic expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^elav-C155 induces neuromuscular junction overgrowth and an increase in bouton number.

(Tian et al., 2011)

Clonal expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Act5C.PP inhibits cell growth.

(Chang and Neufeld, 2009)

Scer\GAL4^da.G32 Atg1^Scer\UAS.cSa embryos show premature elevated autophagy in the amnioserosa at mid-dorsal closure stage, and increased acridine orange staining throughout stage 16, relative to wild type.

Embryos expressing 2X Atg1^Scer\UAS.cSa under the control of Scer\GAL4^{Orct2-cald-GAL4} and Scer\GAL4^Kr.PM show a highly penetrant premature amnioserosa dissociation and dorsal closure defects.

(Mohseni et al., 2009)

Pan-neuronal expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^elav.PLu induces high levels of autophagy. Under these conditions, bouton number is increased more than two-fold.

(Shen and Ganetzky, 2009)

Scer\GAL4^NP2610-3-1-mediated expression of Atg1^Scer\UAS.cSa causes larvae to leave their substrate prematurely and die as late stage larvae or during the first phase of pupation. The airway system of these mutants is heavily disturbed and large regions are filled with liquid, indicative of apoptosis.

(Wagner et al., 2009)

Expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^GMR.PF results in partial lethality. Surviving adults have much smaller eyes than normal.

The partial lethality caused by expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^GMR.PF can be partially suppressed by co-expression of Atg1^{K38Q.Scer\UAS}. The reduced eye size caused by expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^GMR.PF is rescued by co-expression of Atg1^{K38Q.Scer\UAS}.

Expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^hs.PH induces autophagy.

Expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Cg.PA in the fat body induces DNA fragmentation (assayed by TUNEL staining) in 17% of cells.

(Scott et al., 2007)

Expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^hs.PH results in the formation of autophagosomes and autolysosomes throughout fat body cells of fed animals.

Expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Act5C.PP in clones in the fat body results in a 94% decrease in average cell size compared to controls, together with a corresponding decrease in nuclear size and DNA content.

Cells expressing Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Act5C.PP in clones in the wing disc are eliminated within 36 hours of induction, in contrast to wild-type controls. 22% of cells expressing Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Act5C.PP in clones in the wing disc have DNA fragmentation (as shown by TUNEL labeling).

Cells expressing Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Act5C.PP in clones in the fat body die by apoptosis. These cells also have reduced or absent filamentous actin staining at the cell periphery and often become fragmented and/or are engulfed by neighboring wild-type cells.

(Scott et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by dor^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by lt^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by Cul4^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, enhanceable by Psc^HMS01706, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by Psc^HMS01706, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Psc^HMS01706, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, enhanceable by LUBEL^KK106140, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by LUBEL^KK106140, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by LUBEL^KK106140, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, enhanceable by eff^GL00355, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by eff^GL00355, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by eff^GL00355, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, enhanceable by slmb^HMS00946, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by slmb^HMS00946, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by slmb^HMS00946, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by Uba1^JF01977, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by Pex2^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by ntc^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by Prp19^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, enhanceable by Scer\GAL4^Act.PU/hyd^RNAi.UAS.cUa

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, enhanceable by Pcf11^HMS00406, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Pcf11^HMS00406, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa has visible | adult stage phenotype, enhanceable by mask^UAS.cZa/Scer\GAL4^GMR.PU

(Zhu et al., 2017)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, enhanceable by hiw[+]/hiw^EMS

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, enhanceable by hiw[+]/hiw^EMS

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, enhanceable by hiw^EMS

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, enhanceable by hiw^EMS

(Shen and Ganetzky, 2009)

NOT Enhanced by

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-enhanceable by dor^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-enhanceable by lt^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-enhanceable by Ube4A^GD7188, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-enhanceable by Cul4^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, non-enhanceable by Rnf11^HMJ22085, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-enhanceable by Rnf11^HMJ22085, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-enhanceable by Rnf11^HMJ22085, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-enhanceable by mr^HMS02023, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-enhanceable by Mi-2^HMC03329, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-enhanceable by Prp19^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, LamC^UAS.cSa, Scer\GAL4^HCH.Hand has short lived phenotype, non-enhanceable by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa has visible | adult stage phenotype, non-enhanceable by mask^HMS01045/Scer\GAL4^GMR.PU

(Zhu et al., 2017)

Suppressed by

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^elav-C155 has abnormal neuroanatomy | larval stage phenotype, suppressible by Pdzd8[+]/Pdzd8^KO

(Thakur and O'Connor-Giles, 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, suppressible by Uba1^JF01977, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, suppressible | partially by mr^HMS02023, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, suppressible | partially by Ube4A^GD7188, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, suppressible by sip3^HMJ23236, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, suppressible by Pex2^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, suppressible by ntc^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, suppressible | partially by sip3^HMJ23236, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, suppressible | partially by Mi-2^HMC03329, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by sip3^HMJ23236, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, suppressible | partially by Scer\GAL4^Act.PU/hyd^RNAi.UAS.cUa

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible by Atg9^GD2029, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Atg9^GD2029, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible | partially by Cpsf6^HMS00113, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by Cpsf6^HMS00113, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible by CstF64^GD9942, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by CstF64^GD9942, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible by Wdr33^HMC03936, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Wdr33^HMC03936, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible | partially by Cpsf160^GL01166, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Cpsf160^GL01166, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF, trp^P365 has abnormal neuroanatomy | dominant | adult stage | progressive phenotype, suppressible by Pink1^B9

(Huang et al., 2016)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF, trp^P365 has abnormal neuroanatomy | dominant | adult stage | progressive phenotype, suppressible by park¹/park¹

(Huang et al., 2016)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible by wnd¹

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, suppressible by wnd¹

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible | partially by wnd[+]/wnd¹

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, suppressible | partially by wnd[+]/wnd¹

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible by hiw^UAS.fl, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, suppressible by hiw^UAS.fl, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible by nwk^UAS.cCa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, suppressible by nwk^UAS.cCa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible by Atg18a^Δ585/Atg18[+]

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, suppressible by Atg18a^Δ585/Atg18[+]

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible by Atg18a^Δ585

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, suppressible by Atg18a^Δ585

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^NP2610-3-1 has lethal - all die before end of pupal stage phenotype, suppressible | partially by foxo^UAS.GFP, Scer\GAL4^NP2610-3-1

(Wagner et al., 2009)

Atg1^UAS.cSa, Scer\GAL4^NP2610-3-1 has increased cell death phenotype, suppressible by foxo^UAS.GFP, Scer\GAL4^NP2610-3-1

(Wagner et al., 2009)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^GMR.PF

(Scott et al., 2007)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has partially lethal phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^GMR.PF

(Scott et al., 2007)

Atg1^UAS.cSa, Scer\GAL4^Cg.PA has increased cell death phenotype, suppressible by Atg3¹⁰/Atg3¹⁰

(Scott et al., 2007)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has partially lethal phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Scott et al., 2007)

Atg1^UAS.cSa, Scer\GAL4^Act5C.PP has increased cell death | somatic clone phenotype, suppressible | partially by Rheb^AV4, Scer\GAL4^Act5C.PP

(Scott et al., 2007)

Atg1^UAS.cSa, Scer\GAL4^Act5C.PP has increased cell death | somatic clone phenotype, suppressible by Atg8a^KG07569, Scer\GAL4^Act5C.PP

(Scott et al., 2007)

Atg1^UAS.cSa, Scer\GAL4^Act5C.PP has increased cell death | somatic clone phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^Act5C.PP

(Scott et al., 2007)

NOT suppressed by

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-suppressible by Cul4^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-suppressible by Ube4A^GD7188, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-suppressible by mr^HMS02023, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-suppressible by lt^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-suppressible by dor^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has abnormal eye color | adult stage phenotype, non-suppressible by Rnf11^HMJ22085, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-suppressible by Rnf11^HMJ22085, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-suppressible by Mi-2^HMC03329, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, non-suppressible by Prp19^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-suppressible by Rnf11^HMJ22085, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa has visible | adult stage phenotype, non-suppressible by mask^HMS01045/Scer\GAL4^GMR.PU

(Zhu et al., 2017)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, non-suppressible by S6k^STDE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, non-suppressible by S6k^STDE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, non-suppressible by S6k^STDETE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, non-suppressible by S6k^STDETE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, non-suppressible by S6k^TE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, non-suppressible by S6k^TE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, non-suppressible by S6k^KQ.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has increased cell growth rate phenotype, non-suppressible by S6k^KQ.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Enhancer of

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is an enhancer of abnormal eye color | adult stage phenotype of Scer\GAL4^GMR.PF, dor^RNAi.UAS.cUa

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is an enhancer of abnormal eye color | adult stage phenotype of Scer\GAL4^GMR.PF, lt^RNAi.UAS.cUa

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is an enhancer of decreased size | adult stage phenotype of Scer\GAL4^GMR.PF, Ube4A^GD7188

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is an enhancer of abnormal eye color | adult stage phenotype of Cul4^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is an enhancer of decreased size | adult stage phenotype of Prp19^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Prp19^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^elav.PU is an enhancer of short lived phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg1^UAS.cSa, Scer\GAL4^elav.PU is an enhancer of abnormal locomotor behavior | adult stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg1^UAS.cSa/Scer\GAL4^Act5C.PP is an enhancer of decreased cell size | somatic clone phenotype of mTor^ΔP

(Scott et al., 2007)

NOT Enhancer of

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^elav.PU is a non-enhancer of abnormal locomotor behavior | third instar larval stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg1^UAS.cSa, Scer\GAL4^ey.PU is a non-enhancer of partially lethal - majority die phenotype of Rrp4^KK108526, Scer\GAL4^ey.PU

(Yang et al., 2020)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a non-enhancer of short lived phenotype of LamC^UAS.cSa, Scer\GAL4^HCH.Hand, cnc^RNAi.UAS.cUa

(Bhide et al., 2018)

Suppressor of

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^esg.PU is a suppressor of increased cell number | adult stage phenotype of AsnS^HMS01481, Scer\GAL4^esg.PU

(Luo et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage phenotype of AsnS^HMS01481, Scer\GAL4^esg.PU

(Luo et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^elav.PU is a suppressor | partially of visible | adult stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PF, yki^{S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of increased size | adult stage phenotype of Scer\GAL4^GMR.PF, yki^{S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PF, yki^{S74.S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of increased size | adult stage phenotype of Scer\GAL4^GMR.PF, yki^{S74.S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Atg1^UAS.cSa, Scer\GAL4^ey.PU is a suppressor | partially of decreased size | adult stage phenotype of Rrp4^KK108526, Scer\GAL4^ey.PU

(Yang et al., 2020)

Atg1^UAS.cSa, Scer\GAL4^ey.PU is a suppressor | partially of visible | adult stage phenotype of Rrp4^KK108526, Scer\GAL4^ey.PU

(Yang et al., 2020)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a suppressor | partially of short lived phenotype of LamC^R205W.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a suppressor | partially of short lived phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand is a suppressor of short lived phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^NP0001 is a suppressor of increased cell size phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

Scer\GAL4^P0206, Atg1^UAS.cSa/Atg13^UAS.cCa is a suppressor of abnormal developmental rate phenotype of Npc1a^KK101077, Scer\GAL4^P0206

(Danielsen et al., 2016)

Scer\GAL4^P0206, Atg1^UAS.cSa/Atg13^UAS.cCa is a suppressor of increased body size | pupal stage phenotype of Npc1a^KK101077, Scer\GAL4^P0206

(Danielsen et al., 2016)

Atg1^UAS.cSa/Scer\GAL4^GMR.PF is a suppressor of abnormal neuroanatomy | dominant | adult stage | progressive phenotype of trp^P365

(Huang et al., 2016)

Atg1^UAS.cSa, Scer\GAL4^Mhc.PW is a suppressor of visible phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2

(Wu et al., 2013)

Atg1^UAS.cSa, Scer\GAL4^Mhc.PW is a suppressor of visible phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG}

(Wu et al., 2013)

NOT Suppressor of

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^elav.PU is a non-suppressor of abnormal locomotor behavior | third instar larval stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg1^UAS.cSa, Scer\GAL4^ey.PU is a non-suppressor of partially lethal - majority die phenotype of Rrp4^KK108526, Scer\GAL4^ey.PU

(Yang et al., 2020)

Other

Statement

Reference

Atg1^UAS.cSa, Hsap\MAPT^UAS.cAa, Scer\GAL4^{elav.Switch.PO} has increased rate of adult locomotory behavior | progressive | RU486 conditional phenotype

(Chatterjee et al., 2023)

Atg1^UAS.cSa, Chchd2^S81L.UAS, Scer\GAL4^GMR.PU has lethal phenotype

(Baek et al., 2021)

Atg1^UAS.cSa, LamC^UAS.cSa, Scer\GAL4^HCH.Hand has short lived phenotype

(Bhide et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Psc^HMS01706, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by LUBEL^KK106140, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by eff^GL00355, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by slmb^HMS00946, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Pcf11^HMS00406, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has autophagosome | larval stage phenotype, enhanceable by Pcf11^HMS00406, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye disc phenotype, enhanceable by Pcf11^HMS00406, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa has eye phenotype, enhanceable by mask^UAS.cZa/Scer\GAL4^GMR.PU

(Zhu et al., 2017)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, enhanceable by hiw[+]/hiw^EMS

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, enhanceable by hiw[+]/hiw^EMS

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, enhanceable by hiw^EMS

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, enhanceable by hiw^EMS

(Shen and Ganetzky, 2009)

NOT Enhanced by

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Rnf11^HMJ22085, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, LamC^UAS.cSa, Scer\GAL4^HCH.Hand has adult heart phenotype, non-enhanceable by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, LamC^UAS.cSa, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype, non-enhanceable by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, LamC^UAS.cSa, Scer\GAL4^HCH.Hand has nuclear envelope | adult stage phenotype, non-enhanceable by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, LamC^UAS.cSa, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype, non-enhanceable by cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa has eye phenotype, non-enhanceable by mask^HMS01045/Scer\GAL4^GMR.PU

(Zhu et al., 2017)

Suppressed by

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^elav-C155 has NMJ bouton | increased number | larval stage phenotype, suppressible by Pdzd8[+]/Pdzd8^KO

(Thakur and O'Connor-Giles, 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by sip3^HMJ23236, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible by CstF64^GD9942, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible by Wdr33^HMC03936, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible by Cpsf160^GL01166, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Atg9^GD2029, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Cpsf6^HMS00113, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by CstF64^GD9942, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Wdr33^HMC03936, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Cpsf160^GL01166, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has autophagosome | larval stage phenotype, suppressible by Atg9^GD2029, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has autophagosome | larval stage phenotype, suppressible by Cpsf6^HMS00113, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has autophagosome | larval stage phenotype, suppressible by CstF64^GD9942, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has autophagosome | larval stage phenotype, suppressible by Wdr33^HMC03936, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has autophagosome | larval stage phenotype, suppressible by Cpsf160^GL01166, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible by Atg9^GD2029, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible by Cpsf6^HMS00113, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF, trp^P365 has rhabdomere of eye photoreceptor cell | adult stage | progressive phenotype, suppressible by Pink1^B9

(Huang et al., 2016)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF, trp^P365 has rhabdomere of eye photoreceptor cell | adult stage | progressive phenotype, suppressible by park¹/park¹

(Huang et al., 2016)

Atg1^UAS.cSa, Scer\GAL4^elav-C155 has synapse phenotype, suppressible by Rae1^UAS.Tag:TAP, Scer\GAL4^elav-C155

(Tian et al., 2011)

Atg1^UAS.cSa, Scer\GAL4^elav-C155 has NMJ bouton phenotype, suppressible by Rae1^UAS.Tag:TAP, Scer\GAL4^elav-C155

(Tian et al., 2011)

Atg1^UAS.cSa, Scer\GAL4^elav-C155 has embryonic/larval neuromuscular junction phenotype, suppressible by Rae1^UAS.Tag:TAP, Scer\GAL4^elav-C155

(Tian et al., 2011)

Atg1^UAS.cSa, Scer\GAL4^Kr.PM, Scer\GAL4^{Orct2-cald-GAL4} has amnioserosa phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^Kr.PM, Scer\GAL4^{Orct2-cald-GAL4}

(Mohseni et al., 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, suppressible by wnd¹

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, suppressible by wnd¹

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, suppressible | partially by wnd[+]/wnd¹

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, suppressible | partially by wnd[+]/wnd¹

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, suppressible by hiw^UAS.fl, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, suppressible by hiw^UAS.fl, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, suppressible by Atg18a^Δ585/Atg18[+]

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, suppressible by Atg18a^Δ585/Atg18[+]

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, suppressible by Atg18a^Δ585

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, suppressible by Atg18a^Δ585

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^NP2610-3-1 has embryonic/larval tracheal section phenotype, suppressible | partially by foxo^UAS.GFP, Scer\GAL4^NP2610-3-1

(Wagner et al., 2009)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^GMR.PF

(Scott et al., 2007)

Atg1^UAS.cSa, Scer\GAL4^hs.PH has fat body phenotype, suppressible by gig¹⁰⁹/gig¹⁹²

(Scott et al., 2007)

NOT suppressed by

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Rnf11^HMJ22085, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa has eye phenotype, non-suppressible by mask^HMS01045/Scer\GAL4^GMR.PU

(Zhu et al., 2017)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, non-suppressible by nwk^UAS.cCa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, non-suppressible by nwk^UAS.cCa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, non-suppressible by S6k^STDE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, non-suppressible by S6k^STDE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, non-suppressible by S6k^STDETE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, non-suppressible by S6k^STDETE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, non-suppressible by S6k^TE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, non-suppressible by S6k^TE.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has NMJ bouton phenotype, non-suppressible by S6k^KQ.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Atg1^UAS.cSa, Scer\GAL4^elav.PLu has neuromuscular junction phenotype, non-suppressible by S6k^KQ.UAS, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Enhancer of

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, Ube4A^GD7188

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Cul4^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Prp19^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Atg1^UAS.cSa/Scer\GAL4^Act5C.PP is an enhancer of fat body | somatic clone phenotype of mTor^ΔP

(Scott et al., 2007)

NOT Enhancer of

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^elav.PU is a non-enhancer of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg1^UAS.cSa, Scer\GAL4^elav.PU is a non-enhancer of microtubule | third instar larval stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a non-enhancer of adult heart phenotype of LamC^UAS.cSa, Scer\GAL4^HCH.Hand, cnc^RNAi.UAS.cUa

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a non-enhancer of nucleus | adult stage phenotype of LamC^UAS.cSa, Scer\GAL4^HCH.Hand, cnc^RNAi.UAS.cUa

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a non-enhancer of nuclear envelope | adult stage phenotype of LamC^UAS.cSa, Scer\GAL4^HCH.Hand, cnc^RNAi.UAS.cUa

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a non-enhancer of myofibril | adult stage phenotype of LamC^UAS.cSa, Scer\GAL4^HCH.Hand, cnc^RNAi.UAS.cUa

(Bhide et al., 2018)

Suppressor of

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^esg.PU is a suppressor of intestinal stem cell | increased number | adult stage phenotype of AsnS^HMS01481, Scer\GAL4^esg.PU

(Luo et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^esg.PU is a suppressor of adult gut phenotype of AsnS^HMS01481, Scer\GAL4^esg.PU

(Luo et al., 2025)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, yki^{S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Atg1^UAS.cSa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, yki^{S74.S168A.UAS.Tag:FLAG}

(Tyra et al., 2020)

Atg1^UAS.cSa, Scer\GAL4^ey.PU is a suppressor | partially of eye phenotype of Rrp4^KK108526, Scer\GAL4^ey.PU

(Yang et al., 2020)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a suppressor | partially of adult heart | progressive phenotype of LamC^R205W.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a suppressor | partially of myofibril | adult stage phenotype of LamC^R205W.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a suppressor | partially of adult heart phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a suppressor | partially of nucleus | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a suppressor | partially of nuclear envelope | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a suppressor | partially of myofibril | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a suppressor | partially of adult abdominal fat mass phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^HCH.Hand is a suppressor | partially of lipid droplet | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand is a suppressor of adult heart phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand is a suppressor of nucleus | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand is a suppressor of nuclear envelope | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand is a suppressor of myofibril | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand is a suppressor of adult abdominal fat mass phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa/cnc^RNAi.UAS.cUa, Scer\GAL4^HCH.Hand is a suppressor of lipid droplet | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^HCH.Hand

(Bhide et al., 2018)

Atg1^UAS.cSa, Scer\GAL4^NP0001 is a suppressor of adult midgut epithelium phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

Atg1^UAS.cSa/Scer\GAL4^GMR.PF is a suppressor of rhabdomere of eye photoreceptor cell | adult stage | progressive phenotype of trp^P365

(Huang et al., 2016)

Atg1^UAS.cSa/Scer\GAL4^GMR.PF is a suppressor of mitochondrion | adult stage | progressive phenotype of trp^P365

(Huang et al., 2016)

Atg1^UAS.cSa, Scer\GAL4^Mhc.PW is a suppressor of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2

(Wu et al., 2013)

Atg1^UAS.cSa, Scer\GAL4^Mhc.PW is a suppressor of mitochondrion phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2

(Wu et al., 2013)

Atg1^UAS.cSa, Scer\GAL4^Mhc.PW is a suppressor of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG}

(Wu et al., 2013)

Atg1^UAS.cSa, Scer\GAL4^Mhc.PW is a suppressor of mitochondrion phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG}

(Wu et al., 2013)

Scer\GAL4^fkh.PH/Atg1^UAS.cSa is a suppressor of embryonic/larval salivary gland phenotype of drpr^Δ5

(McPhee et al., 2010)

NOT Suppressor of

Statement

Reference

Atg1^UAS.cSa, Scer\GAL4^elav.PU is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Atg1^UAS.cSa, Scer\GAL4^elav.PU is a non-suppressor of microtubule | third instar larval stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Other

Statement

Reference

Atg1^UAS.cSa, LamC^UAS.cSa, Scer\GAL4^HCH.Hand has adult heart phenotype

(Bhide et al., 2018)

Atg1^UAS.cSa, LamC^UAS.cSa, Scer\GAL4^HCH.Hand has myofibril | adult stage phenotype

(Bhide et al., 2018)

Atg1^UAS.cSa, LamC^UAS.cSa, Scer\GAL4^HCH.Hand has nucleus | adult stage phenotype

(Bhide et al., 2018)

Atg1^UAS.cSa, LamC^UAS.cSa, Scer\GAL4^HCH.Hand has nuclear envelope | adult stage phenotype

(Bhide et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Atg1^Scer\UAS.cSa suppresses the increased midgut cell size resulting from the adulthood-only expression of Atg9^HMS01246 under the control of Scer\GAL4^{Myo31DF-NP0001}.

(Wen et al., 2017)

The pupariation delay and increased pupal size observed in flies expressing Npc1a^KK101077 under the Scer\GAL4^P0206 driver is rescued by simultaneous co-expression of Atg1^Scer\UAS.cSa and Atg13^Scer\UAS.cCa.

(Danielsen et al., 2016)

Expression of Atg1^Scer\UAS.cSa driven by Scer\GAL4^GMR.PF (to induce autophagy) partially suppresses age-dependent retinal degeneration (loss of rhabdomeres from photoreceptors) and restores mitochondrial morphology in trp^P365/+ flies. Pink1^B9 suppresses the ability of Scer\GAL4^GMR.PF>Atg1^Scer\UAS.cSa to suppress age-dependent retinal degeneration (loss of rhabdomeres from photoreceptors) in trp^P365/+ flies.

(Huang et al., 2016)

The ability of rictor^Δ2 to enhance the abnormal wing posture and mitochondrial aggregation phenotypes seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is blocked by co-expression of Atg1^Scer\UAS.cSa.

The ability of trc^{K122A.Scer\UAS.T:Zzzz\FLAG} to enhance the abnormal wing posture and mitochondrial aggregation phenotypes seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is blocked by co-expression of Atg1^Scer\UAS.cSa.

(Wu et al., 2013)

Atg1^Scer\UAS.cSa-induced synaptic overgrowth is suppressed by coexpression of Rae1^{Scer\UAS.T:Zzzz\TAP} (where both are expressed presynaptically under the control of Scer\GAL4^elav-C155).

(Tian et al., 2011)

Expression of Atg1^Scer\UAS.cSa in the salivary glands under the control of Scer\GAL4^fkh.PH in drpr^Δ5 mutant animals completely suppresses the persistent salivary gland tissue phenotype.

(McPhee et al., 2010)

Clonal expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Act5C.PP in a Atg13^unspecified background inhibits cell growth.

(Chang and Neufeld, 2009)

A wnd¹ heterozygous background partially suppresses the high levels of autophagy and bouton number found upon expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^elav.PLu. A wnd¹ homozygous background completely suppresses the neuromuscular junction overgrowth phenotype.

Expression of bsk^DN.Scer\UAS under the control of Scer\GAL4^elav.PLu partially suppresses the high levels of autophagy and bouton number found upon expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^elav.PLu.

Co-expression of hiw^Scer\UAS.fl with Atg1^Scer\UAS.cSa, under the control of Scer\GAL4^elav.PLu significantly suppresses Atg1^Scer\UAS.cSa-mediated neuromuscular junction overgrowth.

Co-expression of nwk^Scer\UAS.cCa with Atg1^Scer\UAS.cSa, under the control of Scer\GAL4^elav.PLu fails to suppress Atg1^Scer\UAS.cSa-mediated neuromuscular junction overgrowth.

A hiw^EMS heterozygous or homozygous background significantly enhances the high levels of autophagy and bouton number found upon expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^elav.PLu.

A Atg18^Δ585 heterozygous background significantly suppresses neuromuscular junction overgrowth caused by neuronal expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^elav.PLu. Removal of both copies of Atg18 confers almost complete suppression.

Co-expression of S6k^{STDE.Scer\UAS} under the control of Scer\GAL4^elav.PLu, fails to suppress the neuromuscular junction overgrowth phenotype found upon expression of Atg1^Scer\UAS.cSa.

Co-expression of S6k^{STDETE.Scer\UAS} under the control of Scer\GAL4^elav.PLu, fails to suppress the neuromuscular junction overgrowth phenotype found upon expression of Atg1^Scer\UAS.cSa.

Co-expression of S6k^TE.Scer\UAS under the control of Scer\GAL4^elav.PLu, fails to suppress the neuromuscular junction overgrowth phenotype found upon expression of Atg1^Scer\UAS.cSa.

Co-expression of S6k^KQ.Scer\UAS under the control of Scer\GAL4^elav.PLu, fails to suppress the neuromuscular junction overgrowth phenotype found upon expression of Atg1^Scer\UAS.cSa.

(Shen and Ganetzky, 2009)

Co-expression of foxo^{Scer\UAS.cWa.T:Avic\GFP} rescues the Atg1^Scer\UAS.cSa Scer\GAL4^NP2610-3-1 phenotype, rescuing larval lethality almost completely to adulthood, though the larval tracheas show some abnormalities, such as a slight thickening of the epithelium.

(Wagner et al., 2009)

The partial lethality and reduced eye size caused by expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^GMR.PF is rescued by co-expression of th^Scer\UAS.cHa.

The induction of autophagy caused by expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^hs.PH is suppressed by Aut1¹⁰/Df(3L)Cat.

The induction of cell death caused by expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Cg.PA in the fat body is suppressed by Aut1¹⁰/Aut1¹⁰.

(Scott et al., 2007)

The induction of autophagy caused by expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^hs.PH is significantly suppressed by Atg8a^KG07569.

The elimination of cells expressing Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Act5C.PP from the wing disc is significantly reduced in a Atg8a^KG07569 background.

The induction of autophagy in the fat body of normally fed animals that is caused by expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^hs.PH is significantly reduced if the animals are also carrying gig¹⁰⁹/gig¹⁹².

The elimination of cells expressing Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Act5C.PP from the wing disc is delayed by co-expression of Rheb^AV4.

Expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Act5C.PP in Tor^ΔP clones in the fat body results in a further decrease in cells size compared to Tor^ΔP single mutant clones.

(Scott et al., 2007)

Xenogenetic Interactions

Statement

Reference

The premature amnioserosa dissociation and dorsal closure defects seen in 2X Atg1^Scer\UAS.cSa Scer\GAL4^{Orct2-cald-GAL4} Scer\GAL4^Kr.PM embryos are completely suppressed by co-expression of BacA\p35^Scer\UAS.cHa.

(Mohseni et al., 2009)

The partial lethality caused by expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^GMR.PF is rescued by co-expression of BacA\p35^Scer\UAS.cHa.

(Scott et al., 2007)

Co-expression of BacA\p35^Scer\UAS.cHa delays the death of cells expressing Atg1^Scer\UAS.cSa under the control of Scer\GAL4^Act5C.PP in clones in the wing disc, although these cells are eventually eliminated from the disc.

(Scott et al., 2007)

Complementation and Rescue Data

Rescues

Atg1^UAS.cSa/Scer\GAL4^elav.PLu rescues Atg1^Δ3D

(Shen and Ganetzky, 2009)

Partially rescues

Scer\GAL4^hs.PH/Atg1^UAS.cSa partially rescues Atg1^Δ3D

(Scott et al., 2007)

Fails to rescue

Atg1^UAS.cSa/Scer\GAL4^{Atg1-MI07056-TG4.0} fails to rescue Atg1^{MI07056-TG4.0}/Df(3L)BSC613

(Lee et al., 2018)

Comments

The lethality of Atg1^Δ3D homozygotes is partially rescued (to 34% viability) by expression of Atg1^Scer\UAS.cSa under the control of Scer\GAL4^hs.PH in the absence of heat shock.

Atg1^Δ3D homozygous larvae expressing Atg1^Scer\UAS.cSa under the control of Scer\GAL4^hs.PH in the absence of heat shock show no detectable autophagy when well fed, whereas starvation of these animals induces autophagy, indicating that starvation-induced autophagy is rescued.

(Scott et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

51654

y¹ w^*; P{UAS-Atg1.S}6A

51655

y¹ w^*; P{UAS-Atg1.S}6B

Notes on Origin

Discoverer