FlyBase Allele Report: Dmel\Wdr45[KO]

General Information

Symbol

Dmel\Wdr45^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0411029

Feature type

allele

Associated gene

Dmel\Wdr45

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Celle et al., 2026)

Progenitor genotype

Cytology

Description

7bp deletion within Wdr45 (nucleotides 222-229) that results in a frameshift and premature stop codon.

(Celle et al., 2026)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

commissure | embryonic stage

(Celle et al., 2026)

embryonic/larval neuromuscular junction | larval stage

(Celle et al., 2026)

larval intersegmental nerve | embryonic stage

(Celle et al., 2026)

larval segmental nerve | embryonic stage

(Celle et al., 2026)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Wdr45^KO has decreased rate of adult locomotory behavior | recessive | progressive phenotype, non-enhanceable by Scer\GAL4^elav.PU/Hsap\LAMP2^UAS.cIa

(Celle et al., 2026)

Wdr45^KO has decreased rate of adult locomotory behavior | recessive | progressive phenotype, non-enhanceable by Scer\GAL4^elav.PU/Atg1^UAS.cSa

(Celle et al., 2026)

Suppressed by

Statement

Reference

Wdr45^KO has decreased rate of adult locomotory behavior | recessive | progressive phenotype, suppressible by Scer\GAL4^elav.PU/Hsap\WDR45^UAS.Tag:HA

(Celle et al., 2026)

Wdr45^KO has bang sensitive | codominant phenotype, suppressible by Scer\GAL4^elav.PU/Hsap\LAMP2^UAS.cIa

(Celle et al., 2026)

Wdr45^KO has short lived | semidominant phenotype, suppressible by Scer\GAL4^elav.PU/Hsap\LAMP2^UAS.cIa

(Celle et al., 2026)

Wdr45^KO has bang sensitive | codominant phenotype, suppressible by Scer\GAL4^elav.PU/Atg1^UAS.cSa

(Celle et al., 2026)

Wdr45^KO has short lived | semidominant phenotype, suppressible by Scer\GAL4^elav.PU/Atg1^UAS.cSa

(Celle et al., 2026)

NOT suppressed by

Statement

Reference

Wdr45^KO has decreased rate of adult locomotory behavior | recessive | progressive phenotype, non-suppressible by Scer\GAL4^elav.PU/Hsap\LAMP2^UAS.cIa

(Celle et al., 2026)

Wdr45^KO has decreased rate of adult locomotory behavior | recessive | progressive phenotype, non-suppressible by Scer\GAL4^elav.PU/Atg1^UAS.cSa

(Celle et al., 2026)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Wdr45^KO is rescued by Wdr45^UAS.GFP/Scer\GAL4^elav.PU

(Celle et al., 2026)

Wdr45^KO is rescued by Wdr45^UAS.GFP/Scer\GAL4^{Wdr45-CR70359-KO-kG4}

(Celle et al., 2026)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Wdr45^KO

dwdr45^KO

(Celle et al., 2026)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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