FlyBase Allele Report: Dmel\LUBEL[KK106140]

FB2025_05 , released December 11, 2025

FB2025_05 , released December 11, 2025

Allele: Dmel\LUBEL^KK106140

General Information

Symbol

Dmel\LUBEL^KK106140

Species

D. melanogaster

Name

FlyBase ID

FBal0234020

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Also Known As

UAS-LUBEL RNAi

Key Links

Genomic Maps

Transgenic product class

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^2xAPP.SP.UAS

(Choi et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^Mhc.PU

(Lee et al., 2021)

increased cell size | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Umargamwala et al., 2025)

increased size | adult stage, with Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Phenotype Manifest In

dorsal longitudinal indirect flight muscle cell | adult stage, with Scer\GAL4^Mhc.PU

(Lee et al., 2021)

embryonic/larval midgut cell | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Umargamwala et al., 2025)

eye, with Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

LUBEL^KK106140, Scer\GAL4^GMR.PF is an enhancer of decreased size | adult stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

LUBEL^KK106140, Scer\GAL4^GMR.PF is an enhancer of abnormal eye color | adult stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

LUBEL^KK106140, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Phenotype Manifest In

Enhancer of

Statement

Reference

LUBEL^KK106140, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

v100651

P{KK106140}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG11321^KK106140

LUBEL^KK106140

LUi^KK

(Lee et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections