FlyBase Allele Report: Dmel\Wdr33[HMC03936]

General Information

Symbol

Dmel\Wdr33^HMC03936

Species

D. melanogaster

Name

FlyBase ID

FBal0294494

Feature type

allele

Associated gene

Dmel\Wdr33

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC03936}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC03936}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC03936

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of primary ovarian insufficiency

CEA

(Gorsi et al., 2022)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Tang et al., 2018)

female sterile, with Scer\GAL4^VP16.otu

(Yan and Perrimon, 2015)

lethal, with Scer\GAL4^nub-AC-62

(Yan and Perrimon, 2015)

lethal | female limited, with Scer\GAL4^dome-PG14

(Yan and Perrimon, 2015)

Phenotype Manifest In

autophagosome | larval stage | somatic clone | conditional, with Scer\GAL4^Act.PU

(Tang et al., 2018)

embryonic/larval fat body | larval stage | somatic clone | conditional, with Scer\GAL4^Act.PU

(Tang et al., 2018)

Detailed Description

Statement

Reference

Larval fat body clones expressing Wdr33^HMC03936 under the control of Scer\GAL4^Act.PU show impaired induction of autophagosomes (identified as mCherry-Atg8 puncta) in response to starvation.

(Tang et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Wdr33^HMC03936, Scer\GAL4^GMR.PU is a suppressor of abnormal size | adult stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Wdr33^HMC03936, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

Wdr33^HMC03936, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Wdr33^HMC03936, Scer\GAL4^GMR.PU is a suppressor of autophagosome | larval stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Wdr33^HMC03936, Scer\GAL4^GMR.PU is a suppressor of eye disc phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PU

(Tang et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

55249

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03936}attP40

Notes on Origin

Discoverer

Comments

Supplemental Dataset_S01.

(Yan and Perrimon, 2015)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG1109^HMC03936

Wdr33^HMC03936

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close