FlyBase Allele Report: Dmel\S6k[STDE.UAS]

General Information

Symbol

Dmel\S6k^STDE.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0141553

Feature type

allele

Associated gene

Dmel\S6k

Associated Insertion(s)

Carried in Construct

P{UAS-S6k.STDE}

Also Known As

UAS-S6K.STDE, UAS-S6K^STDE, UAS-S6K-STDE

Key Links

Transgenic product class

missense_variant

(Barcelo and Stewart, 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Barcelo and Stewart, 2002)

Mutagen

in vitro construct

(Barcelo and Stewart, 2002)

Progenitor genotype

Carried in construct

P{UAS-S6k.STDE}

Cytology

Description

UASt regulatory sequences drive expression of a mutated form of S6k (carries the amino acid replacements S418D and T422E).

(Barcelo and Stewart, 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

S6k

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Liu and Lu, 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal feeding behavior, with Scer\GAL4^Ilp2.PW

(Wu et al., 2005)

abnormal neuroanatomy | P-stage, with Scer\GAL4^Tab2-201Y

(Rabinovich et al., 2016)

abnormal neurophysiology | larval stage, with Scer\GAL4^G14

(Penney et al., 2012)

visible, with Scer\GAL4^ap-md544

(Das et al., 2014, Barcelo and Stewart, 2002)

Phenotype Manifest In

adult mushroom body gamma-lobe | P-stage, with Scer\GAL4^Tab2-201Y

(Rabinovich et al., 2016)

axon | P-stage, with Scer\GAL4^Tab2-201Y

(Rabinovich et al., 2016)

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^G14

(Penney et al., 2012)

wing, with Scer\GAL4^ap-md544

(Das et al., 2014, Barcelo and Stewart, 2002)

Detailed Description

Statement

Reference

Expression of S6k^{STDE.Scer\UAS} under the control of Scer\GAL4^Tab2-201Y leads to a significant increase in axonal regrowth of mushroom body gamma neurons in P-stage brains cultured ex vivo.

(Rabinovich et al., 2016)

Expression of S6k^{STDE.Scer\UAS} under the control of Scer\GAL4^ap-md544 results in a bending downward of the wing blade.

(Das et al., 2014)

Expression via Scer\GAL4^wor.PA and Scer\GAL80^ase.PN does not prevent the normal shrinkage and disappearance of pupal neuroblasts.

(Homem et al., 2014)

Expression of S6k^{STDE.Scer\UAS} under the control of Scer\GAL4^elav.PLu has little effect on neuromuscular junction growth.

(Shen and Ganetzky, 2009)

S6k^{STDE.Scer\UAS} expression, under the control of Scer\GAL4^Ilp2 in fasted third instar larvae results in an attenuated feeding response to both liquid and solid foods. No significant difference was observed in the size or developmental rate of mutant larvae to wild-type controls.

(Wu et al., 2005)

Expression of S6k^{STDE.Scer\UAS} under the control of Scer\GAL4^ap-md544 results in wings which bend down (the wings bend down more than in flies expressing S6k^Scer\UAS.cMa under the control of Scer\GAL4^ap-md544).

(Barcelo and Stewart, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

S6k^STDE.UAS, Scer\GAL4^G14 has abnormal neurophysiology | larval stage phenotype, suppressible by eIF4E1^S058911/eIF4E1[+]

(Penney et al., 2012)

Suppressor of

Statement

Reference

S6k^STDE.UAS/Scer\GAL4^Tab2-201Y is a suppressor | partially of abnormal neuroanatomy | somatic clone phenotype of Eip75B^Δ51

(Rabinovich et al., 2016)

S6k^STDE.UAS/Scer\GAL4^Tab2-201Y is a suppressor | partially of abnormal neuroanatomy | somatic clone phenotype of Hr51^LL04325

(Yaniv et al., 2012)

NOT Suppressor of

Statement

Reference

S6k^STDE.UAS, Scer\GAL4^elav.PLu is a non-suppressor of abnormal neuroanatomy phenotype of Atg1^UAS.cSa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

S6k^STDE.UAS, Scer\GAL4^elav.PLu is a non-suppressor of increased cell growth rate phenotype of Atg1^UAS.cSa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

S6k^STDE.UAS, Scer\GAL4^G14 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible by eIF4E1^S058911/eIF4E1[+]

(Penney et al., 2012)

NOT suppressed by

Statement

Reference

S6k^STDE.UAS, Scer\GAL4^e16A has wing hair phenotype, non-suppressible by trbl^UAS.Tag:FLAG, Scer\GAL4^e16A

(Das et al., 2014)

Suppressor of

Statement

Reference

S6k^STDE.UAS/Scer\GAL4^Tab2-201Y is a suppressor | partially of adult mushroom body gamma-lobe | somatic clone | adult stage phenotype of Eip75B^Δ51

(Rabinovich et al., 2016)

S6k^STDE.UAS/Scer\GAL4^Tab2-201Y is a suppressor | partially of gamma Kenyon cell | somatic clone phenotype of Hr51^LL04325

(Yaniv et al., 2012)

NOT Suppressor of

Statement

Reference

S6k^STDE.UAS, Scer\GAL4^elav.PLu is a non-suppressor of NMJ bouton phenotype of Atg1^UAS.cSa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

S6k^STDE.UAS, Scer\GAL4^elav.PLu is a non-suppressor of neuromuscular junction phenotype of Atg1^UAS.cSa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Other

Statement

Reference

Hr51^LL04325, S6k^STDE.UAS, Scer\GAL4^Tab2-201Y has alpha/beta Kenyon cell | somatic clone phenotype

(Yaniv et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of S6k^{STDE.Scer\UAS} under the control of Scer\GAL4^Tab2-201Y partially rescues the gamma lobe regrowth defects of Eip75B^Δ51/Eip75B^Δ51 mushroom body neuron clones.

(Rabinovich et al., 2016)

Expression of trbl^{Scer\UAS.T:Zzzz\FLAG} suppresses the bending downward of the wing blade seen when S6k^{STDE.Scer\UAS} is expressed under the control of Scer\GAL4^ap-md544, resulting in a flat wing blade.

(Das et al., 2014)

Expression of S6k^{STDE.Scer\UAS} in Hr51^LL04325 MARCM neuroblast clones partially suppresses the developmental regrowth defect. In these clones, γ axons do not occupy the entire adult lobe but instead grow to the dorsal and ventral extremities of the adult γ-lobe and in some cases only to its ventral portion.

(Yaniv et al., 2012)

Co-expression of S6k^{STDE.Scer\UAS} under the control of Scer\GAL4^elav.PLu, fails to suppress the neuromuscular junction overgrowth phenotype found upon expression of Atg1^Scer\UAS.cSa.

(Shen and Ganetzky, 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6913

w¹¹¹⁸; P{UAS-S6k.STDE}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

S6k^{STDE.Scer\UAS}

S6k^STDE.UAS

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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