FlyBase Allele Report: Dmel\eIF4E1[S058911]

General Information

Symbol

Dmel\eIF4E1^S058911

Species

D. melanogaster

Name

FlyBase ID

FBal0120511

Feature type

allele

Associated gene

Dmel\eIF4E1

Associated Insertion(s)

P{lacW}eIF4E1^S058911

Carried in Construct

Also Known As

eIF4E^S058911, eIF4E^589/11

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Deak et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{lacW}eIF4E1^S058911

Cytology

Description

Insertion of P{lacW} at nucleotide position +1140 (coordinates according to FBrf0088373).

(Lachance et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:9,401,331..9,401,331

(Wang et al., 2025, Calap-Quintana et al., 2015, Lachance et al., 2002, Szeged Stock Center, 1998-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Hsap\LRRK2^UAS.cVa

(Penney et al., 2016)

modeled by Lrrk^UAS.cIa

(Penney et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cyst progenitor cell | decreased number | somatic clone

(Wang et al., 2025)

ommatidium, with eIF4E1^{Ser251Ala.t8.9}

(Lachance et al., 2002)

wing, with eIF4E1^{Ser251Ala.t8.9}

(Lachance et al., 2002)

wing disc, with eIF4E1^{Ser251Ala.t8.9}

(Lachance et al., 2002)

wing disc, with eIF4E1^{Ser251Asp.t8.9}

(Lachance et al., 2002)

Detailed Description

Statement

Reference

Development is arrested in the first larval instar, although the larvae survive for several days. Developmental delay with eIF-4E^{Ser251Ala.t8.9} is 3 to 4 days.

(Lachance et al., 2002)

Early lethal.

(Szeged Stock Center, 1998-, Deak et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

eIF4E1^S058911/eIF4E1[+] is a suppressor of abnormal neurophysiology | third instar larval stage phenotype of Lrrk^UAS.cIa, Scer\GAL4^Mhc.PW

(Penney et al., 2016)

eIF4E1^S058911/eIF4E1[+] is a suppressor | partially of abnormal neurophysiology | third instar larval stage phenotype of Hsap\LRRK2^UAS.cVa, Scer\GAL4^Mhc.PW

(Penney et al., 2016)

eIF4E1^S058911/eIF4E1[+] is a suppressor of abnormal neurophysiology | larval stage phenotype of S6k^STDE.UAS, Scer\GAL4^G14

(Penney et al., 2012)

eIF4E1^S058911/eIF4E1[+] is a suppressor | partially of abnormal neurophysiology | larval stage phenotype of GluRIIA^SP16/Df(2L)cl-h4

(Penney et al., 2012)

eIF4E1^S058911/eIF4E1[+] is a suppressor of abnormal neurophysiology | larval stage phenotype of Scer\GAL4^G14, mTor^{WT.UAS.Tag:FLAG}

(Penney et al., 2012)

eIF4E1^S058911/eIF4E1^{Ser251Ala.t8.9}, Scer\GAL4^da.G32 is a suppressor of decreased body size phenotype of Lk6^EP30.18, Scer\GAL4^da.G32

(Reiling et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

eIF4E1^S058911/eIF4E1[+] is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Lrrk^UAS.cIa, Scer\GAL4^Mhc.PW

(Penney et al., 2016)

eIF4E1^S058911/eIF4E1[+] is a suppressor | partially of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Hsap\LRRK2^UAS.cVa, Scer\GAL4^Mhc.PW

(Penney et al., 2016)

eIF4E1^S058911/eIF4E1[+] is a suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of S6k^STDE.UAS, Scer\GAL4^G14

(Penney et al., 2012)

eIF4E1^S058911/eIF4E1[+] is a suppressor | partially of embryonic/larval neuromuscular junction | larval stage phenotype of GluRIIA^SP16/Df(2L)cl-h4

(Penney et al., 2012)

eIF4E1^S058911/eIF4E1[+] is a suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of Scer\GAL4^G14, mTor^{WT.UAS.Tag:FLAG}

(Penney et al., 2012)

eIF4E1^S058911/eIF-4E[+] is a suppressor of ovariole phenotype of bam^z3-2884/bam^Δ86

(Shen et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

eIF4E1^S058911/+ suppresses the increase in excitatory junction current amplitude and quantal content seen in larvae NMJs expressing Lrrk^Scer\UAS.cIa under the control of Scer\GAL4^Mhc.PW.

(Penney et al., 2016)

The eIF-4E^S058911 allele dominantly suppresses the bam^z3-2884/bam^Δ86 ovariole phenotype.

(Shen et al., 2009)

The small body phenotype caused by expression of Lk6^EP30.18 under the control of Scer\GAL4^da.G32 is not seen if the flies are also expressing eIF-4E^{Ser251Ala.t8.9} in a eIF-4E^S058911/eIF-4E^S058911 background.

(Reiling et al., 2005)

No reduction in pole cell number is seen in the progeny of vas^PH165/+ ; eIF-4E^S058911/+ females.

(Carrera et al., 2000)

Xenogenetic Interactions

Statement

Reference

eIF4E1^S058911/+ partially suppresses the increase in excitatory junction current amplitude and quantal content seen in larvae NMJs expressing Hsap\LRRK2^Scer\UAS.cVa under the control of Scer\GAL4^Mhc.PW.

(Penney et al., 2016)

Complementation and Rescue Data

Fails to complement

eIF4E1^S071513

(Lachance et al., 2002)

eIF4E1^67Af

(Lachance et al., 2002)

eIF4E1⁰⁷²³⁸

(Lachance et al., 2002)

Rescued by

eIF4E1^S058911 is rescued by eIF4E1^{Ser251Asp.t8.9}

(Lachance et al., 2002)

eIF4E1^S058911 is rescued by eIF4E1^+t8.9

(Lachance et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

8648

y¹ w^*; P{lacW}eIF4E1^S058911/TM3, Sb¹

8655

w^*; P{eIF4E1^Ser251Asp.8.9}2; P{lacW}eIF4E1^S058911

8654

w^*; P{eIF4E1^Ser251Ala.8.9}2/CyO; P{lacW}eIF4E1^S058911/TM3, Sb¹

Notes on Origin

Discoverer

Comments

Relatively strong allele.

(Lachance et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

0589/11

(Deak et al., 1997)

eIF-4E^589/11

(Lachance et al., 2002)

eIF-4E^LOF

(Calap-Quintana et al., 2015)

eIF-4E^S058911

eIF-4e^S058911

(Calap-Quintana et al., 2015)

eIF4E1^S058911

(Wang et al., 2025)

eIF4E1^s058911

(Rode et al., 2018)

eIF4E^589/11

(Reiling et al., 2005, Carrera et al., 2000)

eIF4E^S058911

(Shen et al., 2009)

eIF4E^s058911

(Rode et al., 2018, Penney et al., 2016, Penney et al., 2012)

l(3)589/11

(Lachance et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections