FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\eIF4E1
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General Information
Symbol
Dmel\eIF4E1
Species
D. melanogaster
Name
eukaryotic translation initiation factor 4E1
Annotation Symbol
CG4035
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015218
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Summary
eukaryotic translation initiation factor 4E1 (eIF4E1) encodes a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. The product of eIF4E1 binds the 7-methyl-guanosine cap structure of mRNA. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

eIF4E, eIF-4E, eIF4E-1, eIF4E-2, deIF4E

Key Links
Genomic Location
Cytogenetic map
67B4-67B4
Sequence location
Recombination map
3-29
RefSeq locus
NT_037436 REGION:9399618..9402460
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
enables eukaryotic initiation factor 4G binding
inferred from physical interaction with FLYBASE:eIF4G1; FB:FBgn0023213
(Hernandez et al., 2005, Hernandez et al., 1998)
enables protein binding
inferred from physical interaction with UniProtKB:Q9VD44
(Kwak et al., 2008)
inferred from physical interaction with FLYBASE:Thor; FB:FBgn0261560
(Hernandez et al., 2005)
enables RNA 7-methylguanosine cap binding
inferred from direct assay
(Hernandez et al., 2012, Cho et al., 2005, Hernandez et al., 2005, Zapata et al., 1994)
enables RNA cap binding
inferred from direct assay
(Lavoie et al., 1996)
enables translation initiation factor activity
inferred from genetic interaction with SGD:S000005499
(Hernandez et al., 2005)
inferred from direct assay
(Lavoie et al., 1996)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables RNA 7-methylguanosine cap binding
inferred from biological aspect of ancestor with PANTHER:PTN000238660
(GO Reference Genome Project, 2011-)
enables RNA binding
inferred from electronic annotation with InterPro:IPR001040, InterPro:IPR019770
(InterPro Project Members, 2004-)
enables translation initiation factor activity
inferred from electronic annotation with InterPro:IPR001040, InterPro:IPR019770
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with MGI:MGI:95305
(Hernandez and Sierra, 1995)
inferred from sequence or structural similarity with UniProtKB:P06730
(Hernandez and Sierra, 1995)
inferred from biological aspect of ancestor with PANTHER:PTN000238660
(GO Reference Genome Project, 2011-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in RNA metabolic process
inferred from direct assay
(Lavoie et al., 1996)
involved_in translational initiation
inferred from direct assay
(Lavoie et al., 1996)
inferred from genetic interaction with SGD:S000005499
(Hernandez et al., 2005)
involved_in translation
inferred from direct assay
(Zapata et al., 1994)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in translational initiation
inferred from electronic annotation with InterPro:IPR001040, InterPro:IPR019770
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000238660
(GO Reference Genome Project, 2011-)
involved_in translation
inferred from sequence or structural similarity with MGI:MGI:95305
(Hernandez and Sierra, 1995)
inferred from sequence or structural similarity with UniProtKB:P06730
(Hernandez and Sierra, 1995)
Cellular Component (8 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Cohen et al., 2001)
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in cytosol
inferred from direct assay
(Ottone et al., 2011, Sigrist et al., 2000)
part_of eukaryotic translation initiation factor 4F complex
inferred from direct assay
(Igreja et al., 2014, Zapata et al., 1994)
inferred from physical interaction with FLYBASE:eIF4G1; FB:FBgn0023213
(Hernandez et al., 2005)
is_active_in muscle cell postsynaptic specialization
inferred from direct assay
(Menon et al., 2004)
is_active_in neuromuscular junction
inferred from direct assay
(Menon et al., 2004)
located_in neuronal ribonucleoprotein granule
inferred from direct assay
(Barbee et al., 2006)
located_in nuclear body
inferred from direct assay
(Cohen et al., 2001)
located_in P-body
inferred from direct assay
(Liu and Gall, 2007)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from electronic annotation with InterPro:IPR019770
(InterPro Project Members, 2004-)
located_in cytosol
inferred from sequence or structural similarity with MGI:MGI:95305
(Hernandez and Sierra, 1995)
inferred from sequence or structural similarity with UniProtKB:P06730
(Hernandez and Sierra, 1995)
part_of eukaryotic translation initiation factor 4F complex
non-traceable author statement
(Hernandez et al., 1997)
inferred from biological aspect of ancestor with PANTHER:PTN000238660
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the eukaryotic initiation factor 4E family. (P48598)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
eukaryotic translation initiation factor 4E1 (eIF4E1) encodes a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. The product of eIF4E1 binds the 7-methyl-guanosine cap structure of mRNA. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
CYTOPLASMIC TRANSLATION INITIATION FACTORS -
Cytoplasmic (or eukaryotic) translation initiation factors function in the initiation stage of ribosome-mediated translation in the cytoplasm. (Adapted from FBrf0233552 and PMID:20094052).
EIF4E-CUP COMPLEX -
The eIF4E-cup complex is a cytoplasmic translational repression complex. (Adapted from FBrf0167488.)
Protein Function (UniProtKB)
Recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:8663200). In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934).
(UniProt, P48598)
Summary (Interactive Fly)

binds to the mRNA 5' cap thus controlling a crucial step in translation initiation - required for cell growth - promotes dedifferentiation of neuroblasts back to a stem cell-like state thus functioning as an oncogene - a target of Ago2 in translational repression - functions as a splice factor for msl-2 and Sxl pre-mRNAs

Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\eIF4E1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P48598)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
eIF4E1-RA
FBtr0076490
NM_168334
1430
259
eIF4E1-RB
FBtr0076487
NM_080090
1484
259
eIF4E1-RC
FBtr0076488
NM_168333
1156
248
eIF4E1-RD
FBtr0076489
NM_168335
1723
259
eIF4E1-RE
FBtr0076492
NM_168336
1524
259
eIF4E1-RF
FBtr0076493
NM_168337
1452
259
eIF4E1-RG
FBtr0076491
NM_168338
1358
259
eIF4E1-RH
FBtr0333884
NM_001274697
1492
259
eIF4E1-RI
FBtr0333885
NM_001274698
1793
259
Additional Transcript Data and Comments
Reported size (kB)

2.0, 1.7, 1.4 (northern blot)

(Lavoie et al., 1996)

2.0, 1.5, 1.2 (northern blot)

(Hernandez and Sierra, 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
eIF4E1-PA
FBpp0076218
29.2
259
6.17
P48598
NP_729481
AAF50283
eIF4E1-PB
FBpp0076215
29.2
259
6.17
P48598
NP_524829
AAF50282
eIF4E1-PC
FBpp0076216
27.8
248
5.04
NP_729480
AAF50281
eIF4E1-PD
FBpp0076217
29.2
259
6.17
P48598
NP_729482
AAN11963
eIF4E1-PE
FBpp0076220
29.2
259
6.17
P48598
NP_729483
AAN11964
eIF4E1-PF
FBpp0076221
29.2
259
6.17
P48598
NP_729484
AAN11965
eIF4E1-PG
FBpp0076219
29.2
259
6.17
P48598
NP_729485
AAN11966
eIF4E1-PH
FBpp0306016
29.2
259
6.17
P48598
NP_001261626
AGB94321
eIF4E1-PI
FBpp0306017
29.2
259
6.17
P48598
NP_001261627
AGB94322
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

259 aa isoforms: eIF4E1-PA, eIF4E1-PB, eIF4E1-PD, eIF4E1-PE, eIF4E1-PF, eIF4E1-PG, eIF4E1-PH, eIF4E1-PI
Additional Polypeptide Data and Comments
Reported size (kDa)

259, 248 (aa)

(Hernandez et al., 1997)

248 (aa)

(Lavoie et al., 1996)

259 (aa); 29 (kD)

(Hernandez and Sierra, 1995)

35 (kD)

(Maroto and Sierra, 1989)
Comments
External Data
Subunit Structure (UniProtKB)

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E1 and eIF4G1 (PubMed:25702871). Recruited by cup in oocytes and in early embryos, preventing the interaction with eIF4G (PubMed:14685270, PubMed:14691132, PubMed:14723848, PubMed:22832024, PubMed:26294658). The interaction with cup therefore prevents the translation of key transcripts such as oskar (osk) and nanos (nos) in some regions in the early embryo (PubMed:14685270, PubMed:14691132, PubMed:14723848, PubMed:22832024, PubMed:26294658). Interacts with mxt (PubMed:23716590, PubMed:26294658). Interacts with 4E-T and Thor (PubMed:11389445, PubMed:14645523, PubMed:25702871, PubMed:26294658). Forms a RNP containing at least me31B, eIF4E1, cup, tral and pAbp; this interaction is required for the translational silencing of maternal mRNAs during the maternal-to-zygotic transition (PubMed:28875934).

(UniProt, P48598)
Post Translational Modification

Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.

(UniProt, P48598)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF4E1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.20

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Hernandez et al., 1997)
larval somatic muscle cell
(Hernandez et al., 1997)
embryonic/larval salivary gland
(Hernandez et al., 1997)
larval digestive system
(Hernandez et al., 1997)
posterior midgut primordium
(Hernandez et al., 1997)
anterior midgut primordium
(Hernandez et al., 1997)
primordial germ cell
(Hernandez et al., 1997)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Hernandez and Sierra, 1995)
Additional Descriptive Data

eIF4E1 transcripts are expressed throughout embryogenesis in all cells. They accumulate at higher levels in some tissues at certain developmental stages. Transcripts preferentially accumulate in the pole cells from early stages up through germ band extension. Transcripts accumulate at high levels in the endodermal primordia that will give rise to the anterior and posterior midguts as well as in the mesodermal layer and the salivary gland primordia. At later stages, high expression is observed in the endodermal layer of the gut and in th somatic muscle.

(Hernandez et al., 1997)

The 1.4kb eIF4E1 transcript is lower in abundance than the larger two in early embryos.

(Lavoie et al., 1996)

eIF4E1 transcripts are detected throughout development on northern blots.

(Hernandez and Sierra, 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male & spermatogenesis
hub cell
(Ghosh and Lasko, 2015)
male germline stem cell
(Ghosh and Lasko, 2015)
cyst cell of testis
(Ghosh and Lasko, 2015)
spermatogonium
(Ghosh and Lasko, 2015)
primary spermatocyte
(Ghosh and Lasko, 2015)
secondary spermatocyte
(Ghosh and Lasko, 2015)
comet stage spermatid
(Ghosh and Lasko, 2015)
spermatid cyst cell
(Ghosh and Lasko, 2015)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
ovary
(Pisa et al., 2009)
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Hernandez et al., 2012)
first instar larval stage
organism
(Hernandez et al., 2012)
pupal stage
organism
(Hernandez et al., 2012)
adult stage | male
testis
(Hernandez et al., 2012)
adult stage | female
ovary
(Hernandez et al., 2012)
Additional Descriptive Data

eIF4E1 protein is expressed during many stages of spermatogenesis, both in the germ cells and surrounding somatic cyst cells. eIF4E1 protein is detected in the hub cells containing the stem cell niche at the apical tip of the testes, in spermatogonia, primary and secondary spermatocytes,and in spermatids in the early stages elongation. eIF4E1 protein is not detected in mature elongated spermatid bundles undergoing differentiation, but is detected in surrounding somatic cyst cells.

(Ghosh and Lasko, 2015)

eIF4E1 protein is expressed in all tissues analyzed.

(Hernandez et al., 2012)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Cohen et al., 2001)
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in cytosol
inferred from direct assay
(Ottone et al., 2011, Sigrist et al., 2000)
part_of eukaryotic translation initiation factor 4F complex
inferred from direct assay
(Igreja et al., 2014, Zapata et al., 1994)
inferred from physical interaction with FLYBASE:eIF4G1; FB:FBgn0023213
(Hernandez et al., 2005)
is_active_in muscle cell postsynaptic specialization
inferred from direct assay
(Menon et al., 2004)
is_active_in neuromuscular junction
inferred from direct assay
(Menon et al., 2004)
located_in neuronal ribonucleoprotein granule
inferred from direct assay
(Barbee et al., 2006)
located_in nuclear body
inferred from direct assay
(Cohen et al., 2001)
located_in P-body
inferred from direct assay
(Liu and Gall, 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\eIF4E1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 27 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of eIF4E1
Transgenic constructs containing regulatory region of eIF4E1
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH
lethal, with Scer\GAL4insc-Mz1407
lethal, with Scer\GAL4pnr-MD237
lethal (with Df(3L)29A6)
lethal (with Df(3L)AC1)
lethal | embryonic stage | recessive
lethal | larval stage | recessive
lethal | male, with Scer\GAL4Bx-MS1096
lethal | recessive
lethal - all die before end of first instar larval stage
lethal - all die before end of first instar larval stage (with eIF4E167Af)
lethal - all die before end of first instar larval stage (with eIF4E1Scim-a)
lethal - all die before end of larval stage
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during embryonic stage, with Scer\GAL4en-e16E
lethal - all die during embryonic stage | recessive
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
partially lethal, with eIF4E167Af
partially lethal, with eIF4E107238
partially lethal, with eIF4E1S058911
partially lethal, with eIF4E1S071513
partially lethal, with eIF4E1Ser251Ala.t8.9
partially lethal - majority die | female, with Scer\GAL4Bx-MS1096
viable
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile | germline clone
male sterile, with Scer\GAL4VP16.bam
male sterile, with Scer\GAL4VP16.nanos.UTR
Other Phenotypes
Allele
abnormal developmental rate
abnormal developmental rate, with eIF4E167Af
abnormal developmental rate, with eIF4E107238
abnormal developmental rate, with eIF4E1S058911
abnormal developmental rate, with eIF4E1S071513
abnormal developmental rate, with eIF4E1Ser251Ala.t8.9
abnormal meiotic cell cycle | dominant
abnormal meiotic cell cycle | male limited, with Scer\GAL4VP16.bam
abnormal mitotic cell cycle
abnormal neuroanatomy, with Scer\GAL4Mhc.PW
abnormal neuroanatomy, with Scer\GAL4Mhc.Switch.PO
abnormal neuroanatomy | adult stage, with Scer\GAL4ple.PF
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4elav-C155
abnormal neurophysiology, with Scer\GAL4Mhc.PW
abnormal size | larval stage
chemical sensitive, with Scer\GAL4da.G32
decreased cell number | somatic clone | spermatogenesis
decreased cell number | spermatogenesis, with Scer\GAL4tj.PU
decreased cell size, with eIF4E1S058911
decreased cell size, with eIF4E1Ser251Ala.t8.9
decreased occurrence of cell division | larval stage
increased cell death | embryonic stage
increased cell size, with eIF4E1S058911
increased cell size, with eIF4E1Ser251Asp.t8.9
some die during embryonic stage, with Scer\GAL4en-e16E
some die during embryonic stage | recessive
some die during first instar larval stage
some die during first instar larval stage (with eIF4E167Af)
some die during first instar larval stage (with eIF4E1Scim-a)
some die during larval stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during third instar larval stage
visible, with eIF4E167Af
visible, with eIF4E107238
visible, with eIF4E1S058911
visible, with eIF4E1S071513
visible, with eIF4E1Ser251Ala.t8.9
wild-type
Phenotype manifest in
Allele
bouton, with Scer\GAL4Mhc.PW
cyst progenitor cell | decreased number, with Scer\GAL4tj.PU
cyst progenitor cell | decreased number | somatic clone
dopaminergic neuron, with Scer\GAL4ple.PF
elongation stage spermatid, with Scer\GAL4VP16.bam
embryonic/first instar larval cuticle, with Scer\GAL4nanos.PG
embryonic/larval neuromuscular junction, with Scer\GAL4Mhc.Switch.PO
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4hs.2sev
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
individualization stage spermatid, with Scer\GAL4VP16.bam
interommatidial bristle | ectopic, with Scer\GAL4ey.PH
interommatidial bristle | ectopic, with Scer\GAL4GMR.PF
interommatidial bristle | ectopic, with Scer\GAL4hs.2sev
larval intersegmental nerve, with Scer\GAL4elav-C155
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
larval somatic muscle cell, with Scer\GAL4Mef2.PR
mitosis & nuclear chromosome
mitotic interphase
neuromuscular junction, with Scer\GAL4Mhc.PW
NMJ bouton | increased number | third instar larval stage
NMJ bouton | increased number | third instar larval stage, with Scer\GAL4elav-C155
nucleus | larval stage
ommatidium, with eIF4E1S058911
ommatidium, with eIF4E1Ser251Ala.t8.9
spermatid, with Scer\GAL4VP16.nanos.UTR
spermatocyte, with Scer\GAL4VP16.nanos.UTR
testis, with Scer\GAL4C587
testis, with Scer\GAL4VP16.nanos.UTR
type I bouton, with Scer\GAL4Mhc.Switch.PO
wing, with eIF4E167Af
wing, with eIF4E107238
wing, with eIF4E1S058911
wing, with eIF4E1S071513
wing, with eIF4E1Ser251Ala.t8.9
wing, with Scer\GAL4Bx-MS1096
wing disc, with eIF4E1S058911
wing disc, with eIF4E1Ser251Ala.t8.9
wing disc, with eIF4E1Ser251Asp.t8.9
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (4)
Hsap\EIF4E
14 of 14
Yes
Yes
Hsap\EIF4E1B
13 of 14
No
Yes
Hsap\EIF4E2
5 of 14
No
No
1  
Hsap\EIF4E3
4 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Eif4e
13 of 14
Yes
Yes
Rnor\Eif4e2
4 of 14
No
No
Rnor\Eif4e3
4 of 14
No
Yes
Rnor\Eif4e1b
1 of 14
No
Yes
Mus musculus (laboratory mouse) (4)
Mmus\Eif4e
14 of 14
Yes
Yes
Mmus\Eif4e1b
13 of 14
No
Yes
Mmus\Eif4e2
4 of 14
No
No
Mmus\Eif4e3
4 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (8)
Xtro\eif4e
11 of 13
Yes
Yes
Xtro\eif4e1b
10 of 13
No
Yes
Xtro\eif4e3
2 of 13
No
Yes
Xtro\eif4e2
1 of 13
No
No
Xtro\ganc
1 of 13
No
No
Xtro\kirrel2
1 of 13
No
No
Xtro\mark2
1 of 13
No
No
Xtro\MGC89871
1 of 13
No
No
Danio rerio (Zebrafish) (7)
Drer\eif4ea
14 of 14
Yes
Yes
Drer\eif4eb
14 of 14
Yes
Yes
Drer\eif4e1b
13 of 14
No
Yes
Drer\eif4e1c
13 of 14
No
Yes
Drer\eif4e2
5 of 14
No
No
Drer\eif4e2rs1
4 of 14
No
No
Drer\eif4e3
4 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\ife-3
13 of 14
Yes
Yes
Cele\ife-5
8 of 14
No
Yes
Cele\ife-1
7 of 14
No
Yes
Cele\ife-2
7 of 14
No
Yes
Cele\ife-4
4 of 14
No
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP007172
11 of 12
Yes
Yes
Agam\AgaP_AGAP002948
4 of 12
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\EIF4E
13 of 13
Yes
Yes
Atha\AT1G29550
12 of 13
No
Yes
Atha\eIF4E3
12 of 13
No
Yes
Atha\LSP1
12 of 13
No
Yes
Atha\NCBP
4 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CDC33
12 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\tif45
11 of 12
Yes
Yes
Spom\tif452
11 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:eIF4E1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
eIF4E3
12 of 13
eIF4E4
12 of 13
eIF4E5
12 of 13
eIF4E7
11 of 13
eIF4E6
10 of 13
eIF4EHP
5 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
EIF4E; eukaryotic translation initiation factor 4E
14 of 14
133440
    EIF4E1B; eukaryotic translation initiation factor 4E family member 1B
    13 of 14
        EIF4E2; eukaryotic translation initiation factor 4E family member 2
        5 of 14
        605895
             
            EIF4E3; eukaryotic translation initiation factor 4E family member 3
            4 of 14
            609896
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                eIF4E1 - 4E-T
                anti tag coimmunoprecipitation, anti tag western blot, x-ray crystallography, western blot, isothermal titration calorimetry, predetermined participant, pull down, molecular weight estimation by staining
                (Ruscica et al., 2019, Peter et al., 2015, Igreja et al., 2014)
                eIF4E1 - AGO1
                anti bait coimmunoprecipitation, western blot
                (Iwasaki et al., 2009)
                eIF4E1 - AGO2
                anti bait coimmunoprecipitation, western blot
                (Iwasaki et al., 2009)
                eIF4E1 - CG5347
                two hybrid
                (Hu et al., 2017.6.13)
                eIF4E1 - Diap1
                anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, enzymatic study, pull down
                (Lee et al., 2007)
                eIF4E1 - Dsor1
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Friedman et al., 2011)
                eIF4E1 - Gld2
                pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation
                (Kwak et al., 2008)
                eIF4E1 - Gsc
                two hybrid
                (Hu et al., 2017.6.13)
                eIF4E1 - Lk6
                enzymatic study, autoradiography, anti tag coimmunoprecipitation, anti tag western blot
                (Arquier et al., 2005, Parra-Palau et al., 2005)
                eIF4E1 - RpL10Ab
                pull down, western blot
                (Antic et al., 2015)
                eIF4E1 - SERCA
                two hybrid
                (Santalla et al., 2022)
                eIF4E1 - Sumo
                anti tag coimmunoprecipitation, Identification by mass spectrometry, comigration in sds page, anti tag western blot, pull down, covalent binding, western blot
                (Pirone et al., 2017, Nie et al., 2009)
                eIF4E1 - Sxl
                anti tag coimmunoprecipitation, quantitative reverse transcription pcr, anti bait coimmunoprecipitation, western blot
                (Graham et al., 2011)
                eIF4E1 - Thor
                anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry, pull down, molecular weight estimation by staining, anti bait coimmunoprecipitation, anti tag western blot, isothermal titration calorimetry, predetermined participant, peptide massfingerprinting, far western blotting, autoradiography, x-ray crystallography, two hybrid
                (Grüner et al., 2016, Vinayagam et al., 2016, Peter et al., 2015, Peter et al., 2015, Igreja et al., 2014, Hernández et al., 2013, Hernandez et al., 2012, Glatter et al., 2011, Hernandez et al., 2005)
                eIF4E1 - U2af38
                anti bait coimmunoprecipitation, western blot
                (Graham et al., 2011)
                eIF4E1 - U2af50
                anti bait coimmunoprecipitation, western blot
                (Graham et al., 2011)
                eIF4E1 - aub
                anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry, affinity technology, tag visualisation by luciferase assay
                (Ramat et al., 2020, Ma et al., 2017)
                eIF4E1 - bcd
                pull down, western blot, autoradiography
                (Niessing et al., 2002)
                eIF4E1 - bel
                pull down, western blot
                (Yarunin et al., 2011)
                eIF4E1 - bru1
                anti bait coimmunoprecipitation, western blot
                (Nakamura et al., 2004)
                eIF4E1 - cup
                pull down, autoradiography, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, colocalization, fluorescence microscopy, inferred by author, molecular weight estimation by staining, isothermal titration calorimetry, predetermined participant, two hybrid, x-ray crystallography
                (Salgania et al., 2024, Peter et al., 2015, Igreja et al., 2014, Kinkelin et al., 2012, Igreja and Izaurralde, 2011, Iwasaki et al., 2009, Nakamura et al., 2004, Nelson et al., 2004, Zappavigna et al., 2004, Wilhelm et al., 2003)
                eIF4E1 - eIF4E3
                pull down, molecular weight estimation by staining
                (Layana et al., 2023)
                eIF4E1 - eIF4G1
                pull down, molecular weight estimation by staining, anti bait coimmunoprecipitation, western blot, isothermal titration calorimetry, predetermined participant, anti tag coimmunoprecipitation, two hybrid, affinity chromatography technology, autoradiography, anti tag western blot, Identification by mass spectrometry, classical fluorescence spectroscopy, x-ray crystallography, cosedimentation
                (Wang et al., 2017, Grüner et al., 2016, Zuberek et al., 2016, Ghosh and Lasko, 2015, Peter et al., 2015, Igreja et al., 2014, Hernández et al., 2013, Hernandez et al., 2012, Iwasaki et al., 2009, Baker and Fuller, 2007, Hernandez et al., 2005, Hernandez et al., 2004, Zappavigna et al., 2004, Hernandez et al., 1998, Zapata et al., 1994)
                eIF4E1 - eIF4G2
                anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot, two hybrid
                (Ghosh and Lasko, 2015, Hernandez et al., 2012, Baker and Fuller, 2007)
                eIF4E1 - exu
                anti tag coimmunoprecipitation, western blot
                (Wilhelm et al., 2003)
                eIF4E1 - fl(2)d
                anti bait coimmunoprecipitation, western blot
                (Graham et al., 2011)
                eIF4E1 - me31B
                anti bait coimmunoprecipitation, western blot, fluorescent resonance energy transfer, fluorescence microscopy, anti tag coimmunoprecipitation, two hybrid, pull down, molecular weight estimation by staining, peptide massfingerprinting
                (Layana et al., 2023, Wang et al., 2017, Nakamura et al., 2004)
                eIF4E1 - mxt
                pull down, anti tag western blot, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, two hybrid, far western blotting, autoradiography
                (Peter et al., 2015, Hernández et al., 2013)
                eIF4E1 - pAbp
                anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot, anti tag coimmunoprecipitation
                (Wang et al., 2017, Lim et al., 2011)
                eIF4E1 - park
                pull down, western blot
                (Ottone et al., 2011)
                eIF4E1 - smg
                anti bait coimmunoprecipitation, western blot
                (Nelson et al., 2004)
                eIF4E1 - snRNP-U1-70K
                anti bait coimmunoprecipitation, western blot
                (Graham et al., 2011)
                eIF4E1 - snf
                anti bait coimmunoprecipitation, western blot
                (Graham et al., 2011)
                eIF4E1 - tyf
                anti tag coimmunoprecipitation, anti tag western blot
                (Lim et al., 2011)
                eIF4E1 - yps
                anti bait coimmunoprecipitation, western blot
                (Wilhelm et al., 2003)
                RNA-protein
                Physical Interaction
                Assay
                References
                eIF4E1 - Sxl
                anti tag coimmunoprecipitation, quantitative reverse transcription pcr, anti bait coimmunoprecipitation, western blot
                (Graham et al., 2011)
                eIF4E1 - nanos
                pull down, western blot
                (Jeske et al., 2011)
                eIF4E1 - pum
                electrophoretic mobility shift assay, autoradiography
                (Menon et al., 2004)
                Summary of Genetic Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                eIF4E1
                enhanceable
                cup
                (Menon et al., 2015)
                eIF4E1
                enhanceable
                Dcr-2
                (Dietzl et al., 2007)
                eIF4E1
                suppressible
                Lk6
                (Arquier et al., 2005)
                eIF4E1
                suppressible
                Lrrk
                (Imai et al., 2008)
                eIF4E1
                suppressible
                pum
                (Menon et al., 2004)
                eIF4E1|park
                suppressible
                Thor
                (Ottone et al., 2011)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                bam
                suppressible
                eIF4E1
                (Shen et al., 2009)
                bru1
                suppressible
                eIF4E1
                (Yan and Macdonald, 2004)
                ct
                suppressible
                eIF4E1
                (Krupp et al., 2005)
                ct
                enhanceable
                eIF4E1
                (Krupp et al., 2005)
                cup
                enhanceable
                eIF4E1
                (Zappavigna et al., 2004)
                ftz
                enhanceable
                eIF4E1
                (Kankel et al., 2004)
                GluRIIA
                suppressible
                eIF4E1
                (Penney et al., 2012)
                Lk6
                suppressible
                eIF4E1
                (Reiling et al., 2005)
                Lrrk
                suppressible
                eIF4E1
                (Penney et al., 2016, Imai et al., 2008)
                mTor
                suppressible
                eIF4E1
                (Penney et al., 2012)
                park
                suppressible
                eIF4E1
                (Ottone et al., 2011)
                path
                suppressible
                eIF4E1
                (Lin et al., 2015)
                Pi3K92E|btl::Egfr
                suppressible
                eIF4E1
                (Read et al., 2009)
                S6k
                suppressible
                eIF4E1
                (Penney et al., 2012)
                External Data
                Subunit Structure (UniProtKB)
                eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E1 and eIF4G1 (PubMed:25702871). Recruited by cup in oocytes and in early embryos, preventing the interaction with eIF4G (PubMed:14685270, PubMed:14691132, PubMed:14723848, PubMed:22832024, PubMed:26294658). The interaction with cup therefore prevents the translation of key transcripts such as oskar (osk) and nanos (nos) in some regions in the early embryo (PubMed:14685270, PubMed:14691132, PubMed:14723848, PubMed:22832024, PubMed:26294658). Interacts with mxt (PubMed:23716590, PubMed:26294658). Interacts with 4E-T and Thor (PubMed:11389445, PubMed:14645523, PubMed:25702871, PubMed:26294658). Forms a RNP containing at least me31B, eIF4E1, cup, tral and pAbp; this interaction is required for the translational silencing of maternal mRNAs during the maternal-to-zygotic transition (PubMed:28875934).
                (UniProt, P48598 )
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3L
                Recombination map
                3-29
                Cytogenetic map
                67B4-67B4
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                67B4-67B4
                Limits computationally determined from genome sequence between P{EP}Hsp26EP3336&P{EP}Hsp26EP3315 and P{PZ}fry02240
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                67A8-67B2
                (Lasko, 1996.4.9)
                67A2-67B1
                (Hernandez, 1996.7.5)
                67B1-67B2
                (determined by in situ hybridisation)
                (Spradling et al., 1999)
                67B-67B
                (determined by in situ hybridisation)
                (Szeged Stock Center, 1998-, Deak et al., 1997)
                67A8-67B2
                (determined by in situ hybridisation)
                (Lavoie et al., 1996)
                67A-67A
                (Lachance et al., 1996)
                67B1-67B2
                (BDGP Project Members, 1994-1999)
                Experimentally Determined Recombination Data
                Location

                3-29

                (FlyBase, 2016)

                3-23.0

                (Comeron et al., 2012)

                3-

                (Lachance et al., 1996, Lasko, 1996.4.9)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (17)
                Genomic Clones (13)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (153)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                Antibody Information
                Laboratory Generated Antibodies
                 

                polyclonal

                (Briney et al., 2025, Cao et al., 2020, Peter et al., 2015, Nishihara et al., 2013, Igreja and Izaurralde, 2011, Maroto and Sierra, 1989)
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                    Other Comments

                    RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

                    (Goshima et al., 2007)

                    dsRNA made from templates generated with primers directed against this gene reduces mean cell diameter. Silencing both eIF-4E and S6k together does not reduce mean cell diameter to the same extent as rapamycin treatment.

                    (Guertin et al., 2006)

                    cup is required to localise eIF-4E to the posterior of the oocyte.

                    (Wilhelm et al., 2003)

                    eIF-4E is phosphorylated on Ser251.

                    (Lachance et al., 2002)

                    The phosphorylation of eIF-4E at Ser251 is biologically significant and is essential for normal growth and development.

                    (Lachance et al., 2002)

                    Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

                    (Harvie et al., 1998)

                    Cloning and sequencing of eIF-4E revealed the existance of three mRNAs that are generated by alternative splicing of a primary transcript and all have different 5' untranslated leader regions. eIF-4E is a single copy gene. Expression of eIF-4E is spatially and temporally controlled during embryonic development. eIF-4E is ubiquitously expressed during embryogenesis but transcripts preferentially accumulate in certain tissues, particularly in the pole cells at different developmental stages.

                    (Hernandez et al., 1997)

                    eIF-4E produces two different cap-binding proteins by alternative splicing.

                    (Lavoie et al., 1996)

                    eIF-4E protein from both control and heat shocked cells has been purified and characterised.

                    (Duncan et al., 1995)

                    Isolated from a 0 to 20 hour embryo cDNA library using a polyclonal antibody against eIF-4E.

                    (Hernandez and Sierra, 1995)

                    An eIF-4E cDNA has been cloned and sequenced, and its expression pattern has been analysed.

                    (Hernandez and Sierra, 1995)

                    Drosophila elongation factor 4F consists of two subunits, a polypeptide of about 200kD and the product of eIF-4E, the cap-binding protein.

                    (Hernandez et al., 1995)

                    Drosophila initiation factor eIF-4F is composed of two subunits, one is encoded by eIF-4E and the other by eIF-4G, a 200kD protein.

                    (Zapata et al., 1994)

                    Translation of the majority of non-heat shock mRNAs and Hsp83 mRNA is very dependent on eIF-4E. In contrast, translation of Hsp70 mRNAs and to a lesser extent the mRNAs for the small heat shock proteins is almost independent of eIF-4E.

                    (Zapata et al., 1991)
                    Relationship to Other Genes
                    Source for database merge of

                    Source for merge of: eIF-4E l(3)S025007 l(3)S026009 l(3)S058711 l(3)S091912

                    (Szeged Stock Center, 1998-)

                    Source for merge of: eIF-4E l(3)07238

                    (Spradling et al., 1999)

                    Source for merge of: eIF-4E l(3)67Af

                    (Lachance et al., 2002)
                    Additional comments
                    Nomenclature History
                    Source for database identify of

                    Source for identity of: eIF4E1 eIF-4E

                    (Marygold et al., 2017)
                    Nomenclature comments
                    Etymology
                    Synonyms and Secondary IDs (56)
                    Reported As
                    Symbol Synonym
                    0260/09
                    (Deak et al., 1997)
                    0587/11
                    (Deak et al., 1997)
                    0589/11
                    (Deak et al., 1997)
                    0919/12
                    (Deak et al., 1997)
                    1004/13
                    (Deak et al., 1997)
                    7238
                    (Harvie et al., 1998)
                    CBP
                    (Jacquier et al., 2007, Whitman and Raftery, 2005, Zapata et al., 1991)
                    CG4035
                    (Yue et al., 2022, Vasudevan et al., 2020, Kolkhof et al., 2017, Marygold et al., 2017, Na et al., 2016, Horan et al., 2015, Hosono et al., 2015, White-Grindley et al., 2014, Schertel et al., 2013, Chen et al., 2012, Tettweiler et al., 2012, Cammarato et al., 2011, Glatter et al., 2011, Jäger and Dorner, 2010, Ni et al., 2010.12.1, Slack et al., 2010, Zhang et al., 2010, Keleman et al., 2009.8.5, Pisa et al., 2009, Ducat et al., 2008, Hughes et al., 2008, Puri et al., 2008, Goshima et al., 2007, Quinones-Coello, 2007, Gong et al., 2004, Kraut et al., 2001, Kraut et al., 2001, Lasko, 2000)
                    CT13384
                    (Xie and Ding, 2000)
                    CT39424
                    (Xie and Ding, 2000)
                    CT39426
                    (Xie and Ding, 2000)
                    D-eIF4E
                    (Myrick and Dearolf, 2000)
                    EIF-4E
                    (Krejčová et al., 2023)
                    EIF4E
                    (Sofola et al., 2007)
                    Eif4E
                    Eif4e
                    (Lachance et al., 1996)
                    IF4E
                    (Mushegian et al., 1998)
                    dEif-4e
                    (Nishimura et al., 2011)
                    dEif4e
                    (Wessells et al., 2009)
                    deIF-4E
                    (Guertin et al., 2006)
                    deIF4E
                    (Gareau et al., 2013, Garrey et al., 2010, Read et al., 2009, Arquier et al., 2008, Imai et al., 2008, Miron et al., 2001)
                    eIF 4E
                    (Ducat et al., 2008)
                    eIF-4E
                    (Heigwer et al., 2023, Park et al., 2021, Kim and Choi, 2019, Calap-Quintana et al., 2018, Muñoz-Soriano et al., 2018, Hsu and Drummond-Barbosa, 2017, Pirone et al., 2017, Elgart et al., 2016, Na et al., 2016, Sarov et al., 2016, Calap-Quintana et al., 2015, Dent et al., 2015, Horan et al., 2015, Ghosh et al., 2014, Merlo et al., 2014, White-Grindley et al., 2014, Kwon et al., 2013, Schertel et al., 2013, Sen et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Abruzzi et al., 2011, Friedman et al., 2011, Glatter et al., 2011, Neumüller et al., 2011, Delanoue et al., 2010, Gan et al., 2010, Silicheva et al., 2010, Slack et al., 2010, Alvarez-Ponce et al., 2009, Dworkin et al., 2009, Wessells et al., 2009, Hughes et al., 2008, Puri et al., 2008, Adryan et al., 2007, Baker and Fuller, 2007, Buszczak et al., 2007, Curtis et al., 2007, Dietzl et al., 2007, Fuller and Baker, 2007.6.28, Goshima et al., 2007, Grewal et al., 2007, Hoshizaki and Gibbs, 2007, Marygold et al., 2007, Quinones-Coello, 2007, Valencia-Sanchez et al., 2006, Menon et al., 2004)
                    eIF-4E1
                    (Hernandez and Vazquez-Pianzola, 2005)
                    eIF-4E1,2
                    (Hernadez and Rivera Pomar, 2003)
                    eIF-4E2
                    (Hernandez and Vazquez-Pianzola, 2005)
                    eIF-4EII
                    (Nelson et al., 2004)
                    eIF-4e
                    (Gong et al., 2004, Myrick and Dearolf, 1999)
                    eIF4E
                    (Bayer et al., 2024, Salgania et al., 2024, Bayer et al., 2023, Deliu et al., 2022, Peng and Gavis, 2022, Connacher and Goldstrohm, 2021, Blatt et al., 2020, Buddika et al., 2020, Lasko, 2020, Luo et al., 2020, Thackray et al., 2020, Titlow et al., 2020, Vasudevan et al., 2020, Zhao et al., 2020, Ruscica et al., 2019, Rode et al., 2018, Von Stetina et al., 2018, Wang et al., 2018, Broyer et al., 2017, Ma et al., 2017, Wang et al., 2017, Grüner et al., 2016, Penney et al., 2016, Sanchez et al., 2016, Ghosh and Lasko, 2015, Menon et al., 2015, Peter et al., 2015, Peter et al., 2015, Yan et al., 2015, Igreja et al., 2014, Majzoub et al., 2014, Zacharogianni et al., 2014, Nishihara et al., 2013, Olson et al., 2013, Zekri et al., 2013, Ferrero et al., 2012, Killip and Grewal, 2012, Mihailovich et al., 2012, Penney et al., 2012, Ganesan et al., 2011, Jeske et al., 2011, Lim et al., 2011, Ottone et al., 2011, Read, 2011, Shimada et al., 2011, Singh et al., 2011, Yarunin et al., 2011, Cauchi et al., 2010, Garrey et al., 2010, Gehrke et al., 2010, Jäger and Dorner, 2010, Liu and Lu, 2010, Duncan et al., 2009, Farny et al., 2009, Iwasaki et al., 2009, Lee et al., 2009, Nie et al., 2009, Nuzhdin et al., 2009, Read et al., 2009, Shen et al., 2009, Duncan, 2008, Hernandez et al., 2008, Hughes et al., 2008, Imai et al., 2008, Kwak et al., 2008, Layalle et al., 2008, McNeill et al., 2008, Teleman et al., 2008, Franklin-Dumont et al., 2007, Grewal et al., 2007, Lasko and Sonenberg, 2007, Lee et al., 2007, Lee et al., 2007, Liu and Gall, 2007, Baker and Fuller, 2006, Kozak, 2006, Li and Li, 2006, Bourouis et al., 2005, Cho et al., 2005, Macdonald, 2005, Parra-Palau et al., 2005, Reiling et al., 2005, Semotok et al., 2005, Teleman et al., 2005, Graham et al., 2004, Hernandez et al., 2004, Jenkins and Lasko, 2004, Macdonald, 2004, Wilhelm et al., 2004, Yan and Macdonald, 2004, Zappavigna et al., 2004, Chakkalakal and Jasmin, 2003, Gamberi et al., 2003, Graham et al., 2003, Oldham and Hafen, 2003, Wilhelm et al., 2003, Wilhelm et al., 2003, Darnell, 2002, Lachance et al., 2002, Niessing et al., 2002, Saucedo and Edgar, 2002, Sigrist et al., 2002, Van Buskirk and Schupbach, 2002, Cohen et al., 2001, Graham et al., 2001, Bernal and Kimbrell, 2000, Carrera et al., 2000, DiAntonio, 2000, Graham et al., 2000, Lasko, 2000, Miron et al., 2000, Schoenfeld et al., 2000, Sigrist et al., 2000, Lachance et al., 1999, Lehner, 1999, Miron et al., 1999, Lachance et al., 1998, Lachance and Lasko, 1997, Miron et al., 1997, Lasko, 1996.4.9, Lavoie et al., 1996)
                    eIF4E-1
                    (Zuberek et al., 2016, Ghosh and Lasko, 2015, Hernández et al., 2013, Hernandez et al., 2012, Pisa et al., 2009, Hernandez et al., 2006, Hernandez and Vazquez-Pianzola, 2005, Hernandez et al., 2005, Hernandez et al., 2004)
                    eIF4E-1,2
                    (Reyes and Izquierdo, 2008, Vazquez-Pianzola et al., 2007)
                    eIF4E-1/2
                    (Tettweiler et al., 2012, Hernandez et al., 2004)
                    eIF4E-2
                    (Zuberek et al., 2016, Hernández et al., 2013, Hernandez et al., 2012, Pisa et al., 2009, Hernandez et al., 2006, Hernandez and Vazquez-Pianzola, 2005, Hernandez et al., 2005)
                    eIF4E1
                    (Dyson et al., 2025, He et al., 2025, Rangone et al., 2024, Wilby and Weil, 2023, Frappaolo et al., 2022, Ribot et al., 2022, Santalla et al., 2022, Kaufman et al., 2020, Texada et al., 2020, Fingerhut et al., 2019, Hu et al., 2017.6.13, Marygold et al., 2017, Baker and Fuller, 2007)
                    eIF4EI
                    (Cho et al., 2005)
                    eIF4F
                    (Luo et al., 2020)
                    eIF4e
                    (Lu et al., 2021, Lin et al., 2015, Khurana et al., 2006, Ephrussi and St. Johnston, 2004)
                    eIf4E1
                    (Kagemann et al., 2025)
                    eiF4E
                    (Sankaranarayanan and Weil, 2020)
                    eif-4E
                    (Brumby et al., 2004)
                    eif-4e
                    (Wessells et al., 2007)
                    eif4e
                    (Graham et al., 2011, Sofola et al., 2007)
                    elF4E
                    (Haussmann et al., 2022, Aguilera-Gomez et al., 2017, Zacharogianni et al., 2014)
                    l(3)07238
                    (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)
                    l(3)67Af
                    (Leicht and Bonner, 1988)
                    l(3)S025007
                    l(3)S026009
                    l(3)S058711
                    l(3)S091912
                    Name Synonyms
                    Eukaryotic initiation factor 4E
                    (Cammarato et al., 2011, Gouw et al., 2009, Hernandez et al., 1995)
                    Eukaryotic translation initiation factor 4E
                    (Lachance et al., 2002)
                    cap binding protein
                    (Zapata et al., 1991)
                    eukaryotic initiation factor 4E
                    (Yarunin et al., 2011, Parra-Palau et al., 2005, Schoenfeld et al., 2000)
                    eukaryotic translation initiation factor 4E
                    (Calap-Quintana et al., 2015, Ottone et al., 2011, Pisa et al., 2009)
                    eukaryotic translation initiation factor 4E1
                    lethal(3)67Af
                    Secondary FlyBase IDs
                    • FBgn0002202
                    • FBgn0010921
                    • FBgn0013947
                    • FBgn0028178
                    • FBgn0035984
                    • FBgn0060598
                    • FBgn0060792
                    • FBgn0061015
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    Study result (0)
                    Result
                    Result Type
                    Title
                    External Crossreferences and Linkouts ( 109 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                    FlyMine - An integrated database for Drosophila genomics
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL - MARRVEL (model organism gene)
                    PDB - An information portal to biological macromolecular structures
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    References (335)