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General Information
Symbol
Dmel\eIF4E1UAS.cRa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Rivera-Pomar
FlyBase ID
FBal0117540
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-eIF4E, UAS-eIF-4E
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of eIF4E1.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing ThorScer\UAS.cMa under the control of Scer\GAL4da.G32 are more sensitive to hydrogen peroxide compared to control flies.

60 day old flies expressing eIF-4EScer\UAS.cRa under the control of Scer\GAL4ple.PF show a significant reduction in the number of dopaminergic neurons in the protocerebral posterior medial 1 and 2 clusters and in the protocerebral posterior lateral 1 cluster compared to control flies

Overexpression of eIF-4EScer\UAS.cRa in muscle 6/7 under the control of Scer\GAL4Mhc.Switch.PO produces an increase in the number of type 1b boutons compared to controls.

The mean amplitude of miniature postsynaptic currents (mEJCs) at the neuromuscular junction is indistinguishable from wild type in flies expressing eIF-4EScer\UAS.cRa under the control of Scer\GAL4Mhc.PW. Evoked postsynaptic currents (eEJCs) are significantly larger than in wild-type. The number of junctional boutons per neuromuscular junction is increased compared to wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The decrease in the number of dopaminergic neurons in the protocerebral posterior medial 1 and 2 clusters and in the protocerebral posterior lateral 1 cluster that is seen in 60 day old adults expressing eIF-4EScer\UAS.cRa under the control of Scer\GAL4ple.PF is suppressed if the flies are also homozygous for Lrrkunspecified.

Simultaneous expression of pumScer\UAS.fl and eIF-4EScer\UAS.cRa in muscles (using Scer\GAL4Mhc.Switch.PO) results in the increase in 1b bouton number conferred by overexpressing eIF-4EScer\UAS.cRa being completely suppressed by the overexpression of pumScer\UAS.fl. 1b bouton numbers in larvae overexpressing both eIF-4EScer\UAS.cRa and pumScer\UAS.fl are not significantly different from those in larvae overexpressing only pumScer\UAS.fl.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
eIF-4EScer\UAS.cRa
eIF4E1Scer\UAS.cRa
eIF4E1UAS.cRa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Rivera-Pomar
Secondary FlyBase IDs
    References (5)