FlyBase Allele Report: Dmel\eIF4E1[07238]

General Information

Symbol

Dmel\eIF4E1⁰⁷²³⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0009599

Feature type

allele

Associated gene

Dmel\eIF4E1

Associated Insertion(s)

P{PZ}eIF4E1⁰⁷²³⁸

Carried in Construct

Also Known As

eif4E⁰⁷²³⁸, l(3)07238

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}eIF4E1⁰⁷²³⁸

Cytology

Description

Insertion of P{PZ} at nucleotide position +502 (coordinates according to FBrf0088373).

(Lachance et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:9,401,969..9,401,969 [+]

(Sofola et al., 2007, Andrade and Cook, 2005.7.22, Lachance et al., 2002, Spradling et al., 1999, Harvie et al., 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing, with eIF4E1^{Ser251Ala.t8.9}

(Lachance et al., 2002)

Detailed Description

Statement

Reference

Development is arrested in the second larval instar, although the larvae survive for up to 10 days. Developmental delay with eIF-4E^{Ser251Ala.t8.9} is 1 to 2 days.

(Lachance et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

eIF4E1⁰⁷²³⁸/eIF-4E[+], park^P23 has viable | pupal stage phenotype, suppressible by Thor^Δ1034-2617

(Ottone et al., 2011)

NOT Enhancer of

Statement

Reference

eIF4E1⁰⁷²³⁸/eIF-4E[+] is a non-enhancer of visible phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

eIF4E1⁰⁷²³⁸ is a non-enhancer of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

eIF4E1⁰⁷²³⁸ is a non-enhancer of abnormal mitotic cell cycle | maternal effect phenotype of png¹⁰⁵⁸/png³³¹⁸

(Lee et al., 2001)

Suppressor of

Statement

Reference

eIF4E1⁰⁷²³⁸/eIF-4E[+] is a suppressor of partially lethal - majority die | pupal stage phenotype of park^P23

(Ottone et al., 2011)

eIF4E1⁰⁷²³⁸/eIF-4E[+] is a suppressor of abnormal body size phenotype of park^P23

(Ottone et al., 2011)

eIF4E1⁰⁷²³⁸/eIF-4E[+] is a suppressor | partially of female sterile phenotype of park^P23

(Ottone et al., 2011)

eIF4E1⁰⁷²³⁸/eIF-4E[+] is a suppressor of chemical sensitive phenotype of Lrrk^I1915T.UAS, Scer\GAL4^da.G32

(Imai et al., 2008)

NOT Suppressor of

Statement

Reference

eIF4E1⁰⁷²³⁸/eIF-4E[+] is a non-suppressor of visible phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

eIF4E1⁰⁷²³⁸ is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

eIF4E1⁰⁷²³⁸ is a non-suppressor of abnormal mitotic cell cycle | maternal effect phenotype of png¹⁰⁵⁸/png³³¹⁸

(Lee et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

eIF4E1⁰⁷²³⁸/eIF-4E[+] is an enhancer of ovary phenotype of cup⁸

(Zappavigna et al., 2004)

eIF4E1⁰⁷²³⁸/eIF-4E[+] is an enhancer of egg chamber phenotype of cup²¹

(Zappavigna et al., 2004)

eIF4E1⁰⁷²³⁸/eIF-4E[+] is an enhancer of ovary phenotype of cup²¹

(Zappavigna et al., 2004)

NOT Enhancer of

Statement

Reference

eIF4E1⁰⁷²³⁸/eIF-4E[+] is a non-enhancer of wing phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

eIF4E1⁰⁷²³⁸/eIF-4E[+] is a non-enhancer of nurse cell & chromosome phenotype of cup²¹

(Zappavigna et al., 2004)

Suppressor of

Statement

Reference

eIF4E1⁰⁷²³⁸/eIF-4E[+] is a suppressor of egg chamber phenotype of park^P23

(Ottone et al., 2011)

eIF4E1⁰⁷²³⁸/eIF-4E[+] is a suppressor of ovary phenotype of park^P23

(Ottone et al., 2011)

NOT Suppressor of

Statement

Reference

eIF4E1⁰⁷²³⁸/eIF-4E[+] is a non-suppressor of wing phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The pupal lethality observed in park^P23/park^P23 mutant animals is suppressed in a eIF-4E⁰⁷²³⁸/+ background. Pupal lethality is restored in Thor^Δ1034-2617/Thor^Δ1034-2617; park^P23, eIF-4E⁰⁷²³⁸/park^P23 animals.

The number of mature oocytes oviposited from park^P23, eIF-4E⁰⁷²³⁸/park^P23 mutant females mated to wild-type males is 42.8 oocytes/mother, and the rate of larval hatching is 40.5%, much improved compared to park^P23 homozygous mutant females.

eIF-4E⁰⁷²³⁸/+ significantly abrogates the oogenesis defects in park^P23/park^P23 mutant females. Most egg chambers appear normal in these animals, and the reduced size of park^P23/park^P23 ovaries is rescued in a eIF-4E⁰⁷²³⁸/+ background. Oogenesis defects are not restored in Thor^Δ1034-2617/Thor^Δ1034-2617; park^P23, eIF-4E⁰⁷²³⁸/park^P23 mutant animals.

(Ottone et al., 2011)

The increased sensitivity to paraquat that is seen in flies expressing Lrrk^{I1915T.Scer\UAS} under the control of Scer\GAL4^da.G32 is suppressed to wild-type levels of sensitivity if the flies are also heterozygous for eIF-4E⁰⁷²³⁸.

(Imai et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Jarid2^j2B8

(BDGP Project Members, 1994-1999)

l(3)j2B9^j2B9

(BDGP Project Members, 1994-1999)

l(3)rK145^rK145

(BDGP Project Members, 1994-1999)