FlyBase Allele Report: Dmel\png[1058]

General Information

Symbol

Dmel\png¹⁰⁵⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0013907

Feature type

allele

Associated gene

Dmel\png

Associated Insertion(s)

Carried in Construct

Also Known As

png^13-1058

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lindsley and Zimm, 1992)

Progenitor genotype

Cytology

Description

Amino acid replacement: R265C.

(Fenger et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:1,356,741..1,356,741 [-]

Nucleotide change:

C1356741T

Amino acid change:

R265C | png-PA

Reported amino acid change:

R265C|FBrf0129806

Comment:

site of nucleic acid difference inferred by FlyBase based on stated amino acid change

(Fenger et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | maternal effect

(Lee et al., 2001)

abnormal mitotic cell cycle | maternal effect (with png³³¹⁸)

(Lee et al., 2001)

female sterile

(Lindsley and Zimm, 1992)

lethal | maternal effect

(Shamanski and Orr-Weaver, 1991, Mohler and Carroll, 1984)

Phenotype Manifest In

egg & nucleus

(Renault et al., 2003)

fertilized egg | maternal effect

(Elfring et al., 1997)

nuclear chromosome

(Shamanski and Orr-Weaver, 1991)

nucleus

(Shamanski and Orr-Weaver, 1991)

nucleus | oogenesis

(Pellicena-Palle et al., 1997)

pronucleus

(Elfring et al., 1997)

Detailed Description

Statement

Reference

png²/png⁵ females produce two classes of embryos 30-55% are "multinucleate" (indicating that some mitotic division has occurred), containing more than 5 giant polyploid nuclei. The remaining embryos contain up to 5 giant polyploid nuclei (indicating a lack of mitotic divisions). Homozygous females produce 5-9% of "multinucleate" embryos.

(Lee et al., 2001)

The meiotic products and pronuclei of embryos derived from homozygous mothers overreplicate.

(Elfring et al., 1997)

Homozygous females lay eggs in which the meiotic products and the pronucleus undergo extensive DNA replication resulting in a 'giant nuclei' phenotype. dhd^J5 does not suppress the premature initiation of DNA synthesis in double mutants.

(Pellicena-Palle et al., 1997)

Unfertilised eggs from a homozygous mother initiate DNA replication inappropriately and in fertilised eggs DNA replication is uncoupled from nuclear division, both unfertilised and fertilised eggs have one giant polyploid nuclei. Chromosomes in the embryos are never condensed and do not appear polytene. Premature replication begins at the earliest during passage into the uterus. Trans-heterozygotes with the multiple nuclei alleles, png² and png⁴, produce embryos with multiple polyploid nuclei.

(Shamanski and Orr-Weaver, 1991)

Embryonic defects detectable during preblastoderm stages.

(Mohler and Carroll, 1984)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by CycA^hs.PK

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(2R)173/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by +/Df(2R)44CE

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(2R)59AB/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by +/Df(2R)59AD

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by CycB[+]/CycB²

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(2R)M60E/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(2R)X58-7/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(2R)nap9/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(3L)Ly/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(3L)W4/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(3L)fz-GF3b/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(3L)st-f13/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by +/Df(3R)C4

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(3R)Scr/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(3R)crb87-4/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by CycE⁰⁵²⁰⁶

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(2L)C144/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by +/Df(2L)E55

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by +/Df(2L)dp-79b

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(2L)r10/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(3R)e-BS2/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Df(2R)pk78s/+

(Lee et al., 2001)

NOT Enhanced by

Statement

Reference

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-enhanceable by AspRS^k04508

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-enhanceable by CycA⁵

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-enhanceable by CycB3²

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-enhanceable by Df(3L)HR119

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-enhanceable by CycA⁵

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-enhanceable by eIF3h^k09003

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-enhanceable by eIF4E1⁰⁷²³⁸

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-enhanceable by eIF4A^k01501

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-enhanceable by RpL30^k00308

(Lee et al., 2001)

Suppressed by

Statement

Reference

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by CycB3^+t9

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by Scer\GAL4^{VP16.nanos.UTR}/CycB^D46.UASp

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by CycB^hs.PK

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by Df(2R)B5/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by Df(2R)PC4/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by Df(2R)Px2/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by Df(2R)cn9/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by Df(3L)66C-G28/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by Df(3R)Cha7/+

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by +/Df(3R)ry615

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B^j6E7

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by dap⁰⁴⁴⁵⁴

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by eEF5⁰¹²⁹⁶

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by eEF5¹⁰⁵³⁰

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by mts[+]/mts^k09822

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by mts^s5286

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible | partially by Df(2L)osp29/+

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by CycB^+t10

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by Scer\GAL4^{VP16.nanos.UTR}/CycB^D46.UASp

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by CycB^hs.PK

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by Df(2L)osp29/+

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by Df(2R)Px2/+

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by Df(2R)cn9/+

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by Df(3R)Cha7/+

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by +/Df(3R)ry615

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by Pp1-87B^j6E7

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by eEF5⁰¹²⁹⁶/eIF-5A[+]

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by eEF5¹⁰⁵³⁰

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by mts^k09822

(Lee et al., 2001)

png¹⁰⁵⁸ has abnormal mitotic cell cycle | maternal effect phenotype, suppressible by mts^s5286

(Lee et al., 2001)

NOT suppressed by

Statement

Reference

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-suppressible by AspRS^k04508

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-suppressible by CycB3²

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-suppressible by Df(3L)HR119

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-suppressible by eIF3h^k09003

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-suppressible by eIF4E1⁰⁷²³⁸

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-suppressible by eIF4A^k01501

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has abnormal mitotic cell cycle | maternal effect phenotype, non-suppressible by RpL30^k00308

(Lee et al., 2001)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

png¹⁰⁵⁸ has egg & nucleus phenotype, non-enhanceable by gnu^UAS.EGFP/Scer\GAL4^{VP16.mat.αTub67C}

(Renault et al., 2003)

png¹⁰⁵⁸ has phenotype, non-enhanceable by Df(1)bi-D3

(Lee et al., 2001)

png¹⁰⁵⁸/png³³¹⁸ has phenotype, non-enhanceable by Df(1)bi-D3

(Lee et al., 2001)

NOT suppressed by

Statement

Reference

png¹⁰⁵⁸ has egg & nucleus phenotype, non-suppressible by gnu^UAS.EGFP/Scer\GAL4^{VP16.mat.αTub67C}

(Renault et al., 2003)

png¹⁰⁵⁸/png³³¹⁸ has phenotype, non-suppressible by Df(1)bi-D3

(Lee et al., 2001)

png¹⁰⁵⁸ has phenotype, non-suppressible by Df(1)bi-D3

(Lee et al., 2001)

Suppressor of

Statement

Reference

png¹⁰⁵⁸ is a suppressor of nurse cell & nucleus phenotype of Scer\GAL4^{VP16.mat.αTub67C}, gnu^UAS.EGFP

(Renault et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of homozygous png⁵ to gnu^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} animals completely restores ovarian function, though the eggs don't hatch and the png⁵ giant nuclei phenotype remains.

(Renault et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

png^171a

(Fenger et al., 2000)

png¹⁷²

(Fenger et al., 2000)

png²⁴⁶

(Fenger et al., 2000)

png⁵⁰

(Fenger et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

38437

y¹ png¹⁰⁵⁸ w^*/FM6

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

fs(1)13-1058

(Lindsley and Zimm, 1992)

fs(1)M2^13-1058

(Mohler and Carroll, 1984)

png¹⁰⁵⁸

(Ramat et al., 2024, Avilés-Pagán et al., 2021, Zhu et al., 2018, Hara et al., 2017, Sitaram et al., 2014, Orr-Weaver, 2008.5.5, Lee et al., 2003, Renault et al., 2003, Lee et al., 2001, Fenger et al., 2000, Elfring et al., 1997)

png^13-1058

(Tadros et al., 2003, Lee et al., 2001, Fenger et al., 2000, Elfring et al., 1997, Liu et al., 1997, Pellicena-Palle et al., 1997, Shamanski and Orr-Weaver, 1991)

png⁵

(Orr-Weaver, 2008.5.5)

Name Synonyms

Secondary FlyBase IDs

References (17)

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