FB2026_03 , released September 17, 2026
Gene: Dmel\png
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General Information
Symbol
Dmel\png
Species
D. melanogaster
Name
pan gu
Annotation Symbol
CG11420
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000826
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
pan gu (png) encodes a Ser/Thr kinase that controls the translation of hundreds of mRNAs, such as CycB and smg, during the oocyte-to-embryo transition. The activation of the product of png requires the formation of a complex with the two activating subunits encoded by plu and gnu. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

EG:8D8.5 , fs(1)M2

Key Links
Genomic Location
Cytogenetic map
1F4-1F4
Sequence location
Recombination map
1-0.1
RefSeq locus
NC_004354 REGION:1356488..1357601
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein serine/threonine kinase activity
inferred from direct assay
(Hara et al., 2017, Fenger et al., 2000)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719
(InterPro Project Members, 2004-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR008271
(InterPro Project Members, 2004-)
enables protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN002546316
(GO Reference Genome Project, 2011-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in egg activation
inferred from mutant phenotype
(Tadros et al., 2003)
involved_in positive regulation of mitotic cell cycle, embryonic
inferred from mutant phenotype
(Fenger et al., 2000)
acts_upstream_of positive regulation of translation
inferred from mutant phenotype
(Zavortink et al., 2020)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in negative regulation of cytoplasmic mRNA processing body assembly
traceable author statement
(Avilés-Pagán et al., 2021)
involved_in regulation of mitotic cell cycle
traceable author statement
(Lee and Orr-Weaver, 2003)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of protein kinase complex
inferred from physical interaction with UniProtKB:O46308,UniProtKB:P42570
(Hara et al., 2017)
part_of serine/threonine protein kinase complex
inferred from physical interaction with FLYBASE:plu; FB:FBgn0003114
(Fenger et al., 2000)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002546316
(GO Reference Genome Project, 2011-)
Gene Group / Complex (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
pan gu (png) encodes a Ser/Thr kinase that controls the translation of hundreds of mRNAs, such as CycB and smg, during the oocyte-to-embryo transition. The activation of the product of png requires the formation of a complex with the two activating subunits encoded by plu and gnu. [Date last reviewed: 2019-03-14]
Gene Group / Complex (FlyBase)
UNCLASSIFIED CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -
This group comprises conventional protein kinase domain kinases that do not classify under other groups in FlyBase.
Summary (Interactive Fly)

serine/threonine kinase - inhibits DNA replication in the unfertilized egg and permits the accumulation of Cyclin B during early mitotic divisions - controls the translation of hundreds of mRNAs, such as CyclinB and Smaug, during the oocyte-to-embryo transition - active Png kinase requires the formation of a complex with the two activating subunits Plutonium and Giant nuclei.

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\png for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O46308)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
png-RA
FBtr0070234
NM_058144
1114
291
Additional Transcript Data and Comments
Reported size (kB)

1.3 (northern blot)

(Fenger et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
png-PA
FBpp0070225
33.1
291
8.28
O46308
NP_477492
AAF45611
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

291 (aa); 33 (kD predicted)

(Fenger et al., 2000)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\png using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.23

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 1 -- 6

Comment: reference states 0-3 hr AEL

(Fenger et al., 2000)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
adult stage | female
(Fenger et al., 2000)
Additional Descriptive Data

Expression is detected predominantly in adult females and 0-3 hr embryos. Expression is barely detectable in 3-6 hr embryos. Expression is also detected in the Schneider L2 embryonic cell line.

(Fenger et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 15

Comment: reference states 0-12 hr AEL

(Fenger et al., 2000)
unfertilized egg stage
unfertilized egg
(Fenger et al., 2000)
Additional Descriptive Data

png protein is expressed at high levels in unfertilized eggs and 0-2 hr embryos. Low levels of expression are detected in 6-12 hr embryos. No expression is detected in larval salivary glands, larval brains or imaginal discs.

(Fenger et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of protein kinase complex
inferred from physical interaction with UniProtKB:O46308,UniProtKB:P42570
(Hara et al., 2017)
part_of serine/threonine protein kinase complex
inferred from physical interaction with FLYBASE:plu; FB:FBgn0003114
(Fenger et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\png in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of png
Transgenic constructs containing regulatory region of png
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (29)
Hsap\NEK2
3 of 14
Yes
No
Hsap\NEK6
3 of 14
Yes
Yes
Hsap\NEK7
3 of 14
Yes
Yes
Hsap\NEK1
2 of 14
No
No
Hsap\NEK3
2 of 14
No
No
Hsap\NEK5
2 of 14
No
No
Hsap\NEK8
2 of 14
No
No
Hsap\NEK11
2 of 14
No
No
Hsap\AAK1
1 of 14
No
No
Hsap\AURKA
1 of 14
No
No
Hsap\BMP2K
1 of 14
No
No
Hsap\GAK
1 of 14
No
No
2  
Hsap\HCK
1 of 14
No
No
Hsap\LCK
1 of 14
No
No
Hsap\LYN
1 of 14
No
No
Hsap\MAP3K9
1 of 14
No
No
Hsap\MAP3K20
1 of 14
No
No
Hsap\MYLK2
1 of 14
No
No
Hsap\MYLK3
1 of 14
No
No
Hsap\MYLK4
1 of 14
No
No
Hsap\NEK4
1 of 14
No
No
Hsap\NEK10
1 of 14
No
No
Hsap\NUAK1
1 of 14
No
No
2  
Hsap\NUAK2
1 of 14
No
No
2  
Hsap\PRKAA1
1 of 14
No
No
2  
Hsap\RPS6KA1
1 of 14
No
No
Hsap\RPS6KA3
1 of 14
No
No
1  
Hsap\SGK1
1 of 14
No
No
Hsap\STK16
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (15)
Rnor\Nek2l1
3 of 14
Yes
No
Rnor\Nek2
3 of 14
Yes
No
Rnor\Nek6
3 of 14
Yes
Yes
Rnor\Nek7
3 of 14
Yes
Yes
Rnor\Nek1
2 of 14
No
No
Rnor\Nek3
2 of 14
No
No
Rnor\Nek5
2 of 14
No
No
Rnor\Aurka
1 of 14
No
No
Rnor\Nek4
1 of 14
No
No
Rnor\Nek8
1 of 14
No
No
Rnor\Nek10
1 of 14
No
Yes
Rnor\Nek11
1 of 14
No
No
Rnor\Nuak1
1 of 14
No
No
Rnor\Nuak2
1 of 14
No
No
Rnor\Prkaa1
1 of 14
No
No
Mus musculus (laboratory mouse) (14)
Mmus\Nek2
3 of 14
Yes
No
Mmus\Nek1
2 of 14
No
No
Mmus\Nek3
2 of 14
No
No
Mmus\Nek5
2 of 14
No
No
Mmus\Nek6
2 of 14
No
No
Mmus\Nek7
2 of 14
No
No
Mmus\Aurka
1 of 14
No
No
Mmus\Nek4
1 of 14
No
No
Mmus\Nek8
1 of 14
No
No
Mmus\Nek10
1 of 14
No
No
Mmus\Nek11
1 of 14
No
No
Mmus\Nuak1
1 of 14
No
No
Mmus\Nuak2
1 of 14
No
No
Mmus\Prkaa1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (23)
Xtro\nek5
3 of 13
Yes
Yes
Xtro\LOC100328980
2 of 13
No
No
Xtro\LOC100486125
2 of 13
No
No
Xtro\LOC100486333
2 of 13
No
No
Xtro\LOC100494322
2 of 13
No
No
Xtro\nek1
2 of 13
No
No
Xtro\nek6
2 of 13
No
No
Xtro\nek7
2 of 13
No
No
Xtro\nek11
2 of 13
No
No
Xtro\aurka
1 of 13
No
No
Xtro\LOC100145764
1 of 13
No
No
Xtro\LOC116406512
1 of 13
No
No
Xtro\map3k20
1 of 13
No
No
Xtro\nek2
1 of 13
No
No
Xtro\nek3
1 of 13
No
No
Xtro\nek8
1 of 13
No
No
Xtro\nek10
1 of 13
No
Yes
Xtro\nuak1
1 of 13
No
No
Xtro\nuak2
1 of 13
No
No
Xtro\scin
1 of 13
No
No
Xtro\sgk1
1 of 13
No
No
Xtro\stimate
1 of 13
No
No
Xtro\stk16
1 of 13
No
No
Danio rerio (Zebrafish) (17)
Drer\nek1
3 of 14
Yes
No
Drer\nek2
3 of 14
Yes
No
Drer\nek3
3 of 14
Yes
No
Drer\nek7
3 of 14
Yes
Yes
Drer\nek12
2 of 14
No
No
Drer\si:dkey-192d15.2
2 of 14
No
Yes
Drer\aurka
1 of 14
No
No
Drer\aurkb
1 of 14
No
No
Drer\LOC107980443
1 of 14
No
No
Drer\nek4
1 of 14
No
No
Drer\nek6
1 of 14
No
No
Drer\nek8
1 of 14
No
No
Drer\nek10
1 of 14
No
Yes
Drer\nek11
1 of 14
No
No
Drer\nuak1a
1 of 14
No
No
Drer\nuak1b
1 of 14
No
No
Drer\prkaa1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (17)
Cele\nekl-2
4 of 14
Yes
Yes
Cele\nekl-1
3 of 14
No
No
Cele\nekl-3
2 of 14
No
No
Cele\nekl-4
2 of 14
No
Yes
Cele\aak-2
1 of 14
No
No
Cele\air-1
1 of 14
No
No
Cele\C03B1.5
1 of 14
No
No
Cele\D2045.7
1 of 14
No
No
Cele\F49C5.4
1 of 14
No
No
Cele\frk-1
1 of 14
No
No
Cele\gakh-1
1 of 14
No
No
Cele\mekk-3
1 of 14
No
Yes
Cele\mtk-1
1 of 14
No
No
Cele\sel-5
1 of 14
No
No
Cele\T07F12.4
1 of 14
No
No
Cele\unc-22
1 of 14
No
No
Cele\unc-82
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP007669
11 of 12
Yes
Yes
Agam\AgaP_AGAP006872
2 of 12
No
No
Agam\AgaP_AGAP001793
1 of 12
No
No
Agam\AgaP_AGAP002469
1 of 12
No
No
Agam\AgaP_AGAP002686
1 of 12
No
No
Agam\AgaP_AGAP003040
1 of 12
No
No
Agam\AgaP_AGAP003715
1 of 12
No
No
Agam\AgaP_AGAP006746
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (43)
Atha\AT1G18160
1 of 13
Yes
No
Atha\AT1G67890
1 of 13
Yes
No
Atha\AT1G73660
1 of 13
Yes
No
Atha\AT2G32850
1 of 13
Yes
No
Atha\AT3G46930
1 of 13
Yes
No
Atha\AT4G24480
1 of 13
Yes
No
Atha\AT4G31170
1 of 13
Yes
No
Atha\AT4G32250
1 of 13
Yes
Yes
Atha\ATMRK1
1 of 13
Yes
No
Atha\AUR3
1 of 13
Yes
No
Atha\CIPK5
1 of 13
Yes
No
Atha\CIPK8
1 of 13
Yes
No
Atha\CIPK9
1 of 13
Yes
No
Atha\CIPK12
1 of 13
Yes
No
Atha\CIPK13
1 of 13
Yes
No
Atha\CIPK15
1 of 13
Yes
No
Atha\CIPK18
1 of 13
Yes
Yes
Atha\CIPK19
1 of 13
Yes
No
Atha\CIPK20
1 of 13
Yes
No
Atha\CIPK23
1 of 13
Yes
No
Atha\CIPK25
1 of 13
Yes
No
Atha\CTR1
1 of 13
Yes
No
Atha\HT1
1 of 13
Yes
No
Atha\KEG
1 of 13
Yes
Yes
Atha\KIN10
1 of 13
Yes
No
Atha\KIN11
1 of 13
Yes
No
Atha\MAP3KA
1 of 13
Yes
No
Atha\MAPKKK5
1 of 13
Yes
No
Atha\MAPKKK6
1 of 13
Yes
No
Atha\MAPKKK7
1 of 13
Yes
No
Atha\MAPKKK20
1 of 13
Yes
Yes
Atha\NEK1
1 of 13
Yes
No
Atha\NEK2
1 of 13
Yes
No
Atha\NEK3
1 of 13
Yes
No
Atha\NEK4
1 of 13
Yes
No
Atha\NEK5
1 of 13
Yes
No
Atha\NEK6
1 of 13
Yes
No
Atha\Nek7
1 of 13
Yes
No
Atha\PK3
1 of 13
Yes
No
Atha\SOS2
1 of 13
Yes
No
Atha\STY8
1 of 13
Yes
No
Atha\STY17
1 of 13
Yes
No
Atha\STY46
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\AKL1
1 of 13
Yes
No
Scer\ARK1
1 of 13
Yes
No
Scer\BCK1
1 of 13
Yes
No
Scer\CMK1
1 of 13
Yes
No
Scer\CMK2
1 of 13
Yes
No
Scer\ENV7
1 of 13
Yes
No
Scer\KIN3
1 of 13
Yes
No
Scer\PRK1
1 of 13
Yes
No
Scer\SNF1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\fin1
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:png. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (10)
Nek2
3 of 13
niki
3 of 13
AMPKα
1 of 13
aurA
1 of 13
aux
1 of 13
CG1227
1 of 13
MAPk-Ak2
1 of 13
Mekk1
1 of 13
Nak
1 of 13
S6kII
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    NEK2; NIMA related kinase 2
    model of  retinitis pigmentosa 67
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NEK2; NIMA related kinase 2
    3 of 14
    604043
    NEK6; NIMA related kinase 6
    3 of 14
    604884
        NEK7; NIMA related kinase 7
        3 of 14
        606848
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            png
            enhanceable
            CycA
            (Lee et al., 2001)
            png
            suppressible
            CycB3
            (Lee et al., 2001)
            png
            suppressible
            CycB
            (Lee et al., 2001)
            png
            enhanceable
            CycB
            (Lee et al., 2001)
            png
            enhanceable
            CycE
            (Lee et al., 2001)
            png
            suppressible
            dap
            (Lee et al., 2001)
            png
            suppressible
            eEF5
            (Lee et al., 2001)
            png
            enhanceable
            l(2)10481
            (Lee et al., 2001)
            png
            suppressible
            mts
            (Lee et al., 2001)
            png
            suppressible
            Pp1-87B
            (Lee et al., 2001)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            gnu
            suppressible
            png
            (Renault et al., 2003)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            X
            Recombination map
            1-0.1
            Cytogenetic map
            1F4-1F4
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            1F4-1F4
            Limits computationally determined from genome sequence between P{EP}EP1542 and P{EP}futschEP1419
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            1F-2A
            (Fenger, 2000.9.18)
            Experimentally Determined Recombination Data
            Location

            1-0.1

            (FlyBase, 2016, Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (12)
            Genomic Clones (10)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (35)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Hara et al., 2017, Fenger et al., 2000)
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                  (Kiger et al., 2003)

                  png+ function is required for the presence of plu protein.

                  (Elfring et al., 1997)

                  Mutations in png cause inappropriate DNA replication in unfertilised eggs, eggs have giant polyploid nuclei. This phenotype suggests that png is required to repress DNA replication before fertilisation. and the gene plays a role in coordinating S phase and nuclear division.

                  (Fenger et al., 1995)

                  Wild type png function is required to maintain repression of DNA replication until fertilisation. pngmay also play a direct role in coupling S phase and mitosis during the early cleavage divisions.

                  (Shamanski and Orr-Weaver, 1991)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: png EG:8D8.5

                  (FlyBase, 1996-)
                  Additional comments

                  Source for merge of png EG:8D8.5 was sequence comparison ( date:001108 ).

                  (FlyBase, 1996-)
                  Nomenclature History
                  Source for database identify of
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (9)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 41 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  References (118)