Su(var)3-6, PP1α87B, PP1, PP1 87B, Su-var(3)6
Gene model reviewed during 5.50
Low-frequency RNA-Seq exon junction(s) not annotated.
There is only one protein coding transcript and one polypeptide associated with this gene
302 (aa); 34.5 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pp1-87B using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Pp1-87B in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
Mutants block mitosis, alter heterochromatin and cause pupal lethality.
Flies deficient for protein phosphatase 1 show behavioral abnormalities, with impaired associative olfactory learning and visual conditioning. Also reduced mobility and flight activity.
A haplo-dependent suppressor of position effect variegation without the triplo enhancer effect, flies with two additional copies show normal mottling.
Encodes a serine/threonine specific protein phosphatase.
Identification: Isolated from a Drosophila head cDNA library, using a rabbit muscle PP-1α cDNA as a probe.