FlyBase Gene Report: Dmel\CanA1

General Information

Symbol

Dmel\CanA1

Species

D. melanogaster

Name

Calcineurin A1

Annotation Symbol

CG1455

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010015

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

protein-serine/threonine phosphatase (3.1.3.16)

Gene Summary

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (By similarity). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). This subunit may have a role in the calmodulin activation of calcineurin (Probable). At the periactive zone of synaptic boutons at neuromuscular junctions, promotes formation of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) microdomains and subsequent synaptic vesicle reformation during Ca(2+) channel-dependent activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (PubMed:33300871). This function may be fwe-dependent (PubMed:33300871). (UniProt, P48456)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

calcineurin, CaN, PP2B 21EF

Key Links

Genomic Location

Cytogenetic map

100B1-100B1

Sequence location

3R:31,039,374..31,046,821 [+]

Recombination map

3-102

RefSeq locus

NT_033777 REGION:31039374..31046821

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables calcium-dependent protein serine/threonine phosphatase activity

inferred from sequence or structural similarity

(Guerini et al., 1992)

enables calmodulin binding

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(GO Reference Genome Project, 2011-)

enables calmodulin-dependent protein phosphatase activity

inferred from electronic annotation with InterPro:IPR043360

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(GO Reference Genome Project, 2011-)

enables hydrolase activity

inferred from electronic annotation with InterPro:IPR004843, InterPro:IPR006186

(InterPro Project Members, 2004-)

enables protein serine/threonine phosphatase activity

inferred from sequence or structural similarity

(Chen et al., 1992)

Biological Process (8 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in medium-term memory

inferred from direct assay

(Tomita et al., 2011)

involved_in negative regulation of epidermal growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731

(Sullivan and Rubin, 2002)

involved_in positive regulation of type 2 mitophagy

inferred from genetic interaction with FLYBASE:Pink1; FB:FBgn0029891

(Marchesan et al., 2024)

involved_in regulation of innate immune response

inferred from direct assay

(Dijkers and O'Farrell, 2007)

involved_in response to Gram-negative bacterium

inferred from mutant phenotype

(Chen et al., 2022)

involved_in response to nitric oxide

inferred from direct assay

(Dijkers and O'Farrell, 2007)

inferred from mutant phenotype

(Chen et al., 2022)

involved_in sleep

inferred from direct assay

(Nakai et al., 2011, Tomita et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in calcineurin-mediated signaling

inferred from electronic annotation with InterPro:IPR043360

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of calcineurin complex

inferred from sequence or structural similarity

(Guerini et al., 1992)

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(GO Reference Genome Project, 2011-)

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(GO Reference Genome Project, 2011-)

located_in synaptic vesicle

non-traceable author statement

(Lloyd et al., 2000)

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Pathway (FlyBase)

NEGATIVE REGULATORS OF EGFR SIGNALING PATHWAY

Protein Family (UniProt)

Belongs to the PPP phosphatase family. PP-2B subfamily. (P48456)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein serine/threonine phosphatase activity

(1) O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (3.1.3.16)

(2) O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (3.1.3.16)

Summaries

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -: The Phosphoprotein Phosphatase (PPP) family members are serine/threonine phosphatases. They often function in association with regulatory subunits. (Adapted from PMID:11230548 and PMID:19879837).

Pathway (FlyBase)

NEGATIVE REGULATORS OF EGFR SIGNALING PATHWAY -: Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.

Protein Function (UniProtKB)

(UniProt, P48456)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CanA1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P48456)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CanA1-RA

FBtr0085732

NM_079861

2628

622

CanA1-RB

FBtr0304582

NM_001260448

2530

596

CanA1-RD

FBtr0334546

NM_001260449

3064

622

Additional Transcript Data and Comments

Reported size (kB)

1.998 (compiled cDNA)

(Guerini et al., 1992)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CanA1-PA

FBpp0085094

69.1

622

7.82

FBpp0293124

66.3

596

7.24

FBpp0306613

69.1

622

7.82

P48456

NP_001247378

AFH06695

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

622 aa isoforms: CanA1-PA, CanA1-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

568 (aa); 65 (kD)

(Guerini et al., 1992)

Comments

External Data

Subunit Structure (UniProtKB)

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

(UniProt, P48456)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CanA1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CanA1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.44

Transcript Expression

Additional Descriptive Data

CanA1 transcripts are not detected in any stages on northern blots presumably due to low abundance.

(Guerini et al., 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CanA1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CanA1

View exonic expression by tissue for Dmel\CanA1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010015

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43670/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010015

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010015

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010015

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1455

Flygut - An atlas of the Drosophila adult midgut

FBgn0010015

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CanA1

Transgenic constructs containing regulatory region of CanA1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6260

(Ryder, 2004.4.26)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

partially lethal - majority live, with Scer\GAL4^elav.PU

CanA1^JF01871

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CanA1^GD8366

viable, with Scer\GAL4^Mef2.PR

CanA1^GD8366

viable, with Scer\GAL4^tin.CΔ4

CanA1^GD8366

Other Phenotypes

Allele

abnormal locomotor behavior

abnormal memory, with Scer\GAL4^elav-C155

CanA1^GD16976

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^VGlut1-OK371

CanA1^JF01871

abnormal sleep

abnormal sleep, with Scer\GAL4^elav-C155

CanA1^GD16976

decreased rate of movement, with Scer\GAL4^elav-C155

CanA1^GD16976

some die during pupal stage, with Scer\GAL4^pnr-MD237

visible, with Scer\GAL4^pnr-MD237

CanA1^GD16976

Phenotype manifest in

Allele

embryonic/larval hypodermal muscle cell | third instar larval stage, with Scer\GAL4^VGlut1-OK371

larval glial cell | increased number, with Scer\GAL4^elav.PU

CanA1^JF01871

mesonotum, with Scer\GAL4^pnr-MD237

CanA1^GD16976

microtubule | third instar larval stage, with Scer\GAL4^VGlut1-OK371

CanA1^{RNAi.320-1160.UAS}

mitochondrion | adult stage

CanA1^f01787

NMJ bouton | decreased number | third instar larval stage, with Scer\GAL4^VGlut1-OK371

trichogen cell, with Scer\GAL4^pnr-MD237

CanA1^GD16976

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (13)

Hsap\PPP3CB

12 of 14

Yes

11 of 14

10 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (13)

Rnor\Ppp3cb

11 of 14

Yes

Rnor\Ppp3cc

11 of 14

Yes

10 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (13)

Mmus\Ppp3cb

12 of 14

Yes

11 of 14

9 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (12)

Xtro\ppp3cb

7 of 13

Yes

Xtro\ppp3ca

5 of 13

Xtro\ppp3cc

5 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\rhof

1 of 13

Yes

Xtro\septin10

1 of 13

Danio rerio (Zebrafish) (16)

Drer\ppp3ccb

12 of 14

Yes

11 of 14

10 of 14

10 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (45)

Cele\tax-6

11 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP001279

7 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (32)

Atha\PP2A-1

3 of 13

Yes

Atha\PP2A-2

3 of 13

Yes

Atha\PP2A-3

3 of 13

Yes

Atha\PP2A-4

3 of 13

Yes

Atha\PPX1

3 of 13

Yes

Atha\PPX2

3 of 13

Yes

Atha\TOPP1

3 of 13

Yes

Atha\TOPP2

3 of 13

Yes

Atha\TOPP3

3 of 13

Yes

Atha\TOPP4

3 of 13

Yes

Atha\TOPP5

3 of 13

Yes

Atha\TOPP6

3 of 13

Yes

Atha\TOPP7

3 of 13

Yes

Atha\TOPP8

3 of 13

Yes

Atha\TOPP9

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Atha\AT3G09970

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\SLP2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (13)

Scer\CMP2

12 of 13

Yes

11 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (11)

Spom\ppb1

11 of 12

Yes

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

Escherichia coli (enterobacterium) (3)

Ecol\apaH

1 of 11

Yes

Ecol\pphA

1 of 11

Yes

Ecol\pphB

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CanA1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (18)

CanA-14F

11 of 13

Pp2B-14D

11 of 13

flw

3 of 13

mts

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

PpV

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

CanA1^GD8366

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPP3CB; protein phosphatase 3 catalytic subunit beta

12 of 14

114106

PPP3CC; protein phosphatase 3 catalytic subunit gamma

11 of 14

114107

PPP3CA; protein phosphatase 3 catalytic subunit alpha

10 of 14

PROTEIN PHOSPHATASE 3, CATALYTIC SUBUNIT, ALPHA ISOFORM; PPP3CA

developmental and epileptic encephalopathy 91

PPP1CA; protein phosphatase 1 catalytic subunit alpha

3 of 14

176875

PPP1CB; protein phosphatase 1 catalytic subunit beta

3 of 14

600590

NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR 2; NSLH2

Noonan syndrome-like disorder with loose anagen hair 2

PPP1CC; protein phosphatase 1 catalytic subunit gamma

3 of 14

176914

PPP2CA; protein phosphatase 2 catalytic subunit alpha

3 of 14

176915

HOUGE-JANSSENS SYNDROME 3; HJS3

PPP2CB; protein phosphatase 2 catalytic subunit beta

3 of 14

176916

PPP4C; protein phosphatase 4 catalytic subunit

3 of 14

602035

PPP6C; protein phosphatase 6 catalytic subunit

3 of 14

612725

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CanA1 - Pp2B-14D

experimental knowledge based

(Guruharsha et al., 2011)

CanA1 - Rel

anti tag coimmunoprecipitation, anti tag western blot

(Dijkers and O'Farrell, 2007)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

brm

suppressible

CanA1

(Tegeder et al., 2019)

iav

suppressible

CanA1

(Wong et al., 2014)

External Data

Subunit Structure (UniProtKB)

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

(UniProt, P48456 )

Linkouts

BioGRID - A database of protein and genetic interactions.

68520

DroID - A comprehensive database of gene and protein interactions.

FBgn0010015

MIST (protein-protein) - An integrated Molecular Interaction Database

43670

Pathways

Signaling Pathways (FlyBase)

NEGATIVE REGULATORS OF EGFR SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Wnt signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P48456

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-102

Cytogenetic map

100B1-100B1

Sequence location

3R:31,039,374..31,046,821 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100B1-100B1

Limits computationally determined from genome sequence between P{lacW}l(3)s2500^s2500 and P{PZ}Aph-4⁰⁷⁰²⁸&P{PZ}dco^rK215

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

100B2-100B2

(determined by in situ hybridisation)

(Yang et al., 2000)

21E-21F

(Guerini, 1992.11.30)

21E-21F

(determined by in situ hybridisation)

(Guerini et al., 1992)

Experimentally Determined Recombination Data

Location

3-102

(FlyBase, 2016)

3-98.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

83343

w¹¹¹⁸; P{UAS-CanA1.Δ.HA}4B

29211

w¹¹¹⁸; Mi{ET1}CanA1^MB11454

25850

y¹ v¹; P{TRiP.JF01871}attP2

80327

y¹ v¹; P{TKO.GS03287}attP40

42342

y¹ w^*; Mi{MIC}CanA1^MI05747

43015

y¹ w^*; Mi{MIC}CanA1^MI05596

Kyoto

104305

w^*; P{GawB}CanA1^NP2738 / TM3, Sb¹ Ser¹

VDRC

v32283

w¹¹¹⁸; P{GD8366}v32283

v32284

w¹¹¹⁸; P{GD8366}v32284/CyO

v341038

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00041}attP40/CyO-GFP

v341453

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00523}attP40/CyO-GFP

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (18)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE54552

Other clones

DPiM_RE54552

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010015

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010015

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

CanA1 mediates the action of nitric oxide.

(Dijkers and O'Farrell, 2007)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Two subunits of Drosophila calcineurin have been cloned.

(Guerini et al., 1992)

The primary structure, amino acid sequence and regulation of CanA1 has been determined and compared to human and bovine calcineurin proteins.

(Klee and Guerini, 1990)

Relationship to Other Genes

Source for database merge of

Source for merge of: CanA1 PpD14

(Bayraktaroglu, 2000.8.7)

Additional comments

The CanA-14F gene may be derived from the CanA1 gene by retroposition.

(Betran et al., 2002)

Nomenclature History

Source for database identify of

Source for identity of: CanA1 CG1455

(Yao, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (24)

Reported As

Symbol Synonym

CAN A1/PP2B

(Morrison et al., 2000)

CG1455

(Fukuoh et al., 2014, Kanamori et al., 2013, Perkins et al., 2009.1.15, Philipps et al., 2004, Morrison et al., 2000)

CNA1

(Guerini, 1992.11.30)

CaN

(Toprak et al., 2020, Vajente et al., 2020, Sartain and Wolfner, 2013)

CaNA1

(Armstrong and Frank, 2022)

Can

Cana1

(Bandyopadhyay et al., 2006)

CnA

(Tomita et al., 2011)

CnnA21EF

(Hong and Ganetzky, 1996)

D14

(Chen et al., 1992)

DmCanA1-100B

(Cohen et al., 2005)

PP2B

(Helps et al., 1998)

PP2B 21EF

(Cohen, 1997, Brown et al., 1994)

PpD14

canA

(Sullivan and Rubin, 2002)

canA1

(Li et al., 2020, Gupta et al., 2014, Wong et al., 2014, Kanamori et al., 2013)

pMY4

(Yang et al., 2000)

Name Synonyms

Calcineurin

(Dijkers and O'Farrell, 2007)

Calcineurin A

(Tomita et al., 2011)

Calcineurin A1

(Li and Dijkers, 2015, Gupta et al., 2014)

Protein phosphatase D14

calcineurin

(Potdar and Sheeba, 2013, Sartain and Wolfner, 2013, Dijkers and O'Farrell, 2007, Sullivan and Rubin, 2002, Sullivan and Rubin, 2000)

protein phosphatase from PCR fragment D14

(Chen, 1993.1.7)

Secondary FlyBase IDs

FBgn0004466
FBgn0005780

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43670

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P48456

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P48456

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P48456

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010015

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43670/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010015

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010015

FlyMine - An integrated database for Drosophila genomics

FBgn0010015

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1455

MARRVEL_MODEL - MARRVEL (model organism gene)

43670

Linkouts

BioGRID - A database of protein and genetic interactions.

68520

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010015

DroID - A comprehensive database of gene and protein interactions.

FBgn0010015

DRSC - Results frm RNAi screens

FBgn0010015

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CanA1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010015

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010015

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1455

Flygut - An atlas of the Drosophila adult midgut

FBgn0010015

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010015

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Wnt signaling pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

43670

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P48456

References (98)

The following external sites may use different assemblies or annotations than FlyBase.

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