FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term protein serine/threonine phosphatase activity ID (Ontology) GO:0004722 (Gene Ontology)
Definition Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
Also Known As"serine/threonine specific protein phosphatase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 protein serine/threonine phosphatase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | protein serine/threonine phosphatase activity       --
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phosphatase activity_____________________
catalytic activity, acting on a protein__|
                                         phosphoprotein phosphatase activity
                                          |__protein serine/threonine phosphatase activity  64 rec.
                                              |__[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity 1 rec.
                                              |__calcium-dependent protein serine/threonine phosphatase activity 4 rec.
                                              |   |__calmodulin-dependent protein phosphatase activity 3 rec.
                                              |__MAP kinase serine/threonine phosphatase activity
                                              |__myosin phosphatase activity 2 rec.
                                              |__RNA polymerase II CTD heptapeptide repeat phosphatase activity 5 rec.
                                                  |__RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
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Is a phosphoprotein phosphatase activity
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Synonyms
  • "magnesium-dependent protein serine/threonine phosphatase activity" RELATED
    "phosphatase I" NARROW
    "phosphatase II" NARROW
    "phosphatase III" NARROW
    "protein phosphatase type 1 activity" NARROW
    "protein phosphatase type 2A activity" NARROW
    "protein phosphatase type 2B activity" NARROW
    "protein phosphatase type 2C activity" NARROW
    "protein phosphatase-1" NARROW[ EC:3 ]
    "protein phosphatase-2A" NARROW[ EC:3 ]
    "protein phosphatase-2B" NARROW[ EC:3 ]
    "protein phosphatase-2C" NARROW[ EC:3 ]
    "protein serine phosphatase activity" NARROW
    "protein threonine phosphatase activity" NARROW
    "serine/threonine specific protein phosphatase activity" EXACT
Secondary IDs
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EC:3.1.3.16
MetaCyc:3.1.3.16-RXN
Reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2"
Reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate"
Reactome:R-HSA-163689 "PP2A complex dephosphorylates pChREBP (MLXIPL)"
Reactome:R-HSA-163750 "PP2A complex dephosphorylates pPFKFB1"
Reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin"
Reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT"
Reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A"
Reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34"
Reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A"
Reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3"
Reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3"
Reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1"
Reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1"
Reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex"
Reactome:R-HSA-380949 "AMPK is dephosphorylated"
Reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1"
Reactome:R-HSA-429730 "PPM1L dephosphorylates multiphospho-CERT1-2"
Reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN"
Reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1"
Reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs"
Reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1"
Reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338"
Reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P"
Reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1"
Reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2"
Reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6"
Reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24"
Reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2"
Reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma"
Reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO"
Reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5"
Reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4"
Reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII"
Reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1"
Reactome:R-HSA-9658445 "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs"
Reactome:R-HSA-9660536 "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex"
Reactome:R-HSA-9660538 "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs"
Reactome:R-HSA-9686524 "PP6-PPP6R3 dephosphorylates TERF2"
Reactome:R-HSA-9831948 "P:PP1 dephosphorylates M2-1"
Reactome:R-HSA-9853385 "PPP1CC dephosphorylates PLK1"
Reactome:R-HSA-9861725 "PGAM5 dodecamer dephosphorylates p-S336-ME1"
Reactome:R-HSA-9865226 "PP2A dephosphorylates serine-127 of YAP1"
Reactome:R-HSA-9865238 "PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin"
Reactome:R-HSA-9912527 "H139Hfs13* PPM1K does not dephosphorylate BCKDH"
Reactome:R-HSA-9970190 "PP1 dephosphorylates RNA Pol II"
RHEA:12849
RHEA:20629
RHEA:47004
RHEA:53988