FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
Help Close All Open All
General Information
Term protein serine/threonine phosphatase activity ID (Ontology) GO:0004722 (Gene Ontology)
Definition Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
Also Known As "serine/threonine specific protein phosphatase activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      43
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 protein serine/threonine phosphatase activity (all annotations which use CV term, excluding "NOT" statements)      15     43
     enables | protein serine/threonine phosphatase activity       --      43
Spanning Tree (Parents/Children)
Only view relationship: 
phosphatase activity_____________________
catalytic activity, acting on a protein__|
                                         phosphoprotein phosphatase activity
                                          |__protein serine/threonine phosphatase activity  62 rec.
                                              |__[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity 1 rec.
                                              |__calcium-dependent protein serine/threonine phosphatase activity 4 rec.
                                              |   |__calmodulin-dependent protein phosphatase activity 3 rec.
                                              |__MAP kinase serine/threonine phosphatase activity
                                              |__myosin phosphatase activity 2 rec.
                                              |__RNA polymerase II CTD heptapeptide repeat phosphatase activity 5 rec.
                                                  |__RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a phosphoprotein phosphatase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "magnesium-dependent protein serine/threonine phosphatase activity" RELATED
    "phosphatase I" NARROW
    "phosphatase II" NARROW
    "phosphatase III" NARROW
    "protein phosphatase type 1 activity" NARROW
    "protein phosphatase type 2A activity" NARROW
    "protein phosphatase type 2B activity" NARROW
    "protein phosphatase type 2C activity" NARROW
    "protein phosphatase-1" NARROW[ EC:3 ]
    "protein phosphatase-2A" NARROW[ EC:3 ]
    "protein phosphatase-2B" NARROW[ EC:3 ]
    "protein phosphatase-2C" NARROW[ EC:3 ]
    "protein serine phosphatase activity" NARROW
    "protein threonine phosphatase activity" NARROW
    "serine/threonine specific protein phosphatase activity" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
EC:3.1.3.16
MetaCyc:3.1.3.16-RXN
Reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2"
Reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate"
Reactome:R-HSA-163689 "Dephosphorylation of pChREBP (Ser 196) by PP2A"
Reactome:R-HSA-163750 "Dephosphorylation of phosphoPFKFB1 by PP2A complex"
Reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin"
Reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT"
Reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A"
Reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34"
Reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A"
Reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3"
Reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3"
Reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1"
Reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1"
Reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex"
Reactome:R-HSA-380949 "AMPK is dephosphorylated"
Reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1"
Reactome:R-HSA-429730 "PPM1L dephosphorylates multiphospho-CERT1-2"
Reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN"
Reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1"
Reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs"
Reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1"
Reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338"
Reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P"
Reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1"
Reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2"
Reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6"
Reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH"
Reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24"
Reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2"
Reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma"
Reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO"
Reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5"
Reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4"
Reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII"
Reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1"
Reactome:R-HSA-9658445 "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs"
Reactome:R-HSA-9660536 "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex"
Reactome:R-HSA-9660538 "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs"
Reactome:R-HSA-9686524 "PP6-PPP6R3 dephosphorylates TERF2"
Reactome:R-HSA-9831948 "P:PP1 dephosphorylates M2-1"
Reactome:R-HSA-9853385 "PPP1CC dephosphorylates PLK1"
Reactome:R-HSA-9861725 "PGAM5 dodecamer dephosphorylates p-S336-ME1"
Reactome:R-HSA-9865226 "PP2A dephosphorylates serine-127 of YAP1"
Reactome:R-HSA-9865238 "PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin"
Reactome:R-HSA-9912527 "H139Hfs13* PPM1K does not dephosphorylate BCKDH"
RHEA:20629
RHEA:47004