FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

calcineurin-mediated signaling

ID (Ontology)

GO:0097720 (Gene Ontology)

Definition

Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression.[ PubMed:25655284 PubMed:25878052 PubMed:26851544 ]

Also Known As

"calcineurin-mediated signalling"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
calcineurin-mediated signaling (all annotations which use CV term, excluding "NOT" statements)
involved_in \| calcineurin-mediated signaling

Spanning Tree (Parents/Children)

  intracellular signaling cassette
   |__calcium-mediated signaling
       |__calcineurin-mediated signaling  12 rec.
           |__calcineurin-NFAT signaling cascade 7 rec.
           |   |__regulation of calcineurin-NFAT signaling cascade(+) 6 rec.
           |__regulation of calcineurin-mediated signaling 6 rec.
               |__negative regulation of calcineurin-mediated signaling(+)
               |__positive regulation of calcineurin-mediated signaling(+) 1 rec.
               |__regulation of calcineurin-NFAT signaling cascade(+) 6 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	calcium-mediated signaling
Part of
Synonyms & Secondary IDs
Synonyms
	"calcineurin signaling" RELATED "calcineurin-mediated signalling" EXACT
Secondary IDs

External Crossreferences & Linkouts