FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term calcineurin-mediated signaling ID (Ontology) GO:0097720 (Gene Ontology)
Definition Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression.[ PubMed:25655284 PubMed:25878052 PubMed:26851544 ]
Also Known As "calcineurin-mediated signalling"
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       5
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 Genes
 calcineurin-mediated signaling (all annotations which use CV term, excluding "NOT" statements)       5
     involved_in | calcineurin-mediated signaling       5
Spanning Tree (Parents/Children)
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  intracellular signaling cassette
   |__calcium-mediated signaling
       |__calcineurin-mediated signaling  12 rec.
           |__calcineurin-NFAT signaling cascade 7 rec.
           |   |__regulation of calcineurin-NFAT signaling cascade(+) 6 rec.
           |__regulation of calcineurin-mediated signaling 6 rec.
               |__negative regulation of calcineurin-mediated signaling(+)
               |__positive regulation of calcineurin-mediated signaling(+) 1 rec.
               |__regulation of calcineurin-NFAT signaling cascade(+) 6 rec.
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Is a calcium-mediated signaling
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Synonyms
  • "calcineurin signaling" RELATED
    "calcineurin-mediated signalling" EXACT
Secondary IDs
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