FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: NEGATIVE REGULATORS OF EGFR SIGNALING PATHWAY
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General Information
Name
NEGATIVE REGULATORS OF EGFR SIGNALING PATHWAY
Species
D. melanogaster
Symbol
EGFR-N
FlyBase ID
FBgg0000950
Date last reviewed
2025-06-11
Number of members
38
Description
Description
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Notes and selected reviews

rho-5 has been included as a negative regulator of the EGFR pathway. However, it acts upstream of the pathway, down-regulating the production of secreted receptor ligand (FBrf0213387).

Biological Process Gene Ontology (GO) term(s)
negative regulation of epidermal growth factor receptor signaling pathway
Related Gene Groups
Parent group(s)
EGFR SIGNALING PATHWAY
Physical Interaction Network
Members (38)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
EGFR-N
Negative Regulators of Epidermal Growth Factor Receptor Signaling Pathway
NEGATIVE REGULATORS OF EGFR SIGNALING PATHWAY
Negative Regulators of EGFR Signaling Pathway
Secondary FlyBase ID(s)
References (66)