FlyBase Gene Report: Dmel\CanA-14F

General Information

Symbol

Dmel\CanA-14F

Species

D. melanogaster

Name

Calcineurin A at 14F

Annotation Symbol

CG9819

Feature Type

protein_coding_gene

FlyBase ID

FBgn0267912

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

protein-serine/threonine phosphatase (3.1.3.16)

Gene Summary

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. (UniProt, Q9VXF1)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

MRE12, Calcineurin, CanA14F

Key Links

Genomic Location

Cytogenetic map

14E3-14F1

Sequence location

X:16,560,684..16,587,172 [-]

Recombination map

1-54

RefSeq locus

NC_004354 REGION:16560684..16587172

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables calmodulin-dependent protein phosphatase activity

inferred from mutant phenotype

(Takeo et al., 2006)

enables protein binding

inferred from physical interaction with UniProtKB:Q9XZL8

(Takeo et al., 2012, Takeo et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables calmodulin binding

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(GO Reference Genome Project, 2011-)

enables calmodulin-dependent protein phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR043360

(InterPro Project Members, 2004-)

enables hydrolase activity

inferred from electronic annotation with InterPro:IPR004843, InterPro:IPR006186

(InterPro Project Members, 2004-)

enables protein serine/threonine phosphatase activity

inferred from sequence or structural similarity

(Chen et al., 1992)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in sleep

inferred from direct assay

(Nakai et al., 2011, Tomita et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in calcineurin-mediated signaling

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR043360

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of calcineurin complex

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(GO Reference Genome Project, 2011-)

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Protein Family (UniProt)

Belongs to the PPP phosphatase family. PP-2B subfamily. (Q9VXF1)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein serine/threonine phosphatase activity

(1) O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (3.1.3.16)

(2) O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (3.1.3.16)

Summaries

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -: The Phosphoprotein Phosphatase (PPP) family members are serine/threonine phosphatases. They often function in association with regulatory subunits. (Adapted from PMID:11230548 and PMID:19879837).

Protein Function (UniProtKB)

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

(UniProt, Q9VXF1)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CanA-14F for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VXF1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.46

Gene model reviewed during 5.41

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CanA-14F-RA

FBtr0074292

NM_167523

3052

584

CanA-14F-RB

FBtr0074293

NM_167524

6837

584

CanA-14F-RC

FBtr0305198

NM_001258788

7965

584

CanA-14F-RD

FBtr0332870

NM_001272693

4007

584

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CanA-14F-PA

FBpp0074067

64.3

584

5.96

FBpp0074068

64.3

584

5.96

FBpp0293728

64.3

584

5.96

FBpp0305092

64.3

584

5.96

Q9VXF1

NP_001259622

AGB95464

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

584 aa isoforms: CanA-14F-PA, CanA-14F-PB, CanA-14F-PC, CanA-14F-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with sra in a complex that contains Pp2B-14D.

(UniProt, Q9VXF1)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CanA-14F using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.05

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult optic lobe

(Tomita et al., 2011)

adult brain

(Tomita et al., 2011)

retina

(Tomita et al., 2011)

Additional Descriptive Data

CanA-14F is widely expressed in the adult brain, optic lobe, and retina.

(Tomita et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CanA-14F in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CanA-14F

View exonic expression by tissue for Dmel\CanA-14F

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

8674098/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267912

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030758

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267912

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9819

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CanA-14F

Transgenic constructs containing regulatory region of CanA-14F

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 24 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^elav-C155

viable

CanA-14F^EY08594

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CanA-14F^GD14690

viable, with Scer\GAL4^Mef2.PR

CanA-14F^GD14690

viable, with Scer\GAL4^pnr-MD237

CanA-14F^GD14690

viable, with Scer\GAL4^tin.CΔ4

CanA-14F^GD14690

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

CanA-14F^HMS01880

fertile

CanA-14F^EY08594

Other Phenotypes

Allele

abnormal locomotor behavior

CanA-14F^KO

abnormal locomotor behavior, with Scer\GAL4^elav.PLu

CanA-14F^Act.UAS

abnormal sleep

CanA-14F^KO

abnormal sleep, with Scer\GAL4^elav.PLu

CanA-14F^Act.UAS

abnormal sleep, with Scer\GAL4^elav-C155

CanA-14F^GD14690

abnormal sleep | heat sensitive, with Scer\GAL4^elav-C155, Scer\GAL80^ts.αTub84B

increased rate of movement, with Scer\GAL4^elav-C155

CanA-14F^GD14690

increased rate of movement, with Scer\GAL4^elav-C155, Scer\GAL80^ts.αTub84B

CanA-14F^UAS.Tag:MYC

Phenotype manifest in

Allele

mitochondrion | adult stage

CanA-14F^f02374

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (13)

Hsap\PPP3CA

13 of 14

Yes

Hsap\PPP3CB

13 of 14

Yes

Hsap\PPP3CC

13 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (13)

Rnor\Ppp3ca

13 of 14

Yes

Rnor\Ppp3cb

12 of 14

Yes

Rnor\Ppp3cc

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (13)

Mmus\Ppp3cb

13 of 14

Yes

Mmus\Ppp3ca

12 of 14

Yes

Mmus\Ppp3cc

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\ppp3cb

10 of 13

Yes

Xtro\ppp3ca

8 of 13

Yes

4 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ppp5c

1 of 13

Xtro\rhof

1 of 13

Yes

Xtro\septin10

1 of 13

Danio rerio (Zebrafish) (16)

Drer\ppp3ca

13 of 14

Yes

Drer\ppp3cb

13 of 14

Yes

Drer\ppp3ccb

13 of 14

Yes

Drer\ppp3cca

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (47)

Cele\tax-6

13 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP001279

12 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (32)

Atha\AT5G10900

3 of 13

Yes

Atha\PP2A-1

3 of 13

Yes

Atha\PP2A-2

3 of 13

Yes

Atha\PP2A-3

3 of 13

Yes

Atha\PP2A-4

3 of 13

Yes

Atha\PPX1

3 of 13

Yes

Atha\PPX2

3 of 13

Yes

Atha\TOPP1

3 of 13

Yes

Atha\TOPP2

3 of 13

Yes

Atha\TOPP3

3 of 13

Yes

Atha\TOPP4

3 of 13

Yes

Atha\TOPP5

3 of 13

Yes

Atha\TOPP6

3 of 13

Yes

Atha\TOPP7

3 of 13

Yes

Atha\TOPP8

3 of 13

Yes

Atha\TOPP9

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Atha\AT3G09970

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\SLP2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (13)

Scer\CNA1

12 of 13

Yes

11 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Schizosaccharomyces pombe (Fission yeast) (11)

Spom\ppb1

12 of 12

Yes

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Yes

Escherichia coli (enterobacterium) (3)

Ecol\apaH

2 of 11

Yes

Ecol\pphA

2 of 11

Yes

Ecol\pphB

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CanA-14F. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (18)

Pp2B-14D

12 of 13

CanA1

11 of 13

CG11597

3 of 13

flw

3 of 13

mts

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

PpV

3 of 13

3 of 13

2 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PPP3CA; protein phosphatase 3 catalytic subunit alpha

model of developmental and epileptic encephalopathy 91

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

CanA-14F^GD14690

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

CanA-14F^HMS01880

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

CanA-14F^CA.UAS.cUa

ameliorates Parkinson's disease 6

modeled by Pink1^B9

(Marchesan et al., 2024)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPP3CA; protein phosphatase 3 catalytic subunit alpha

13 of 14

PROTEIN PHOSPHATASE 3, CATALYTIC SUBUNIT, ALPHA ISOFORM; PPP3CA

developmental and epileptic encephalopathy 91

PPP3CB; protein phosphatase 3 catalytic subunit beta

13 of 14

114106

PPP3CC; protein phosphatase 3 catalytic subunit gamma

13 of 14

114107

PPP1CA; protein phosphatase 1 catalytic subunit alpha

3 of 14

176875

PPP1CB; protein phosphatase 1 catalytic subunit beta

3 of 14

600590

NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR 2; NSLH2

Noonan syndrome-like disorder with loose anagen hair 2

PPP1CC; protein phosphatase 1 catalytic subunit gamma

3 of 14

176914

PPP2CA; protein phosphatase 2 catalytic subunit alpha

3 of 14

176915

HOUGE-JANSSENS SYNDROME 3; HJS3

PPP2CB; protein phosphatase 2 catalytic subunit beta

3 of 14

176916

PPP4C; protein phosphatase 4 catalytic subunit

3 of 14

602035

PPP6C; protein phosphatase 6 catalytic subunit

3 of 14

612725

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CanA-14F - Cam

lambda phage display

(Xu et al., 1998)

CanA-14F - Pvr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

CanA-14F - dos

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

CanA-14F - sra

anti tag coimmunoprecipitation, multidimensional protein identification technology, western blot

(Takeo et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CanA-14F

enhanceable

sra

(Nakai et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

sra

suppressible

CanA-14F

(Nakai et al., 2011)

External Data

Subunit Structure (UniProtKB)

Interacts with sra in a complex that contains Pp2B-14D.

(UniProt, Q9VXF1 )

Linkouts

MIST (genetic) - An integrated Molecular Interaction Database

8674098

MIST (protein-protein) - An integrated Molecular Interaction Database

8674098

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Wnt signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

retrogene

(dos Santos, 2014, Miskei et al., 2011, Betran et al., 2002)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-54

Cytogenetic map

14E3-14F1

Sequence location

X:16,560,684..16,587,172 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

14E3-14F1

Limits computationally determined from genome sequence between P{EP}EP1547^EP1547 and P{EP}CG4928^EP1341

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

14D-14D

(Hong, 1995.6.28)

14D-14F

(determined by in situ hybridisation)

(Madueno et al., 1995)

Experimentally Determined Recombination Data

Location

1-54

(FlyBase, 2016)

1-55.5

(Comeron et al., 2012)

(Hong, 1995.6.28)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

81693

y¹ v¹; P{TKO.GS03313}attP40

85641

w¹¹¹⁸ PBac{WH}CanA-14F^f02374

58249

y¹ v¹; P{TRiP.HMJ22270}attP40/CyO

61729

y¹ w^* Mi{MIC}CanA-14F^MI15488

17478

y¹ w^67c23 P{EPgy2}CanA-14F^EY08594

38966

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01880}attP40

NIG-Fly

9819R-1

P{NIG.9819R}1

9819R-3

P{NIG.9819R}3

HMJ22270

y¹ v¹; P{TRiP.HMJ22270}attP40/CyO

VDRC

v109858

P{KK110900}VIE-260B

v30105

w¹¹¹⁸; P{GD14690}v30105

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (19)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0267912

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CanA-14F MRE12

(FlyBase Genome Annotators, 2014)

Additional comments

MRE12 corresponds to a portion of the 3' UTR of CanA-14F.

(FlyBase Genome Annotators, 2014)

The CanA-14F gene may have been derived from a related phosphoprotein phosphatase gene by retroposition and subsequent tandem duplication.

(Miskei et al., 2011)

The CanA-14F gene may be derived from the CanA1 gene by retroposition.

(Betran et al., 2002)

Nomenclature History

Source for database identify of

Source for identity of: CanA-14F CG9819

(Sullivan and Rubin, 2002)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

CG9819

(Kanamori et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Wheeler et al., 2004, Betran et al., 2002, Sullivan and Rubin, 2002)

CaN

(Toprak et al., 2020)

CaNA-14F

(Armstrong and Frank, 2022)

CanA14F

(Peng et al., 2024, Zarndt et al., 2017)

CnnA14D

(Hong, 1995.6.28)

CnnA14D(I)

(Hong, 1995.6.29)

D27

(Chen et al., 1992)

DmCanA-14F

(Cohen et al., 2005)

MRE12

(Kageyama, 2007.2.28, Inagaki et al., 2005)

PP2B

(Morrison et al., 2000)

PpD27

canA-14F

(Sullivan and Rubin, 2002)

Name Synonyms

Calcineurin

(Dijkers and O'Farrell, 2007, Xu et al., 1998)

Calcineurin A at 14F

(Shafer, 2025, Tomita et al., 2017, Sullivan and Rubin, 2002)

Protein phosphatase D27

calcineurin

(Dijkers and O'Farrell, 2007)

calcineurin A at 14F

(Li and Dijkers, 2015)

mRNA-like ncRNA in embryogenesis 12

protein phosphatase from PCR fragment D27

(Chen, 1993.1.7)

Secondary FlyBase IDs

FBgn0030758
FBgn0005782
FBgn0086544

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External Crossreferences and Linkouts ( 68 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

8674098

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VXF1

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VXF1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VXF1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

8674098/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267912

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267912

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9819

MARRVEL_MODEL - MARRVEL (model organism gene)

8674098

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0267912

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030758

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0267912

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9819

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Wnt signaling pathway

MIST (genetic) - An integrated Molecular Interaction Database

8674098

MIST (protein-protein) - An integrated Molecular Interaction Database

8674098

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (83)

The following external sites may use different assemblies or annotations than FlyBase.

-1.05

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