FlyBase Gene Report: Dmel\PpV

General Information

Symbol

Dmel\PpV

Species

D. melanogaster

Name

Protein phosphatase V

Annotation Symbol

CG12217

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003139

Gene Model Status

Current

Stock Availability

14 publicly available

Enzyme Name (EC)

protein-serine/threonine phosphatase (3.1.3.16)

Gene Summary

Protein phosphatase V (PpV) encodes the catalytic subunit of the protein phosphatase 6 (PP6), which negatively regulates JNK and AMPK signaling. PpV product is essential for lipid homeostasis and Ras-induced tumorigenesis. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

5F4-5F4

Sequence location

X:6,371,065..6,372,915 [-]

Recombination map

1-16

RefSeq locus

NC_004354 REGION:6371065..6372915

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables hydrolase activity

inferred from electronic annotation with InterPro:IPR004843, InterPro:IPR006186

(InterPro Project Members, 2004-)

enables protein serine/threonine phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN002268602

(GO Reference Genome Project, 2011-)

inferred from sequence model

(Mann et al., 1993)

inferred from electronic annotation with InterPro:IPR047129

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in G1/S transition of mitotic cell cycle

inferred from genetic interaction with SGD:S000002205

(Mann et al., 1993)

involved_in mitotic cell cycle

inferred from mutant phenotype

(Chen et al., 2007)

involved_in negative regulation of JNK cascade

inferred from mutant phenotype

(Ma et al., 2017)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in G1/S transition of mitotic cell cycle

inferred from biological aspect of ancestor with PANTHER:PTN000185366

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Mann et al., 1993)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000185365

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Protein Family (UniProt)

Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily. (Q27884)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein serine/threonine phosphatase activity

(1) O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (3.1.3.16)

(2) O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (3.1.3.16)

Summaries

Gene Snapshot

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -: The Phosphoprotein Phosphatase (PPP) family members are serine/threonine phosphatases. They often function in association with regulatory subunits. (Adapted from PMID:11230548 and PMID:19879837).

Protein Function (UniProtKB)

May be involved in controlling cellularization or in regulating transcription of the genes involved in this process.

(UniProt, Q27884)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\PpV for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q27884)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

PpV-RA

FBtr0070921

NM_078506

1675

303

PpV-RB

FBtr0331430

NM_001272343

1603

303

PpV-RC

FBtr0331431

NM_001272344

1599

303

PpV-RD

FBtr0331432

NM_001272345

1622

303

Additional Transcript Data and Comments

Reported size (kB)

2.0 (northern blot)

(Mann et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

PpV-PA

FBpp0070883

34.8

303

5.42

FBpp0303847

34.8

303

5.42

FBpp0303848

34.8

303

5.42

FBpp0303849

34.8

303

5.42

Q27884

NP_001259274

AGB95119

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

303 aa isoforms: PpV-PA, PpV-PB, PpV-PC, PpV-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

303 (aa); 34.7 (kD predicted)

(Mann et al., 1993)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PpV using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

PpV_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.15

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Mann et al., 1993)

embryonic stage 4

organism

Comment: late embryonic stage 4

(Mann et al., 1993)

embryonic stage 5

organism

Comment: early embryonic stage 5

(Mann et al., 1993)

Additional Descriptive Data

Northern blots show that the PpV transcript is expressed at high levels in 0-4 hours of embryogenesis, and is present at low levels at other developmental stages. PpV transcript is detected in late synytial blastoderm-early cellular blastoderm stage embryos, in the cytoplasm. PpV transcript is not easily detectable in embryos before or after this stage.

(Mann et al., 1993)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4

organism

Comment: late embryonic stage 4

(Mann et al., 1993)

embryonic stage 5

organism

Comment: early embryonic stage 5

(Mann et al., 1993)

Additional Descriptive Data

As with PpV transcript, an increase in PpV protein is evident in late syncytial blastoderm-early cellular blastoderm stage embryos, and the protein accumulates in the cytoplasm.

(Mann et al., 1993)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Mann et al., 1993)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\PpV in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\PpV

View exonic expression by tissue for Dmel\PpV

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31582/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003139

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003139

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003139

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12217

Flygut - An atlas of the Drosophila adult midgut

FBgn0003139

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of PpV

Transgenic constructs containing regulatory region of PpV

Aberrations (Deficiencies and Duplications) ( 19 )

Inferred from experimentation ( 19 )

Gene disrupted in

Df(1)Exel6239

(Liu et al., 2019, Ryder, 2004.4.26)

Gene not disrupted in

Gene not duplicated in

Dp(1;3)DC156

(Liu et al., 2019)

Dp(1;3)DC157

(Liu et al., 2019)

Gene duplicated in

(Liu et al., 2019)

(Liu et al., 2019)

(Liu et al., 2019)

(Liu et al., 2019)

(Liu et al., 2019)

Inferred from location ( 24 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

PpV^GD7532

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

PpV^GD7532

lethal - all die during embryonic stage | germline clone | non-rescuable maternal effect

PpV^X9

viable, with Scer\GAL4^Mef2.PR

PpV^GD7532

viable, with Scer\GAL4^pnr-MD237

PpV^GD7532

viable, with Scer\GAL4^tin.CΔ4

PpV^GD7532

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

PpV^GL00398

female sterile | germline clone

PpV^X9

Other Phenotypes

Allele

abnormal mitotic cell cycle | germline clone | maternal effect | pre-blastoderm stage

PpV^X9

abnormal mitotic cell cycle | pre-blastoderm stage

PpV^X9

abnormal size | maternal effect | pre-blastoderm stage | somatic clone

PpV^X9

increased cell death | germline clone | oogenesis stage S9

PpV^X9

increased cell death | germline clone | oogenesis stage S10

PpV^X9

increased cell number | larval stage, with Scer\GAL4^Hml.Δ

PpV^KK108896

increased cell number | larval stage, with Scer\GAL4^lz-gal4

increased cell size | larval stage, with Scer\GAL4^lz-gal4

PpV^KK108896

increased occurrence of cell division | larval stage, with Scer\GAL4^lz-gal4

PpV^KK108896

increased size | larval stage, with Scer\GAL4^lz-gal4

PpV^KK108896

some die during embryonic stage

PpV^X9

some die during larval stage

PpV^X9

some die during P-stage

PpV^X9

visible, with Scer\GAL4^Bx-MS1096

visible, with Scer\GAL4^pnr-MD237

PpV^GD7532

Phenotype manifest in

Allele

chromosome | embryonic stage 4 | germline clone | maternal effect

PpV^X9

chromosome | germline clone | maternal effect | pre-blastoderm stage

PpV^X9

chromosome | pre-blastoderm stage

PpV^X9

cytoskeleton | larval stage, with Scer\GAL4^lz-gal4

PpV^KK108896

embryo | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

PpV^GL00398

embryonic/larval crystal cell | increased number | larval stage, with Scer\GAL4^Hml.Δ

PpV^KK108896

embryonic/larval crystal cell | increased number | larval stage, with Scer\GAL4^lz-gal4

embryonic/larval crystal cell | larval stage | conditional, with Scer\GAL4^lz-gal4

PpV^UAS.Tag:MYC

germ band | extended germ band stage | germline clone

PpV^X9

nuclear envelope | germline clone | maternal effect | pre-blastoderm stage

PpV^X9

nucleus | embryonic stage 4 | germline clone | maternal effect

PpV^X9

nucleus | germline clone | maternal effect | pre-blastoderm stage

PpV^X9

nurse cell | germline clone | oogenesis stage S9

PpV^X9

nurse cell | germline clone | oogenesis stage S10

PpV^X9

primary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4^lz-gal4

PpV^KK108896

trichogen cell, with Scer\GAL4^pnr-MD237

PpV^GD7532

wing, with Scer\GAL4^Bx-MS1096

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (13)

Hsap\PPP6C

14 of 14

Yes

5 of 14

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (14)

Rnor\Ppp6c

14 of 14

Yes

5 of 14

5 of 14

5 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (13)

Mmus\Ppp6c

13 of 14

Yes

5 of 14

5 of 14

5 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\ppp6c

11 of 13

Yes

4 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (17)

Drer\ppp6c

14 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (47)

Cele\pph-6

11 of 14

Yes

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP003017

12 of 12

Yes

5 of 12

5 of 12

4 of 12

3 of 12

3 of 12

3 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (32)

Atha\FYPP1

13 of 13

Yes

Atha\FYPP3

13 of 13

Yes

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

Yes

Atha\AT5G10900

3 of 13

Yes

Atha\BSL1

3 of 13

Yes

Atha\BSL2

3 of 13

Yes

Atha\BSL3

3 of 13

Yes

Atha\BSU1

3 of 13

Yes

Atha\PP7

3 of 13

Yes

Atha\PP5.2

2 of 13

Atha\AT3G09960

1 of 13

Yes

Atha\AT3G09970

1 of 13

Yes

Atha\SGT1A

1 of 13

Atha\SGT1B

1 of 13

Atha\SLP1

1 of 13

Yes

Atha\SLP2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (13)

Scer\SIT4

11 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (11)

Spom\ppe1

11 of 12

Yes

Spom\ppa1

4 of 12

Spom\ppa2

4 of 12

Spom\SPAC22H10.04

4 of 12

Yes

4 of 12

3 of 12

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Yes

Escherichia coli (enterobacterium) (3)

Ecol\pphA

2 of 11

Yes

Ecol\pphB

2 of 11

Yes

Ecol\apaH

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:PpV. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (18)

CG11597

6 of 13

mts

6 of 13

Pp4-19C

6 of 13

flw

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

PpV^NIG.12217R

exacerbates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-PR^PO-36.UAS

(Park et al., 2021)

PpV^UASp.N.EGFP

ameliorates cancer

modeled by Ras85D^V12.UAS, l(2)gl⁴

(Ma et al., 2017)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPP6C; protein phosphatase 6 catalytic subunit

14 of 14

612725

PPP2CA; protein phosphatase 2 catalytic subunit alpha

5 of 14

176915

HOUGE-JANSSENS SYNDROME 3; HJS3

PPP2CB; protein phosphatase 2 catalytic subunit beta

5 of 14

176916

PPP4C; protein phosphatase 4 catalytic subunit

5 of 14

602035

PPP1CA; protein phosphatase 1 catalytic subunit alpha

4 of 14

176875

PPP1CB; protein phosphatase 1 catalytic subunit beta

4 of 14

600590

NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR 2; NSLH2

Noonan syndrome-like disorder with loose anagen hair 2

PPP1CC; protein phosphatase 1 catalytic subunit gamma

4 of 14

176914

PPEF1; protein phosphatase with EF-hand domain 1

3 of 14

300109

PPP3CA; protein phosphatase 3 catalytic subunit alpha

3 of 14

PROTEIN PHOSPHATASE 3, CATALYTIC SUBUNIT, ALPHA ISOFORM; PPP3CA

developmental and epileptic encephalopathy 91

PPP3CB; protein phosphatase 3 catalytic subunit beta

3 of 14

114106

PPP3CC; protein phosphatase 3 catalytic subunit gamma

3 of 14

114107

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

PpV - Raf

anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting

(Friedman et al., 2011, Friedman et al., 2011)

PpV - Tap42

anti tag coimmunoprecipitation, anti tag western blot

(Wang et al., 2012)

PpV - wdb

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation

(Liu et al., 2021)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Ma et al., 2017)

enhanceable

(Ma et al., 2017)

suppressible

(Luo et al., 2025)

suppressible

(Luo et al., 2025)

suppressible

(Ma et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Acn

suppressible

PpV

(Nandi et al., 2022)

Acn

enhanceable

PpV

(Nandi et al., 2022)

enhanceable

(Ma et al., 2017)

enhanceable

(Ma et al., 2017)

suppressible

(Ma et al., 2017)

enhanceable

(Ma et al., 2017)

suppressible

(Ma et al., 2017)

suppressible

(Ma et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58069

DroID - A comprehensive database of gene and protein interactions.

FBgn0003139

MIST (protein-protein) - An integrated Molecular Interaction Database

31582

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q27884

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-16

Cytogenetic map

5F4-5F4

Sequence location

X:6,371,065..6,372,915 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

5F4-5F4

Limits computationally determined from genome sequence between P{EP}EP1402&P{EP}CG15893^EP1634 and P{EP}Ctr1A^EP1364&P{EP}EP1445

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

6A1-6A2

(determined by in situ hybridisation)

(Mann et al., 1993)

Experimentally Determined Recombination Data

Location

1-16

(FlyBase, 2016)

1-16.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

53769

w^*; P{UASp-PpV.EGFP.C}2

53770

w^*; P{UASp-PpV.EGFP.N}3

53768

w^*; P{UASp-PpV.EGFP.N}2/CyO

82142

y¹ PpV^Δ1 P{neoFRT}19A/FM6

80852

y¹, v¹; P{TKO.GS04661}attP40

36064

y¹ sc^* v¹ sev²¹; P{TRiP.GL00398}attP2

FlyORF

F000874

M{UAS-PpV.ORF.3xHA}ZH-86Fb

12217R-1

12217R-2

v101997

v31690

w¹¹¹⁸; P{GD7532}v31690

v342898

P{hsFLP}1, y1 w1118; P{HD_CFD02500}attP40/CyO-GFP

More stocks available...

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (31)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0003139

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003139

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Liu et al., 2021, Mann et al., 1993)

monoclonal

(Liu et al., 2019)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

PpV was identified by sequence similarity to Pp1-87B. Complementation studies indicate that it can functionally rescue a temperature sensitive yeast mutant, SIT4. The pattern and timing of PpV expression in the embryo suggests it may play a role in the introduction of a G₂ phase in the cell cycle, elevated zygotic transcription or cellularization.

(Mann et al., 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG12217

(Çiçek et al., 2016, Hosono et al., 2015, Yin et al., 2014, Schertel et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Wheeler et al., 2004, Morrison et al., 2000)

DmPpV-6A

(Cohen et al., 2005)

PP6

(Bielinski and Mumby, 2007)

PPPV6A

(Cohen, 1995.7.7)

PPV

(Wang et al., 2012, Chen et al., 2007, Wheeler et al., 2004, Morrison et al., 2000, Helps et al., 1998, Anonymous, 1994, Chen et al., 1992, Cohen et al., 1990)

PPV 6A

(Cohen, 1997)

PpV

(Chang et al., 2022, Bilder et al., 2021, Liu et al., 2021, Liu et al., 2021, Ostalé et al., 2021, Pang et al., 2021, Park et al., 2021, Graves et al., 2020, Ma et al., 2017, Transgenic RNAi Project members, 2017-, Sopko et al., 2014, Carter, 2013, Schertel et al., 2013, Yamamoto et al., 2013-, Friedman et al., 2011, Friedman et al., 2011, Friedman et al., 2011, Bielinski and Mumby, 2007)

PpV_C

(Yin et al., 2014)

Ppv

(Deng et al., 2009)

dPP6

(Bielinski and Mumby, 2007)

ppv

(Chi et al., 2018)

Name Synonyms

Protein phosphatase V

(Graves et al., 2020)

protein phosphatase V

(Yin et al., 2014)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31582

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q27884

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q27884

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PGI3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q27884

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31582/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003139

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003139

FlyMine - An integrated database for Drosophila genomics

FBgn0003139

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12217

MARRVEL_MODEL - MARRVEL (model organism gene)

31582

Linkouts

BioGRID - A database of protein and genetic interactions.

58069

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0003139

DroID - A comprehensive database of gene and protein interactions.

FBgn0003139

DRSC - Results frm RNAi screens

FBgn0003139

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

PpV_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003139

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003139

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12217

Flygut - An atlas of the Drosophila adult midgut

FBgn0003139

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011181

MIST (protein-protein) - An integrated Molecular Interaction Database

31582

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q27884

References (79)

The following external sites may use different assemblies or annotations than FlyBase.

-0.15

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