FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Pp2B-14D
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General Information
Symbol
Dmel\Pp2B-14D
Species
D. melanogaster
Name
Protein phosphatase 2B at 14D
Annotation Symbol
CG9842
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011826
Gene Model Status
Current
Stock Availability
10 publicly available
Enzyme Name (EC)
protein-serine/threonine phosphatase (3.1.3.16)
Gene Summary
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. (UniProt, Q27889)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

CnnA14D, canA, calcineurin, PP2B 14D, Pp2B

Key Links
Genomic Location
Cytogenetic map
14E1-14E3
Sequence location
Recombination map
1-54
RefSeq locus
NC_004354 REGION:16554627..16560016
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables calmodulin-dependent protein phosphatase activity
inferred from mutant phenotype
(Brown et al., 1994)
enables protein binding
inferred from physical interaction with FLYBASE:sra; FB:FBgn0086370
(Takeo et al., 2006)
inferred from physical interaction with UniProtKB:Q9XZL8
(Takeo et al., 2012)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables calcium-dependent protein serine/threonine phosphatase activity
inferred from sequence or structural similarity
(Brown et al., 1994)
enables calmodulin binding
inferred from biological aspect of ancestor with PANTHER:PTN000746105
(GO Reference Genome Project, 2011-)
traceable author statement
(Montell, 1999)
enables calmodulin-dependent protein phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN000746105
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR043360
(InterPro Project Members, 2004-)
enables hydrolase activity
inferred from electronic annotation with InterPro:IPR004843, InterPro:IPR006186
(InterPro Project Members, 2004-)
enables protein serine/threonine phosphatase activity
inferred from sequence or structural similarity
(Chen et al., 1992)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in female meiotic nuclear division
inferred from mutant phenotype
(Takeo et al., 2006)
involved_in meiotic cell cycle
inferred from genetic interaction with FLYBASE:sra; FB:FBgn0086370
(Takeo et al., 2010)
involved_in regulation of embryonic development
inferred from mutant phenotype
(Takeo et al., 2010)
involved_in sleep
inferred from direct assay
(Nakai et al., 2011)
involved_in wing disc development
inferred from mutant phenotype
(Takeo et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in calcineurin-mediated signaling
inferred from electronic annotation with InterPro:IPR043360
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000746105
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of calcineurin complex
inferred from biological aspect of ancestor with PANTHER:PTN000746105
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity
(Brown et al., 1994)
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000746105
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the PPP phosphatase family. PP-2B subfamily. (Q27889)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
protein serine/threonine phosphatase activity
(1) O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (3.1.3.16)
(2) O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (3.1.3.16)
Summaries
Gene Group (FlyBase)
PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -
The Phosphoprotein Phosphatase (PPP) family members are serine/threonine phosphatases. They often function in association with regulatory subunits. (Adapted from PMID:11230548 and PMID:19879837).
Protein Function (UniProtKB)
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
(UniProt, Q27889)
Summary (Interactive Fly)

Calcium-dependent protein serine/threonine phosphatase - negatively regulates Egf receptor signaling - calcineurin isoforms are involved in Drosophila toll immune signaling correcting calcineurin and GSK-3β signaling can prevent amyloid precursor protein-induced pathologies

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Pp2B-14D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q27889)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.46

Gene model reviewed during 5.41

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pp2B-14D-RA
FBtr0074294
NM_078649
3253
570
Pp2B-14D-RB
FBtr0305593
NM_001258787
4551
570
Pp2B-14D-RC
FBtr0309793
NM_001258786
5390
570
Additional Transcript Data and Comments
Reported size (kB)

4.5, 2.0 (northern blot)

(Hong and Ganetzky, 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Pp2B-14D-PA
FBpp0074069
63.1
570
5.73
Q27889
NP_523373
AAF48622
Pp2B-14D-PB
FBpp0294044
63.1
570
5.73
Q27889
NP_001245716
AFH07429
Pp2B-14D-PC
FBpp0301546
63.1
570
5.73
Q27889
NP_001245715
AFH07428
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

570 aa isoforms: Pp2B-14D-PA, Pp2B-14D-PB, Pp2B-14D-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

578 (aa)

(Hong and Ganetzky, 1996)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with sra in a complex that contains CanA-14F.

(UniProt, Q27889)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pp2B-14D using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.08

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval peripheral nervous system
(Hong and Ganetzky, 1996)
central nervous system
(Hong and Ganetzky, 1996)
embryonic stage 1 -- 5
organism
(Hong and Ganetzky, 1996)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage -- adult stage
(Hong and Ganetzky, 1996)
Additional Descriptive Data

Pp2B-14D is expressed ubiquitously before gastrulation, but disappears after gastrulation. After the start of neurogenesis, expression is detected in the CNS and the PNS.

(Hong and Ganetzky, 1996)

Two and 4.5 kb Pp2B-14D transcripts were detected in larvae and adults.

(Hong and Ganetzky, 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pp2B-14D in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 26 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pp2B-14D
Transgenic constructs containing regulatory region of Pp2B-14D
Aberrations (Deficiencies and Duplications) ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4how-24B
lethal, with Scer\GAL4Mef2.PR
lethal - all die during larval stage, with Scer\GAL4Act5C.PI
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal - majority die | germline clone, with Scer\GAL4VP16.nanos.UTR
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
female sterile, with Scer\GAL4VP16.nanos.UTR
Other Phenotypes
Allele
abnormal locomotor behavior
abnormal locomotor behavior, with Scer\GAL4elav.PLu
abnormal meiotic cell cycle, with Scer\GAL4VP16.nanos.UTR
abnormal size, with Scer\GAL4en-e16E
abnormal size | adult stage
abnormal size | adult stage, with Scer\GAL4tin.CΔ4
abnormal sleep
abnormal sleep, with Scer\GAL4elav.PLu
increased size | adult stage, with Scer\GAL4tin.CΔ4
short lived
visible
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4hs.2sev
Phenotype manifest in
Allele
adult heart
adult heart, with Scer\GAL4tin.CΔ4
adult heart muscle cell, with Scer\GAL4tin.CΔ4
egg & nuclear chromosome, with Scer\GAL4VP16.nanos.UTR
egg & spindle, with Scer\GAL4VP16.nanos.UTR
eye
eye, with Scer\GAL4GMR.PF
eye photoreceptor cell, with Scer\GAL4hs.2sev
interommatidial bristle, with Scer\GAL4GMR.PF
ommatidium
ommatidium, with Scer\GAL4GMR.PF
oocyte & nuclear chromatin, with Scer\GAL4VP16.nanos.UTR
oocyte & nucleus, with Scer\GAL4VP16.nanos.UTR
photoreceptor cell R3, with Scer\GAL4hs.2sev
photoreceptor cell R4, with Scer\GAL4hs.2sev
photoreceptor cell R7, with Scer\GAL4hs.2sev
posterior crossvein, with Scer\GAL4en-e16E
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4en-e16E
wing blade, with Scer\GAL4en-e16E
wing blade posterior compartment, with Scer\GAL4en-e16E
wing vein, with Scer\GAL4en-e16E
wing vein L5, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (13)
Hsap\PPP3CA
13 of 14
Yes
Yes
2  
Hsap\PPP3CB
13 of 14
Yes
Yes
1  
Hsap\PPP3CC
13 of 14
Yes
Yes
Hsap\PPP1CA
3 of 14
No
No
1  
Hsap\PPP1CB
3 of 14
No
No
Hsap\PPP1CC
3 of 14
No
No
2  
Hsap\PPP2CA
3 of 14
No
No
Hsap\PPP2CB
3 of 14
No
No
Hsap\PPP4C
3 of 14
No
No
Hsap\PPP6C
3 of 14
No
No
Hsap\PPEF1
2 of 14
No
No
Hsap\PPP5C
2 of 14
No
No
Hsap\PPEF2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (13)
Rnor\Ppp3ca
13 of 14
Yes
Yes
Rnor\Ppp3cb
12 of 14
No
Yes
Rnor\Ppp3cc
12 of 14
No
Yes
Rnor\Ppp1ca
3 of 14
No
No
Rnor\Ppp1cb
3 of 14
No
No
Rnor\Ppp1cc
3 of 14
No
No
Rnor\Ppp2ca
3 of 14
No
No
Rnor\Ppp2cb
3 of 14
No
No
Rnor\Ppp4c
3 of 14
No
No
Rnor\Ppp6c
3 of 14
No
No
Rnor\LOC100362453
2 of 14
No
No
Rnor\Ppef1
1 of 14
No
No
Rnor\Ppp5c
1 of 14
No
No
Mus musculus (laboratory mouse) (13)
Mmus\Ppp3cb
13 of 14
Yes
Yes
Mmus\Ppp3ca
12 of 14
No
Yes
Mmus\Ppp3cc
12 of 14
No
Yes
Mmus\Ppp1ca
3 of 14
No
No
Mmus\Ppp1cb
3 of 14
No
No
Mmus\Ppp1cc
3 of 14
No
No
Mmus\Ppp2ca
3 of 14
No
No
Mmus\Ppp2cb
3 of 14
No
No
Mmus\Ppp4c
3 of 14
No
No
Mmus\Ppp6c
3 of 14
No
No
Mmus\Ppef1
1 of 14
No
No
Mmus\Ppef2
1 of 14
No
No
Mmus\Ppp5c
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (13)
Xtro\ppp3cb
10 of 13
Yes
Yes
Xtro\ppp3ca
8 of 13
No
Yes
Xtro\ppp3cc
4 of 13
No
No
Xtro\ppp1cb
2 of 13
No
No
Xtro\ppp1cc
2 of 13
No
No
Xtro\ppp4c
2 of 13
No
No
Xtro\ppp6c
2 of 13
No
No
Xtro\csf1
1 of 13
No
No
Xtro\LOC105948070
1 of 13
No
No
Xtro\ogn
1 of 13
No
Yes
Xtro\ppp5c
1 of 13
No
No
Xtro\rhof
1 of 13
No
Yes
Xtro\septin10
1 of 13
No
No
Danio rerio (Zebrafish) (16)
Drer\ppp3ca
13 of 14
Yes
Yes
Drer\ppp3cb
13 of 14
Yes
Yes
Drer\ppp3ccb
13 of 14
Yes
Yes
Drer\ppp3cca
12 of 14
No
Yes
Drer\ppp1caa
3 of 14
No
No
Drer\ppp1cab
3 of 14
No
No
Drer\ppp1cb
3 of 14
No
No
Drer\ppp2caa
3 of 14
No
No
Drer\ppp2cab
3 of 14
No
No
Drer\ppp4ca
3 of 14
No
No
Drer\ppp4cb
3 of 14
No
No
Drer\ppp6c
3 of 14
No
No
Drer\ppp1cc
2 of 14
No
No
Drer\ppp2cb
2 of 14
No
No
Drer\ppef1
1 of 14
No
No
Drer\ppp1cbl
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (47)
Cele\tax-6
13 of 14
Yes
Yes
Cele\C06A1.3
3 of 14
No
No
Cele\C09H5.7
3 of 14
No
No
Cele\C24H11.1
3 of 14
No
No
Cele\C24H11.2
3 of 14
No
No
Cele\C25A6.1
3 of 14
No
No
Cele\C34D4.2
3 of 14
No
No
Cele\C47A4.3
3 of 14
No
No
Cele\F22D6.9
3 of 14
No
No
Cele\F23B12.1
3 of 14
No
No
Cele\F25B3.4
3 of 14
No
No
Cele\F26B1.5
3 of 14
No
No
Cele\F42G8.8
3 of 14
No
No
Cele\F49E11.7
3 of 14
No
No
Cele\F52H3.6
3 of 14
No
No
Cele\F58G1.3
3 of 14
No
No
Cele\gsp-2
3 of 14
No
No
Cele\gsp-3
3 of 14
No
No
Cele\gsp-4
3 of 14
No
No
Cele\let-92
3 of 14
No
No
Cele\pph-1
3 of 14
No
No
Cele\pph-4.1
3 of 14
No
No
Cele\pph-6
3 of 14
No
No
Cele\R08A2.2
3 of 14
No
No
Cele\R08C7.8
3 of 14
No
No
Cele\T25B9.2
3 of 14
No
No
Cele\Y69E1A.4
3 of 14
No
No
Cele\Y71G12B.30
3 of 14
No
No
Cele\ZC477.2
3 of 14
No
No
Cele\ZK938.1
3 of 14
No
No
Cele\C23G10.1
2 of 14
No
No
Cele\C27B7.6
2 of 14
No
No
Cele\C30A5.4
2 of 14
No
No
Cele\F40E3.5
2 of 14
No
Yes
Cele\F44B9.9
2 of 14
No
No
Cele\gsp-1
2 of 14
No
No
Cele\pph-4.2
2 of 14
No
No
Cele\R13A5.11
2 of 14
No
No
Cele\T16G12.7
2 of 14
No
No
Cele\W03D8.2
2 of 14
No
No
Cele\Y40H4A.2
2 of 14
No
No
Cele\ZK354.9
2 of 14
No
No
Cele\F20D6.6
1 of 14
No
No
Cele\pef-1
1 of 14
No
No
Cele\pph-5
1 of 14
No
No
Cele\R03D7.8
1 of 14
No
No
Cele\ZC477.10
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP001279
12 of 12
Yes
Yes
Agam\AgaP_AGAP003017
3 of 12
No
No
Agam\AgaP_AGAP003779
3 of 12
No
No
Agam\AgaP_AGAP010172
3 of 12
No
No
Agam\AgaP_AGAP011166
3 of 12
No
No
Agam\AgaP_AGAP003114
2 of 12
No
No
Agam\AgaP_AGAP004151
2 of 12
No
No
Agam\AgaP_AGAP011414
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (32)
Atha\AT5G10900
3 of 13
Yes
Yes
Atha\PP2A-1
3 of 13
Yes
No
Atha\PP2A-2
3 of 13
Yes
No
Atha\PP2A-3
3 of 13
Yes
No
Atha\PP2A-4
3 of 13
Yes
No
Atha\PPX1
3 of 13
Yes
No
Atha\PPX2
3 of 13
Yes
No
Atha\TOPP1
3 of 13
Yes
No
Atha\TOPP2
3 of 13
Yes
No
Atha\TOPP3
3 of 13
Yes
No
Atha\TOPP4
3 of 13
Yes
No
Atha\TOPP5
3 of 13
Yes
No
Atha\TOPP6
3 of 13
Yes
No
Atha\TOPP7
3 of 13
Yes
No
Atha\TOPP8
3 of 13
Yes
No
Atha\TOPP9
3 of 13
Yes
No
Atha\AT1G48120
2 of 13
No
No
Atha\BSL1
2 of 13
No
No
Atha\BSL3
2 of 13
No
No
Atha\FYPP1
2 of 13
No
No
Atha\FYPP3
2 of 13
No
No
Atha\PP2A
2 of 13
No
No
Atha\PP5.2
2 of 13
No
No
Atha\PP7
2 of 13
No
No
Atha\AT3G09960
1 of 13
No
Yes
Atha\AT3G09970
1 of 13
No
Yes
Atha\BSL2
1 of 13
No
No
Atha\BSU1
1 of 13
No
No
Atha\SGT1A
1 of 13
No
No
Atha\SGT1B
1 of 13
No
No
Atha\SLP1
1 of 13
No
Yes
Atha\SLP2
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (13)
Scer\CNA1
12 of 13
Yes
Yes
Scer\CMP2
11 of 13
No
No
Scer\PPH21
4 of 13
No
No
Scer\PPH22
4 of 13
No
No
Scer\GLC7
3 of 13
No
No
Scer\PPG1
3 of 13
No
No
Scer\PPH3
3 of 13
No
No
Scer\SIT4
3 of 13
No
No
Scer\PPN2
2 of 13
No
No
Scer\PPQ1
2 of 13
No
No
Scer\PPT1
2 of 13
No
No
Scer\PPZ1
2 of 13
No
No
Scer\PPZ2
2 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (11)
Spom\ppb1
12 of 12
Yes
Yes
Spom\dis2
3 of 12
No
No
Spom\sds21
3 of 12
No
No
Spom\SPAC22H10.04
3 of 12
No
No
Spom\ppa1
2 of 12
No
No
Spom\ppa2
2 of 12
No
No
Spom\ppe1
2 of 12
No
No
Spom\pzh1
2 of 12
No
No
Spom\SPBC26H8.05c
2 of 12
No
No
Spom\SPBC3F6.01c
1 of 12
No
No
Spom\SPCC1840.07c
1 of 12
No
Yes
Escherichia coli (enterobacterium) (3)
Ecol\apaH
2 of 11
Yes
No
Ecol\pphA
2 of 11
Yes
No
Ecol\pphB
1 of 11
No
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Pp2B-14D. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (18)
CanA-14F
12 of 13
CanA1
11 of 13
CG11597
3 of 13
flw
3 of 13
mts
3 of 13
Pp1-13C
3 of 13
Pp1-87B
3 of 13
Pp1α-96A
3 of 13
Pp4-19C
3 of 13
PpD3
3 of 13
PpD5
3 of 13
PpD6
3 of 13
PpN58A
3 of 13
PpV
3 of 13
PpY-55A
3 of 13
Pp1-Y1
2 of 13
Pp1-Y2
2 of 13
rdgC
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 7 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PPP3CA; protein phosphatase 3 catalytic subunit alpha
13 of 14
PROTEIN PHOSPHATASE 3, CATALYTIC SUBUNIT, ALPHA ISOFORM; PPP3CA
 
PPP3CB; protein phosphatase 3 catalytic subunit beta
13 of 14
114106
       
      PPP3CC; protein phosphatase 3 catalytic subunit gamma
      13 of 14
      114107
          PPP1CA; protein phosphatase 1 catalytic subunit alpha
          3 of 14
          176875
               
              PPP1CB; protein phosphatase 1 catalytic subunit beta
              3 of 14
              600590
              PPP1CC; protein phosphatase 1 catalytic subunit gamma
              3 of 14
              176914
                   
                  PPP2CA; protein phosphatase 2 catalytic subunit alpha
                  3 of 14
                  176915
                    PPP2CB; protein phosphatase 2 catalytic subunit beta
                    3 of 14
                    176916
                        PPP4C; protein phosphatase 4 catalytic subunit
                        3 of 14
                        602035
                            PPP6C; protein phosphatase 6 catalytic subunit
                            3 of 14
                            612725
                                Functional Complementation Data
                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                Interactions
                                Summary of Physical Interactions
                                Summary of Genetic Interactions
                                Interaction Browsers
                                View in FlyBase Interactions Browser   View in MIST tool (external link)
                                Please look at the allele data for full details of the genetic interactions
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Pp2B-14D
                                suppressible
                                CanB2
                                (Lee et al., 2014, Takeo et al., 2010, Sullivan and Rubin, 2002)
                                Pp2B-14D
                                enhanceable
                                CanB
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                enhanceable
                                CE2-1
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                enhanceable
                                CE2-2
                                (Sullivan and Rubin, 2002)
                                CanB|Pp2B-14D
                                enhanceable
                                CE2-2
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                enhanceable
                                CE2-3
                                (Sullivan and Rubin, 2002)
                                CanB|Pp2B-14D
                                enhanceable
                                CE2-3
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                enhanceable
                                CE3-1
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                enhanceable
                                CE3-2
                                (Sullivan and Rubin, 2002)
                                CanB|Pp2B-14D
                                enhanceable
                                CE3-2
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                enhanceable
                                CE3-3
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                enhanceable
                                Crtc
                                (Wang et al., 2008)
                                Pp2B-14D
                                suppressible
                                Crtc
                                (Wang et al., 2008)
                                Pp2B-14D|CanB
                                suppressible
                                CS3-1
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                suppressible
                                CS3-1
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                suppressible
                                CS3-2
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D|CanB
                                suppressible
                                CS3-2
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                suppressible
                                CS3-4
                                (Sullivan and Rubin, 2002)
                                CanB|Pp2B-14D
                                enhanceable
                                Egfr
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                suppressible
                                galectin
                                (Lee et al., 2014)
                                Pp2B-14D
                                suppressible
                                Galk
                                (Lee et al., 2014)
                                Pp2B-14D
                                suppressible
                                gl
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                suppressible
                                Mef2
                                (Lee et al., 2014)
                                CanB|Pp2B-14D
                                enhanceable
                                pnt
                                (Sullivan and Rubin, 2002)
                                CanB|Pp2B-14D
                                enhanceable
                                Ras85D
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                suppressible
                                Ras85D
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D|CanB
                                suppressible
                                RasGAP1
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                suppressible
                                RasGAP1
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                suppressible
                                sgg
                                (Shaw and Chang, 2013)
                                Pp2B-14D|CanB
                                suppressible
                                sl
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                suppressible
                                sl
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                suppressible
                                sra
                                (Takeo et al., 2010, Takeo et al., 2006)
                                Pp2B-14D
                                enhanceable
                                sra
                                (Nakai et al., 2011, Takeo et al., 2010)
                                Pp2B-14D
                                suppressible
                                sty
                                (Lee et al., 2014, Sullivan and Rubin, 2002)
                                Pp2B-14D|CanB
                                suppressible
                                sty
                                (Sullivan and Rubin, 2002)
                                Pp2B-14D
                                enhanceable
                                sty
                                (Sullivan and Rubin, 2002)
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Acn
                                suppressible
                                Pp2B-14D
                                (Nandi et al., 2022)
                                sra
                                suppressible
                                Pp2B-14D
                                (Shaw and Chang, 2013, Nakai et al., 2011)
                                External Data
                                Subunit Structure (UniProtKB)
                                Interacts with sra in a complex that contains CanA-14F.
                                (UniProt, Q27889 )
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                DroID - A comprehensive database of gene and protein interactions.
                                MIST (genetic) - An integrated Molecular Interaction Database
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Pathways
                                Signaling Pathways (FlyBase)
                                Metabolic Pathways
                                FlyBase
                                External Links
                                External Data
                                Linkouts
                                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                Class of Gene
                                Genomic Location and Detailed Mapping Data
                                Chromosome (arm)
                                X
                                Recombination map
                                1-54
                                Cytogenetic map
                                14E1-14E3
                                Sequence location
                                FlyBase Computed Cytological Location
                                Cytogenetic map
                                Evidence for location
                                14E1-14E3
                                Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
                                Experimentally Determined Cytological Location
                                Cytogenetic map
                                Notes
                                References
                                14D-14D
                                (Hong, 1995.6.28)
                                14D1-14D4
                                (Brown, 1994.9.22)
                                14D1-14D4
                                (determined by in situ hybridisation)
                                (Brown et al., 1994)
                                Experimentally Determined Recombination Data
                                Location

                                1-54

                                (FlyBase, 2016)

                                1-55.5

                                (Comeron et al., 2012)

                                1-

                                (Hong, 1995.6.28)
                                Left of (cM)
                                Right of (cM)
                                Notes
                                Stocks and Reagents
                                Stocks (10)
                                Genomic Clones (9)
                                 

                                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                cDNA Clones (33)
                                 

                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                cDNA clones, fully sequenced
                                BDGP DGC clones
                                Other clones
                                Drosophila Genomics Resource Center cDNA clones

                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                cDNA Clones, End Sequenced (ESTs)
                                BDGP DGC clones
                                Other clones
                                RNAi and Array Information
                                Linkouts
                                DRSC - Results frm RNAi screens
                                Antibody Information
                                Laboratory Generated Antibodies
                                 
                                Commercially Available Antibodies
                                 
                                Cell Line Information
                                Publicly Available Cell Lines
                                 
                                  Other Stable Cell Lines
                                   
                                    Other Comments

                                    The region that includes para contains a complex of neurally expressed genes, Cnx14D, Arp14D, Pp2B-14D and Cap. These five genes may represent a functionally related group sharing some coordinate regulatory mechanism.

                                    (Hong and Ganetzky, 1996)
                                    Relationship to Other Genes
                                    Source for database merge of

                                    Source for merge of: Pp2B-14D PpD33

                                    (FlyBase, 1996-)
                                    Additional comments

                                    The Pp2B-14D gene may have been derived from a related phosphoprotein phosphatase gene by retroposition and subsequent tandem duplication.

                                    (Miskei et al., 2011)

                                    The Pp2B-14D gene may have been derived from the CanA1 gene by retroposition.

                                    (Bai et al., 2007, Langille and Clark, 2007)

                                    Source for merge of Pp2B-14D PpD33 was sequence comparison ( date:050803 ).

                                    (FlyBase, 1996-)
                                    Nomenclature History
                                    Source for database identify of
                                    Nomenclature comments
                                    Etymology
                                    Synonyms and Secondary IDs (27)
                                    Reported As
                                    Symbol Synonym
                                    CG9842
                                    (Neuert et al., 2017, Çiçek et al., 2016, Hosono et al., 2015, Kanamori et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Wheeler et al., 2004, Morrison et al., 2000, Verstreken and Bellen, 2000.9.4)
                                    CaN
                                    (Peng et al., 2021, Vonhoff and Keshishian, 2017)
                                    CaNA
                                    (Shaw and Chang, 2013)
                                    CanA
                                    (Lee et al., 2014)
                                    CanA-14D
                                    (Gualtieri et al., 2025)
                                    CanA14D
                                    CnA
                                    (Takeo et al., 2010)
                                    CnnA14D
                                    (Hong and Ganetzky, 1996, Hong, 1995.6.28, Hong, 1995.6.29)
                                    D33
                                    (Chen et al., 1992)
                                    DmPp2B-14D
                                    (Cohen et al., 2005)
                                    PP2B
                                    (Helps et al., 1998)
                                    PP2B 14D
                                    (Morrison et al., 2000, Cohen, 1997, Cohen, 1994.5.16)
                                    PP2B-14D
                                    (Ha et al., 2009)
                                    Pp12-14D
                                    (Whitfield, 2000.5.8)
                                    Pp2B
                                    (Dondi et al., 2024, Zarndt et al., 2017)
                                    Pp2B-14D
                                    (Ham et al., 2023, Armstrong and Frank, 2022, Chang et al., 2022, Pun et al., 2022, Deng et al., 2020, Weiss et al., 2019, Kweon et al., 2018, Hu et al., 2017.6.13, Neuert et al., 2017, Ota et al., 2017, Transgenic RNAi Project members, 2017-, John et al., 2016, Schwartz et al., 2016, Li and Dijkers, 2015, dos Santos, 2014, Lee et al., 2014, Singh et al., 2014, Sopko et al., 2014, Shaw and Chang, 2013, Japanese National Institute of Genetics, 2012.5.21, Takeo et al., 2012, Friedman et al., 2011, Miskei et al., 2011, Nakai et al., 2011, Tomita et al., 2011, Takeo et al., 2010, Ha et al., 2009, Wang et al., 2008, Bai et al., 2007, Bai et al., 2007, Dijkers and O'Farrell, 2007, Langille and Clark, 2007, Langille and Clark, 2007, Stuart et al., 2007, Takeo et al., 2006, Takeo et al., 2006, Stanyon et al., 2004, Wheeler et al., 2004)
                                    Pp2B-14D/CaN
                                    (Yin et al., 2013)
                                    Pp2B-14DF
                                    Pp2b-14D
                                    (Ray et al., 2016)
                                    PpD33
                                    calneur
                                    (Bodaleo and Gonzalez-Billault, 2016)
                                    canA
                                    (Sullivan and Rubin, 2002, Sullivan and Rubin, 2001, Sullivan and Rubin, 2001)
                                    Name Synonyms
                                    Calcineurin
                                    (Vonhoff and Keshishian, 2017, Dijkers and O'Farrell, 2007, Xu et al., 1998)
                                    Protein phosphatase 2B at 14D
                                    (John et al., 2016)
                                    Protein phosphatase D33
                                    calcineurin
                                    (Bodaleo and Gonzalez-Billault, 2016, Dijkers and O'Farrell, 2007, Montell, 1999)
                                    protein phosphatase from PCR fragment D33
                                    (Chen, 1993.1.7)
                                    Secondary FlyBase IDs
                                    • FBgn0005782
                                    • FBgn0005783
                                    • FBgn0015613
                                    Datasets (0)
                                    Study focus (0)
                                    Experimental Role
                                    Project
                                    Project Type
                                    Title
                                    Study result (0)
                                    Result
                                    Result Type
                                    Title
                                    External Crossreferences and Linkouts ( 58 )
                                    Sequence Crossreferences
                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                    Other crossreferences
                                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                    FlyMine - An integrated database for Drosophila genomics
                                    InterPro - A database of protein families, domains and functional sites
                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                    MARRVEL_MODEL - MARRVEL (model organism gene)
                                    Linkouts
                                    BioGRID - A database of protein and genetic interactions.
                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                    DroID - A comprehensive database of gene and protein interactions.
                                    DRSC - Results frm RNAi screens
                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                    Flygut - An atlas of the Drosophila adult midgut
                                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                    MIST (genetic) - An integrated Molecular Interaction Database
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                    References (112)