FB2026_02 , released June 18, 2026
Allele: Dmel\Pp2B-14DDN.UASp
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General Information
Symbol
Dmel\Pp2B-14DDN.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0246314
Feature type
allele
Associated gene
Dmel\Pp2B-14D
Associated Insertion(s)
Carried in Construct
P{UASp-Pp2B-14D.DN}
Key Links
Transgenic product class
missense_variant
(Takeo et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Takeo et al., 2010)
Mutagen
in vitro construct
(Takeo et al., 2010)
Progenitor genotype
Carried in construct
P{UASp-Pp2B-14D.DN}
Cytology
Description

UASp regulatory sequences drive expression of a H217Q mutant form of Pp2B-14D.

(Takeo et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Pp2B-14D
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  epilepsy
      modeled by zyd1
      (Weiss et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Co-expression of Pp2B-14DDN.Scer\UAS.P\T with Pp2B-14Dact.Scer\UAS driven by Scer\GAL4en-e16E suppresses the Pp2B-14Dact.Scer\UAS-induced wing phenotypes, whereas expression of Pp2B-14DDN.Scer\UAS.P\T alone does not affect wing morphology.

      Embryos derived from mothers expressing Pp2B-14DDN.Scer\UAS.P\T in the germ-line by Scer\GAL4nos.UTR.T:Hsim\VP16 exhibit semi-lethality. Cells in most of the early embryos of these mutants enter into mitotic stages.

      (Takeo et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Pp2B-14DDN.Scer\UAS.P\T under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 fails to rescue the meiotic defects in 97.3% of Pp2B-14DKO CanA-14FKO double mutant eggs.

      (Takeo et al., 2012)

      Heterozygosity for sraKO enhances the lethality resulting from the overexpression of Pp2B-14DDN.Scer\UAS.P\T in the female germ-line driven by Scer\GAL4nos.UTR.T:Hsim\VP16. Most of the mutant cells fail to complete meiosis. Defects in these eggs vary from oocyte to oocyte, but a large number of eggs lack a characteristic structure of polar bodies known as the rosette structure formed after two rounds of meiotic division.

      Co-expression of sraScer\UAS.cEa driven by Scer\GAL4nos.UTR.T:Hsim\VP16 suppresses the embryonic lethality resulting from the overexpression of Pp2B-14DDN.Scer\UAS.P\T in the female germ-line.

      (Takeo et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pp2B-14DDN.Scer\UAS.P\T
      Pp2B-14DDN.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (3)