FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GalkMB10638
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General Information
Symbol
Dmel\GalkMB10638
Species
D. melanogaster
Name
FlyBase ID
FBal0240027
Feature type
allele
Associated gene
Dmel\Galk
Associated Insertion(s)
Mi{ET1}GalkMB10638
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}GalkMB10638
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  cardiomyopathy
        modeled by Pp2B-14Dact.tin.C.EYFP
        (Lee et al., 2014)
        modeled by Pp2B-14Dact.UAS.EYFP
        (Lee et al., 2014)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        GalkMB10638/+ does not cause significant shortening of lifespan, cardiac enlargement or reduced fractional shortening in adult hearts.

        (Lee et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        GalkMB10638/Galk[+] is a suppressor of abnormal size | adult stage phenotype of Pp2B-14Dact.tin.C.EYFP

        (Lee et al., 2014)

        GalkMB10638/Galk[+] is a suppressor of short lived phenotype of Pp2B-14Dact.tin.C.EYFP

        (Lee et al., 2014)

        GalkMB10638/Galk[+] is a suppressor of abnormal size | adult stage phenotype of Pp2B-14Dact.UAS.EYFP, Scer\GAL4tin.CΔ4

        (Lee et al., 2014)

        GalkMB10638/Galk[+] is a suppressor | partially of visible phenotype of Pp2B-14Dact.UAS.EYFP, Scer\GAL4en-e16E

        (Lee et al., 2014)
        NOT Suppressor of
        Statement
        Reference

        GalkMB10638/Galk[+] is a non-suppressor of lethal - all die during P-stage phenotype of Pp2B-14Dact.UAS.EYFP, Scer\GAL4Mef2.PR

        (Lee et al., 2014)

        GalkMB10638/Galk[+] is a non-suppressor of abnormal size | dominant | adult stage phenotype of wupAhdp-2

        (Lee et al., 2014)
        Phenotype Manifest In
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        GalkMB10638/Galk[+] is a non-suppressor of adult heart phenotype of wupAhdp-2

        (Lee et al., 2014)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        GalkMB10638/+ rescues the shortened lifespan, cardiac enlargement and reduced fractional shortening phenotypes of flies expressing Pp2B-14Dact.tin.C.T:Avic\GFP-EYFP.

        GalkMB10638/+ rescues the increased heart wall thickness phenotype of flies expressing Pp2B-14Dact.Scer\UAS.T:Avic\GFP-EYFP under the control of Scer\GAL4tin.CΔ4.

        GalkMB10638/+ partially rescues the abnormal wing vein phenotypes of flies expressing Pp2B-14Dact.Scer\UAS.T:Avic\GFP-EYFP under the control of Scer\GAL4en-e16E.

        GalkMB10638/+ fails to rescue the lethality of flies expressing Pp2B-14Dact.Scer\UAS.T:Avic\GFP-EYFP under the control of Scer\GAL4Mef2.PR.

        GalkMB10638/+ fails to rescue the cardiac dilation and reduced fractional shortening phenotypes of wupAhdp-2/+ mutants.

        (Lee et al., 2014)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        CG5288MB10638
        (Bellen, 2009.10.19)
        GalkMB10638
        Name Synonyms
        Secondary FlyBase IDs
          References (2)