FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pp2B-14DAct.Δ.UAS
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General Information
Symbol
Dmel\Pp2B-14DAct.Δ.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0319768
Feature type
allele
Associated gene
Dmel\Pp2B-14D
Associated Insertion(s)
Carried in Construct
P{UAS-Pp2B-14D.Act.Δ}
Key Links
Transgenic product class
inframe_deletion
(Shaw and Chang, 2013)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Shaw and Chang, 2013)
Mutagen
in vitro construct
(Shaw and Chang, 2013)
Progenitor genotype
Carried in construct
P{UAS-Pp2B-14D.Act.Δ}
Cytology
Description

UAS regulatory sequences drive expression of a constitutively active form of Pp2B-14D that lacks its auto-inhibitory domain (most of the Cam binding domain is also deleted).

(Shaw and Chang, 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Pp2B-14D
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Alzheimer's disease
      modeled by Hsap\APP695.UAS.Tag:MYC
      (Shaw and Chang, 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Pp2B-14DAct.Δ.Scer\UAS exacerbates Syt1 aggregate accumulations at NMJ axons and restores locomotor behavior in Scer\GAL4elav.PU>Hsap\APP695.Scer\UAS.T:Hsap\MYC larvae. Co-expression of Pp2B-14DAct.Δ.Scer\UAS suppresses the ability of sraScer\UAS.T:Ivir\HA1 to protect against Scer\GAL4elav.PU>Hsap\APP695.Scer\UAS.T:Hsap\MYC induced larval axonal transport and locomotion defects. sgg1 suppresses the effect of Pp2B-14DAct.Δ.Scer\UAS exacerbating the aggregation in motor axons in the NMJ of Scer\GAL4elav.PU>Hsap\APP695.Scer\UAS.T:Hsap\MYC third instar larvae.

      (Shaw and Chang, 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CaNAct
      (Shaw and Chang, 2013)
      Pp2B-14DAct.Δ.Scer\UAS
      Pp2B-14DAct.Δ.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)