FlyBase Allele Report: Dmel\sgg[1]

General Information

Symbol

Dmel\sgg¹

Species

D. melanogaster

Name

FlyBase ID

FBal0015479

Feature type

allele

Associated gene

Dmel\sgg

Associated Insertion(s)

Carried in Construct

Also Known As

sgg^b12, l(1)zw3^b12, zw3^b12

Key Links

Allele class

hypomorphic allele - genetic evidence

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Bourouis et al., 1990)

hypomorphic allele - genetic evidence

(Ruel et al., 1993)

Mutagen

X ray

(Perrimon and Smouse, 1989)

Progenitor genotype

Caused by aberration

In(1)62b12

Cytology

Description

Caused by an inversion that breaks the transcription unit.

(Heitzler and Simpson, 1991)

Inversion breakpoint within sgg.

(Bourouis et al., 1990)

Associated with an inversion (undescribed).

(Siegfried et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{695.UAS.Tag:MYC}

(Shaw and Chang, 2013)

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

exacerbates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^UAS.cBa

(Tziortzouda et al., 2024)

modeled by Hsap\FUS^{R521G.UAS.cBa}

(Tziortzouda et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

external sensory organ precursor cell | somatic clone

(Heitzler and Simpson, 1991)

macrochaeta | ectopic | maternal effect | somatic clone

(Perrimon and Smouse, 1989)

macrochaeta | somatic clone

(Heitzler and Simpson, 1991)

wing | maternal effect | somatic clone

(Perrimon and Smouse, 1989)

wing hair | maternal effect | somatic clone

(Perrimon and Smouse, 1989)

Detailed Description

Statement

Reference

sgg¹ mutant third instar larvae display crawling defects: the larvae crawl more slowly and switch directions more frequently than wild-type controls.

(Jakubowski et al., 2012)

Most of the eggs derived from mothers carrying sgg¹ mutant germline clones are unable to complete meiosis. 86.4% of eggs show an anaphase I-arrested chromosome configuration. Metaphase I arrest appeared normal in the mature oocytes.

(Takeo et al., 2012)

Metaphase in hemizygous sgg¹ mutant male larval neuroblasts is delayed compared to wild type controls. The mitotic spindles are curved or bent and the metaphase plate of chromosomes is frequently shifted off-axis and near the cortex. However, many, if not all, of the cells with abnormalities are able to exit mitosis. Spindle microtubule structure is disrupted in sgg¹ mutant neuroblasts. Gaps are seen between microtubule bundles, rather than appearing centrally in the cell as is seen in wild type and overall intensity of microtubules is lower. Treatment with colchicine shows that the spindle assembly checkpoint is disrupted; 11.5% of sgg¹ mutant cells undergo premature sister chromatid separation in contrast to only 1.1% in wild type.

(Wojcik, 2008)

Mutant clones differentiate an excess of neural precursors, penetrance is incomplete so some epidermis remains between the bristles. Along the borders mutant bristles are found: sgg^- cells have a neural fate. Wild type precursors also form along the mosaic border.

(Heitzler and Simpson, 1991)

Germline clones survive, embryos die.

(Robbins, 1990)

Embryos lack most of ventral denticles.

(Siegfried et al., 1990)

Clonal analysis shows differentiation of large numbers of supernumerary bristles. The microchaetae and macrochaetae are found in their normal positions.

(Simpson, 1990)

Hemizygous progeny derived from heterozygous females die during early larval stages. Homozygous clones in the wing show homeotic transformation of hairs into bristles.

(Perrimon and Smouse, 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

sgg[+]/sgg¹ is an enhancer of visible | dominant phenotype of L²

(Singh et al., 2005)

Suppressor of

Statement

Reference

sgg[+]/sgg¹ is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

sgg[+]/sgg¹ is a suppressor of visible phenotype of Scer\GAL4^en-e16E, crol^UAS.cMa

(Mitchell et al., 2008)

sgg¹ is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

NOT Suppressor of

Statement

Reference

sgg¹ is a non-suppressor of abnormal memory | adult stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^c739

(Shaw et al., 2015)

Other

Statement

Reference

L^rev6-3, sgg[+]/sgg¹ has visible | dominant phenotype

(Singh et al., 2005)

L[+]/L^rev6-3, sgg¹ has visible phenotype

(Singh et al., 2005)

scrib^smi97B, sgg¹ has abnormal smell perception | dominant | female phenotype

(Anholt et al., 2003)

scrib[+]/scrib^smi97B, sgg¹ has abnormal smell perception | dominant | female phenotype

(Anholt et al., 2003)

Phenotype Manifest In

Suppressed by

Statement

Reference

sgg¹ has phenotype, suppressible by Rnor\Gsk3b^hs.PR

(Ruel et al., 1993)

NOT suppressed by

Statement

Reference

sgg¹ has phenotype, non-suppressible by Rnor\Gsk3a^hs.PR

(Ruel et al., 1993)

Enhancer of

Statement

Reference

sgg[+]/sgg¹ is an enhancer of eye phenotype of L²

(Singh et al., 2005)

Suppressor of

Statement

Reference

sgg¹ is a suppressor of axon | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Shaw and Chang, 2013)

sgg¹ is a suppressor of synaptic vesicle | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Shaw and Chang, 2013)

sgg¹ is a suppressor of axon | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Pp2B-14D^Act.Δ.UAS, Scer\GAL4^elav.PU

(Shaw and Chang, 2013)

sgg¹ is a suppressor of synaptic vesicle | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Pp2B-14D^Act.Δ.UAS, Scer\GAL4^elav.PU

(Shaw and Chang, 2013)

sgg[+]/sgg¹ is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

sgg[+]/sgg¹ is a suppressor of wing blade posterior compartment phenotype of Scer\GAL4^en-e16E, crol^UAS.cMa

(Mitchell et al., 2008)

sgg¹ is a suppressor of eye | anterior phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

sgg¹ is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

sgg¹ is a suppressor of ommatidium phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

Other

Statement

Reference

L^rev6-3, sgg[+]/sgg¹ has eye | ventral phenotype

(Singh et al., 2005)

L^rev6-3, sgg¹ has eye | ventral phenotype

(Singh et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The reduced size of the posterior compartment of the wing that is seen in animals expressing crol^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E is suppressed if they are also heterozygous sgg¹.

(Mitchell et al., 2008)

sgg¹/+ ; L²/+ flies show complete elimination of the eye field in 15% of cases. sgg¹/+ ; L^rev6-3/+ flies show loss of the ventral eye.

(Singh et al., 2005)

Xenogenetic Interactions

Statement

Reference

Introducing the sgg¹ mutation to flies expressing Hsap\APP^{695.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^c739 does not result in any rescue of short term memory defects.

(Shaw et al., 2015)

sgg¹ suppresses Syt1 aggregation in motor axons in the NMJ of Scer\GAL4^elav.PU>Hsap\APP^{695.Scer\UAS.T:Hsap\MYC} third instar larvae. sgg¹ suppresses the effect of Pp2B-14D^{Act.Δ.Scer\UAS} exacerbating the aggregation in motor axons in the NMJ of Scer\GAL4^elav.PU>Hsap\APP^{695.Scer\UAS.T:Hsap\MYC} third instar larvae.

(Shaw and Chang, 2013)

One copy of sgg¹ suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

(Ambegaokar and Jackson, 2011)

Rnor\Gsk-3α^hs.PR does not rescue sgg¹ at all, even under maximal heat shock. Rnor\Gsk-3β^hs.PR can partially rescue sgg¹.

(Ruel et al., 1993)

Complementation and Rescue Data

Rescued by

sgg¹ is rescued by sgg^UASp.cTa

(Takeo et al., 2012)

sgg¹ is rescued by sgg^A.hs

(Wojcik, 2008)

sgg¹ is rescued by sgg^mR10

(Ruel et al., 1993)

sgg¹ is rescued by sgg^hs.P

(Ruel et al., 1993)

Partially rescued by

sgg¹ is partially rescued by sgg^mR39

(Ruel et al., 1993)

Not rescued by

sgg¹ is not rescued by sgg^mR46

(Ruel et al., 1993)

Comments

Expression of sgg^{Scer\UAS.P\T.cTa} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} rescues the meiotic defects seen in sgg¹ mutant germline clones.

(Takeo et al., 2012)

Expression of sgg^A.hs rescues the curved spindle phenotype seen in the neuroblasts of hemizygous and homozygous sgg¹ mutant larvae.

(Wojcik, 2008)

sgg^mR10 rescues hemizygous males to viable and (poorly) fertile adults. sgg^mR39 rescues similarly but less efficiently, but sgg^mR46 does not rescue at all.

(Ruel et al., 1993)

Maximal heat shock of animals bearing sgg^hs.P rescues the sgg¹ mutant phenotype. Lower heat shock produces bristle hyperplasia expected of a hypomorphic allele, a phenotype similar to that of N^l1N-ts1 when exposed to the restrictive temperature during early pupal periods.

(Ruel et al., 1993)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4095

sgg¹/FM7a/Dp(1;2;Y)w⁺

Kyoto

107584

sgg¹/FM7a/Dp(1;2;Y)w⁺

Notes on Origin

Discoverer

Judd, 12th Feb. 1962.

Comments

Shows a maternal-zygotic interaction, demonstrated in males carrying mutant allele from heterozygous mother and variegating allele in the paternally derived Dp(1;4)mg.

(Robbins, 1990)

With respect to circadian period length, the following alleles can be ranked from longest to shortest: sgg^EP1576 = sgg^twkr/+ = sgg¹/sgg^EP1576 < sgg^twkr/sgg^twkr < sgg¹/sgg^twkr.

(Wolf et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

l(1)zw3^b12

(Robbins, 1990, Siegfried et al., 1990, Judd et al., 1972)

sgg¹

(Tziortzouda et al., 2024, Titus et al., 2023, Wang and Baker, 2019, Sato and Shibuya, 2018, Shaw et al., 2015, Sreedharan et al., 2015, Tan et al., 2014, Shaw and Chang, 2013, Jakubowski et al., 2012, Kuroda et al., 2012, Ambegaokar and Jackson, 2011, Popodi, 2010.10.8, Mitchell et al., 2008, Wolf et al., 2007, Khurana et al., 2006)

sgg^b12

(Takeo et al., 2012, Ruel et al., 1993, Ruel et al., 1993, Simpson et al., 1993, Simpson et al., 1992, Heitzler and Simpson, 1991, Bourouis et al., 1990)

zw3^b12

(Wojcik, 2008, Perrimon and Smouse, 1989, Robbins, 1983)

Name Synonyms

Secondary FlyBase IDs

References (34)

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