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General Information
Symbol
Zzzz\poly-PRPO-36.UAS
Species
a. artificial
Name
FlyBase ID
FBal0300906
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-PR36, PR36, PR-36
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of 36 pure repeats of a "protein-only" version of Zzzz\poly-PR using alternative codons to those found within the GGGGCC repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 2 )
 

FlyBase curator comment: "FTDALS1" is associated with G4C2 transcripts and dipeptide repeat proteins derived from human C9ORF72.

FlyBase curator comment: "FTDALS1" is associated with dipeptide repeat proteins derived from human C9ORF72.

Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Zzzz\poly-PRPO-36.UAS under the control of Scer\GAL4GMR.PU leads to presence of black necrotic tissue in the eye.

Adults expressing Zzzz\poly-PRPO-36.UAS under the control of Scer\GAL4Toll-6-D42 show loss of motor neurons in the antennal lobe. Adults expressing Zzzz\poly-GR36.UAS.EGFP under the control of Scer\GAL4elav-C155 also show a significant decrease in climbing ability, as compared to controls.

The expression of Zzzz\poly-GRPO-36.Scer\UAS leads to a severe rough eye phenotype (Scer\GAL4GMR.PF-driven expression) and to a moderate decrease in adult locomotor activity in climbing assays (Scer\GAL4da.G32-driven expression), as compared to controls.

The expression of Zzzz\poly-PRPO-36.UAS under the control of Scer\GAL4CCAP.PI leads a significant decrease in the axonal transport of both mitochondria and (NPY-positive) vesicles (i.e. significant decreases in anterograde and retrograde transport and reciprocal significant increase in the stationary fraction), in third instar larval motor neurons, as compared to controls.

Expression under the control of Scer\GAL4Toll-6-D42 leads to a significant decrease in larval and adult locomotion (in climbing and crawling assays, respectively), as compared to controls.

Expression of Zzzz\poly-PRPO-36.Scer\UAS using Scer\GAL4GMR.PU causes eye degeneration and lethality.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
NOT suppressed by
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The severe rough eye phenotype and the moderate decrease in adult locomotor induced by the expression of Zzzz\poly-PRPO-36.Scer\UAS, under the control of Scer\GAL4GMR.PF and Scer\GAL4da.G32, respectively, are not suppressed by the co-expression of SF2GD12097.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Zzzz\poly-PRPO-36.Scer\UAS
Zzzz\poly-PRPO-36.UAS
Name Synonyms
Secondary FlyBase IDs
    References (11)