FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene: Dmel\iav
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General Information
Symbol
Dmel\iav
Species
D. melanogaster
Name
inactive
Annotation Symbol
CG4536
Feature Type
FlyBase ID
FBgn0086693
Gene Model Status
Stock Availability
Gene Summary
inactive (iav) encodes a protein involved in the response to different stimuli such as startle, heat or sound. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)
Also Known As

TRPV

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
1-18
RefSeq locus
NC_004354 REGION:6813978..6818156
Sequence
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (29 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:wtrw; FB:FBgn0260005
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity
inferred from sequence or structural similarity with FLYBASE:pyx; FB:FBgn0035113
inferred from biological aspect of ancestor with PANTHER:PTN000061616
inferred from electronic annotation with InterPro:IPR005821, InterPro:IPR024862
Biological Process (20 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
involved_in response to heat
inferred from mutant phenotype
involved_in startle response
inferred from mutant phenotype
inferred from mutant phenotype
involved_in thermotaxis
inferred from mutant phenotype
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
non-traceable author statement
inferred from sequence or structural similarity
inferred from sequence or structural similarity with FLYBASE:pyx; FB:FBgn0035113
inferred from sequence or structural similarity
inferred from electronic annotation with InterPro:IPR005821
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
is_active_in plasma membrane
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with FLYBASE:pyx; FB:FBgn0035113
located_in membrane
inferred from electronic annotation with InterPro:IPR005821, InterPro:IPR024862
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000061616
Protein Family (UniProt)
-
Summaries
Gene Snapshot
inactive (iav) encodes a protein involved in the response to different stimuli such as startle, heat or sound. [Date last reviewed: 2019-08-01]
Gene Group (FlyBase)
TRANSIENT RECEPTOR POTENTIAL ION CHANNELS -
The Transient Receptor Potential (TRP) channel family are cation channels conserved from invertebrates to humans. TRP channels respond to diverse stimuli and are involved in a number of environmental sensory pathways. (Adapted from FBrf0220930 and FBrf0225477).
MECHANOSENSITIVE TRANSIENT RECEPTOR POTENTIAL ION CHANNELS -
The Transient Receptor Potential (TRP) ion channels are cation channels. Some members of the TRP family have been shown to be gated by mechanical stimulation (Adapted from FBrf0248531.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
iav: inactive (J.C. Hall)
iav1 noted (Kaplan, 1977) to be extremely inactive as adult, with normal external morphology; population of mutants remains quiet and spread out evenly in a container; will walk or fly when container disturbed, but settles into inactivity soon afterward. iav2 noted (Homyk and Sheppard, 1977) to be inactive and difficult to arouse for flight (and, when it does, seems to hover and fixate on objects); to jump and fly abnormally short distances; to exhibit slow running or climbing ability and optomotor response; to be debilitated after mechanical shock (especially in adults more than two weeks old). Gynandromorph analysis of iav2 adult behavioral impairments suggests primary focus could be neural (Homyk, 1977). Open-field activity tests of iav1 and iav2 (O'Dell and Burnet, 1988) showed both to exhibit reduced speed as well as amount of locomotion (the former meaning number of squares in the activity chambered visited/unit time, the latter the proportion of time spent moving); male activity levels higher than for females (also found for wild-type); lower than wildtype levels of activity at all ages between time of eclosion and approximately one-month; yet, unlike wild type, speed and amount of activity increase (in tests of iav2) in parallel between days 1 and 2 of adulthood (reaching a much lower than normal plateau). In tests of homozygous iav1 and iav2 females (with normal males), mating propensity reduced and courtship durations extended, though such females showed normal compositions of cuticular hydrocarbons and were highly attractive to courting males (O'Dell et al., 1989); mutant males with normal females exhibited slightly reduced mating success; mutant males crossed with mutant females had very low mating success rate. Lower than normal octopamine levels, especially in extracts from adult heads (O'Dell et al., 1987), with dopamine and norepinephrine levels apparently normal.
Summary (Interactive Fly)

transient receptor potential vanilloid channel - expressed in chordotonal neurons where it is involved in temperature preference - expressed in antenna were it is involved in hearing

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\iav for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9W3W0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0070969
3512
1123
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0070930
124.7
1123
5.98
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\iav using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.19

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
is_active_in plasma membrane
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{iav-GAL4.K}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{iav-GAL4.U}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{iav-GFP.597}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{iav-GFP.Cterm}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{iav-lexA.O}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{iav-QF.P}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: PBac{iav-GAL4.P}
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\iav in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of iav
Transgenic constructs containing regulatory region of iav
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (20)
8 of 14
Yes
No
1  
8 of 14
Yes
No
5 of 14
No
No
 
2  
5 of 14
No
No
5 of 14
No
No
6  
4 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
6  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
3  
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (19)
8 of 14
Yes
No
8 of 14
Yes
No
6 of 14
No
No
5 of 14
No
No
4 of 14
No
No
4 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Mus musculus (laboratory mouse) (19)
8 of 14
Yes
No
8 of 14
Yes
No
5 of 14
No
No
5 of 14
No
No
4 of 14
No
No
4 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (32)
6 of 13
Yes
No
5 of 13
No
No
5 of 13
No
No
5 of 13
No
No
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
Danio rerio (Zebrafish) (27)
8 of 14
Yes
No
8 of 14
Yes
No
6 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (10)
13 of 14
Yes
Yes
6 of 14
No
No
6 of 14
No
No
5 of 14
No
No
5 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (10)
12 of 12
Yes
Yes
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (7)
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
3 of 13
Yes
Yes
1 of 13
No
No
1 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:iav. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Drosophila melanogaster (Fruit fly) (5)
10 of 13
1 of 13
1 of 13
1 of 13
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Dmel gene
    Ortholog showing functional complementation
    Supporting References
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-18
    Cytogenetic map
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    6D3-6D3
    Limits computationally determined from genome sequence between P{EP}C3GEP1613 and P{EP}EP1388EP1388&P{EP}EP1573
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Determined by deficiency and duplication mapping.
    Experimentally Determined Recombination Data
    Location

    1-18.8

    Left of (cM)
    Right of (cM)
    Notes

    Based on mapping of iav1; iavhypoB-1 mapped to 1-20.7.

    Stocks and Reagents
    Stocks (13)
    Genomic Clones (12)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (4)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                iav is required in larvae for choosing the preferred temperature of 17.5[o]C over 14[o]C through avoidance of 14[o]C, and this behaviour is mediated by increases in the number of turns and turning angles at this lower temperature.

                Larvae simultaneously injected with dsRNAs against iav and nan show normal thermotactic behaviour.

                Mutant flies fail to become sensitized to cocaine.

                Mutants of iav show reductions in locomotor activity and exhibit poor mating success. Levels of the putative neurotransmitter octapamine are 10% that of wild type. In a courtship paradigm iav mutant males show an abnormal learning phenotype as a consequence of the octapamine deficiency.

                Lower than normal octopamine levels, especially in extracts from adult heads with dopamine and norepinephrine levels apparently normal.

                Allelism of iav1 to iavhypoB-1 shown by O'Dell and Burnet (1986) in open field tests of heterozygotes; they also note that both mutations are recessive.

                Relationship to Other Genes
                Source for database merge of

                Source for merge of: iav CG4536

                Additional comments

                Source for merge of: iav hypoB

                Nomenclature History
                Source for database identify of
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (12)
                Reported As
                Symbol Synonym
                hypoB
                iav
                (Flores-Iga et al., 2026, Mudunuri et al., 2026, Hunter and Leib, 2024, Sang and Lee, 2024, Spalthoff et al., 2023, Yamanouchi et al., 2023, Karagas et al., 2022, Li et al., 2022, Philyaw et al., 2022, Tian et al., 2022, Xiang et al., 2022, Fernández-Hernández et al., 2021, Li and Montell, 2021, Li et al., 2021, Pacheco et al., 2021, Chvilicek et al., 2020, Crava et al., 2020, Himmel and Cox, 2020, Jacobs and Sehgal, 2020, Jiang et al., 2020, Keder et al., 2020, Kitani-Morii and Noto, 2020, Kwon et al., 2020, Ping et al., 2020, Sun et al., 2020, Zhang et al., 2020, Zhang et al., 2020, He et al., 2019, Huang et al., 2019, Rimal and Lee, 2019, Tsai et al., 2019, Zhou et al., 2019, Clemens et al., 2018, Shin et al., 2018, Yan et al., 2018, Zanini et al., 2018, Bussmann and Storkebaum, 2017, Park et al., 2017, Versteven et al., 2017, Jeong et al., 2016, Akitake et al., 2015, Grotewiel and Bettinger, 2015, Karak et al., 2015, Nesterov et al., 2015, Menuz et al., 2014, Schneider and Levine, 2014, Wong et al., 2014, Garbaczewska et al., 2013, Matsuo and Kamikouchi, 2013, Shearin et al., 2013, Yan et al., 2013, Newton et al., 2012, Schneider et al., 2012, Senthilan et al., 2012, Tsubouchi et al., 2012, Cachero et al., 2011, Nadrowski et al., 2011, Petersen and Stowers, 2011, Kim et al., 2010, Kwon et al., 2010, Kwon et al., 2010, Lee et al., 2010, Wasbrough et al., 2010, Sun et al., 2009, Anaka et al., 2008, Kwon et al., 2008, Lee et al., 2008, Lee et al., 2008, Morey et al., 2008, Ruan and Wu, 2008, Laurençon et al., 2007, Lumpkin and Caterina, 2007, Roshina and Pasyukova, 2007, Gopfert et al., 2006, Carhan et al., 2005, Montell, 2005, Gong et al., 2004, Saraswati et al., 2004, McClung and Hirsh, 1999, O'Dell and Burnet, 1986)
                Secondary FlyBase IDs
                • FBgn0029904
                • FBgn0001246
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 27 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Flygut - An atlas of the Drosophila adult midgut
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                References (216)