FlyBase Allele Report: Dmel\iav[hypoB-1]

Mutant flies show significantly reduced speed and precision of movements during walking compared to controls. They have a reduced ability to successfully traverse gaps compared to wild type, even at short gap distances of 2.5mm.

(Akitake et al., 2015)

Mutant larvae show a normal behavioural response to gentle touch.

(Yan et al., 2013)

Cho neurons in mutant larvae exhibit a lower spontaneous firing rate and no increase in action potential firing in response to sound. Ca[2+] imaging also reveals no response of mutant Cho neurons to sound.

(Zhang et al., 2013)

Mutant flies exhibit the wild type avoidance of aristolochic acid in food choice assays.

(Kim et al., 2010)

Mutant adults show normal avoidance of 1% citronellal in a direct airborne repellent test (DART) assay.

(Kwon et al., 2010)

Mutant larvae move more slowly than wild-type larvae at both 14[o] and 17.5[o]C.

The normal preference of third instar larvae for 17.5[o]C over 14[o]C in a two-way choice test is eliminated in mutant larvae. This elimination of the preference for 17.5[o]C is seen regardless of the release site of the larvae (either in the middle of the plate at the boundary between the two temperature zones or at either end of the plate at the extreme end of either temperature zone). In contrast to wild type, in mutant larvae, the total number of turns and the average turning angles do not increase at 14[o]C. At 17.5[o]C, the mutant larvae show average turning angles similar to that of wild type.

The ability of mutant larvae to discriminate between 17.5[o] and 16[o]C and to discriminate between 14.5[o] and 16[o]C is eliminated, but they show normal preference for 17.5[o] over 12[o]C. The mutant larvae aso show normal selection of 17.5[o] over either 22 or 24[o]C.

The normal preference of third instar larvae for 17.5[o]C over 14[o]C in a two-way choice test is eliminated in iav^hypoB-1/Df(1)pod1^Δ17 larvae.

(Kwon et al., 2010)

Mutants retain a preference for 18[o]C (i.e. are thermotactic).

(Kwon et al., 2008)

The toxicity of cinnamic alcohol, eugenol, trans-anethole and 2-phenyethyl propionate is remarkably increased in mutants compared to wild type, although the toxicity of p-cymene, methyl salicylate and geraniol is not altered in mutants compared to wild type.

(Enan, 2005)

The survival of 1 day old mutant males and females is significantly decreased compared to wild-type flies when they are exposed to 4 hours heat stress (38^oC). 6 day old mutant females also show reduced survival under these conditions. Under normal conditions mutant flies have close to wild-type fertility. If the flies are subjected to heat stress on day 8 after eclosion, mutant flies show a drop in fertility on the day of the stress which returns to control levels on the following day, while wild-type flies show a drop in fertility virtually to zero on the day of the stress and this low level is seen for 3 consecutive days.

(Chentsova et al., 2002)

Mutant females are susceptible to p-Cresol.

(O'Dell, 1993)

Open-field activity tests of mutant adults showed reduced speed as well as amount of locomotion (the former meaning number of squares in the activity chambered visited/unit time, the latter the proportion of time spent moving); male activity levels higher than for females (also found for wild-type).

(O'Dell and Burnet, 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

iav^hypoB-1 has abnormal neuroanatomy | third instar larval stage | dominant phenotype, non-enhanceable by RyR¹⁶

(Wong et al., 2014)

iav^hypoB-1 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^VGlut1-OK371/SERCA^JF01948

(Wong et al., 2014)

iav^hypoB-1 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^VGlut1-OK371/CanA1^JF01871

(Wong et al., 2014)

iav^hypoB-1 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^VGlut1-OK371/Itpr^JF01957

(Wong et al., 2014)

Suppressed by

Statement

Reference

iav^hypoB-1 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by CanA1^{Δ.UAS.Tag:HA}/Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by sgg^DN.UAS.cUa/Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by RyR^{+tCH321-24D03}

(Wong et al., 2014)

iav^hypoB-1 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Scer\GAL4^VGlut1-OK371/Hsap\TRPV1^UAS.cUa

(Wong et al., 2014)

NOT suppressed by

Statement

Reference

iav^hypoB-1 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by nan^UAS.cUa/Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Hsap\TRPV4^UAS.cUa

(Wong et al., 2014)

iav^hypoB-1 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Bhal\NaChBac^UAS.EGFP

(Wong et al., 2014)

NOT Enhancer of

Statement

Reference

iav^hypoB-1 is a non-enhancer of abnormal neuroanatomy | third instar larval stage phenotype of CanA1^JF01871, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-enhancer of abnormal neuroanatomy | third instar larval stage | dominant phenotype of RyR¹⁶

(Wong et al., 2014)

iav^hypoB-1 is a non-enhancer of abnormal neuroanatomy | third instar larval stage phenotype of SERCA^JF01948, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Itpr^JF01957, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

NOT Suppressor of

Statement

Reference

iav^hypoB-1 is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of CanA1^JF01871, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of SERCA^JF01948, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-suppressor of abnormal neuroanatomy | dominant | third instar larval stage phenotype of RyR¹⁶

(Wong et al., 2014)

iav^hypoB-1 is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Itpr^JF01957, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

iav^hypoB-1 has NMJ bouton | third instar larval stage | decreased number phenotype, non-enhanceable by Scer\GAL4^VGlut1-OK371/Itpr^JF01957

(Wong et al., 2014)

iav^hypoB-1 has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^VGlut1-OK371/Itpr^JF01957

(Wong et al., 2014)

iav^hypoB-1 has NMJ bouton | third instar larval stage | decreased number phenotype, non-enhanceable by RyR¹⁶

(Wong et al., 2014)

iav^hypoB-1 has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-enhanceable by RyR¹⁶

(Wong et al., 2014)

iav^hypoB-1 has NMJ bouton | third instar larval stage | decreased number phenotype, non-enhanceable by Scer\GAL4^VGlut1-OK371/SERCA^JF01948

(Wong et al., 2014)

iav^hypoB-1 has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^VGlut1-OK371/SERCA^JF01948

(Wong et al., 2014)

iav^hypoB-1 has NMJ bouton | third instar larval stage | decreased number phenotype, non-enhanceable by Scer\GAL4^VGlut1-OK371/CanA1^JF01871

(Wong et al., 2014)

iav^hypoB-1 has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^VGlut1-OK371/CanA1^JF01871

(Wong et al., 2014)

Suppressed by

Statement

Reference

iav^hypoB-1 has NMJ bouton | third instar larval stage | decreased number phenotype, suppressible by Scer\GAL4^VGlut1-OK371/Hsap\TRPV1^UAS.cUa

(Wong et al., 2014)

iav^hypoB-1 has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, suppressible by Scer\GAL4^VGlut1-OK371/Hsap\TRPV1^UAS.cUa

(Wong et al., 2014)

iav^hypoB-1 has NMJ bouton | third instar larval stage | decreased number phenotype, suppressible by CanA1^{Δ.UAS.Tag:HA}/Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by CanA1^{Δ.UAS.Tag:HA}/Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, suppressible by CanA1^{Δ.UAS.Tag:HA}/Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 has microtubule | third instar larval stage phenotype, suppressible by CanA1^{Δ.UAS.Tag:HA}/Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 has NMJ bouton | third instar larval stage | decreased number phenotype, suppressible | partially by RyR^{+tCH321-24D03}

(Wong et al., 2014)

iav^hypoB-1 has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, suppressible | partially by RyR^{+tCH321-24D03}

(Wong et al., 2014)

iav^hypoB-1 has NMJ bouton | third instar larval stage | decreased number phenotype, suppressible by sgg^DN.UAS.cUa/Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, suppressible by sgg^DN.UAS.cUa/Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

NOT suppressed by

Statement

Reference

iav^hypoB-1 has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Hsap\TRPV4^UAS.cUa

(Wong et al., 2014)

iav^hypoB-1 has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Bhal\NaChBac^UAS.EGFP

(Wong et al., 2014)

iav^hypoB-1 has NMJ bouton | third instar larval stage | decreased number phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Bhal\NaChBac^UAS.EGFP

(Wong et al., 2014)

iav^hypoB-1 has NMJ bouton | third instar larval stage | decreased number phenotype, non-suppressible by nan^UAS.cUa/Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-suppressible by nan^UAS.cUa/Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 has NMJ bouton | third instar larval stage | decreased number phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Hsap\TRPV4^UAS.cUa

(Wong et al., 2014)

NOT Enhancer of

Statement

Reference

iav^hypoB-1 is a non-enhancer of NMJ bouton | third instar larval stage | decreased number phenotype of CanA1^JF01871, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-enhancer of NMJ bouton | third instar larval stage | decreased number phenotype of RyR¹⁶

(Wong et al., 2014)

iav^hypoB-1 is a non-enhancer of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of RyR¹⁶

(Wong et al., 2014)

iav^hypoB-1 is a non-enhancer of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of CanA1^JF01871, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-enhancer of NMJ bouton | third instar larval stage | decreased number phenotype of SERCA^JF01948, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-enhancer of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of SERCA^JF01948, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-enhancer of NMJ bouton | third instar larval stage | decreased number phenotype of Itpr^JF01957, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-enhancer of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of Itpr^JF01957, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

NOT Suppressor of

Statement

Reference

iav^hypoB-1 is a non-suppressor of NMJ bouton | third instar larval stage | decreased number phenotype of CanA1^JF01871, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-suppressor of NMJ bouton | third instar larval stage | decreased number phenotype of SERCA^JF01948, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-suppressor of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of SERCA^JF01948, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-suppressor of NMJ bouton | third instar larval stage | decreased number phenotype of RyR¹⁶

(Wong et al., 2014)

iav^hypoB-1 is a non-suppressor of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of CanA1^JF01871, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-suppressor of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of RyR¹⁶

(Wong et al., 2014)

iav^hypoB-1 is a non-suppressor of NMJ bouton | third instar larval stage | decreased number phenotype of Itpr^JF01957, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

iav^hypoB-1 is a non-suppressor of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of Itpr^JF01957, Scer\GAL4^VGlut1-OK371

(Wong et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

hypoC¹

(O'Dell and Burnet, 1986)

Rescued by

iav^hypoB-1 is rescued by iav^+t9.2

(Wong et al., 2014)

iav^hypoB-1 is rescued by iav^UAS.cKa/Scer\GAL4^Toll-6-D42

(Wong et al., 2014)

iav^hypoB-1 is rescued by Scer\GAL4^VGlut1-OK371/iav^UAS.cKa

(Wong et al., 2014)

iav^hypoB-1 is rescued by Scer\GAL4^iav.PK/iav^UAS.cKa

(Kwon et al., 2010)

iav^hypoB-1 is rescued by iav^UAS.cKa/Scer\GAL4^pain-GAL4

(Kwon et al., 2010)

iav^hypoB-1 is rescued by Scer\GAL4^nan.PK/iav^UAS.cKa

(Kwon et al., 2010)

Not rescued by

iav^hypoB-1 is not rescued by iav^UAS.cKa/Scer\GAL4^ato.3.6

(Wong et al., 2014)

iav^hypoB-1 is not rescued by Scer\GAL4^Mef2.PR/iav^UAS.cKa

(Wong et al., 2014)

Comments

Expression of iav^Scer\UAS.cKa under the control of one of Scer\GAL4^iav.PK, Scer\GAL4^pain-GAL4 or Scer\GAL4^nan.PK rescues the deficit in cool temperature discrimination (distinguishing between 17.5[o] and 14[o]C) of iav^hypoB-1 larvae.

(Kwon et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

101174

iav^hypoB-1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

hypo B¹

(O'Dell and Burnet, 1986, Homyk, 1977)

hypo^B

(Akitake et al., 2015)

hypoB¹

(Millburn, 2016.2.4, Homyk and Sheppard, 1977)

hypoactive-B¹

(Chentsova et al., 2002)

iav

(Enan, 2005)

iav¹

(Jeong et al., 2024, Zhao et al., 2024, Lee et al., 2023, Li and Montell, 2021, Li et al., 2021, Pacheco et al., 2021, Jiang et al., 2020, Sun et al., 2020, Chang et al., 2016, Millburn, 2016.2.4, Akitake et al., 2015, Wong et al., 2014, Yan et al., 2013, Zhang et al., 2013, Kim et al., 2010, Kwon et al., 2010, Kwon et al., 2010, Kwon et al., 2008, Roshina and Pasyukova, 2007)

iav²

(O'Dell, 1993, O'Dell and Burnet, 1988)

iav^hypoB-1

Name Synonyms

hypoactive-B1

(O'Dell, 1993, O'Dell and Burnet, 1988)

inactive2

(O'Dell and Burnet, 1988)

Secondary FlyBase IDs

References (26)

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