FlyBase Allele Report: Dmel\RyR[+tCH321-24D03]

General Information

Symbol

Dmel\RyR^{+tCH321-24D03}

Species

D. melanogaster

Name

FlyBase ID

FBal0284364

Feature type

allele

Associated gene

Dmel\RyR

Associated Insertion(s)

Carried in Construct

PBac{CH321-24D03}

Also Known As

RyR^24D03

Key Links

Transgenic product class

genomic_DNA

(Gao et al., 2013)

wild_type

(Gao et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Gao et al., 2013)

wild_type

(Gao et al., 2013)

Mutagen

in vitro construct

(Gao et al., 2013)

Progenitor genotype

Carried in construct

PBac{CH321-24D03}

Cytology

Description

Pacman clone CH321-24D03, which includes RyR.

(Gao et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

RyR

Encoded product / tool

RyR

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive

(Gao et al., 2013)

lethal

(Gao et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Animals carrying a single copy of RyR^{+tCH321-24D03} in a wild-type background show significant hypersensitivity to halothane compared to wild-type controls.

The addition of more than one copy of RyR^{+tCH321-24D03} in a wild-type background results in lethality.

(Gao et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

RyR^{+tCH321-24D03} is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of iav^hypoB-1

(Wong et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

RyR^{+tCH321-24D03} is a suppressor | partially of NMJ bouton | third instar larval stage | decreased number phenotype of iav^hypoB-1

(Wong et al., 2014)

RyR^{+tCH321-24D03} is a suppressor | partially of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of iav^hypoB-1

(Wong et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

RyR^{+tCH321-24D03} rescues RyR^GS21220

(Gao et al., 2013)

Comments

RyR^{+tCH321-24D03} rescues the halothane-resistant phenotype of RyR^GS21220/+ animals.

(Gao et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

RyR^{+tCH321-24D03}

RyR^24D03

(Wong et al., 2021, Wong et al., 2014)

dRyr^24D03

(Gao et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close