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FB2026_01
,
released March 12, 2026
Chk1, lemp, last empress, 1C, dChk1
kinase - Chk1 homolog - cell cycle checkpoint protein - grp replication-checkpoint mutations and DNA damage trigger a Chk2-dependent block at the Drosophila midblastula transition
Please see the JBrowse view of Dmel\grp for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Shares 5' UTR with upstream gene.
Gene model reviewed during 5.49
2.5, 2.0 (northern blot)
513 (aa)
Phosphorylated in a MEI-41/ATR dependent manner in response to DNA damage or the presence of unreplicated DNA.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\grp using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
grp transcripts are detected at high levels in the oocyte and in early embryogenesis (abundant and homogeneous in the first 12 nuclear cycles), decline until cellularization, and remain at low levels in late embryogenesis and in larval stages. Levels are higher in pupariation. The transcript is abundant in adult females but not in adult males.
Comment: 0-12 hr AEL
JBrowse - Visual display of RNA-Seq signals
View Dmel\grp in JBrowse2-52
2-50.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Expression is enriched in embryonic gonads.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities, chromosome alignment defects, lagging chromatids are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Transcription unit identified during molecular analysis of the her gene region.
Mutations in grp block the morphological and biochemical changes that accompany the midblastula transition (MBT), lead to a continuation of the maternal cell-cycle programme and disrupt DNA-replication checkpoint control of cell-cycle progression.
X-irradiation of grp derived embryos results in metaphase arrest even during the pre-migration and initial cortical nuclear cycles.
Deficiency analysis localized grp to 36A8-36D1.
Defined in a screen of maternal-effect lethal mutations that cause defects in nuclear movement, organization or morphology during the syncytial embryonic divisions.
Isolated from a genomic library using a Pka-C1 probe.
grp may encode a protein kinase.
Gene in D.melanogaster encoding product related (by sequence comparison) to the serine-threonine protein kinases of mammals. Isolated from Drosophila clones obtained with mammalian probes.
Source for merge of: grp lemp
Source for merge of: grp Pk36A
Source for merge of: grp l(2)k15102
Annotation CG4711 has been restored as a distinct annotation from CG17161 in release 3.2 of the genome annotation. In addition, release 3.2 annotations CG17161 (which corresponds to grp) and CG4711 encode alternative transcripts which share untranslated sequences, but encode non-overlapping open reading frames.
Release 1 annotation CG4711 (which was eliminated in release 2 of the genome annotation) has been merged with CG17161 in release 3 of the genome annotation.
